Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing

Structural biology of GABA B receptor

(2018) Aurel Frangaj et al.   NEUROPHARMACOLOGY

Activity-dependent plasticity of presynaptic GABAB receptors at parallel fiber synapses

(2018) Adeline Orts-Del'Immagine et al.   SYNAPSE

Memantine reduces the production of amyloid-β peptides through modulation of amyloid precursor protein trafficking

(2017) Kaori Ito et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Deficits in the activity of presynaptic γ-aminobutyric acid type B receptors contribute to altered neuronal excitability in fragile X syndrome

(2017) Ji-Yong Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal Chloride Regulation via KCC2 Is Modulated through a GABA B Receptor Protein Complex

(2017) Rebecca Wright et al.   JOURNAL OF NEUROSCIENCE

Trafficking in Alzheimer’s Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin

(2017) Simone Eggert et al.   MOLECULAR NEUROBIOLOGY

Not just amyloid: physiological functions of the amyloid precursor protein family

(2017) Ulrike C. Müller et al.   NATURE REVIEWS NEUROSCIENCE

AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability

(2017) Aline Brechet et al.   Nature Communications

APP modulates KCC2 expression and function in hippocampal GABAergic inhibition

(2017) Ming Chen et al.   eLife

Leda-1/Pianp is targeted to the basolateral plasma membrane by a distinct intracellular juxtamembrane region and modulates barrier properties and E-Cadherin processing

(2016) Konstantin Evdokimov et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Phospho-dependent Accumulation of GABA B Rs at Presynaptic Terminals after NMDAR Activation

(2016) Saad Hannan et al.   Cell Reports

Identification of Differentially Expressed Genes through Integrated Study of Alzheimer’s Disease Affected Brain Regions

(2016) Nisha Puthiyedth et al.   PLoS One

Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway

(2015) Utpal Das et al.   NATURE NEUROSCIENCE

Modular composition and dynamics of native GABAB receptors identified by high-resolution proteomics

(2015) Jochen Schwenk et al.   NATURE NEUROSCIENCE

Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome

(2015) Emanuela Pasciuto et al.   NEURON

Loss of Striatonigral GABAergic Presynaptic Inhibition Enables Motor Sensitization in Parkinsonian Mice

(2015) Anders Borgkvist et al.   NEURON

Differential Release of  -Amyloid from Dendrite- Versus Axon-Targeted APP

(2014) S. R. DeBoer et al.   JOURNAL OF NEUROSCIENCE

Quantitative analysis of APP axonal transport in neurons: role of JIP1 in enhanced APP anterograde transport

(2014) Kyoko Chiba et al.   MOLECULAR BIOLOGY OF THE CELL

GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease

(2014) Seonmi Jo et al.   NATURE MEDICINE

Auxiliary GABAB Receptor Subunits Uncouple G Protein βγ Subunits from Effector Channels to Induce Desensitization

(2014) Rostislav Turecek et al.   NEURON

A Function for EHD Family Proteins in Unidirectional Retrograde Dendritic Transport of BACE1 and Alzheimer’s Disease Aβ Production

(2014) Virginie Buggia-Prévot et al.   Cell Reports

APP Homodimers Transduce an Amyloid-β-Mediated Increase in Release Probability at Excitatory Synapses

(2014) Hilla Fogel et al.   Cell Reports

JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors

(2013) Meng-meng Fu et al.   JOURNAL OF CELL BIOLOGY

Activity-Induced Convergence of APP and BACE-1 in Acidic Microdomains via an Endocytosis-Dependent Pathway

(2013) Utpal Das et al.   NEURON

The Specific α-Neurexin Interactor Calsyntenin-3 Promotes Excitatory and Inhibitory Synapse Development

(2013) Katherine L. Pettem et al.   NEURON

Analysis of the Overall Structure of the Multi-Domain Amyloid Precursor Protein (APP)

(2013) Ina Coburger et al.   PLoS One

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

Distinct roles of GABAB1a- and GABAB1b-containing GABABreceptors in spontaneous and evoked termination of persistent cortical activity

(2012) Michael T. Craig et al.   JOURNAL OF PHYSIOLOGY-LONDON

Regulation of neuronal GABAB receptor functions by subunit composition

(2012) Martin Gassmann et al.   NATURE REVIEWS NEUROSCIENCE

Endoplasmic Reticulum Sorting and Kinesin-1 Command the Targeting of Axonal GABAB Receptors

(2012) Viviana Valdés et al.   PLoS One

Sushi domains confer distinct trafficking profiles on GABABreceptors

(2012) Saad Hannan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extending the Dynamic Range of Label-free Mass Spectrometric Quantification of Affinity Purifications

(2011) Wolfgang Bildl et al.   MOLECULAR & CELLULAR PROTEOMICS

A conditional knockout resource for the genome-wide study of mouse gene function

(2011) William C. Skarnes et al.   NATURE

Identification of NEEP21 as a  -Amyloid Precursor Protein-Interacting Protein In Vivo That Modulates Amyloidogenic Processing In Vitro

(2010) E. M. Norstrom et al.   JOURNAL OF NEUROSCIENCE

The Sushi Domains of GABAB Receptors Function as Axonal Targeting Signals

(2010) B. Biermann et al.   JOURNAL OF NEUROSCIENCE

Prolonged activation of NMDA receptors promotes dephosphorylation and alters postendocytic sorting of GABAB receptors

(2010) M. Terunuma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NMDA receptor-dependent GABAB receptor internalization via CaMKII phosphorylation of serine 867 in GABAB1

(2010) N. Guetg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY