Natural Bioactive Compounds As Protectors Of Mitochondrial Dysfunction In Cardiovascular Diseases And Aging

Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction

(2019) Anna Walaszczyk et al.   AGING CELL

Cellular senescence in cardiac diseases

(2019) Ippei Shimizu et al.   Journal of Cardiology

Emerging senolytic agents derived from natural products

(2019) Wen Li et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Eicosanoids, prostacyclin and cyclooxygenase in the cardiovascular system

(2018) Jane A Mitchell et al.   BRITISH JOURNAL OF PHARMACOLOGY

The isothiocyanate sulforaphane modulates platelet function and protects against cerebral thrombotic dysfunction

(2018) Scarlett Gillespie et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nutrition and Cardiovascular Disease—an Update

(2018) Kate J. Bowen et al.   Current Atherosclerosis Reports

Berries containing anthocyanins with enhanced methylation profiles are more effective at ameliorating high fat diet-induced metabolic damage

(2018) Emily Skates et al.   FOOD AND CHEMICAL TOXICOLOGY

Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older AdultsNovelty and Significance

(2018) Matthew J. Rossman et al.   HYPERTENSION

Senescent cells: a therapeutic target for cardiovascular disease

(2018) Bennett G. Childs et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial fission protein, dynamin-related protein 1, contributes to the promotion of hypertensive cardiac hypertrophy and fibrosis in Dahl-salt sensitive rats

(2018) Prottoy Hasan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Berry anthocyanin intake and cardiovascular health

(2018) Aedín Cassidy   MOLECULAR ASPECTS OF MEDICINE

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Fisetin Confers Cardioprotection against Myocardial Ischemia Reperfusion Injury by Suppressing Mitochondrial Oxidative Stress and Mitochondrial Dysfunction and Inhibiting Glycogen Synthase Kinase 3β Activity

(2018) Karthi Shanmugam et al.   Oxidative Medicine and Cellular Longevity

Mediterranean Diet and Cardiovascular Disease Prevention: What Do We Know?

(2018) Jordi Salas-Salvadó et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases

(2018) Maria Angela Incalza et al.   VASCULAR PHARMACOLOGY

Sulforaphane, a Natural Isothiocyanate Compound, Improves Cardiac Function and Remodeling by Inhibiting Oxidative Stress and Inflammation in a Rabbit Model of Chronic Heart Failure

(2018) Tongliang Ma et al.   MEDICAL SCIENCE MONITOR

Regulation of platelet activation and thrombus formation by reactive oxygen species

(2018) Jianlin Qiao et al.   Redox Biology

Role of N-Acetylcysteine and Coenzyme Q10 in the Amelioration of Myocardial Energy Expenditure and Oxidative Stress, Induced by Carbon Tetrachloride Intoxication in Rats

(2018) Nayira A. Abd Elbaky et al.   Dose-Response

Fisetin is a senotherapeutic that extends health and lifespan

(2018) Matthew J. Yousefzadeh et al.   EBioMedicine

Aging: the next cardiovascular disease?

(2017) Giovanni G Camici et al.   EUROPEAN HEART JOURNAL

Divergent roles of endothelial nitric oxide synthases system in maintaining cardiovascular homeostasis

(2017) Shigeo Godo et al.   FREE RADICAL BIOLOGY AND MEDICINE

151 Nox5 induces vascular dysfunction and arterial remodelling independently of blood pressure elevation in ang ii-infused nox5-expressing mice

(2017) Augusto Montezano et al.   HEART

Melatonin protects cardiac microvasculature against ischemia/reperfusion injury via suppression of mitochondrial fission-VDAC1-HK2-mPTP-mitophagy axis

(2017) Hao Zhou et al.   JOURNAL OF PINEAL RESEARCH

The Clinical Potential of Senolytic Drugs

(2017) James L. Kirkland et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Luteolin: A Flavonoid that Has Multiple Cardio-Protective Effects and Its Molecular Mechanisms

