Journal
MOLECULAR NUTRITION & FOOD RESEARCH
Volume 59, Issue 5, Pages 918-926Publisher
WILEY
DOI: 10.1002/mnfr.201400863
Keywords
Broccoli; Cholesterol; Glucoraphanin; Sulforaphane
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Funding
- Technology Strategy Board
- UK Biotechnology and Biological Sciences Research Council [BB/J004545/1]
- Seminis Vegetable Seeds Inc.
- Biotechnology and Biological Sciences Research Council [BBS/E/F/00041700, BBS/E/F/00044431] Funding Source: researchfish
- BBSRC [BBS/E/F/00044431] Funding Source: UKRI
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Scope: Cruciferous-rich diets have been associated with reduction in plasma LDL-cholesterol (LDL-C), which may be due to the action of isothiocyanates derived from glucosinolates that accumulate in these vegetables. This study tests the hypothesis that a diet rich in high glucoraphanin (HG) broccoli will reduce plasma LDL-C. Methods and results: One hundred and thirty volunteers were recruited to two independent double-blind, randomly allocated parallel dietary intervention studies, and were assigned to consume either 400 g standard broccoli or 400 g HG broccoli per week for 12 weeks. Plasma lipids were quantified before and after the intervention. In study 1 (37 volunteers), the HG broccoli diet reduced plasma LDL-C by 7.1% (95% CI: -1.8%, -12.3%, p = 0.011), whereas standard broccoli reduced LDL-C by 1.8% (95% CI+ 3.9%, -7.5%, ns). In study 2 (93 volunteers), the HG broccoli diet resulted in a reduction of 5.1% (95% CI: -2.1%, -8.1%, p=0.001), whereas standard broccoli reduced LDL-C by 2.5% (95% CI: + 0.8%, -5.7%, ns). When data from the two studies were combined the reduction in LDL-C by the HG broccoli was significantly greater than standard broccoli (p = 0.031). Conclusion: Evidence from two independent human studies indicates that consumption of high glucoraphanin broccoli significantly reduces plasma LDL-C.
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