Amyloid, APP, and Electrical Activity of the Brain

Secreted amyloid-β precursor protein functions as a GABABR1a ligand to modulate synaptic transmission

(2019) Heather C. Rice et al.   SCIENCE

The Role of NMDA Receptors in Alzheimer’s Disease

(2019) Jinping Liu et al.   Frontiers in Neuroscience

Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing

(2019) Margarita C. Dinamarca et al.   Nature Communications

Molecular Modulation of Human α7 Nicotinic Receptor by Amyloid-β Peptides

(2019) Matías Lasala et al.   Frontiers in Cellular Neuroscience

Secreted APP Modulates Synaptic Activity: A Novel Target for Therapeutic Intervention?

(2019) Christian Haass et al.   NEURON

In vivo Ca 2+ imaging of astrocytic microdomains reveals a critical role of the amyloid precursor protein for mitochondria

(2019) Elena Montagna et al.   GLIA

Lack of β-amyloid cleaving enzyme-1 (BACE1) impairs long-term synaptic plasticity but enhances granule cell excitability and oscillatory activity in the dentate gyrus in vivo

(2019) Matej Vnencak et al.   Brain Structure & Function

Identification of neurotoxic cross-linked amyloid-β dimers in the Alzheimer’s brain

(2019) Gunnar Brinkmalm et al.   BRAIN

APP-Mediated Signaling Prevents Memory Decline in Alzheimer’s Disease Mouse Model

(2019) Carole Deyts et al.   Cell Reports

What Happens with the Circuit in Alzheimer's Disease in Mice and Humans?

(2018) Benedikt Zott et al.   Annual Review of Neuroscience

The Amyloid Precursor Protein Intracellular Domain Is an Effector Molecule of Metaplasticity

(2018) Emilie Trillaud-Doppia et al.   BIOLOGICAL PSYCHIATRY

Anti-Amyloid-β Monoclonal Antibodies for Alzheimer’s Disease: Pitfalls and Promise

(2018) Christopher H. van Dyck   BIOLOGICAL PSYCHIATRY

A Systematic Review and Meta-Analysis of the Effectiveness of Acetylcholinesterase Inhibitors and Memantine in Treating the Cognitive Symptoms of Dementia

(2018) Ruth Knight et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognition

(2018) Max C Richter et al.   EMBO JOURNAL

AMPA-ergic regulation of amyloid-β levels in an Alzheimer’s disease mouse model

(2018) Jane C. Hettinger et al.   Molecular Neurodegeneration

Brain regional synchronous activity predicts tauopathy in 3×TgAD mice

(2018) Dong Liu et al.   NEUROBIOLOGY OF AGING

Intracellular Ca2+stores control in vivo neuronal hyperactivity in a mouse model of Alzheimer’s disease

(2018) Chommanad Lerdkrai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha prevents development of memory and plasticity deficits in a mouse model of Alzheimer's disease

(2018) Valerie T. Y. Tan et al.   Molecular Brain

Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity

(2018) Gaël Barthet et al.   Nature Communications

Therapeutic targeting of the pathological triad of extrasynaptic NMDA receptor signaling in neurodegenerations

(2017) Hilmar Bading   JOURNAL OF EXPERIMENTAL MEDICINE

APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission

(2017) Sandra Schilling et al.   JOURNAL OF NEUROSCIENCE

Human Brain-Derived Aβ Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP

(2017) Zemin Wang et al.   JOURNAL OF NEUROSCIENCE

Not just amyloid: physiological functions of the amyloid precursor protein family

(2017) Ulrike C. Müller et al.   NATURE REVIEWS NEUROSCIENCE

Secreted amyloid precursor protein-alpha can restore novel object location memory and hippocampal LTP in aged rats

(2017) Monica Xiong et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

BACE inhibition-dependent repair of Alzheimer’s pathophysiology

(2017) Aylin D. Keskin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippocampal-prefrontal theta-gamma coupling during performance of a spatial working memory task

(2017) Makoto Tamura et al.   Nature Communications

Physiological and pathophysiological control of synaptic GluN2B-NMDA receptors by the C-terminal domain of amyloid precursor protein

(2017) Paula A Pousinha et al.   eLife

Physiological Concentrations of Amyloid Beta Regulate Recycling of Synaptic Vesicles via Alpha7 Acetylcholine Receptor and CDK5/Calcineurin Signaling

(2017) Vesna Lazarevic et al.   Frontiers in Molecular Neuroscience

Novel Insights into the Physiological Function of the APP (Gene) Family and Its Proteolytic Fragments in Synaptic Plasticity

(2017) Susann Ludewig et al.   Frontiers in Molecular Neuroscience

Therapeutic Potential of Secreted Amyloid Precursor Protein APPsα

(2017) Bruce G. Mockett et al.   Frontiers in Molecular Neuroscience

APP as a Protective Factor in Acute Neuronal Insults

(2017) Dimitri Hefter et al.   Frontiers in Molecular Neuroscience

FE65 and FE65L1 share common synaptic functions and genetically interact with the APP family in neuromuscular junction formation

(2017) Paul Strecker et al.   Scientific Reports

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D‐serine homeostasis

(2016) Chengyu Zou et al.   EMBO JOURNAL

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Amyloid precursor-like protein 1 (APLP1) exhibits stronger zinc-dependent neuronal adhesion than amyloid precursor protein and APLP2

(2016) Magnus C. Mayer et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid Precursor Protein Protects Neuronal Network Function after Hypoxia via Control of Voltage-Gated Calcium Channels

(2016) D. Hefter et al.   JOURNAL OF NEUROSCIENCE

Restoring Soluble Amyloid Precursor Protein α Functions as a Potential Treatment for Alzheimer's Disease

(2016) Ahsan Habib et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

A single amino acid difference between the intracellular domains of amyloid precursor protein and amyloid-like precursor protein 2 enables induction of synaptic depression and block of long-term potentiation

(2016) Emilie Trillaud-Doppia et al.   NEUROBIOLOGY OF DISEASE

Cholinergic neurodegeneration in an Alzheimer mouse model overexpressing amyloid-precursor protein with the Swedish-Dutch-Iowa mutations

(2016) Bettina Maria Foidl et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Both pre- and post-synaptic alterations contribute to aberrant cholinergic transmission in superior cervical ganglia of APP −/− mice

(2016) Zhao-Lin Cai et al.   NEUROPHARMACOLOGY

Amyloid-β effects on synapses and memory require AMPA receptor subunit GluA3

(2016) Niels R. Reinders et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired theta-gamma coupling in APP-deficient mice

(2016) Xiaomin Zhang et al.   Scientific Reports

APP Is a Context-Sensitive Regulator of the Hippocampal Presynaptic Active Zone

(2016) Melanie Laßek et al.   PLoS Computational Biology

Amyloid-β-Induced Dysregulation of AMPA Receptor Trafficking

(2016) Sumasri Guntupalli et al.   NEURAL PLASTICITY

The Neuroprotective Properties of the Amyloid Precursor Protein Following Traumatic Brain Injury

(2016) Stephanie Plummer et al.   Aging and Disease

Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer’s disease mouse model

(2015) Romain Fol et al.   ACTA NEUROPATHOLOGICA

Cellular Functions of the Amyloid Precursor Protein from Development to Dementia

(2015) Rik van der Kant et al.   DEVELOPMENTAL CELL

Regional β-amyloid burden does not correlate with cognitive or language deficits in Alzheimer's disease presenting as aphasia

(2015) Y. Jung et al.   EUROPEAN JOURNAL OF NEUROLOGY

Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning

(2015) György Buzsáki   HIPPOCAMPUS

Deletion of the amyloid precursor-like protein 1 (APLP1) enhances excitatory synaptic transmission, reduces network inhibition but does not impair synaptic plasticity in the mouse dentate gyrus

(2015) Matej Vnencak et al.   JOURNAL OF COMPARATIVE NEUROLOGY

APLP1 and APLP2, members of the APP family of proteins, behave similarly to APP in that they associate with NMDA receptors and enhance NMDA receptor surface expression

(2015) Sarah L. Cousins et al.   JOURNAL OF NEUROCHEMISTRY

The APP Intracellular Domain Is Required for Normal Synaptic Morphology, Synaptic Plasticity, and Hippocampus-Dependent Behavior

(2015) M. Klevanski et al.   JOURNAL OF NEUROSCIENCE

η-Secretase processing of APP inhibits neuronal activity in the hippocampus

(2015) Michael Willem et al.   NATURE

Decreased amyloid-β and increased neuronal hyperactivity by immunotherapy in Alzheimer's models

(2015) Marc Aurel Busche et al.   NATURE NEUROSCIENCE

How amyloid, sleep and memory connect

(2015) Brendan P Lucey et al.   NATURE NEUROSCIENCE

Modular composition and dynamics of native GABAB receptors identified by high-resolution proteomics

(2015) Jochen Schwenk et al.   NATURE NEUROSCIENCE

Seizures in Alzheimer’s disease

(2015) H.A. Born   NEUROSCIENCE

Calcium Channel Blockers, Progression to Dementia, and Effects on Amyloid Beta Peptide Production

(2015) Mark A. Lovell et al.   Oxidative Medicine and Cellular Longevity

Precocious Alterations of Brain Oscillatory Activity in Alzheimer’s Disease: A Window of Opportunity for Early Diagnosis and Treatment

(2015) Valentine Hamm et al.   Frontiers in Cellular Neuroscience

APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses

(2015) Tomas Fanutza et al.   eLife

Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity

(2014) Meike Hick et al.   ACTA NEUROPATHOLOGICA

Endoplasmic Reticulum Stress Mediates Amyloid β Neurotoxicity via Mitochondrial Cholesterol Trafficking

(2014) Elisabet Barbero-Camps et al.   AMERICAN JOURNAL OF PATHOLOGY

Reciprocal disruption of neuronal signaling and Aβ production mediated by extrasynaptic NMDA receptors: a downward spiral

(2014) Travis Rush et al.   CELL AND TISSUE RESEARCH

Amyloid Precursor Protein Knockout Diminishes Synaptic Vesicle Proteins at the Presynaptic Active Zone in Mouse Brain

(2014) Melanie Laßek et al.   Current Alzheimer Research

Mint Proteins Are Required for Synaptic Activity-dependent Amyloid Precursor Protein (APP) Trafficking and Amyloid β Generation

(2014) Sarah E. Sullivan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Presynaptic Ca2+, Synaptic Plasticity and Contextual Fear Conditioning by a N-terminal  -Amyloid Fragment

(2014) J. L. M. Lawrence et al.   JOURNAL OF NEUROSCIENCE

The Amyloid Precursor Protein Controls Adult Hippocampal Neurogenesis through GABAergic Interneurons

(2014) B. Wang et al.   JOURNAL OF NEUROSCIENCE

Intracellular Accumulation of Amyloid-  (A ) Protein Plays a Major Role in A -Induced Alterations of Glutamatergic Synaptic Transmission and Plasticity

(2014) C. Ripoli et al.   JOURNAL OF NEUROSCIENCE

Differential role of APP and APLPs for neuromuscular synaptic morphology and function

(2014) Maja Klevanski et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

APP Is Cleaved by Bace1 in Pre-Synaptic Vesicles and Establishes a Pre-Synaptic Interactome, via Its Intracellular Domain, with Molecular Complexes that Regulate Pre-Synaptic Vesicles Functions

(2014) Dolores Del Prete et al.   PLoS One

Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway

(2014) N Milosch et al.   Cell Death & Disease

M1 muscarinic acetylcholine receptor in Alzheimer’s disease

(2014) Shangtong Jiang et al.   Neuroscience Bulletin

Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expression

(2014) Sascha W Weyer et al.   Acta Neuropathologica Communications

The Changing Landscape of Voltage-Gated Calcium Channels in Neurovascular Disorders and in Neurodegenerative Diseases

(2013) Mauro Cataldi   Current Neuropharmacology

Deregulation of excitatory neurotransmission underlying synapse failure in Alzheimer's disease

(2013) Andrea C. Paula-Lima et al.   JOURNAL OF NEUROCHEMISTRY

Postnatal Disruption of the Disintegrin/Metalloproteinase ADAM10 in Brain Causes Epileptic Seizures, Learning Deficits, Altered Spine Morphology, and Defective Synaptic Functions

(2013) J. Prox et al.   JOURNAL OF NEUROSCIENCE

Spike bursts increase amyloid-β 40/42 ratio by inducing a presenilin-1 conformational change

(2013) Iftach Dolev et al.   NATURE NEUROSCIENCE

Nuclear calcium signalling in the regulation of brain function

(2013) Hilmar Bading   NATURE REVIEWS NEUROSCIENCE

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

Incidence of stroke in people with Alzheimer disease: A national register-based approach

(2013) A.-M. Tolppanen et al.   NEUROLOGY

Enhancement of long-term depression by soluble amyloid β protein in rat hippocampus is mediated by metabotropic glutamate receptor and involves activation of p38MAPK, STEP and caspase-3

(2013) X. Chen et al.   NEUROSCIENCE

Hippocampal Network Oscillations in APP/APLP2-Deficient Mice

(2013) Xiaomin Zhang et al.   PLoS One

AMPA Receptor Activation Promotes Non-Amyloidogenic Amyloid Precursor Protein Processing and Suppresses Neuronal Amyloid-β Production

(2013) Sarah E. Hoey et al.   PLoS One

Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: Implications for diagnostic and therapeutic strategies

(2013) Zhichun Chen et al.   PROGRESS IN NEUROBIOLOGY

Physiological Functions of APP Family Proteins

(2013) U. C. Muller et al.   Cold Spring Harbor Perspectives in Medicine

Trafficking and Proteolytic Processing of APP

(2013) C. Haass et al.   Cold Spring Harbor Perspectives in Medicine

Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance

(2012) Carmela Matrone et al.   AGING CELL

Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

(2012) Laure Verret et al.   CELL

Role of APP and Aβ in Synaptic Physiology

(2012) Zilai Wang et al.   Current Alzheimer Research

Roles of the amyloid precursor protein family in the peripheral nervous system

(2012) John H. Caldwell et al.   MECHANISMS OF DEVELOPMENT

Deletion of the amyloid precursor-like protein 2 (APLP2) does not affect hippocampal neuron morphology or function

(2012) Brea Midthune et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Amyloid precursor protein (APP) regulates synaptic structure and function

(2012) Sheue-Houy Tyan et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Synaptic changes in Alzheimer’s disease and its models

(2012) J. Pozueta et al.   NEUROSCIENCE

APP Knockout Mice Experience Acute Mortality as the Result of Ischemia

(2012) Maya A. Koike et al.   PLoS One

Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation

(2012) Demian Obregon et al.   Nature Communications

Calcium channel blocking as a therapeutic strategy for Alzheimer's disease: The case for isradipine

(2011) Thimmappa S. Anekonda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP

(2011) Sascha W Weyer et al.   EMBO JOURNAL

Soluble A  Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

(2011) S. Li et al.   JOURNAL OF NEUROSCIENCE

Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo

(2011) Tomohiro Umeda et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Neuronal activity regulates the regional vulnerability to amyloid-β deposition

(2011) Adam W Bero et al.   NATURE NEUROSCIENCE

The role of APP and APLP for synaptic transmission, plasticity, and network function: lessons from genetic mouse models

(2011) Martin Korte et al.   EXPERIMENTAL BRAIN RESEARCH

Functions of the APP gene family in the nervous system: insights from mouse models

(2011) Dorothee Aydin et al.   EXPERIMENTAL BRAIN RESEARCH

Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory

(2010) Daniela Puzzo et al.   ANNALS OF NEUROLOGY

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines

(2010) K.J. Lee et al.   NEUROSCIENCE

Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP

(2010) H. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Effects of Amyloid Precursor Protein on Postsynaptic Composition and Activity

(2009) Hyang-Sook Hoe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Subcellular localization and dimerization of APLP1 are strikingly different from APP and APLP2

(2009) D. Kaden et al.   JOURNAL OF CELL SCIENCE

Amyloid precursor protein 695 associates with assembled NR2A- and NR2B-containing NMDA receptors to result in the enhancement of their cell surface delivery

(2009) Sarah L. Cousins et al.   JOURNAL OF NEUROCHEMISTRY

Picomolar Amyloid-  Positively Modulates Synaptic Plasticity and Memory in Hippocampus

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

Expression of Human Amyloid Precursor Protein in Rat Cortical Neurons Inhibits Calcium Oscillations

(2009) S. F. Santos et al.   JOURNAL OF NEUROSCIENCE

 -Secretase Inhibition Reduces Spine Density In Vivo via an Amyloid Precursor Protein-Dependent Pathway

(2009) T. Bittner et al.   JOURNAL OF NEUROSCIENCE

Synaptic NMDA Receptor Activation Stimulates  -Secretase Amyloid Precursor Protein Processing and Inhibits Amyloid-  Production

(2009) S. E. Hoey et al.   JOURNAL OF NEUROSCIENCE

Amyloid Precursor Protein Regulates Cav1.2 L-type Calcium Channel Levels and Function to Influence GABAergic Short-Term Plasticity

(2009) L. Yang et al.   JOURNAL OF NEUROSCIENCE

Amyloid beta from axons and dendrites reduces local spine number and plasticity

(2009) Wei Wei et al.   NATURE NEUROSCIENCE

Amyloid-β as a positive endogenous regulator of release probability at hippocampal synapses

(2009) Efrat Abramov et al.   NATURE NEUROSCIENCE

Experience-dependent structural synaptic plasticity in the mammalian brain

(2009) Anthony Holtmaat et al.   NATURE REVIEWS NEUROSCIENCE

Amyloid Deposition Is Associated with Impaired Default Network Function in Older Persons without Dementia

(2009) Reisa A. Sperling et al.   NEURON

Synaptic transmission is impaired prior to plaque formation in amyloid precursor protein–overexpressing mice without altering behaviorally-correlated sharp wave–ripple complexes

(2009) D. Hermann et al.   NEUROSCIENCE

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1

(2008) Tracy L Young-Pearse et al.   Neural Development

Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory

(2008) Chanel J. Taylor et al.   NEUROBIOLOGY OF DISEASE

Linking Calcium to Aβ and Alzheimer's Disease

(2008) Kim N. Green et al.   NEURON

Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks

(2008) Kishore V. Kuchibhotla et al.   NEURON

Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease

(2008) M. A. Busche et al.   SCIENCE