Role of platelets as mediators that link inflammation and thrombosis in atherosclerosis

Macrophage 12/15 lipoxygenase expression increases plasma and hepatic lipid levels and exacerbates atherosclerosis

(2012) Shunxing Rong et al.   JOURNAL OF LIPID RESEARCH

Preformed CD40L Is Stored in Th1, Th2, Th17, and T Follicular Helper Cells as Well as CD4+8− Thymocytes and Invariant NKT Cells but Not in Treg Cells

(2012) Yoshinobu Koguchi et al.   PLoS One

Endothelial cell-borne platelet bridges selectively recruit monocytes in human and mouse models of vascular inflammation

(2011) Christopher J. Kuckleburg et al.   CARDIOVASCULAR RESEARCH

Association of Blood Monocyte and Platelet Markers with Carotid Artery Characteristics: The Atherosclerosis Risk in Communities Carotid MRI Study

(2011) N. Matijevic et al.   CEREBROVASCULAR DISEASES

Dose-Dependent Modulation of Tissue Factor Protein and Procoagulant Activity in Human Monocyte-Derived Macrophages by Oxidized Low Density Lipoprotein

(2011) Simcha Ron Meisel et al.   Journal of Atherosclerosis and Thrombosis

Lipopolysaccharide Signaling without a Nucleus: Kinase Cascades Stimulate Platelet Shedding of Proinflammatory IL-1 -Rich Microparticles

(2011) G. T. Brown et al.   JOURNAL OF IMMUNOLOGY

Enhanced Levels of Soluble CD40 Ligand Exacerbate Platelet Aggregation and Thrombus Formation Through a CD40-Dependent Tumor Necrosis Factor Receptor–Associated Factor-2/Rac1/p38 Mitogen-Activated Protein Kinase Signaling Pathway

(2010) Daniel Yacoub et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis

(2010) D. Lievens et al.   BLOOD

Human macrophage foam cells degrade atherosclerotic plaques through cathepsin K mediated processes

(2010) Natasha Barascuk et al.   BMC Cardiovascular Disorders

IgG-complex stimulated platelets: A source of sCD40L and RANTES in initiation of inflammatory cascade

(2010) Adam J. Antczak et al.   CELLULAR IMMUNOLOGY

Cellular actors, Toll-like receptors, and local cytokine profile in acute coronary syndromes

(2010) Christophe A. Wyss et al.   EUROPEAN HEART JOURNAL

Relationship between circulating levels of RANTES (regulated on activation, normal T-cell expressed, and secreted) and carotid plaque characteristics: the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study

(2010) Salim S. Virani et al.   EUROPEAN HEART JOURNAL

Circulating soluble CD40 ligand mediates the interaction between neutrophils and platelets in acute coronary syndrome

(2010) Budi Y. Setianto et al.   HEART AND VESSELS

Platelets: Pleiotropic roles in atherogenesis and atherothrombosis

(2010) Matthew D. Linden et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Endogenous ligands of TLR2 and TLR4: agonists or assistants?

(2010) Clett Erridge   JOURNAL OF LEUKOCYTE BIOLOGY

Chronic Systemic Infection Exacerbates Ischemic Brain Damage via a CCL5 (Regulated on Activation, Normal T-Cell Expressed and Secreted)-Mediated Proinflammatory Response in Mice

(2010) A. Denes et al.   JOURNAL OF NEUROSCIENCE

Platelet Aggregates-Induced Human CD34+Progenitor Cell Proliferation and Differentiation to Macrophages and Foam Cells Is Mediated by Stromal Cell Derived Factor 1 in Vitro

(2010) Konstantinos Stellos et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

CD40L induces inflammation and adipogenesis in adipose cells – a potential link between metabolic and cardiovascular disease

(2010) Isabel Platzer et al.   THROMBOSIS AND HAEMOSTASIS

Monomeric C-Reactive Protein Generation on Activated Platelets: The Missing Link Between Inflammation and Atherothrombotic Risk

(2010) Steffen U. Eisenhardt et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Inflammation markers in patients with coronary artery disease – comparison of intracoronary and systemic levels

(2010) Simona Kirbiš et al.   WIENER KLINISCHE WOCHENSCHRIFT

The Role of Carotid Plaque Vulnerability and Inflammation in the Pathogenesis of Acute Ischemic Stroke

(2009) Shifang Ding et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Atherosclerosis proceeds independently of thrombin-induced platelet activation in ApoE−/− mice

(2009) J.R. Hamilton et al.   ATHEROSCLEROSIS

Elevated levels of soluble P-selectin in mice alter blood-brain barrier function, exacerbate stroke, and promote atherosclerosis

(2009) J. Kisucka et al.   BLOOD

Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression

(2009) H. Yang et al.   BLOOD

Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function

(2009) S. M. Schoenwaelder et al.   BLOOD

Platelet α-granules: Basic biology and clinical correlates

(2009) Price Blair et al.   BLOOD REVIEWS

Monocytes and neutrophils expressing myeloperoxidase occur in fibrous caps and thrombi in unstable coronary plaques