(2017) Yuanyuan Luo et al.   Frontiers in Pharmacology

The Mitochondrial Basis of Aging and Age-Related Disorders

(2017) Sarika Srivastava   Genes

The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids

(2016) Aedín Cassidy et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Clarity on the Isoform-Specific Roles of NADPH Oxidases and NADPH Oxidase-4 in Atherosclerosis

(2016) David J.R. Fulton et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Quercetin and the mitochondria: A mechanistic view

(2016) Marcos Roberto de Oliveira et al.   BIOTECHNOLOGY ADVANCES

A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury

(2016) Edward T. Chouchani et al.   Cell Metabolism

Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis

(2016) Michael A. Gimbrone et al.   CIRCULATION RESEARCH

Mitochondrial redox status as a target for cardiovascular disease

(2016) James W Walters et al.   CURRENT OPINION IN PHARMACOLOGY

Targeting Mitochondria in Cardiovascular Diseases

(2016) Filomena Silva et al.   CURRENT PHARMACEUTICAL DESIGN

Cardiovascular disease in Europe: epidemiological update 2016

(2016) Nick Townsend et al.   EUROPEAN HEART JOURNAL

Role of mitochondrial dysfunction in cancer progression

(2016) Chia-Chi Hsu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Effects of xanthine oxidase inhibitors on renal function and blood pressure in hypertensive patients with hyperuricemia

(2016) Kentaro Kohagura et al.   HYPERTENSION RESEARCH

Mitochondrial dynamics, mitophagy and cardiovascular disease

(2016) César Vásquez-Trincado et al.   JOURNAL OF PHYSIOLOGY-LONDON

Global burden of HIV, viral hepatitis, and tuberculosis in prisoners and detainees

(2016) Kate Dolan et al.   LANCET

Molecular and biochemical evidence on the protective effects of embelin and carnosic acid in isoproterenol-induced acute myocardial injury in rats

(2016) Cengiz Kocak et al.   LIFE SCIENCES

The Mitochondrial Basis of Aging

(2016) Nuo Sun et al.   MOLECULAR CELL

Exercise Modulates Oxidative Stress and Inflammation in Aging and Cardiovascular Diseases

(2016) Nada Sallam et al.   Oxidative Medicine and Cellular Longevity

Anthocyanins in cardioprotection: A path through mitochondria

(2016) Julius Liobikas et al.   PHARMACOLOGICAL RESEARCH

Mitochondrial Dysfunction Meets Senescence

(2016) Suchira Gallage et al.   TRENDS IN BIOCHEMICAL SCIENCES

Protective Effect of Quercetin on Posttraumatic Cardiac Injury

(2016) Zehao Jing et al.   Scientific Reports

Supplementation with Selenium and Coenzyme Q10 Reduces Cardiovascular Mortality in Elderly with Low Selenium Status. A Secondary Analysis of a Randomised Clinical Trial

(2016) Urban Alehagen et al.   PLoS One

NOX4 NADPH Oxidase-Dependent Mitochondrial Oxidative Stress in Aging-Associated Cardiovascular Disease

(2015) Aleksandr E. Vendrov et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular RemodelingSignificance

(2015) Stephen P. Gray et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Selective inactivation of NADPH oxidase 2 causes regression of vascularization and the size and stability of atherosclerotic plaques

(2015) I.M. Quesada et al.   ATHEROSCLEROSIS

Mitochondrial dysfunction in aging: Much progress but many unresolved questions

(2015) Brendan A.I. Payne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Nox1 in cardiovascular diseases: regulation and pathophysiology

(2015) M. Gimenez et al.   CLINICAL SCIENCE

Health benefits of anthocyanins and molecular mechanisms: Update from recent decade

(2015) Daotong Li et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Redox signaling, Nox5 and vascular remodeling in hypertension

(2015) Augusto C. Montezano et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Molecular mechanism of endothelial and vascular aging: implications for cardiovascular disease

