Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1

HIV Nef and Vpu protect HIV-infected CD4+ T cells from antibody-mediated cell lysis through down-modulation of CD4 and BST2

(2014) Tram NQ Pham et al.   Retrovirology

Preservation of Tetherin and CD4 Counter-Activities in Circulating Vpu Alleles despite Extensive Sequence Variation within HIV-1 Infected Individuals

(2014) Suzanne Pickering et al.   PLoS Pathogens

Structural Basis for Recruitment and Activation of the AP-1 Clathrin Adaptor Complex by Arf1

(2013) Xuefeng Ren et al.   CELL

Targeting antigen to bone marrow stromal cell-2 expressed by conventional and plasmacytoid dendritic cells elicits efficient antigen presentation

(2013) Jessica M. Moffat et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Structural Basis for the Recognition of Tyrosine-based Sorting Signals by the μ3A Subunit of the AP-3 Adaptor Complex

(2013) Gonzalo A. Mardones et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Electron Density Sharpening as a General Technique in Crystallographic Studies

(2013) Chang Liu et al.   JOURNAL OF MOLECULAR BIOLOGY

Interaction with Cellular CD4 Exposes HIV-1 Envelope Epitopes Targeted by Antibody-Dependent Cell-Mediated Cytotoxicity

(2013) M. Veillette et al.   JOURNAL OF VIROLOGY

The clathrin adaptor complexes as a paradigm for membrane-associated allostery

(2013) Bertram J. Canagarajah et al.   PROTEIN SCIENCE

HIV-1 Vpu affects the anterograde transport and the glycosylation pattern of NTB-A

(2013) Sebastian Bolduan et al.   VIROLOGY

Vpu Binds Directly to Tetherin and Displaces It from Nascent Virions

(2013) Matthew W. McNatt et al.   PLoS Pathogens

Tetherin/BST-2 Antagonism by Nef Depends on a Direct Physical Interaction between Nef and Tetherin, and on Clathrin-mediated Endocytosis

(2013) Ruth Serra-Moreno et al.   PLoS Pathogens

Innate Sensing of HIV-1 Assembly by Tetherin Induces NFκB-Dependent Proinflammatory Responses

(2012) Rui Pedro Galão et al.   Cell Host & Microbe

HIV-1 Vpu Interference with Innate Cell-mediated Immune Mechanisms

(2012) Johan K. Sandberg et al.   CURRENT HIV RESEARCH

Sites of Action of HIV-1 Vpu in BST-2/Tetherin Downregulation

(2012) Juan F. Arias et al.   CURRENT HIV RESEARCH

Stimulation of NF- B Activity by the HIV Restriction Factor BST2

(2012) A. Tokarev et al.   JOURNAL OF VIROLOGY

Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef

(2012) Xiaofei Jia et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Vpu Downmodulates Two Distinct Targets, Tetherin and Gibbon Ape Leukemia Virus Envelope, through Shared Features in the Vpu Cytoplasmic Tail

(2012) Tiffany M. Lucas et al.   PLoS One

A Cytoplasmic Tail Determinant in HIV-1 Vpu Mediates Targeting of Tetherin for Endosomal Degradation and Counteracts Interferon-Induced Restriction

(2012) Tonya Kueck et al.   PLoS Pathogens

Identification of Alternatively Translated Tetherin Isoforms with Differing Antiviral and Signaling Activities

(2012) Luis J. Cocka et al.   PLoS Pathogens

Protein intrinsic disorder as a flexible armor and a weapon of HIV-1

(2011) Bin Xue et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

HIV-1 Vpu Protein Antagonizes Innate Restriction Factor BST-2 via Lipid-embedded Helix-Helix Interactions

(2011) Mark Skasko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of the Endocytic Pathway in the Counteraction of BST-2 by Human Lentiviral Pathogens

(2011) D. Lau et al.   JOURNAL OF VIROLOGY

Separable Determinants of Subcellular Localization and Interaction Account for the Inability of Group O HIV-1 Vpu To Counteract Tetherin

(2011) R. Vigan et al.   JOURNAL OF VIROLOGY

β-TrCP is dispensable for Vpu's ability to overcome the CD317/Tetherin-imposed restriction to HIV-1 release

(2011) Hanna-Mari Tervo et al.   Retrovirology

HIV-1 Vpu Antagonizes BST-2 by Interfering Mainly with the Trafficking of Newly Synthesized BST-2 to the Cell Surface

(2011) Mathieu Dubé et al.   TRAFFIC

HIV-1 Vpu Blocks Recycling and Biosynthetic Transport of the Intrinsic Immunity Factor CD317/Tetherin To Overcome the Virion Release Restriction

(2011) S. Schmidt et al.   mBio

SIV Nef Proteins Recruit the AP-2 Complex to Antagonize Tetherin and Facilitate Virion Release

(2011) Fengwen Zhang et al.   PLoS Pathogens

The ESCRT-0 Component HRS is Required for HIV-1 Vpu-Mediated BST-2/Tetherin Down-Regulation

(2011) Katy Janvier et al.   PLoS Pathogens

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Inhibition of lipid antigen presentation in dendritic cells by HIV-1 Vpu interference with CD1d recycling from endosomal compartments

(2010) M. Moll et al.   BLOOD

A Large-Scale Conformational Change Couples Membrane Recruitment to Cargo Binding in the AP2 Clathrin Adaptor Complex

(2010) Lauren P. Jackson et al.   CELL

Structural Basis of HIV-1 Tethering to Membranes by the BST-2/Tetherin Ectodomain

