NRF2 addiction in cancer cells

Simultaneous K-ras activation and Keap1 deletion cause atrophy of pancreatic parenchyma

(2018) Shin Hamada et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation

(2017) Kouhei Tsuchida et al.   FREE RADICAL BIOLOGY AND MEDICINE

Systemic Activation of NRF2 Alleviates Lethal Autoimmune Inflammation in Scurfy Mice

(2017) Takuma Suzuki et al.   MOLECULAR AND CELLULAR BIOLOGY

NRF2 Activation Impairs Quiescence and Bone Marrow Reconstitution Capacity of Hematopoietic Stem Cells

(2017) Shohei Murakami et al.   MOLECULAR AND CELLULAR BIOLOGY

IL-11 contribution to tumorigenesis in an NRF2 addiction cancer model

(2017) H Kitamura et al.   ONCOGENE

Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus

(2017) Takafumi Suzuki et al.   Nature Communications

Keap1/Nrf2 pathway in kidney cancer: frequent methylation of KEAP1 gene promoter in clear renal cell carcinoma

(2017) Federico Pio Fabrizio et al.   Oncotarget

Enhanced Degradation of Misfolded Proteins Promotes Tumorigenesis

(2017) Liang Chen et al.   Cell Reports

Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis

(2017) Z Fan et al.   Oncogenesis

NRF2 Intensifies Host Defense Systems to Prevent Lung Carcinogenesis, but After Tumor Initiation Accelerates Malignant Cell Growth

(2016) H. Satoh et al.   CANCER RESEARCH

NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer

(2016) Iok In Christine Chio et al.   CELL

Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer

(2016) Evan C. Lien et al.   NATURE CELL BIOLOGY

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

(2016) Eri H. Kobayashi et al.   Nature Communications

Role of KEAP1 / NRF2 and TP53 Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance

(2016) Youngtae Jeong et al.   Cancer Discovery

NRF2 and glutathione are key resistance mediators to temozolomide in glioma and melanoma cells

(2016) Clarissa Ribeiro Reily Rocha et al.   Oncotarget

Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers

(2016) Leonard D. Goldstein et al.   Cell Reports

Clinical implication of Keap1 and phosphorylated Nrf2 expression in hepatocellular carcinoma

(2016) Jiang Chen et al.   Cancer Medicine

NRF2 Is a Key Target for Prevention of Noise-Induced Hearing Loss by Reducing Oxidative Damage of Cochlea

(2016) Yohei Honkura et al.   Scientific Reports

Clinicopathological significance of nuclear factor (erythroid-2)-related factor 2 (Nrf2) expression in gastric cancer

(2015) Yota Kawasaki et al.   BMC CANCER

Nrf2 is a potential prognostic marker and promotes proliferation and invasion in human hepatocellular carcinoma

(2015) Mingxin Zhang et al.   BMC CANCER

TGF-β Promotes Heterogeneity and Drug Resistance in Squamous Cell Carcinoma

(2015) Naoki Oshimori et al.   CELL

Keap1 expression has independent prognostic value in pancreatic adenocarcinomas

(2015) Joel Isohookana et al.   Diagnostic Pathology

Impact of nuclear factor erythroid-derived 2–like 2 and p62/sequestosome expression on prognosis of patients with gliomas

(2015) Mingfei Zhao et al.   HUMAN PATHOLOGY

NRF2 regulates serine biosynthesis in non–small cell lung cancer

(2015) Gina M DeNicola et al.   NATURE GENETICS

Functional Role of NRF2 in Cervical Carcinogenesis

(2015) Jun-Qi Ma et al.   PLoS One

NRF2 Mutation Confers Malignant Potential and Resistance to Chemoradiation Therapy in Advanced Esophageal Squamous Cancer

(2015) Tatsuhiro Shibata et al.   NEOPLASIA

Nrf2 is Useful for Predicting the Effect of Chemoradiation Therapy on Esophageal Squamous Cell Carcinoma

(2014) Yota Kawasaki et al.   ANNALS OF SURGICAL ONCOLOGY

Nrf2 Overexpression Predicts Prognosis and 5-FU Resistance in Gastric Cancer

(2014) Xiu-Feng Hu et al.   Asian Pacific Journal of Cancer Prevention

Myeloid Lineage-Specific Deletion of Antioxidant System Enhances Tumor Metastasis

(2014) K. Hiramoto et al.   Cancer Prevention Research

Oncogenic KRAS Confers Chemoresistance by Upregulating NRF2

(2014) S. Tao et al.   CANCER RESEARCH

Disruption of KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex components by multiple genetic mechanisms: Association with poor prognosis in head and neck cancer

(2014) Victor D. Martinez et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

NF-E2-related factor 2 promotes compensatory liver hypertrophy after portal vein branch ligation in mice

(2014) Keiichi Shirasaki et al.   HEPATOLOGY

Activation of the NRF2 pathway and its impact on the prognosis of anaplastic glioma patients

(2014) Masayuki Kanamori et al.   NEURO-ONCOLOGY

The Nrf2 transcription factor contributes to resistance to cisplatin in bladder cancer

(2014) Annette Hayden et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Nrf2 is required to maintain the self-renewal of glioma stem cells

(2013) Jianhong Zhu et al.   BMC CANCER

Nrf2 Prevents Initiation but Accelerates Progression through the Kras Signaling Pathway during Lung Carcinogenesis

(2013) Hironori Satoh et al.   CANCER RESEARCH

NRF2 immunolocalization in human breast cancer patients as a prognostic factor

(2013) Yoshiaki Onodera et al.   ENDOCRINE-RELATED CANCER

Nrf2 Enhances Cholangiocyte Expansion in Pten-Deficient Livers

(2013) Keiko Taguchi et al.   MOLECULAR AND CELLULAR BIOLOGY

Kinetic, Thermodynamic, and Structural Characterizations of the Association between Nrf2-DLGex Degron and Keap1

(2013) Toshiaki Fukutomi et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulatory Nexus of Synthesis and Degradation Deciphers Cellular Nrf2 Expression Levels

(2013) T. Suzuki et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

Knockdown of NF-E2-related factor 2 inhibits the proliferation and growth of U251MG human glioma cells in a mouse xenograft model

(2013) XIANG-JUN JI et al.   ONCOLOGY REPORTS

Nuclear Nrf2 expression is related to a poor survival in pancreatic adenocarcinoma

(2013) Y. Soini et al.   PATHOLOGY RESEARCH AND PRACTICE

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

Accumulation of p62/SQSTM1 is associated with poor prognosis in patients with lung adenocarcinoma

(2012) Daisuke Inoue et al.   CANCER SCIENCE

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

(2012) S Chowdhry et al.   ONCOGENE

An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma

(2011) Aikseng Ooi et al.   CANCER CELL

Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling

(2011) Julie Adam et al.   CANCER CELL

Keap1 Mutations and Nrf2 Pathway Activation in Epithelial Ovarian Cancer

(2011) P. A. Konstantinopoulos et al.   CANCER RESEARCH

Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells

(2011) Yoshihiro Inami et al.   JOURNAL OF CELL BIOLOGY

SCF/ -TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner

(2011) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Global Downstream Pathway Analysis Reveals a Dependence of Oncogenic NF-E2-Related Factor 2 Mutation on the mTOR Growth Signaling Pathway

(2010) T. Shibata et al.   CANCER RESEARCH

Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung

(2010) Hironori Satoh et al.   CARCINOGENESIS

Nrf2 and Keap1 Abnormalities in Non-Small Cell Lung Carcinoma and Association with Clinicopathologic Features

(2010) L. M. Solis et al.   CLINICAL CANCER RESEARCH

Genetic Analysis of Cytoprotective Functions Supported by Graded Expression of Keap1

(2010) K. Taguchi et al.   MOLECULAR AND CELLULAR BIOLOGY

Loss of Kelch-Like ECH-Associated Protein 1 Function in Prostate Cancer Cells Causes Chemoresistance and Radioresistance and Promotes Tumor Growth

(2010) P. Zhang et al.   MOLECULAR CANCER THERAPEUTICS

Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains

(2010) T. Ogura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

(2008) T. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA