Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs

Celastrol decreases specificity proteins (Sp) and fibroblast growth factor receptor-3 (FGFR3) in bladder cancer cells

(2012) Gayathri Chadalapaka et al.   CARCINOGENESIS

Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors

(2011) Sudhakar Chintharlapalli et al.   BMC CANCER

Oncogene addiction as a foundational rationale for targeted anti-cancer therapy: promises and perils

(2011) Davide Torti et al.   EMBO Molecular Medicine

Curcumin Induces Downregulation of E2F4 Expression and Apoptotic Cell Death in HCT116 Human Colon Cancer Cells; Involvement of Reactive Oxygen Species

(2011) Kyung-Chan Kim et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Inhibition of pituitary tumor-transforming gene-1 in thyroid cancer cells by drugs that decrease specificity proteins

(2011) Sudhakar Chintharlapalli et al.   MOLECULAR CARCINOGENESIS

Pharmacologic Doses of Ascorbic Acid Repress Specificity Protein (Sp) Transcription Factors and Sp-Regulated Genes in Colon Cancer Cells

(2011) Satya S. Pathi et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer

(2011) K Kim et al.   ONCOGENE

Synthesis and cytotoxic potential of heterocyclic cyclohexanone analogues of curcumin

(2010) Babasaheb Yadav et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals

(2010) Subash C. Gupta et al.   CANCER AND METASTASIS REVIEWS

Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth

(2010) Indira Jutooru et al.   EXPERIMENTAL CELL RESEARCH

Inhibition of NFκB and Pancreatic Cancer Cell and Tumor Growth by Curcumin Is Dependent on Specificity Protein Down-regulation

(2010) Indira Jutooru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GT-094, a NO-NSAID, Inhibits Colon Cancer Cell Growth by Activation of a Reactive Oxygen Species-MicroRNA-27a: ZBTB10-Specificity Protein Pathway

(2010) S. S. Pathi et al.   MOLECULAR CANCER RESEARCH

Drugs that Target Specificity Proteins Downregulate Epidermal Growth Factor Receptor in Bladder Cancer Cells

(2010) Gayathri Chadalapaka et al.   MOLECULAR CANCER RESEARCH

Methyl 2-Cyano-3,12-dioxooleana-1,9-dien-28-oate Decreases Specificity Protein Transcription Factors and Inhibits Pancreatic Tumor Growth: Role of MicroRNA-27a

(2010) I. Jutooru et al.   MOLECULAR PHARMACOLOGY

Curcumin-Induced Apoptosis in PC3 Prostate Carcinoma Cells Is Caspase-Independent and Involves Cellular Ceramide Accumulation and Damage to Mitochondria

(2010) Ashley L. Hilchie et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Tolfenamic acid inhibits esophageal cancer through repression of specificity proteins and c-Met

(2009) S. Papineni et al.   CARCINOGENESIS

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model

(2009) Ajaikumar B. Kunnumakkara et al.   INTERNATIONAL JOURNAL OF CANCER

Curcumin Modulates the Radiosensitivity of Colorectal Cancer Cells by Suppressing Constitutive and Inducible NF-κB Activity

(2009) Santosh K. Sandur et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Mechanisms for the activity of heterocyclic cyclohexanone curcumin derivatives in estrogen receptor negative human breast cancer cell lines

(2009) Tiffany J. Somers-Edgar et al.   INVESTIGATIONAL NEW DRUGS

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Curcumin Inhibits the Proteasome Activity in Human Colon Cancer Cells In vitro and In vivo

(2008) V. Milacic et al.   CANCER RESEARCH

Curcumin Decreases Specificity Protein Expression in Bladder Cancer Cells

(2008) G. Chadalapaka et al.   CANCER RESEARCH

Diphenyl Difluoroketone: A Curcumin Derivative with Potent In vivo Anticancer Activity

(2008) D. Subramaniam et al.   CANCER RESEARCH

Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer

(2008) N. Dhillon et al.   CLINICAL CANCER RESEARCH

Rapid reactive oxygen species (ROS) generation induced by curcumin leads to caspase-dependent and -independent apoptosis in L929 cells

(2008) Faisal Thayyullathil et al.   FREE RADICAL BIOLOGY AND MEDICINE