Lack of β-amyloid cleaving enzyme-1 (BACE1) impairs long-term synaptic plasticity but enhances granule cell excitability and oscillatory activity in the dentate gyrus in vivo

BACE1 inhibition more effectively suppresses initiation than progression of β-amyloid pathology

(2018) Finn Peters et al.   ACTA NEUROPATHOLOGICA

Consequences of Pharmacological BACE Inhibition on Synaptic Structure and Function

(2018) Kaichuan Zhu et al.   BIOLOGICAL PSYCHIATRY

Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6

(2018) Kaichuan Zhu et al.   BIOLOGICAL PSYCHIATRY

Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer’s Disease

(2018) Michael F. Egan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synaptic Plasticity and Excitation-Inhibition Balance in the Dentate Gyrus: Insights from In Vivo Recordings in Neuroligin-1, Neuroligin-2, and Collybistin Knockouts

(2018) Peter Jedlicka et al.   NEURAL PLASTICITY

BACE1 Inhibitor MK-8931 Alters Formation but Not Stability of Dendritic Spines

(2018) Tanja Blume et al.   Frontiers in Aging Neuroscience

Not just amyloid: physiological functions of the amyloid precursor protein family

(2017) Ulrike C. Müller et al.   NATURE REVIEWS NEUROSCIENCE

Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2

(2017) Riqiang Yan   Frontiers in Molecular Neuroscience

Alzheimer’s therapy targeting the β-secretase enzyme BACE1: Benefits and potential limitations from the perspective of animal model studies

(2016) Masuo Ohno   BRAIN RESEARCH BULLETIN

Ion channel regulation by β-secretase BACE1 – enzymatic and non-enzymatic effects beyond Alzheimer's disease

(2016) Sandra Lehnert et al.   Channels

Forebrain-specific loss of synaptic GABAA receptors results in altered neuronal excitability and synaptic plasticity in mice

(2016) Gregory A. O'Sullivan et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer’s disease

(2016) Riqiang Yan et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease

(2016) Soraia Barão et al.   TRENDS IN NEUROSCIENCES

Pharmacological Inhibition of BACE1 Impairs Synaptic Plasticity and Cognitive Functions

(2015) Severin Filser et al.   BIOLOGICAL PSYCHIATRY

Deletion of the amyloid precursor-like protein 1 (APLP1) enhances excitatory synaptic transmission, reduces network inhibition but does not impair synaptic plasticity in the mouse dentate gyrus

(2015) Matej Vnencak et al.   JOURNAL OF COMPARATIVE NEUROLOGY

 -Secretase BACE1 Regulates Hippocampal and Reconstituted M-Currents in a  -Subunit-Like Fashion

(2015) S. Hessler et al.   JOURNAL OF NEUROSCIENCE

In vivoevaluation of the dentate gate theory in epilepsy

(2015) Esther Krook-Magnuson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Label-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects β-Site APP Cleaving Enzyme (BACE1) Protease Substrates In Vivo

(2015) Bastian Dislich et al.   MOLECULAR & CELLULAR PROTEOMICS

η-Secretase processing of APP inhibits neuronal activity in the hippocampus

(2015) Michael Willem et al.   NATURE

Secreted Amyloid β-Proteins in a Cell Culture Model Include N-Terminally Extended Peptides That Impair Synaptic Plasticity

(2014) Alfred T. Welzel et al.   BIOCHEMISTRY

The evolution of amidine-based brain penetrant BACE1 inhibitors

(2014) Daniel Oehlrich et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease

(2014) Arun K. Ghosh et al.   CHEMICAL SOCIETY REVIEWS

The Normal and Pathologic Roles of the Alzheimer's β-secretase, BACE1

(2014) Patty Kandalepas et al.   Current Alzheimer Research

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

(2014) Robert Vassar et al.   JOURNAL OF NEUROCHEMISTRY

Targeting the β secretase BACE1 for Alzheimer's disease therapy

(2014) Riqiang Yan et al.   LANCET NEUROLOGY

Postsynaptic Target Specific Synaptic Dysfunctions in the CA3 Area of BACE1 Knockout Mice

(2014) Hui Wang et al.   PLoS One

BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease

(2014) Robert Vassar   Alzheimers Research & Therapy

The Alzheimer’s β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques

(2013) Patty C. Kandalepas et al.   ACTA NEUROPATHOLOGICA

Tonic GABA inhibition in hippocampal dentate granule cells: its regulation and function in temporal lobe epilepsies

