Curcumin synergizes with 5-fluorouracil by impairing AMPK/ULK1-dependent autophagy, AKT activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice

Curcumin induces apoptotic cell death and protective autophagy in human gastric cancer cells

(2017) Wei Li et al.   ONCOLOGY REPORTS

Resistance and tolerance defenses in cancer: Lessons from infectious diseases

(2017) Sheila Rao et al.   SEMINARS IN IMMUNOLOGY

JNK pathway mediates curcumin-induced apoptosis and autophagy in osteosarcoma MG63 cells

(2017) Yaowu Zhang et al.   Experimental and Therapeutic Medicine

Curcumin sensitizes human gastric cancer cells to 5-fluorouracil through inhibition of the NFκB survival-signaling pathway

(2016) Yanting Kang et al.   OncoTargets and Therapy

In situ Proteomic Profiling of Curcumin Targets in HCT116 Colon Cancer Cell Line

(2016) Jigang Wang et al.   Scientific Reports

MiR-22 regulates 5-FU sensitivity by inhibiting autophagy and promoting apoptosis in colorectal cancer cells

(2015) Honghe Zhang et al.   CANCER LETTERS

Curcumin inhibits cancer stem cell phenotypes in ex vivo models of colorectal liver metastases, and is clinically safe and tolerable in combination with FOLFOX chemotherapy

(2015) Mark I. James et al.   CANCER LETTERS

Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancer

(2015) Shusuke Toden et al.   CARCINOGENESIS

Curcumin induces autophagy, inhibits proliferation and invasion by downregulating AKT/mTOR signaling pathway in human melanoma cells

(2015) GUANGMING ZHAO et al.   ONCOLOGY REPORTS

Autophagy: An emerging target for cancer therapy

(2014) Maria Høyer-Hansen et al.   Autophagy

Autophagy is required for G1/G0quiescence in response to nitrogen starvation inSaccharomyces cerevisiae

(2014) Zhenyi An et al.   Autophagy

Autophagy promotes resistance to photodynamic therapy-induced apoptosis selectively in colorectal cancer stem-like cells

(2014) Ming-Feng Wei et al.   Autophagy

Combined autophagy and proteasome inhibition

(2014) Dan T Vogl et al.   Autophagy

Induction of autophagy counteracts the anticancer effect of cisplatin in human esophageal cancer cells with acquired drug resistance

(2014) Le Yu et al.   CANCER LETTERS

Cancer statistics, 2013

(2013) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Curcumin Targets Breast Cancer Stem-like Cells with Microtentacles That Persist in Mammospheres and Promote Reattachment

(2013) M. S. Charpentier et al.   CANCER RESEARCH

Development of Therapeutic Combinations Targeting Major Cancer Signaling Pathways

(2013) Timothy A. Yap et al.   JOURNAL OF CLINICAL ONCOLOGY

Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1

(2013) Jacob M. Gump et al.   NATURE CELL BIOLOGY

ULK1 targets Beclin-1 in autophagy

(2013) Volodymyr Y. Nazarko et al.   NATURE CELL BIOLOGY

Emerging regulation and functions of autophagy

(2013) Patricia Boya et al.   NATURE CELL BIOLOGY

Oxidative Stress Induced by Curcumin Promotes the Death of Cutaneous T-cell Lymphoma (HuT-78) by Disrupting the Function of Several Molecular Targets

(2012) M. A. Khan et al.   MOLECULAR CANCER THERAPEUTICS

Recurrent R-spondin fusions in colon cancer

(2012) Somasekar Seshagiri et al.   NATURE

Autophagy and cancer cell metabolism

(2012) Fred Lozy et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Curcumin enhanced antiproliferative effect of mitomycin C in human breast cancer MCF-7 cells in vitro and in vivo

(2011) Qian-mei Zhou et al.   ACTA PHARMACOLOGICA SINICA

AMPK-Dependent Phosphorylation of ULK1 Induces Autophagy

(2011) Mantong Zhao et al.   Cell Metabolism

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Autophagy and apoptosis: what is the connection?

(2011) Jacob M. Gump et al.   TRENDS IN CELL BIOLOGY

Curcumin Enhances the Effect of Cisplatin in Suppression of Head and Neck Squamous Cell Carcinoma via Inhibition of IKK  Protein of the NF B Pathway

(2010) V. M. Duarte et al.   MOLECULAR CANCER THERAPEUTICS

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Curcumin―The Paradigm of a Multi-Target Natural Compound with Applications in Cancer Prevention and Treatment

(2010) Marie-Hélène Teiten et al.   Toxins

Inhibition of Autophagy by 3-MA Enhances the Effect of 5-FU-Induced Apoptosis in Colon Cancer Cells

(2009) Jie Li et al.   ANNALS OF SURGICAL ONCOLOGY

In vivo activity of novel capecitabine regimens alone and with bevacizumab and oxaliplatin in colorectal cancer xenograft models

(2009) K. Kolinsky et al.   MOLECULAR CANCER THERAPEUTICS

Curcumin Sensitizes Human Colorectal Cancer Xenografts in Nude Mice to  -Radiation by Targeting Nuclear Factor- B-Regulated Gene Products

(2008) A. B. Kunnumakkara et al.   CLINICAL CANCER RESEARCH

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE