How HIV Nef Proteins Hijack Membrane Traffic To Promote Infection

Biological Functions of Autophagy Genes: A Disease Perspective

(2019) Beth Levine et al.   CELL

Diverse Cellular Roles of Autophagy

(2019) Hideaki Morishita et al.   Annual Review of Cell and Developmental Biology

The autophagy protein ATG9A promotes HIV-1 infectivity

(2019) Elodie Mailler et al.   Retrovirology

Structural Basis for Tetherin Antagonism as a Barrier to Zoonotic Lentiviral Transmission

(2019) Cosmo Z. Buffalo et al.   Cell Host & Microbe

Regulation of the Cell Biology of Antigen Cross-Presentation

(2018) J. Magarian Blander   Annual Review of Immunology

HIV-1 Nef Antagonizes SERINC5 Restriction by Downregulation of SERINC5 via the Endosome/Lysosome System

(2018) Jing Shi et al.   JOURNAL OF VIROLOGY

Cargo recognition and degradation by selective autophagy

(2018) Damián Gatica et al.   NATURE CELL BIOLOGY

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A single β-octyl glucoside molecule induces HIV-1 Nef dimer formation in the absence of partner protein binding

(2018) Mousheng Wu et al.   PLoS One

The HIV-1 accessory proteins Nef and Vpu downregulate total and cell surface CD28 in CD4+ T cells

(2018) Emily N. Pawlak et al.   Retrovirology

Nef Secretion into Extracellular Vesicles or Exosomes Is Conserved across Human and Simian Immunodeficiency Viruses

(2018) Ryan P. McNamara et al.   mBio

A Long Cytoplasmic Loop Governs the Sensitivity of the Anti-viral Host Protein SERINC5 to HIV-1 Nef

(2018) Weiwei Dai et al.   Cell Reports

Inside job: how the ESCRTs release HIV-1 from infected cells

(2018) James H. Hurley et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation

(2018) Kyle L. Morris et al.   CELL

Structures, Functions, and Dynamics of ESCRT-III/Vps4 Membrane Remodeling and Fission Complexes

(2018) John McCullough et al.   Annual Review of Cell and Developmental Biology

Bidirectional Control of Autophagy by BECN1 BARA Domain Dynamics

(2018) Chunmei Chang et al.   MOLECULAR CELL

The host-cell restriction factor SERINC5 restricts HIV-1 infectivity without altering the lipid composition and organization of viral particles

(2017) Birthe Trautz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SERINC5 protein inhibits HIV-1 fusion pore formation by promoting functional inactivation of envelope glycoproteins

(2017) Chetan Sood et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nef is secreted in exosomes from Nef.GFP-expressing and HIV-1-infected human astrocytes

(2017) Pia Pužar Dominkuš et al.   JOURNAL OF NEUROVIROLOGY

Maintenance of AP-2-Dependent Functional Activities of Nef Restricts Pathways of Immune Escape from CD8 T Lymphocyte Responses

(2017) Blake Schouest et al.   JOURNAL OF VIROLOGY

Structure of the human MHC-I peptide-loading complex

(2017) Andreas Blees et al.   NATURE

Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3

(2017) Santiago Manrique et al.   Nature Communications

The structure of the COPI coat determined within the cell

(2017) Yury S Bykov et al.   eLife

The comings and goings of MHC class I molecules herald a new dawn in cross-presentation

(2016) J. Magarian Blander   IMMUNOLOGICAL REVIEWS

Tetherin Antagonism by HIV-1 Group M Nef Proteins

(2016) Juan F. Arias et al.   JOURNAL OF VIROLOGY

HIV-1 Nef: Taking Control of Protein Trafficking

(2016) Estela A. Pereira et al.   TRAFFIC

Membrane-Associated Conformation of HIV-1 Nef Investigated with Hydrogen Exchange Mass Spectrometry at a Langmuir Monolayer

(2015) Gregory F. Pirrone et al.   ANALYTICAL CHEMISTRY

Ypt1/Rab1 regulates Hrr25/CK1δ kinase activity in ER–Golgi traffic and macroautophagy

(2015) Juan Wang et al.   JOURNAL OF CELL BIOLOGY

AP-2 Is the Crucial Clathrin Adaptor Protein for CD4 Downmodulation by HIV-1 Nef in Infected Primary CD4+T Cells

(2015) Marcos Vinicius Gondim et al.   JOURNAL OF VIROLOGY

SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef

(2015) Yoshiko Usami et al.   NATURE

HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation

(2015) Annachiara Rosa et al.   NATURE

HIV-1 Nef hijacks clathrin coats by stabilizing AP-1:Arf1 polygons

(2015) Q.-T. Shen et al.   SCIENCE

A structure of the COPI coat and the role of coat proteins in membrane vesicle assembly

(2015) S. O. Dodonova et al.   SCIENCE

Transcriptomic Analysis of mRNAs in Human Monocytic Cells Expressing the HIV-1 Nef Protein and Their Exosomes

(2015) Madeeha Aqil et al.   Biomed Research International

Nef Proteins of Epidemic HIV-1 Group O Strains Antagonize Human Tetherin

(2014) Silvia F. Kluge et al.   Cell Host & Microbe

Interaction of HIV-1 Nef Protein with the Host Protein Alix Promotes Lysosomal Targeting of CD4 Receptor

(2014) Nathaly A. Amorim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction with the Src Homology (SH3-SH2) Region of the Src-family Kinase Hck Structures the HIV-1 Nef Dimer for Kinase Activation and Effector Recruitment

(2014) John Jeff Alvarado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody

(2014) Sebastian Lülf et al.   Retrovirology

AP2 controls clathrin polymerization with a membrane-activated switch

(2014) B. T. Kelly et al.   SCIENCE

HIV-1 Accessory Proteins Adapt Cellular Adaptors to Facilitate Immune Evasion

(2014) David R. Collins et al.   PLoS Pathogens

How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4

(2014) Xuefeng Ren et al.   eLife

Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1

(2014) Xiaofei Jia et al.   eLife

Structural Basis for Recruitment and Activation of the AP-1 Clathrin Adaptor Complex by Arf1

(2013) Xuefeng Ren et al.   CELL

Identification of a candidate therapeutic autophagy-inducing peptide

(2013) Sanae Shoji-Kawata et al.   NATURE

Conformational Transition of Membrane-Associated Terminally Acylated HIV-1 Nef

(2013) Bulent Akgun et al.   STRUCTURE

ALIX and the multivesicular endosome: ALIX in Wonderland

(2013) Christin Bissig et al.   TRENDS IN CELL BIOLOGY

Cargo Recognition in Clathrin-Mediated Endocytosis

(2013) L. M. Traub et al.   Cold Spring Harbor Perspectives in Biology

Tetherin/BST-2 Antagonism by Nef Depends on a Direct Physical Interaction between Nef and Tetherin, and on Clathrin-mediated Endocytosis

(2013) Ruth Serra-Moreno et al.   PLoS Pathogens

Peptide-based Identification of Functional Motifs and their Binding Partners

(2013) Martin N. Shelton et al.   Jove-Journal of Visualized Experiments

Identification of a Novel Binding Site Between HIV Type 1 Nef C-Terminal Flexible Loop and AP2 Required for Nef-Mediated CD4 Downregulation

(2012) Yong-Jiu Jin et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Innate Sensing of HIV-1 Assembly by Tetherin Induces NFκB-Dependent Proinflammatory Responses

(2012) Rui Pedro Galão et al.   Cell Host & Microbe

Reacquisition of Nef-Mediated Tetherin Antagonism in a Single In Vivo Passage of HIV-1 through Its Original Chimpanzee Host

(2012) Nicola Götz et al.   Cell Host & Microbe

Validation of a novel secretion modification region (SMR) of HIV-1 Nef using cohort sequence analysis and molecular modeling

(2012) Patrick E. Campbell et al.   JOURNAL OF MOLECULAR MODELING

Efficient Nef-Mediated Downmodulation of TCR-CD3 and CD28 Is Associated with High CD4+ T Cell Counts in Viremic HIV-2 Infection

(2012) M. Khalid et al.   JOURNAL OF VIROLOGY

Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef

(2012) Xiaofei Jia et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Structures of COPI-Coated Vesicles Reveal Alternate Coatomer Conformations and Interactions

(2012) M. Faini et al.   SCIENCE

HIV-1 Nef Disrupts Intracellular Trafficking of Major Histocompatibility Complex Class I, CD4, CD8, and CD28 by Distinct Pathways That Share Common Elements

(2011) J. A. Leonard et al.   JOURNAL OF VIROLOGY

Down-Modulation of CD8   Is a Fundamental Activity of Primate Lentiviral Nef Proteins

(2011) A. Heigele et al.   JOURNAL OF VIROLOGY

Secretion Modification Region-Derived Peptide Disrupts HIV-1 Nef's Interaction with Mortalin and Blocks Virus and Nef Exosome Release

(2011) M. N. Shelton et al.   JOURNAL OF VIROLOGY

Global landscape of HIV–human protein complexes

(2011) Stefanie Jäger et al.   NATURE

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Molecular Design, Functional Characterization and Structural Basis of a Protein Inhibitor Against the HIV-1 Pathogenicity Factor Nef

(2011) Sebastian Breuer et al.   PLoS One

A Novel Dimer-Tetramer Transition Captured by the Crystal Structure of the HIV-1 Nef

(2011) Pankaj Singh et al.   PLoS One

Conformation of the Dileucine-Based Sorting Motif in HIV-1 Nef Revealed by Intermolecular Domain Assembly

(2011) Florian A. Horenkamp et al.   TRAFFIC

SIV Nef Proteins Recruit the AP-2 Complex to Antagonize Tetherin and Facilitate Virion Release

(2011) Fengwen Zhang et al.   PLoS Pathogens

Pseudo-merohedral twinning and noncrystallographic symmetry in orthorhombic crystals of SIVmac239 Nef core domain bound to different-length TCRζ fragments

(2010) Walter M. Kim et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Genetic Characterization of HIV Type 1 Nef-Induced Vesicle Secretion

(2010) Syed A. Ali et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

HIV Type 1 Nef Is Released from Infected Cells in CD45+ Microvesicles and Is Present in the Plasma of HIV-Infected Individuals

(2010) A.D. Raymond et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Neutron Reflectometry Study of the Conformation of HIV Nef Bound to Lipid Membranes

(2010) Michael S. Kent et al.   BIOPHYSICAL JOURNAL

Tetherin: Holding On and Letting Go

(2010) Daniel Sauter et al.   CELL

A Large-Scale Conformational Change Couples Membrane Recruitment to Cargo Binding in the AP2 Clathrin Adaptor Complex

(2010) Lauren P. Jackson et al.   CELL

Immune Evasion and Counteraction of Restriction Factors by HIV-1 and Other Primate Lentiviruses

(2010) Frank Kirchhoff   Cell Host & Microbe

Conservation and Diversification of Dileucine Signal Recognition by Adaptor Protein (AP) Complex Variants

(2010) Rafael Mattera et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Presence of a vpu Gene and the Lack of Nef-Mediated Downmodulation of T Cell Receptor-CD3 Are Not Always Linked in Primate Lentiviruses

(2010) J. Schmokel et al.   JOURNAL OF VIROLOGY

CD317/Tetherin Is Enriched in the HIV-1 Envelope and Downregulated from the Plasma Membrane upon Virus Infection

(2010) A. Habermann et al.   JOURNAL OF VIROLOGY

BST-2/tetherin: a new component of the innate immune response to enveloped viruses

(2010) David T. Evans et al.   TRENDS IN MICROBIOLOGY

Tetherin Inhibits HIV-1 Release by Directly Tethering Virions to Cells

(2009) David Perez-Caballero et al.   CELL

Nef Proteins from Simian Immunodeficiency Viruses Are Tetherin Antagonists

(2009) Fengwen Zhang et al.   Cell Host & Microbe

Tetherin-Driven Adaptation of Vpu and Nef Function and the Evolution of Pandemic and Nonpandemic HIV-1 Strains

(2009) Daniel Sauter et al.   Cell Host & Microbe

CD28 and CTLA-4 coreceptor expression and signal transduction

(2009) Christopher E. Rudd et al.   IMMUNOLOGICAL REVIEWS

Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages

(2009) George B. Kyei et al.   JOURNAL OF CELL BIOLOGY

The inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV-1 from most other primate lentiviruses

(2009) Nathalie Arhel et al.   JOURNAL OF CLINICAL INVESTIGATION

A Basic Patch on  -Adaptin Is Required for Binding of Human Immunodeficiency Virus Type 1 Nef and Cooperative Assembly of a CD4-Nef-AP-2 Complex

(2009) R. Chaudhuri et al.   JOURNAL OF VIROLOGY

Human Immunodeficiency Virus Type 1 Nef Protein Targets CD4 to the Multivesicular Body Pathway

(2009) L. L. P. daSilva et al.   JOURNAL OF VIROLOGY

HIV-1 Nef membrane association depends on charge, curvature, composition and sequence

(2009) Holger Gerlach et al.   Nature Chemical Biology

HIV Nef is Secreted in Exosomes and Triggers Apoptosis in Bystander CD4+ T Cells

(2009) Metka Lenassi et al.   TRAFFIC

Interactions between SIVNef, SIVGagPol and Alix correlate with viral replication and progression to AIDS in rhesus macaques

(2009) Luciana Jesus da Costa et al.   VIROLOGY

Functional role of Alix in HIV-1 replication

(2009) Ken Fujii et al.   VIROLOGY

Species-Specific Activity of SIV Nef and HIV-1 Vpu in Overcoming Restriction by Tetherin/BST2

(2009) Bin Jia et al.   PLoS Pathogens

HIV-1 Accessory Proteins—Ensuring Viral Survival in a Hostile Environment

(2008) Michael H. Malim et al.   Cell Host & Microbe

The Interferon-Induced Protein BST-2 Restricts HIV-1 Release and Is Downregulated from the Cell Surface by the Viral Vpu Protein

(2008) Nanette Van Damme et al.   Cell Host & Microbe

HLA-B57/B*5801 Human Immunodeficiency Virus Type 1 Elite Controllers Select for Rare Gag Variants Associated with Reduced Viral Replication Capacity and Strong Cytotoxic T-Lymphotye Recognition

(2008) T. Miura et al.   JOURNAL OF VIROLOGY

Broad-Spectrum Inhibition of Retroviral and Filoviral Particle Release by Tetherin

(2008) N. Jouvenet et al.   JOURNAL OF VIROLOGY

A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex

(2008) Bernard T. Kelly et al.   NATURE

Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu

(2008) Stuart J. D. Neil et al.   NATURE

HIV-1 Nef Targets MHC-I and CD4 for Degradation Via a Final Common β-COP–Dependent Pathway in T Cells

(2008) Malinda R. Schaefer et al.   PLoS Pathogens

Transmission of HIV-1 CTL Escape Variants Provides HLA-Mismatched Recipients with a Survival Advantage

(2008) Denis R. Chopera et al.   PLoS Pathogens