Molecular mechanism of endothelial and vascular aging: implications for cardiovascular disease

Post-ischaemic silencing of p66Shcreduces ischaemia/reperfusion brain injury and its expression correlates to clinical outcome in stroke

(2015) R.D. Spescha et al.   EUROPEAN HEART JOURNAL

Short-Term Caloric Restriction Suppresses Cardiac Oxidative Stress and Hypertrophy Caused by Chronic Pressure Overload

(2015) Miyuki Kobara et al.   JOURNAL OF CARDIAC FAILURE

Sirtuin function in aging heart and vessels

(2015) Chiara Cencioni et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Senescence-Induced Oxidative Stress Causes Endothelial Dysfunction

(2015) Raj Bhayadia et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Cardioprotective Signature of Short-Term Caloric Restriction

(2015) Hossein Noyan et al.   PLoS One

The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice

(2014) Lindsey B. Gano et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Age-related loss of SirT1 expression results in dysregulated human vascular smooth muscle cell function

(2014) Anne Marie Thompson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Regulation of Akt Signaling by Sirtuins

(2014) Vinodkumar B. Pillai et al.   CIRCULATION RESEARCH

Resveratrol Does Not Benefit Patients With Nonalcoholic Fatty Liver Disease

(2014) Veronique S. Chachay et al.   Clinical Gastroenterology and Hepatology

CardioPulse

(2014)   EUROPEAN HEART JOURNAL

Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes

(2014) Francesco Paneni et al.   EUROPEAN HEART JOURNAL

The Sirt1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression

(2014) Melroy X. Miranda et al.   EUROPEAN HEART JOURNAL

Genetic deletion of the adaptor protein p66Shc increases susceptibility to short-term ischaemic myocardial injury via intracellular salvage pathways

(2014) Alexander Akhmedov et al.   EUROPEAN HEART JOURNAL

2014 ESC/EACTS Guidelines on myocardial revascularization

(2014)   EUROPEAN HEART JOURNAL

Leukocyte telomere length is not associated with mortality in older men

(2014) Johan Svensson et al.   EXPERIMENTAL GERONTOLOGY

Adaptor Protein p66 Shc Mediates Hypertension-Associated, Cyclic Stretch–Dependent, Endothelial Damage

(2014) Remo D. Spescha et al.   HYPERTENSION

Enhanced age-dependent cerebrovascular dysfunction is mediated by adaptor protein p66Shc

(2014) Yi Shi et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Decreased SIRT3 in aged human mesenchymal stromal/stem cells increases cellular susceptibility to oxidative stress

(2014) Xue-Qing Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Sirtuin 1 attenuates oxidative stress via upregulation of superoxide dismutase 2 and catalase in astrocytes

(2014) Yi Cheng et al.   JOURNAL OF NEUROIMMUNOLOGY

Effect of Resveratrol Administration on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion

(2014) Miriam Méndez-del Villar et al.   Metabolic Syndrome and Related Disorders

Dual Role of Endothelial Nitric Oxide Synthase in Oxidized LDL-Induced, p66Shc-Mediated Oxidative Stress in Cultured Human Endothelial Cells

(2014) Yi Shi et al.   PLoS One

SIRT6 Minor Allele Genotype Is Associated with >5-Year Decrease in Lifespan in an Aged Cohort

(2014) Mindi J. TenNapel et al.   PLoS One

Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2

(2014) W. De Haes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

(2014) L. Katsimpardi et al.   SCIENCE

Small molecule SIRT1 activators for the treatment of aging and age-related diseases

(2014) Basil P. Hubbard et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

(2014) Ricki J. Colman et al.   Nature Communications

Modulation of human longevity by SIRT3 single nucleotide polymorphisms in the prospective study “Treviso Longeva (TRELONG)”

(2013) Diego Albani et al.   AGE

Life-long caloric restriction reduces oxidative stress and preserves nitric oxide bioavailability and function in arteries of old mice

(2013) Anthony J. Donato et al.   AGING CELL

Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy

(2013) Francesco S. Loffredo et al.   CELL

SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks

(2013) Matthew J. Rardin et al.   Cell Metabolism

Deletion of the Activated Protein-1 Transcription Factor JunD Induces Oxidative Stress and Accelerates Age-Related Endothelial Dysfunction

(2013) Francesco Paneni et al.   CIRCULATION

Visible Age-Related Signs and Risk of Ischemic Heart Disease in the General Population

(2013) Mette Christoffersen et al.   CIRCULATION

Association between low SIRT1 expression in visceral and subcutaneous adipose tissues and metabolic abnormalities in women with obesity and type 2 diabetes

(2013) Young Sook Song et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Oxidative stress and vascular inflammation in aging

(2013) Mariam El Assar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Longitudinal Trajectories of Arterial Stiffness and the Role of Blood Pressure

(2013) Majd AlGhatrif et al.   HYPERTENSION

Calorie Restriction Attenuates Cardiac Remodeling and Diastolic Dysfunction in a Rat Model of Metabolic Syndrome

(2013) Miwa Takatsu et al.   HYPERTENSION

Aortic Stiffness Determines Diastolic Blood Flow Reversal in the Descending Thoracic Aorta

(2013) Junichiro Hashimoto et al.   HYPERTENSION

The Influence of Shc Proteins on Life Span in Mice

(2013) Jon J. Ramsey et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Longitudinal Changes in Leukocyte Telomere Length and Mortality in Humans

(2013) Laila Bendix et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Primary Prevention of Cardiovascular Disease with a Mediterranean Diet

(2013) Ramón Estruch et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effects of resveratrol supplementation on plasma lipids: a systematic review and meta-analysis of randomized controlled trials

(2013) Amirhossein Sahebkar   NUTRITION REVIEWS

Peripheral Blood Monocyte Sirt1 Expression Is Reduced in Patients with Coronary Artery Disease

(2013) Alexander Breitenstein et al.   PLoS One

SIRT1 Polymorphism, Long-Term Survival and Glucose Tolerance in the General Population

(2013) Sylwia M. Figarska et al.   PLoS One

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

(2013) B. P. Hubbard et al.   SCIENCE

Surrogate tissue telomere length and cancer risk: Shorter or Longer?

(2012) Lifang Hou et al.   CANCER LETTERS

Gene Silencing of the Mitochondrial Adaptor p66 Shc Suppresses Vascular Hyperglycemic Memory in Diabetes

(2012) Francesco Paneni et al.   CIRCULATION RESEARCH

Deletion of the ageing gene p66Shc reduces early stroke size following ischaemia/reperfusion brain injury

(2012) Remo D. Spescha et al.   EUROPEAN HEART JOURNAL

Elastin Degradation Is Associated With Progressive Aortic Stiffening and All-Cause Mortality in Predialysis Chronic Kidney Disease

(2012) Edward R. Smith et al.   HYPERTENSION

Aging and the Renin-Angiotensin System

(2012) Sara Conti et al.   HYPERTENSION

Large Artery Stiffening and Remodeling Are Independently Associated With All-Cause Mortality and Cardiovascular Events in Chronic Kidney Disease

(2012) Alexandre Karras et al.   HYPERTENSION

Carotid Arterial Stiffness and Its Relationship to Exercise Intolerance in Older Patients With Heart Failure and Preserved Ejection Fraction

(2012) Dalane W. Kitzman et al.   HYPERTENSION

Aortic Stiffness, Blood Pressure Progression, and Incident Hypertension

(2012) Bernhard M. Kaess et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Sirtuins as regulators of metabolism and healthspan

(2012) Riekelt H. Houtkooper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Oxidized Low-Density Lipoprotein Activates p66 Shc via Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1, Protein Kinase C-β, and c-Jun N-Terminal Kinase Kinase in Human Endothelial Cells

(2011) Yi Shi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Expression of the aging gene p66Shc is increased in peripheral blood monocytes of patients with acute coronary syndrome but not with stable coronary artery disease

(2011) Fabian C. Franzeck et al.   ATHEROSCLEROSIS

Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease

(2011) Christian Besler et al.   JOURNAL OF CLINICAL INVESTIGATION

Leukocyte Telomere Length and Mortality in the Cardiovascular Health Study

(2011) A. L. Fitzpatrick et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome

(2011) Matthew D. Hirschey et al.   MOLECULAR CELL

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

Downregulation of the Longevity-Associated Protein Sirtuin 1 in Insulin Resistance and Metabolic Syndrome: Potential Biochemical Mechanisms

(2010) S. V. de Kreutzenberg et al.   DIABETES

SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis

(2010) Sokrates Stein et al.   EUROPEAN HEART JOURNAL

Changes of telomere length with aging

(2010) Kaiyo Takubo et al.   Geriatrics & Gerontology International

SIRT1 Activation by Small Molecules

(2010) Han Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

(2010) Mariela Jaskelioff et al.   NATURE

The cardioprotective effects elicited by p66Shc ablation demonstrate the crucial role of mitochondrial ROS formation in ischemia/reperfusion injury

(2009) Andrea Carpi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Telomere length as a biological marker in malignancy

(2009) Ulrika Svenson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Redundancy of myostatin and growth/differentiation factor 11 function

(2009) Alexandra C McPherron et al.   BMC DEVELOPMENTAL BIOLOGY

Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats

(2009) Erika Koltai et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Why Some Women Look Young for Their Age

(2009) David A. Gunn et al.   PLoS One

Manganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunction

(2008) Philip Wenzel et al.   CARDIOVASCULAR RESEARCH

Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice

(2008) Q.-j. Zhang et al.   CARDIOVASCULAR RESEARCH

SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice

(2008) Alexander S. Banks et al.   Cell Metabolism

Multiple facets of junD gene expression are atypical among AP-1 family members

(2008) J M Hernandez et al.   ONCOGENE

Angiotensin II–Mediated Oxidative DNA Damage Accelerates Cellular Senescence in Cultured Human Vascular Smooth Muscle Cells via Telomere-Dependent and Independent Pathways

(2007) Karl E. Herbert et al.   CIRCULATION RESEARCH