(2015) Giovanni G. Camici et al.   EUROPEAN HEART JOURNAL

Anthocyanins as substrates for mitochondrial complex I - protective effect against heart ischemic injury

(2015) Kristina Skemiene et al.   FEBS Journal

Cardiac mitochondria: A surprise about size

(2015) Nuo Sun et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Flavonoids and mitochondrial pharmacology: A new paradigm for cardioprotection

(2015) Lara Testai   LIFE SCIENCES

Diet rich in high glucoraphanin broccoli reduces plasma LDL cholesterol: Evidence from randomised controlled trials

(2015) Charlotte N. Armah et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Protective Effect of Sevoflurane Postconditioning against Cardiac Ischemia/Reperfusion Injury via Ameliorating Mitochondrial Impairment, Oxidative Stress and Rescuing Autophagic Clearance

(2015) Peng Yu et al.   PLoS One

Piperlongumine Blocks JAK2-STAT3 to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species†

(2015) Hengjie Yuan et al.   PLoS One

Rapamycin attenuates mitochondrial dysfunction via activation of mitophagy in experimental ischemic stroke

(2014) Qiang Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fisetin inhibits high-glucose-induced vascular inflammation in vitro and in vivo

(2014) Soyoung Kwak et al.   INFLAMMATION RESEARCH

Mitochondrial fission is required for cardiomyocyte hypertrophy mediated by a Ca2+-calcineurin signaling pathway

(2014) C. Pennanen et al.   JOURNAL OF CELL SCIENCE

Thrombosis formation on atherosclerotic lesions and plaque rupture

(2014) L. Badimon et al.   JOURNAL OF INTERNAL MEDICINE

High-dose folic acid improves endothelial function by increasing tetrahydrobiopterin and decreasing homocysteine levels

(2014) MIN ZHANG et al.   Molecular Medicine Reports

Mitochondrial dysfunction and oxidative stress in CHF

(2014) Darlington O. Okonko et al.   Nature Reviews Cardiology

Xanthine Oxidase Inhibition by Febuxostat Attenuates Experimental Atherosclerosis in Mice

(2014) Johji Nomura et al.   Scientific Reports

Prophylactic treatment with coenzyme Q10 in patients undergoing cardiac surgery: could an antioxidant reduce complications? A systematic review and meta-analysis

(2014) Fernando de Frutos et al.   Interactive Cardiovascular and Thoracic Surgery

The Effect of Coenzyme Q 10 on Morbidity and Mortality in Chronic Heart Failure

(2014) Svend A. Mortensen et al.   JACC-Heart Failure

Mitochondrial reactive oxygen species: A double edged sword in ischemia/reperfusion vs preconditioning

(2014) Theodore Kalogeris et al.   Redox Biology

The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation

(2014) T.G. Walsh et al.   Redox Biology

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure

(2013) Marc Liesa et al.   Cell Metabolism

The role of key residues in structure, function, and stability of cytochrome-c

(2013) Sobia Zaidi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated Atherosclerosis

(2013) Stephen P. Gray et al.   CIRCULATION

High Anthocyanin Intake Is Associated With a Reduced Risk of Myocardial Infarction in Young and Middle-Aged Women

(2013) Aedín Cassidy et al.   CIRCULATION

Thymoquinone: fifty years of success in the battle against cancer models

(2013) Regine Schneider-Stock et al.   DRUG DISCOVERY TODAY

Cardioprotective Effects of Quercetin in Cardiomyocyte under Ischemia/Reperfusion Injury

(2013) Yi-Wen Chen et al.   Evidence-based Complementary and Alternative Medicine

Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission

(2013) Willard W. Sharp et al.   FASEB JOURNAL

In the eye of the storm: mitochondrial damage during heart and brain ischaemia

(2013) Vilmante Borutaite et al.   FEBS Journal

In search of novel highly active mitochondria-targeted antioxidants: Thymoquinone and its cationic derivatives

(2013) Inna I. Severina et al.   FEBS LETTERS

Dietary quercetin attenuates oxidant-induced endothelial dysfunction and atherosclerosis in apolipoprotein E knockout mice fed a high-fat diet: A critical role for heme oxygenase-1

(2013) Yu Shen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Endothelial Dysfunction in Small Arteries of Essential Hypertensive Patients

(2013) Agostino Virdis et al.   HYPERTENSION

Nitric oxide, a protective molecule in the cardiovascular system

(2013) Jing Lei et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Nitric oxide synthase inhibition and oxidative stress in cardiovascular diseases: Possible therapeutic targets?

(2013) Luc Rochette et al.   PHARMACOLOGY & THERAPEUTICS

Delphinidin-3-Glucoside Protects against Oxidized Low-Density Lipoprotein-Induced Mitochondrial Dysfunction in Vascular Endothelial Cells via the Sodium-Dependent Glucose Transporter SGLT1

(2013) Xin Jin et al.   PLoS One

Bioavailability of anthocyanins and derivatives

(2013) Iva Fernandes et al.   Journal of Functional Foods

Mitochondrial fission induced by platelet-derived growth factor regulates vascular smooth muscle cell bioenergetics and cell proliferation

(2013) Joshua K. Salabei et al.   Redox Biology

Fisetin: A Dietary Antioxidant for Health Promotion

(2012) Naghma Khan et al.   ANTIOXIDANTS & REDOX SIGNALING

Piperlongumine inhibits atherosclerotic plaque formation and vascular smooth muscle cell proliferation by suppressing PDGF receptor signaling

(2012) Dong Ju Son et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cardiovascular Benefits of Black Cumin (Nigella sativa)

(2012) Adel Shabana et al.   Cardiovascular Toxicology

Malvidin-3-glucoside protects endothelial cells up-regulating endothelial NO synthase and inhibiting peroxynitrite-induced NF-kB activation

(2012) Joana Paixão et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Signal Transducer and Activator of Transcription 3 (STAT3) Regulates Collagen-Induced Platelet Aggregation Independently of Its Transcription Factor Activity

(2012) Zhou Zhou et al.   CIRCULATION

Mitochondria and Cardiovascular Aging

(2012) Dao-Fu Dai et al.   CIRCULATION RESEARCH

The Intersection Between Aging and Cardiovascular Disease

(2012) Brian J. North et al.   CIRCULATION RESEARCH

Overview of the therapeutic potential of piplartine (piperlongumine)

(2012) Daniel P. Bezerra et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Mitochondrial dysfunction in heart failure

(2012) Mariana G. Rosca et al.   HEART FAILURE REVIEWS

Anthocyanins block ischemia-induced apoptosis in the perfused heart and support mitochondrial respiration potentially by reducing cytosolic cytochrome c

(2012) Kristina Skemiene et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Impact of Cyanidin-3-Glucoside on Glycated LDL-Induced NADPH Oxidase Activation, Mitochondrial Dysfunction and Cell Viability in Cultured Vascular Endothelial Cells

(2012) Xueping Xie et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Influence of Delphinidin-3-glucoside on Oxidized Low-Density Lipoprotein-Induced Oxidative Stress and Apoptosis in Cultured Endothelial Cells

(2012) Xueping Xie et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Isothiocyanates Ameliorate the Symptom of Heart Dysfunction and Mortality in a Murine AIDS Model by Inhibiting Apoptosis in the Left Ventricle

(2012) Jin-Nyoung Ho et al.   JOURNAL OF MEDICINAL FOOD

Role of platelets as mediators that link inflammation and thrombosis in atherosclerosis

