The HIV-1 accessory proteins Nef and Vpu downregulate total and cell surface CD28 in CD4+ T cells

Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent

(2017) Alice O. Kamphorst et al.   SCIENCE

The interaction between HIV-1 Nef and adaptor protein-2 reduces Nef-mediated CD4 + T cell apoptosis

(2017) Rajesh Abraham Jacob et al.   VIROLOGY

The mTOR Complex Controls HIV Latency

(2016) Emilie Besnard et al.   Cell Host & Microbe

CD28 Costimulation: From Mechanism to Therapy

(2016) Jonathan H. Esensten et al.   IMMUNITY

HIV-1 Nef Impairs the Formation of Calcium Membrane Territories Controlling the Signaling Nanoarchitecture at the Immunological Synapse

(2016) Joana G. Silva et al.   JOURNAL OF IMMUNOLOGY

Latency reversal and viral clearance to cure HIV-1

(2016) D. M. Margolis et al.   SCIENCE

Remodeling of the Host Cell Plasma Membrane by HIV-1 Nef and Vpu: A Strategy to Ensure Viral Fitness and Persistence

(2016) Scott Sugden et al.   Viruses-Basel

LC3C Contributes to Vpu-Mediated Antagonism of BST2/Tetherin Restriction on HIV-1 Release through a Non-canonical Autophagy Pathway

(2016) Ursula Madjo et al.   Cell Reports

A Highly Conserved Residue in HIV-1 Nef Alpha Helix 2 Modulates Protein Expression

(2016) Aaron L. Johnson et al.   mSphere

HIV-1 Nef sequesters MHC-I intracellularly by targeting early stages of endocytosis and recycling

(2016) Brennan S. Dirk et al.   Scientific Reports

HIV-1 Nef: a master manipulator of the membrane trafficking machinery mediating immune evasion

(2015) Emily N. Pawlak et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Nef promotes evasion of human immunodeficiency virus type 1-infected cells from the CTLA-4-mediated inhibition of T-cell activation

(2015) Mohamed El-Far et al.   JOURNAL OF GENERAL VIROLOGY

Serine Phosphorylation of HIV-1 Vpu and Its Binding to Tetherin Regulates Interaction with Clathrin Adaptors

(2015) Tonya Kueck et al.   PLoS Pathogens

Viral Bimolecular Fluorescence Complementation: A Novel Tool to Study Intracellular Vesicular Trafficking Pathways

(2015) Brennan S. Dirk et al.   PLoS One

Lentiviral Nef Proteins Manipulate T Cells in a Subset-Specific Manner

(2014) Hangxing Yu et al.   JOURNAL OF VIROLOGY

HIV-1 Nef and Vpu Are Functionally Redundant Broad-Spectrum Modulators of Cell Surface Receptors, Including Tetraspanins

(2014) C. Haller et al.   JOURNAL OF VIROLOGY

HIV Nef and Vpu protect HIV-infected CD4+ T cells from antibody-mediated cell lysis through down-modulation of CD4 and BST2

(2014) Tram NQ Pham et al.   Retrovirology

HIV-1 Vpr—a still “enigmatic multitasker”

(2014) Carolin A. Guenzel et al.   Frontiers in Microbiology

Interaction with Cellular CD4 Exposes HIV-1 Envelope Epitopes Targeted by Antibody-Dependent Cell-Mediated Cytotoxicity

(2013) M. Veillette et al.   JOURNAL OF VIROLOGY

Down-Regulation of CTLA-4 by HIV-1 Nef Protein

(2013) Mohamed El-Far et al.   PLoS One

Identification of novel key amino acids at the interface of the transmembrane domains of human BST-2 and HIV-1 Vpu

(2013) Xiaojing Pang et al.   Retrovirology

Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef

(2012) Xiaofei Jia et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Cytoplasmic Tail Determinant in HIV-1 Vpu Mediates Targeting of Tetherin for Endosomal Degradation and Counteracts Interferon-Induced Restriction

(2012) Tonya Kueck et al.   PLoS Pathogens

Lysosomal Acidification Mechanisms

(2011) Joseph A. Mindell   Annual Review of Physiology

HIV-1 Nef compensates for disorganization of the immunological synapse by inducing trans-Golgi network-associated Lck signaling

(2011) X. Pan et al.   BLOOD

HIV-1 Nef Disrupts Intracellular Trafficking of Major Histocompatibility Complex Class I, CD4, CD8, and CD28 by Distinct Pathways That Share Common Elements

(2011) J. A. Leonard et al.   JOURNAL OF VIROLOGY

Down-Modulation of CD8   Is a Fundamental Activity of Primate Lentiviral Nef Proteins

(2011) A. Heigele et al.   JOURNAL OF VIROLOGY

Transmembrane Domain Determinants of CD4 Downregulation by HIV-1 Vpu

(2011) J. G. Magadan et al.   JOURNAL OF VIROLOGY

Nef-mediated enhancement of cellular activation and human immunodeficiency virus type 1 replication in primary T cells is dependent on association with p21-activated kinase 2

(2011) Kevin C Olivieri et al.   Retrovirology

β-TrCP is dispensable for Vpu's ability to overcome the CD317/Tetherin-imposed restriction to HIV-1 release

(2011) Hanna-Mari Tervo et al.   Retrovirology

Determinants of Tetherin Antagonism in the Transmembrane Domain of the Human Immunodeficiency Virus Type 1 Vpu Protein

(2010) R. Vigan et al.   JOURNAL OF VIROLOGY

Multilayered Mechanism of CD4 Downregulation by HIV-1 Vpu Involving Distinct ER Retention and ERAD Targeting Steps

(2010) Javier G. Magadán et al.   PLoS Pathogens

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

A novel yeast-based recombination method to clone and propagate diverse HIV-1 isolates

(2009) Dawn M. Dudley et al.   BIOTECHNIQUES

Interleukin-2 Therapy in Patients with HIV Infection

(2009)   NEW ENGLAND JOURNAL OF MEDICINE

Identification of amino acids within the second alpha helical domain of the human immunodeficiency virus type 1 Vpu that are critical for preventing CD4 cell surface expression

(2009) M. Sarah Hill et al.   VIROLOGY

HIV-1 Vpu Neutralizes the Antiviral Factor Tetherin/BST-2 by Binding It and Directing Its Beta-TrCP2-Dependent Degradation

(2009) Bastien Mangeat et al.   PLoS Pathogens

Vpu Antagonizes BST-2–Mediated Restriction of HIV-1 Release via β-TrCP and Endo-Lysosomal Trafficking

(2009) Richard S. Mitchell et al.   PLoS Pathogens

The Interferon-Induced Protein BST-2 Restricts HIV-1 Release and Is Downregulated from the Cell Surface by the Viral Vpu Protein

(2008) Nanette Van Damme et al.   Cell Host & Microbe

Human Immunodeficiency Virus Type 1 Nef Induces Programmed Death 1 Expression through a p38 Mitogen-Activated Protein Kinase-Dependent Mechanism

(2008) K. Muthumani et al.   JOURNAL OF VIROLOGY