(2013) Z.-X. Li et al.   Acta Physiologica

Neuroligin-1 regulates excitatory synaptic transmission, LTP and EPSP-spike coupling in the dentate gyrus in vivo

(2013) Peter Jedlicka et al.   Brain Structure & Function

BACE1 and presenilin/γ-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels

(2013) Carolyn C. Sachse et al.   FASEB JOURNAL

Status epilepticus enhances tonic GABA currents and depolarizes GABA reversal potential in dentate fast-spiking basket cells

(2013) Jiandong Yu et al.   JOURNAL OF NEUROPHYSIOLOGY

Long-term potentiation: Peeling the onion

(2013) Roger A. Nicoll et al.   NEUROPHARMACOLOGY

GABAergic tonic inhibition is regulated by developmental age and epilepsy in the dentate gyrus

(2013) Chun-Yao Lee et al.   NEUROREPORT

BACE1 Regulates Hippocampal Astrogenesis via the Jagged1-Notch Pathway

(2013) Xiangyou Hu et al.   Cell Reports

Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons

(2012) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

BACE1 Inhibition Induces a Specific Cerebrospinal Fluid β-Amyloid Pattern That Identifies Drug Effects in the Central Nervous System

(2012) Niklas Mattsson et al.   PLoS One

Differential effects of strain, circadian cycle, and stimulation pattern on LTP and concurrent LTD in the dentate gyrus of freely moving rats

(2011) Jared B. Bowden et al.   HIPPOCAMPUS

Synaptic Deficits Are Rescued in the p25/Cdk5 Model of Neurodegeneration by the Reduction of  -Secretase (BACE1)

(2011) P. Giusti-Rodriguez et al.   JOURNAL OF NEUROSCIENCE

BACE1 Elevation is Involved in Amyloid Plaque Development in the Triple Transgenic Model of Alzheimer’s Disease: Differential Aβ Antibody Labeling of Early-Onset Axon Terminal Pathology

(2011) Yan Cai et al.   NEUROTOXICITY RESEARCH

β-Site APP-cleaving enzyme 1 (BACE1) cleaves cerebellar Na+ channel β4-subunit and promotes Purkinje cell firing by slowing the decay of resurgent Na+ current

(2011) Tobias Huth et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Functional consequences of the lack of amyloid precursor protein in the mouse dentate gyrus in vivo

(2011) Peter Jedlicka et al.   EXPERIMENTAL BRAIN RESEARCH

Increased Dentate Gyrus Excitability in Neuroligin-2-Deficient Mice in Vivo

(2010) P. Jedlicka et al.   CEREBRAL CORTEX

β-Secretase-1 elevation in aged monkey and Alzheimer’s disease human cerebral cortex occurs around the vasculature in partnership with multisystem axon terminal pathogenesis and β-amyloid accumulation

(2010) Yan Cai et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Effects of adult-generated granule cells on coordinated network activity in the dentate gyrus

(2010) Clay O. Lacefield et al.   HIPPOCAMPUS

Reduced Sodium Channel Nav1.1 Levels in BACE1-null Mice

(2010) Doo Yeon Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Computational modeling of GABAA receptor-mediated paired-pulse inhibition in the dentate gyrus

(2010) Peter Jedlicka et al.   JOURNAL OF COMPUTATIONAL NEUROSCIENCE

Mossy Fiber Long-Term Potentiation Deficits in BACE1 Knock-Outs Can Be Rescued by Activation of  7 Nicotinic Acetylcholine Receptors

(2010) H. Wang et al.   JOURNAL OF NEUROSCIENCE

BACE1 Deficiency Causes Altered Neuronal Activity and Neurodegeneration

(2010) X. Hu et al.   JOURNAL OF NEUROSCIENCE

BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization

(2010) Brian D. Hitt et al.   Molecular Neurodegeneration

Increased network excitability and impaired induction of long-term potentiation in the dentate gyrus of collybistin-deficient mice in vivo

(2009) Peter Jedlicka et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Identification of β-Secretase (BACE1) Substrates Using Quantitative Proteomics

(2009) Matthew L. Hemming et al.   PLoS One

BACE1 Knock-Outs Display Deficits in Activity-Dependent Potentiation of Synaptic Transmission at Mossy Fiber to CA3 Synapses in the Hippocampus

(2008) H. Wang et al.   JOURNAL OF NEUROSCIENCE

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice

(2008) A. V. Savonenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BACE1 gene deletion: Impact on behavioral function in a model of Alzheimer's disease

(2007) Dione Kobayashi et al.   NEUROBIOLOGY OF AGING