(2009) Fabio R Tavora et al.   BMC Cardiovascular Disorders

Control of cell proliferation in atherosclerosis: insights from animal models and human studies

(2009) J. J. Fuster et al.   CARDIOVASCULAR RESEARCH

Innate Immunity and Toll-like Receptor Antagonists: A Potential Role in the Treatment of Cardiovascular Diseases

(2009) Elaine Lin et al.   Cardiovascular Therapeutics

Lipopolysaccharide Stimulates Platelet Secretion and Potentiates Platelet Aggregation via TLR4/MyD88 and the cGMP-Dependent Protein Kinase Pathway

(2009) G. Zhang et al.   JOURNAL OF IMMUNOLOGY

Platelet-bound P-selectin expression in patients with coronary artery disease: impact on clinical presentation and myocardial necrosis, and effect of diabetes mellitus and anti-platelet medication

(2009) K. STELLOS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice

(2009) Rory R Koenen et al.   NATURE MEDICINE

Preliminary evidence for a matrix metalloproteinase-2 (MMP-2)-dependent shedding of soluble CD40 ligand (sCD40L) from activated platelets

(2009) Stephan Reinboldt et al.   PLATELETS

Measurement of platelet P-selectin for remote testing of platelet function during treatment with clopidogrel and/or aspirin

(2009) S. C. Fox et al.   PLATELETS

Soluble CD40 ligand induces human coronary artery smooth muscle cells proliferation and migration

(2009) Hong Chai et al.   SURGERY

Toll-like receptor 2 stimulation of platelets is mediated by purinergic P2X1-dependent Ca2+ mobilisation, cyclooxygenase and purinergic P2Y1 and P2Y12 receptor activation

(2009) Caroline Skoglund et al.   THROMBOSIS AND HAEMOSTASIS

Metalloproteinase Expression in Monocytes and Macrophages and its Relationship to Atherosclerotic Plaque Instability

(2008) Andrew C. Newby   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Platelet GPVI binds to collagenous structures in the core region of human atheromatous plaque and is critical for atheroprogression in vivo

(2008) Christian Schulz et al.   BASIC RESEARCH IN CARDIOLOGY

Platelet-mediated modulation of adaptive immunity: unique delivery of CD154 signal by platelet-derived membrane vesicles

(2008) D. L. Sprague et al.   BLOOD

Separable requirements for cytoplasmic domain of PSGL-1 in leukocyte rolling and signaling under flow

(2008) J. J. Miner et al.   BLOOD

Toll-like receptor 4 ligand can differentially modulate the release of cytokines by human platelets

(2008) Fabrice Cognasse et al.   BRITISH JOURNAL OF HAEMATOLOGY

Atherosclerosis development in apolipoprotein E-null mice deficient for CD69

(2008) Manuel Gómez et al.   CARDIOVASCULAR RESEARCH

Stimulation of Toll-Like Receptor 2 in Human Platelets Induces a Thromboinflammatory Response Through Activation of Phosphoinositide 3-Kinase

(2008) Price Blair et al.   CIRCULATION RESEARCH

Association of serum RANTES concentrations with established cardiovascular risk markers in middle-aged subjects

(2008) Soo Jeong Koh et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

15-Deoxy-Δ12,14-Prostaglandin J2 and Curcumin Modulate the Expression of Toll-like Receptors 4 and 9 in Autoimmune T Lymphocyte

(2008) Wanida Chearwae et al.   JOURNAL OF CLINICAL IMMUNOLOGY

VEGFR1/CXCR4-positive progenitor cells modulate local inflammation and augment tissue perfusion by a SDF-1-dependent mechanism

(2008) Andrew Wragg et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Platelets modulate atherogenesis and progression of atherosclerotic plaques via interaction with progenitor and dendritic cells

(2008) M. GAWAZ et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Toll-like receptors — taking an evolutionary approach

(2008) François Leulier et al.   NATURE REVIEWS GENETICS

Blood Cell-Derived RANTES Mediates Cerebral Microvascular Dysfunction, Inflammation, and Tissue Injury After Focal Ischemia–Reperfusion

(2008) Satoshi Terao et al.   STROKE

Neutrophil CD40 enhances platelet-mediated inflammation

(2008) Pantila Vanichakarn et al.   THROMBOSIS RESEARCH

Regulation of Vasculogenesis by Platelet-Mediated Recruitment of Bone Marrow–Derived Cells

(2007) Daniel C. Rafii et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Atherosclerotic lesion development and Toll like receptor 2 and 4 responsiveness

(2007) A.H. Schoneveld et al.   ATHEROSCLEROSIS

Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes

(2007) M. Tjwa et al.   BLOOD

Platelet-Derived Stromal Cell–Derived Factor-1 Regulates Adhesion and Promotes Differentiation of Human CD34 + Cells to Endothelial Progenitor Cells

(2007) Konstantinos Stellos et al.   CIRCULATION