(2010) Andreas Hinz et al.   Cell Host & Microbe

Degranulation of Natural Killer Cells Following Interaction with HIV-1-Infected Cells Is Hindered by Downmodulation of NTB-A by Vpu

(2010) Ankur H. Shah et al.   Cell Host & Microbe

Disruption of the Murine Ap2β1 Gene Causes Nonsyndromic Cleft Palate

(2010) Wei Li et al.   CLEFT PALATE-CRANIOFACIAL JOURNAL

Antagonism of CD317 Restriction of Human Immunodeficiency Virus Type 1 (HIV-1) Particle Release and Depletion of CD317 Are Separable Activities of HIV-1 Vpu

(2010) C. Goffinet et al.   JOURNAL OF VIROLOGY

Identification of Amino Acids in the Human Tetherin Transmembrane Domain Responsible for HIV-1 Vpu Interaction and Susceptibility

(2010) T. Kobayashi et al.   JOURNAL OF VIROLOGY

Differential Effects of Human Immunodeficiency Virus Type 1 Vpu on the Stability of BST-2/Tetherin

(2010) A. J. Andrew et al.   JOURNAL OF VIROLOGY

Determinants of Tetherin Antagonism in the Transmembrane Domain of the Human Immunodeficiency Virus Type 1 Vpu Protein

(2010) R. Vigan et al.   JOURNAL OF VIROLOGY

Structural insight into the mechanisms of enveloped virus tethering by tetherin

(2010) H. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations

(2010) H. L. Schubert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vpu serine 52 dependent counteraction of tetherin is required for HIV-1 replication in macrophages, but not in ex vivo human lymphoid tissue

(2010) Michael Schindler et al.   Retrovirology

HIV-1 Vpu and HIV-2 Env counteract BST-2/tetherin by sequestration in a perinuclear compartment

(2010) Heiko Hauser et al.   Retrovirology

BST-2/tetherin: a new component of the innate immune response to enveloped viruses

(2010) David T. Evans et al.   TRENDS IN MICROBIOLOGY

Antagonism of Tetherin Restriction of HIV-1 Release by Vpu Involves Binding and Sequestration of the Restriction Factor in a Perinuclear Compartment

(2010) Mathieu Dubé et al.   PLoS Pathogens

HIV-1 Antagonism of CD317 Is Species Specific and Involves Vpu-Mediated Proteasomal Degradation of the Restriction Factor

(2009) Christine Goffinet et al.   Cell Host & Microbe

NMR structural characterization of HIV-1 virus protein U cytoplasmic domain in the presence of dodecylphosphatidylcholine micelles

(2009) Marc Wittlich et al.   FEBS Journal

HIV-1 Accessory Protein Vpu Internalizes Cell-surface BST-2/Tetherin through Transmembrane Interactions Leading to Lysosomes

(2009) Yukie Iwabu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HM1.24 Is Internalized from Lipid Rafts by Clathrin-mediated Endocytosis through Interaction with α-Adaptin

(2009) Naoko Masuyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppression of Tetherin-Restricting Activity upon Human Immunodeficiency Virus Type 1 Particle Release Correlates with Localization of Vpu in the trans-Golgi Network

(2009) M. Dube et al.   JOURNAL OF VIROLOGY

Vpu Directs the Degradation of the Human Immunodeficiency Virus Restriction Factor BST-2/Tetherin via a  TrCP-Dependent Mechanism

(2009) J. L. Douglas et al.   JOURNAL OF VIROLOGY

Tickets to ride: selecting cargo for clathrin-regulated internalization

(2009) Linton M. Traub   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An MHC-I Cytoplasmic Domain/HIV-1 Nef Fusion Protein Binds Directly to the μ Subunit of the AP-1 Endosomal Coat Complex

(2009) Rajendra Kumar Singh et al.   PLoS One

BCA2/Rabring7 Promotes Tetherin-Dependent HIV-1 Restriction

(2009) Kei Miyakawa et al.   PLoS Pathogens

HIV-1 Vpu Neutralizes the Antiviral Factor Tetherin/BST-2 by Binding It and Directing Its Beta-TrCP2-Dependent Degradation

(2009) Bastien Mangeat et al.   PLoS Pathogens

Species-Specific Activity of HIV-1 Vpu and Positive Selection of Tetherin Transmembrane Domain Variants

(2009) Matthew W. McNatt et al.   PLoS Pathogens

Vpu Antagonizes BST-2–Mediated Restriction of HIV-1 Release via β-TrCP and Endo-Lysosomal Trafficking

(2009) Richard S. Mitchell et al.   PLoS Pathogens

The Interferon-Induced Protein BST-2 Restricts HIV-1 Release and Is Downregulated from the Cell Surface by the Viral Vpu Protein

(2008) Nanette Van Damme et al.   Cell Host & Microbe

Viral infection and human disease - insights from minimotifs

(2008) Krishna Kadaveru   Frontiers in Bioscience-Landmark

Broad-Spectrum Inhibition of Retroviral and Filoviral Particle Release by Tetherin

(2008) N. Jouvenet et al.   JOURNAL OF VIROLOGY

The AP-2 Adaptor β2 Appendage Scaffolds Alternate Cargo Endocytosis

(2008) Peter A. Keyel et al.   MOLECULAR BIOLOGY OF THE CELL

A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex

(2008) Bernard T. Kelly et al.   NATURE

Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu

(2008) Stuart J. D. Neil et al.   NATURE

Requirements of the membrane proximal tyrosine and dileucine-based sorting signals for efficient transport of the subtype C Vpu protein to the plasma membrane and in virus release

(2008) Autumn Ruiz et al.   VIROLOGY