Radiation induces senescence and a bystander effect through metabolic alterations

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Autophagy in Premature Senescent Cells Is Activated via AMPK Pathway

(2012) Liujing Guo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Warburg effect: Insights from the past decade

(2012) Mohita Upadhyay et al.   PHARMACOLOGY & THERAPEUTICS

Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis

(2012) Pierre Sonveaux et al.   PLoS One

Lactate: A Metabolic Key Player in Cancer

(2011) F. Hirschhaeuser et al.   CANCER RESEARCH

Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF- B/IL-8 Pathway that Drives Tumor Angiogenesis

(2011) F. Vegran et al.   CANCER RESEARCH

Autophagy in the Cellular Energetic Balance

(2011) Rajat Singh et al.   Cell Metabolism

Tyrosine Phosphorylation of Lactate Dehydrogenase A Is Important for NADH/NAD+ Redox Homeostasis in Cancer Cells

(2011) J. Fan et al.   MOLECULAR AND CELLULAR BIOLOGY

NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

(2011) Claudio Mauro et al.   NATURE CELL BIOLOGY

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

PTTG1 Attenuates Drug-Induced Cellular Senescence

(2011) Yunguang Tong et al.   PLoS One

AMPK regulates metabolism and survival in response to ionizing radiation

(2011) Vanessa E. Zannella et al.   RADIOTHERAPY AND ONCOLOGY

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Depletion of Securin Induces Senescence After Irradiation and Enhances Radiosensitivity in Human Cancer Cells Regardless of Functional p53 Expression

(2010) Wen-Shu Chen et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Ionizing Radiation Activates AMP-Activated Kinase (AMPK): A Target for Radiosensitization of Human Cancer Cells

(2010) Toran Sanli et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Overexpression of the Pituitary Tumor Transforming Gene Induces p53-dependent Senescence through Activating DNA Damage Response Pathway in Normal Human Fibroblasts

(2010) Yi-Hsin Hsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer as a metabolic disease

(2010) Thomas N Seyfried et al.   Nutrition & Metabolism

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

Autophagy facilitates oncogene-induced senescence

(2009) Masako Narita et al.   Autophagy

Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation

(2009) Kelly M Kennedy et al.   Future Oncology

Cancer Cell Metabolism: Warburg and Beyond

(2008) Peggy P. Hsu et al.   CELL

AMP-activated protein kinase and human cancer: cancer metabolism revisited

(2008) F P Kuhajda   INTERNATIONAL JOURNAL OF OBESITY

p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation

(2008) Keiko Kawauchi et al.   NATURE CELL BIOLOGY

Etoposide Induces ATM-Dependent Mitochondrial Biogenesis through AMPK Activation

(2008) Xuan Fu et al.   PLoS One