A single β-octyl glucoside molecule induces HIV-1 Nef dimer formation in the absence of partner protein binding

Cell-based Fluorescence Complementation Reveals a Role for HIV-1 Nef Protein Dimerization in AP-2 Adaptor Recruitment and CD4 Co-receptor Down-regulation

(2016) Sherry T. Shu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo analysis of Nef’s role in HIV-1 replication, systemic T cell activation and CD4+ T cell loss

(2015) Richard L Watkins et al.   Retrovirology

The Accessory Factor Nef Links HIV-1 to Tec/Btk Kinases in an Src Homology 3 Domain-dependent Manner

(2014) Sreya Tarafdar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction with the Src Homology (SH3-SH2) Region of the Src-family Kinase Hck Structures the HIV-1 Nef Dimer for Kinase Activation and Effector Recruitment

(2014) John Jeff Alvarado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deciphering key features in protein structures with the new ENDscript server

(2014) Xavier Robert et al.   NUCLEIC ACIDS RESEARCH

HIV Nef and Vpu protect HIV-infected CD4+ T cells from antibody-mediated cell lysis through down-modulation of CD4 and BST2

(2014) Tram NQ Pham et al.   Retrovirology

Effector Kinase Coupling Enables High-Throughput Screens for Direct HIV-1 Nef Antagonists with Antiretroviral Activity

(2013) Lori A. Emert-Sedlak et al.   CHEMISTRY & BIOLOGY

Interaction with Cellular CD4 Exposes HIV-1 Envelope Epitopes Targeted by Antibody-Dependent Cell-Mediated Cytotoxicity

(2013) M. Veillette et al.   JOURNAL OF VIROLOGY

Discovery of a diaminoquinoxaline benzenesulfonamide antagonist of HIV-1 Nef function using a yeast-based phenotypic screen

(2013) Ronald P Trible et al.   Retrovirology

Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef

(2012) Xiaofei Jia et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nef Alleles from All Major HIV-1 Clades Activate Src-Family Kinases and Enhance HIV-1 Replication in an Inhibitor-Sensitive Manner

(2012) Purushottam S. Narute et al.   PLoS One

Nef functions in BLT mice to enhance HIV-1 replication and deplete CD4+CD8+ thymocytes

(2012) Wei Zou et al.   Retrovirology

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Molecular Design, Functional Characterization and Structural Basis of a Protein Inhibitor Against the HIV-1 Pathogenicity Factor Nef

(2011) Sebastian Breuer et al.   PLoS One

A Novel Dimer-Tetramer Transition Captured by the Crystal Structure of the HIV-1 Nef

(2011) Pankaj Singh et al.   PLoS One

Conformation of the Dileucine-Based Sorting Motif in HIV-1 Nef Revealed by Intermolecular Domain Assembly

(2011) Florian A. Horenkamp et al.   TRAFFIC

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Ligand docking and binding site analysis with PyMOL and Autodock/Vina

(2010) Daniel Seeliger et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Small Molecule Inhibition of HIV-1–Induced MHC-I Down-Regulation Identifies a Temporally Regulated Switch in Nef Action

(2010) Jimmy D. Dikeakos et al.   MOLECULAR BIOLOGY OF THE CELL

Chemical Library Screens Targeting an HIV-1 Accessory Factor/Host Cell Kinase Complex Identify Novel Antiretroviral Compounds

(2009) Lori Emert-Sedlak et al.   ACS Chemical Biology

HIV-1 Nef Dimerization Is Required for Nef-Mediated Receptor Downregulation and Viral Replication

(2009) Jerrod A. Poe et al.   JOURNAL OF MOLECULAR BIOLOGY

HIV-1 Nef membrane association depends on charge, curvature, composition and sequence

(2009) Holger Gerlach et al.   Nature Chemical Biology

Selective targeting of ITK blocks multiple steps of HIV replication

(2008) J. A. Readinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 Nef: at the crossroads

(2008) John L Foster et al.   Retrovirology