LKB1 reduces ROS-mediated cell damage via activation of p38

The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging

(2016) C-C Hsieh et al.   Aging-US

Activity of CEP-9722, a poly (ADP-ribose) polymerase inhibitor, in urothelial carcinoma correlates inversely with homologous recombination repair response to DNA damage

(2014) Weiguo Jian et al.   ANTI-CANCER DRUGS

Targeting the LKB1 Tumor Suppressor

(2014) Rui-Xun Zhao et al.   CURRENT DRUG TARGETS

LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin

(2013) David B. Shackelford et al.   CANCER CELL

p53 regulates a non-apoptotic death induced by ROS

(2013) J Montero et al.   CELL DEATH AND DIFFERENTIATION

Possible involvement of LKB1-AMPK signaling in non-homologous end joining

(2013) A Ui et al.   ONCOGENE

Piperlongumine induces autophagy by targeting p38 signaling

(2013) Y Wang et al.   Cell Death & Disease

AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo

(2012) Brandon Faubert et al.   Cell Metabolism

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

Metformin impairs the growth of liver kinase B1-intact cervical cancer cells

(2012) Xuxian Xiao et al.   GYNECOLOGIC ONCOLOGY

Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs

(2012) D. J. Adams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p38α Mediates Cell Survival in Response to Oxidative Stress via Induction of Antioxidant Genes

(2011) Álvaro Gutiérrez-Uzquiza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

Altered LKB1/CREB-regulated transcription co-activator (CRTC) signaling axis promotes esophageal cancer cell migration and invasion

(2011) Y Gu et al.   ONCOGENE

Mechanisms and functions of p38 MAPK signalling

(2010) Ana Cuadrado et al.   BIOCHEMICAL JOURNAL

Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells

(2010) Daisuke Nakada et al.   NATURE

The Lkb1 metabolic sensor maintains haematopoietic stem cell survival

(2010) Sushma Gurumurthy et al.   NATURE

Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells

(2010) Boyi Gan et al.   NATURE

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

(2010) A. Alexander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene

(2009) Ji Luo et al.   CELL

Activation of the AMPK-FOXO3 Pathway Reduces Fatty Acid-Induced Increase in Intracellular Reactive Oxygen Species by Upregulating Thioredoxin

(2009) X.-N. Li et al.   DIABETES

Serine 209 resides within a putative p38(MAPK) consensus motif and regulates monoamine oxidase-A activity

(2009) Xia Cao et al.   JOURNAL OF NEUROCHEMISTRY

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Somatic LKB1 Mutations Promote Cervical Cancer Progression

(2009) Shana N. Wingo et al.   PLoS One

The Tumor Suppressor LKB1 Regulates Lung Cancer Cell Polarity by Mediating cdc42 Recruitment and Activity

(2008) S. Zhang et al.   CANCER RESEARCH