SOX2 Promotes the Epithelial to Mesenchymal Transition of Esophageal Squamous Cells by Modulating Slug Expression through the Activation of STAT3/HIF-α Signaling

Expression of Sox2 in breast cancer cells promotes the recruitment of M2 macrophages to tumor microenvironment

(2015) Wenjun Mou et al.   CANCER LETTERS

SOX2, a predictor of survival in gastric cancer, inhibits cell proliferation and metastasis by regulating PTEN

(2015) Simeng Wang et al.   CANCER LETTERS

Knockdown of STAT3 expression in SKOV3 cells by biodegradable siRNA–PLGA/CSO conjugate micelles

(2015) Yunchun Zhao et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Loss of CD44 and SOX2 Expression is Correlated with a Poor Prognosis in Esophageal Adenocarcinoma Patients

(2014) Judith Honing et al.   ANNALS OF SURGICAL ONCOLOGY

Neurotensin signaling regulates stem-like traits of glioblastoma stem cells through activation of IL-8/CXCR1/STAT3 pathway

(2014) Ji Zhou et al.   CELLULAR SIGNALLING

Hypoxia promotes vasculogenic mimicry formation by inducing epithelial–mesenchymal transition in ovarian carcinoma

(2014) Jing Du et al.   GYNECOLOGIC ONCOLOGY

Notch1 induces epithelial-mesenchymal transition and the cancer stem cell phenotype in breast cancer cells and STAT3 plays a key role

(2014) XIAOJIN ZHANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

VEGF drives cancer-initiating stem cells through VEGFR-2/Stat3 signaling to upregulate Myc and Sox2

(2014) D Zhao et al.   ONCOGENE

SOX2 promotes the migration and invasion of laryngeal cancer cells by induction of MMP-2 via the PI3K/Akt/mTOR pathway

(2014) NING YANG et al.   ONCOLOGY REPORTS

Increased SOX2 Gene Copy Number Is Associated with FGFR1 and PIK3CA Gene Gain in Non-Small Cell Lung Cancer and Predicts Improved Survival in Early Stage Disease

(2014) Luca Toschi et al.   PLoS One

A ROS/STAT3/HIF-1α signaling cascade mediates EGF-induced TWIST1 expression and prostate cancer cell invasion

(2014) Kyung Hwa Cho et al.   PROSTATE

SOX2 overexpression correlates with poor prognosis in laryngeal squamous cell carcinoma

(2013) Xia-bing Tang et al.   AURIS NASUS LARYNX

Mitochondrial dysfunction represses HIF-1α protein synthesis through AMPK activation in human hepatoma HepG2 cells

(2013) Chia-Chi Hsu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

STAT3 mediates TGF-β1-induced TWIST1 expression and prostate cancer invasion

(2013) Kyung Hwa Cho et al.   CANCER LETTERS

SOX2 promotes tumor metastasis by stimulating epithelial-to-mesenchymal transition via regulation of WNT/β-catenin signal network

(2013) Xuefei Li et al.   CANCER LETTERS

SOX2 promotes tumor growth of esophageal squamous cell carcinoma through the AKT/mammalian target of rapamycin complex 1 signaling pathway

(2013) Yasuyuki Gen et al.   CANCER SCIENCE

SOX2 expression in hypopharyngeal, laryngeal, and sinonasal squamous cell carcinoma

(2013) Rocío González-Márquez et al.   HUMAN PATHOLOGY

Icariin Protects Rat Cardiac H9c2 Cells from Apoptosis by Inhibiting Endoplasmic Reticulum Stress

(2013) Qiufang Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sox2 expression predicts poor survival of hepatocellular carcinoma patients and it promotes liver cancer cell invasion by activating Slug

(2013) Chun Sun et al.   MEDICAL ONCOLOGY

Identification of natural splice variants of SAMHD1 in virus-infected HCC

(2013) YUNPENG SHI et al.   ONCOLOGY REPORTS

Slug is a key mediator of hypoxia induced cadherin switch in HNSCC: Correlations with poor prognosis

(2013) Jiali Zhang et al.   ORAL ONCOLOGY

Silencing of DLGAP5 by siRNA Significantly Inhibits the Proliferation and Invasion of Hepatocellular Carcinoma Cells

(2013) Weijia Liao et al.   PLoS One

Slug Is a Predictor of Poor Prognosis in Esophageal Squamous Cell Carcinoma Patients

(2013) Md. Raghibul Hasan et al.   PLoS One

A review of the current understanding and clinical utility of miRNAs in esophageal cancer

(2013) Naomi S. Sakai et al.   SEMINARS IN CANCER BIOLOGY

SOX2 promotes dedifferentiation and imparts stem cell-like features to pancreatic cancer cells

(2013) M Herreros-Villanueva et al.   Oncogenesis

Sex-determining region Y-box 2 expression predicts poor prognosis in human ovarian carcinoma

(2012) Jing Zhang et al.   HUMAN PATHOLOGY

Targeted silencing of the oncogenic transcription factor SOX2 in breast cancer

(2012) Sabine Stolzenburg et al.   NUCLEIC ACIDS RESEARCH

Silencing SOX2 Induced Mesenchymal-Epithelial Transition and Its Expression Predicts Liver and Lymph Node Metastasis of CRC Patients

(2012) Xu Han et al.   PLoS One

Expression of the embryonic stem cell marker SOX2 in early-stage breast carcinoma

(2011) Claudia Lengerke et al.   BMC CANCER

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

HIF Induces Human Embryonic Stem Cell Markers in Cancer Cells

(2011) J. Mathieu et al.   CANCER RESEARCH

The EMT regulator slug and lung carcinogenesis

(2011) J.-Y. Shih et al.   CARCINOGENESIS

Expression of MET and SOX2 genes in non-small cell lung carcinoma with EGFR mutation

(2011) Yi-Ran Cai   ONCOLOGY REPORTS

Genetic and Epigenetic Modifications of Sox2 Contribute to the Invasive Phenotype of Malignant Gliomas

(2011) Marta M. Alonso et al.   PLoS One

Comprehensive analysis of clinical significance of stem-cell related factors in renal cell cancer

(2011) Yongchao Liu et al.   World Journal of Surgical Oncology

SOX2 identified as a target gene for the amplification at 3q26 that is frequently detected in esophageal squamous cell carcinoma

(2010) Yasuyuki Gen et al.   CANCER GENETICS AND CYTOGENETICS

Esophageal cancer-the five year survivors

(2010) Tad Kim et al.   JOURNAL OF SURGICAL ONCOLOGY

Role of the epithelial-mesenchymal transition regulator Slug in primary human cancers

(2009) Catarina Castro Alves   Frontiers in Bioscience-Landmark

Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis

(2008) Jing Yang et al.   DEVELOPMENTAL CELL

Regulation of Self-Renewal and Pluripotency by Sox2 in Human Embryonic Stem Cells

(2008) Helen Fong et al.   STEM CELLS