(2012) Eduardo Fuentes Q. et al.   PLATELETS

Glucosinolates and isothiocyanates in health and disease

(2012) Albena T. Dinkova-Kostova et al.   TRENDS IN MOLECULAR MEDICINE

Anthocyanins in Cardiovascular Disease

(2012) Taylor C. Wallace   Advances in Nutrition

Dietary anthocyanins protect endothelial cells against peroxynitrite-induced mitochondrial apoptosis pathway and Bax nuclear translocation: an in vitro approach

(2011) Joana Paixão et al.   APOPTOSIS

Tetrahydrobiopterin Deficiency and Nitric Oxide Synthase Uncoupling Contribute to Atherosclerosis Induced by Disturbed Flow

(2011) Li Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

NADPH oxidases in cardiovascular disease: insights from in vivo models and clinical studies

(2011) Alexander Sirker et al.   BASIC RESEARCH IN CARDIOLOGY

Complex I and cytochrome c are molecular targets of flavonoids that inhibit hydrogen peroxide production by mitochondria

(2011) Ricardo Lagoa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Xanthine Oxidase Inhibition For The Treatment Of Cardiovascular Disease: A Systematic Review and Meta-Analysis

(2011) Peter Higgins et al.   Cardiovascular Therapeutics

Cross talk between mitochondria and NADPH oxidases

(2011) Sergey Dikalov   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress and endothelial dysfunction in hypertension

(2011) Eberhard Schulz et al.   HYPERTENSION RESEARCH

Fisetin induces Nrf2-mediated HO-1 expression through PKC-δ and p38 in human umbilical vein endothelial cells

(2011) Seung Eun Lee et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Oxidative Stress as Pathogenesis of Cardiovascular Risk Associated with Metabolic Syndrome

(2010) Hajime Otani   ANTIOXIDANTS & REDOX SIGNALING

Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion

(2010) Kerstin Boengler et al.   BASIC RESEARCH IN CARDIOLOGY

Mitochondrial morphology and cardiovascular disease

(2010) S.-B. Ong et al.   CARDIOVASCULAR RESEARCH

The mtDNA Mutation Spectrum of the Progeroid Polg Mutator Mouse Includes Abundant Control Region Multimers

(2010) Siôn L. Williams et al.   Cell Metabolism

NADPH oxidases in cardiovascular disease

(2010) Ralf P. Brandes et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress and endothelial dysfunction in cerebrovascular disease

(2010) Sophocles Chrissobolis   Frontiers in Bioscience-Landmark

Reactive oxygen species and vascular biology: implications in human hypertension

(2010) Rhian M Touyz et al.   HYPERTENSION RESEARCH

Thymoquinone supplementation attenuates cyclophosphamide-induced cardiotoxicity in rats

(2010) Mahmoud N. Nagi et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Nitric oxide and oxidative stress in vascular disease

(2010) Ulrich Förstermann   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Pathophysiology of Cyclooxygenases in Cardiovascular Homeostasis

(2010) R. S. Sellers et al.   VETERINARY PATHOLOGY

Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE−/− mice

(2009) Courtney P. Judkins et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities

(2009) William I. Sivitz et al.   ANTIOXIDANTS & REDOX SIGNALING

Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study

(2009) Sarah Egert et al.   BRITISH JOURNAL OF NUTRITION

Role of Glycogen Synthase Kinase-3β in Cardioprotection

(2009) Magdalena Juhaszova et al.   CIRCULATION RESEARCH

Role of coenzyme Q10 (CoQ10) in cardiac disease, hypertension and Meniere-like syndrome

(2009) Adarsh Kumar et al.   PHARMACOLOGY & THERAPEUTICS

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Mitochondrial biogenesis and healthy aging

(2008) Guillermo López-Lluch et al.   EXPERIMENTAL GERONTOLOGY

Increasing Oxidative Stress with Progressive Hyperlipidemia in Human: Relation between Malondialdehyde and Atherogenic Index

(2008) Rui-Li Yang et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Quercetin Ameliorates Metabolic Syndrome and Improves the Inflammatory Status in Obese Zucker Rats

(2008) Leonor Rivera et al.   Obesity