HIV-1 Nef: Taking Control of Protein Trafficking

Molecular characterization of HIV-1 Nef and ACOT8 interaction: insights from in silico structural predictions and in vitro functional assays

(2016) Michela Serena et al.   Scientific Reports

HIV-1 Nef: a master manipulator of the membrane trafficking machinery mediating immune evasion

(2015) Emily N. Pawlak et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef

(2015) Nicholas J. Matheson et al.   Cell Host & Microbe

ESCRTs are everywhere

(2015) J. H. Hurley   EMBO JOURNAL

AP-2 Is the Crucial Clathrin Adaptor Protein for CD4 Downmodulation by HIV-1 Nef in Infected Primary CD4+T Cells

(2015) Marcos Vinicius Gondim et al.   JOURNAL OF VIROLOGY

SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef

(2015) Yoshiko Usami et al.   NATURE

HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation

(2015) Annachiara Rosa et al.   NATURE

Intrinsic host restrictions to HIV-1 and mechanisms of viral escape

(2015) Viviana Simon et al.   NATURE IMMUNOLOGY

HIV-1 Nef hijacks clathrin coats by stabilizing AP-1:Arf1 polygons

(2015) Q.-T. Shen et al.   SCIENCE

Forty Years of Clathrin-coated Vesicles

(2015) Margaret S. Robinson   TRAFFIC

Exosomes: Implications in HIV-1 Pathogenesis

(2015) Marisa Madison et al.   Viruses-Basel

Exosome Biogenesis, Regulation, and Function in Viral Infection

(2015) Marta Alenquer et al.   Viruses-Basel

Viral Bimolecular Fluorescence Complementation: A Novel Tool to Study Intracellular Vesicular Trafficking Pathways

(2015) Brennan S. Dirk et al.   PLoS One

Exosomes Are Unlikely Involved in Intercellular Nef Transfer

(2015) Xiaoyu Luo et al.   PLoS One

A Conserved GPG-Motif in the HIV-1 Nef Core Is Required for Principal Nef-Activities

(2015) Marta Martínez-Bonet et al.   PLoS One

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Interaction of HIV-1 Nef Protein with the Host Protein Alix Promotes Lysosomal Targeting of CD4 Receptor

(2014) Nathaly A. Amorim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adaptor proteins involved in polarized sorting

(2014) Juan S. Bonifacino   JOURNAL OF CELL BIOLOGY

Lysine 144, a Ubiquitin Attachment Site in HIV-1 Nef, Is Required for Nef-Mediated CD4 Down-Regulation

(2014) Y.-J. Jin et al.   JOURNAL OF IMMUNOLOGY

Exosomes from Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Cells License Quiescent CD4+ T Lymphocytes To Replicate HIV-1 through a Nef- and ADAM17-Dependent Mechanism

(2014) C. Arenaccio et al.   JOURNAL OF VIROLOGY

The Nef-Like Effect of Murine Leukemia Virus Glycosylated Gag on HIV-1 Infectivity Is Mediated by Its Cytoplasmic Domain and Depends on the AP-2 Adaptor Complex

(2014) Y. Usami et al.   JOURNAL OF VIROLOGY

Nef Neutralizes the Ability of Exosomes from CD4+ T Cells to Act as Decoys during HIV-1 Infection

(2014) Julianne V. de Carvalho et al.   PLoS One

Human semen contains exosomes with potent anti-HIV-1 activity

(2014) Marisa N Madison et al.   Retrovirology

Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation

(2014) Alessia Landi et al.   Retrovirology

How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4

(2014) Xuefeng Ren et al.   eLife

The activity of Nef on HIV-1 infectivity

(2014) Stéphane Basmaciogullari et al.   Frontiers in Microbiology

Structural Basis for Recruitment and Activation of the AP-1 Clathrin Adaptor Complex by Arf1

(2013) Xuefeng Ren et al.   CELL

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Down-Regulation of CTLA-4 by HIV-1 Nef Protein

(2013) Mohamed El-Far et al.   PLoS One

The HIV-1 Nef Protein Binds Argonaute-2 and Functions as a Viral Suppressor of RNA Interference

(2013) Madeeha Aqil et al.   PLoS One

The clathrin adaptor complexes as a paradigm for membrane-associated allostery

(2013) Bertram J. Canagarajah et al.   PROTEIN SCIENCE

ALIX and the multivesicular endosome: ALIX in Wonderland

(2013) Christin Bissig et al.   TRENDS IN CELL BIOLOGY

Identification of a Novel Binding Site Between HIV Type 1 Nef C-Terminal Flexible Loop and AP2 Required for Nef-Mediated CD4 Downregulation

(2012) Yong-Jiu Jin et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

ALIX binds a YPX3L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting

(2012) Michael R. Dores et al.   JOURNAL OF CELL BIOLOGY

AP-3 regulates PAR1 ubiquitin-independent MVB/lysosomal sorting via an ALIX-mediated pathway

(2012) Michael R. Dores et al.   MOLECULAR BIOLOGY OF THE CELL

An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I

(2012) Jimmy D. Dikeakos et al.   MOLECULAR BIOLOGY OF THE CELL

Nef-arious goings-on at the Golgi

(2012) James H Hurley et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef

(2012) Xiaofei Jia et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Proteomic analysis of HIV-1 Nef cellular binding partners reveals a role for exocyst complex proteins in mediating enhancement of intercellular nanotube formation

(2012) Joya Mukerji et al.   Retrovirology

One Protein to Rule them All: Modulation of Cell Surface Receptors and Molecules by HIV Nef

