AMPK Activation Prevents and Reverses Drug-Induced Mitochondrial and Hepatocyte Injury by Promoting Mitochondrial Fusion and Function

Mechanisms of Acetaminophen Hepatotoxicity: Do We Need JNK for Cell Death?

(2016) Hartmut Jaeschke   GASTROENTEROLOGY

c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src

(2016) Sanda Win et al.   HEPATOLOGY

Adverse effects of anti-tuberculosis drugs on HepG2 cell bioenergetics

(2016) E Elmorsy et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

(2016) E. Q. Toyama et al.   SCIENCE

The three ‘P’s of mitophagy: PARKIN, PINK1, and post-translational modifications

(2015) Thomas M. Durcan et al.   GENES & DEVELOPMENT

AICAR and Metformin Exert AMPK-dependent Effects on INS-1E Pancreatic β-cell Apoptosis via Differential Downstream Mechanisms

(2015) Yu-Lu Dai et al.   International Journal of Biological Sciences

Sirtuin 3–dependent mitochondrial dynamic improvements protect against acute kidney injury

(2015) Marina Morigi et al.   JOURNAL OF CLINICAL INVESTIGATION

Lysosomal Cholesterol Accumulation Sensitizes To Acetaminophen Hepatotoxicity by Impairing Mitophagy

(2015) Anna Baulies et al.   Scientific Reports

The unique polarity phenotype of hepatocytes

(2014) Anne Müsch   EXPERIMENTAL CELL RESEARCH

Metformin Impairs Mitochondrial Function in Skeletal Muscle of Both Lean and Diabetic Rats in a Dose-Dependent Manner

(2014) Bart Wessels et al.   PLoS One

A perspective on the epidemiology of acetaminophen exposure and toxicity in the United States

(2014) Marissa Blieden et al.   Expert Review of Clinical Pharmacology

New insights into the function and regulation of mitochondrial fission

(2013) Hidenori Otera et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mechanisms of Drug-induced Liver Injury

(2013) Liyun Yuan et al.   Clinics in Liver Disease

Protein kinase C (PKC) participates in acetaminophen hepatotoxicity through c-jun-N-terminal kinase (JNK)-dependent and -independent signaling pathways

(2013) Behnam Saberi et al.   HEPATOLOGY

Pharmacological approaches to restore mitochondrial function

(2013) Pénélope A. Andreux et al.   NATURE REVIEWS DRUG DISCOVERY

Coordinated elevation of mitochondrial oxidative phosphorylation and autophagy help drive hepatocyte polarization

(2013) D. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria

(2013) Derick Han et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Autophagy and mitophagy in cellular damage control

(2013) Jianhua Zhang   Redox Biology

Targeting autophagy for drug-induced hepatotoxicity

(2012) Hong-Min Ni et al.   Autophagy

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

Drug-Induced Liver Disease

(2012) Timothy J. Davern   Clinics in Liver Disease

A Review of Acetaminophen Poisoning

(2012) Michael J. Hodgman et al.   CRITICAL CARE CLINICS

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

(2012) Mitchell R. McGill et al.   JOURNAL OF CLINICAL INVESTIGATION

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health

(2011) David C. Chan   Annual Review of Genetics

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

New Insights in Drug-Induced Mitochondrial Toxicity

(2011) Sashi Nadanaciva et al.   CURRENT PHARMACEUTICAL DESIGN

Central role of mitochondria in drug-induced liver injury

(2011) Dominique Pessayre et al.   DRUG METABOLISM REVIEWS

Compromising mitochondrial function with the antiretroviral drug efavirenz induces cell survival-promoting autophagy

(2011) Nadezda Apostolova et al.   HEPATOLOGY

Activation of autophagy protects against acetaminophen-induced hepatotoxicity

(2011) Hong-Min Ni et al.   HEPATOLOGY

Loss of autophagy promotes murine acetaminophen hepatotoxicity

(2011) Yuki Igusa et al.   JOURNAL OF GASTROENTEROLOGY

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

Bile acid stimulates hepatocyte polarization through a cAMP-Epac-MEK-LKB1-AMPK pathway

(2011) D. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AICAR inhibits cancer cell growth and triggers cell-type distinct effects on OXPHOS biogenesis, oxidative stress and Akt activation

(2010) Caroline Jose et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Sandwich-cultured hepatocytes: anin vitromodel to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity

(2010) Brandon Swift* et al.   DRUG METABOLISM REVIEWS

Regulation of bile canalicular network formation and maintenance by AMP-activated protein kinase and LKB1

(2010) D. Fu et al.   JOURNAL OF CELL SCIENCE

Mechanisms of Pathogenesis in Drug Hepatotoxicity Putting the Stress on Mitochondria

(2010) D. P. Jones et al.   MOLECULAR INTERVENTIONS

Eaten alive: a history of macroautophagy

(2010) Zhifen Yang et al.   NATURE CELL BIOLOGY

Mitochondrial fusion and fission in cell life and death

(2010) Benedikt Westermann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Oxygen Tension Modulates Acetaminophen-Induced Mitochondrial Oxidant Stress and Cell Injury in Cultured Hepatocytes

(2010) Hui-Min Yan et al.   TOXICOLOGICAL SCIENCES

Current Concepts of Mechanisms in Drug-Induced Hepatotoxicity

(2009) Stefan Russmann et al.   CURRENT MEDICINAL CHEMISTRY

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

AM251 suppresses the viability of HepG2 cells through the AMPK (AMP-activated protein kinase)–JNK (c-Jun N-terminal kinase)–ATF3 (activating transcription factor 3) pathway

(2008) Yun Mi Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

A Chemical Inhibitor of DRP1 Uncouples Mitochondrial Fission and Apoptosis

(2008) Atsushi Tanaka et al.   MOLECULAR CELL

Interspecies differences in acetaminophen sensitivity of human, rat, and mouse primary hepatocytes

(2008) Katalin Jemnitz et al.   TOXICOLOGY IN VITRO