(2011) Alessia Landi et al.   CURRENT HIV RESEARCH

The ESCRT Pathway

(2011) William M. Henne et al.   DEVELOPMENTAL CELL

HIV-1 Nef Disrupts Intracellular Trafficking of Major Histocompatibility Complex Class I, CD4, CD8, and CD28 by Distinct Pathways That Share Common Elements

(2011) J. A. Leonard et al.   JOURNAL OF VIROLOGY

ADP Ribosylation Factor 1 Activity Is Required To Recruit AP-1 to the Major Histocompatibility Complex Class I (MHC-I) Cytoplasmic Tail and Disrupt MHC-I Trafficking in HIV-1-Infected Primary T Cells

(2011) E. R. Wonderlich et al.   JOURNAL OF VIROLOGY

Secretion Modification Region-Derived Peptide Disrupts HIV-1 Nef's Interaction with Mortalin and Blocks Virus and Nef Exosome Release

(2011) M. N. Shelton et al.   JOURNAL OF VIROLOGY

How Ubiquitin Functions with ESCRTs

(2011) S. Brookhart Shields et al.   TRAFFIC

Genetic Characterization of HIV Type 1 Nef-Induced Vesicle Secretion

(2010) Syed A. Ali et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

HIV Type 1 Nef Is Released from Infected Cells in CD45+ Microvesicles and Is Present in the Plasma of HIV-Infected Individuals

(2010) A.D. Raymond et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

ADAM-17: the enzyme that does it all

(2010) Monika Gooz   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Conservation and Diversification of Dileucine Signal Recognition by Adaptor Protein (AP) Complex Variants

(2010) Rafael Mattera et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 Nef Binds a Subpopulation of MHC-I throughout Its Trafficking Itinerary and Down-regulates MHC-I by Perturbing Both Anterograde and Retrograde Trafficking

(2010) Ling Yi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small Molecule Inhibition of HIV-1–Induced MHC-I Down-Regulation Identifies a Temporally Regulated Switch in Nef Action

(2010) Jimmy D. Dikeakos et al.   MOLECULAR BIOLOGY OF THE CELL

The Role of Ubiquitination in Lysosomal Trafficking of δ-Opioid Receptors

(2010) Anastasia G. Henry et al.   TRAFFIC

Multilayered Mechanism of CD4 Downregulation by HIV-1 Vpu Involving Distinct ER Retention and ERAD Targeting Steps

(2010) Javier G. Magadán et al.   PLoS Pathogens

Membrane Traffic Within the Golgi Apparatus

(2009) Benjamin S. Glick et al.   Annual Review of Cell and Developmental Biology

ESCRT proteins and the regulation of endocytic delivery to lysosomes: Figure 1

(2009) J. Paul Luzio et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Nef Proteins from Simian Immunodeficiency Viruses Are Tetherin Antagonists

(2009) Fengwen Zhang et al.   Cell Host & Microbe

Massive Secretion by T Cells Is Caused by HIV Nef in Infected Cells and by Nef Transfer to Bystander Cells

(2009) Claudia Muratori et al.   Cell Host & Microbe

A Basic Patch on  -Adaptin Is Required for Binding of Human Immunodeficiency Virus Type 1 Nef and Cooperative Assembly of a CD4-Nef-AP-2 Complex

(2009) R. Chaudhuri et al.   JOURNAL OF VIROLOGY

Human Immunodeficiency Virus Type 1 Nef Protein Targets CD4 to the Multivesicular Body Pathway

(2009) L. L. P. daSilva et al.   JOURNAL OF VIROLOGY

HIV-1 Nef membrane association depends on charge, curvature, composition and sequence

(2009) Holger Gerlach et al.   Nature Chemical Biology

An MHC-I Cytoplasmic Domain/HIV-1 Nef Fusion Protein Binds Directly to the μ Subunit of the AP-1 Endosomal Coat Complex

(2009) Rajendra Kumar Singh et al.   PLoS One

HIV Nef is Secreted in Exosomes and Triggers Apoptosis in Bystander CD4+ T Cells

(2009) Metka Lenassi et al.   TRAFFIC

Intracellular Assembly and Trafficking of MHC Class I Molecules

(2009) Julie G. Donaldson et al.   TRAFFIC

Interactions between SIVNef, SIVGagPol and Alix correlate with viral replication and progression to AIDS in rhesus macaques

(2009) Luciana Jesus da Costa et al.   VIROLOGY

Species-Specific Activity of SIV Nef and HIV-1 Vpu in Overcoming Restriction by Tetherin/BST2

(2009) Bin Jia et al.   PLoS Pathogens

HIV-1 Nef Binds PACS-2 to Assemble a Multikinase Cascade That Triggers Major Histocompatibility Complex Class I (MHC-I) Down-regulation

(2008) Katelyn M. Atkins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor  -chain

(2008) Y. Yamashita et al.   JOURNAL OF CELL SCIENCE

A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex

(2008) Bernard T. Kelly et al.   NATURE

HIV-1 Nef: at the crossroads

(2008) John L Foster et al.   Retrovirology

HIV-1 Nef Targets MHC-I and CD4 for Degradation Via a Final Common β-COP–Dependent Pathway in T Cells

(2008) Malinda R. Schaefer et al.   PLoS Pathogens

Selective downmodulation of HLA-A and -B by Nef alleles from different groups of primate lentiviruses

(2007) Anke Specht et al.   VIROLOGY