Review
Oncology
Shunli Chu, Xiaolu Shi, Ye Tian, Fengxiang Gao
Summary: The complexity of the tumor microenvironment can be overcome by using pH-responsive polymers for targeted drug delivery, improving treatment efficacy and reducing adverse reactions.
FRONTIERS IN ONCOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Alexander M. Demin, Alexandra G. Pershina, Artem S. Minin, Olga Ya Brikunova, Aidar M. Murzakaev, Natalya A. Perekucha, Alexander Romashchenko, Oleg B. Shevelev, Mikhail A. Uimin, Iliya Byzov, Dina Malkeyeva, Elena Kiseleva, Lina Efimova, Sergey V. Vtorushin, Ludmila M. Ogorodova, Victor P. Krasnov
Summary: The study demonstrates the use of pHLIP-modified MNPs for high-specificity nanodrug accumulation in the acidic tumor microenvironment, showing low cytotoxicity and high cellular uptake rates. In vivo experiments in BALB/c mice show a significantly higher accumulation rate of pHLIP-modified MNPs in tumors compared to PEGylated MNPs.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Multidisciplinary Sciences
Qingqing Yin, Anni Pan, Binlong Chen, Zenghui Wang, Mingmei Tang, Yue Yan, Yaoqi Wang, Heming Xia, Wei Chen, Hongliang Du, Meifang Chen, Chuanxun Fu, Yanni Wang, Xia Yuan, Zhihao Lu, Qiang Zhang, Yiguang Wang
Summary: The authors developed a binary ratiometric nanoreporter that quantifies intracellular nanoparticle uptake and predicts nanotherapeutic responses. This technology accurately quantifies the internalisation of nanoparticles in tumor cells, enabling the prediction of therapeutic responses and personalized cancer therapy.
NATURE COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Yu Zou, Quan Zhou, Yinan Zhao, Defu Zhi, Huiying Chen, Rui Wang, Benzhi Ju, Shubiao Zhang
Summary: Ionizable lipids, such as the optimized lipid EDM, show efficient gene delivery and gene silencing in A549 cells. EDM is capable of escaping the endosome quickly and releasing the gene in the cytoplasm.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Polymer Science
Nour M. AlSawaftah, Nahid S. Awad, William G. Pitt, Ghaleb A. Husseini
Summary: Stimuli-responsive nanoparticles have shown promising potential in overcoming the limitations of conventional chemotherapy. pH-sensitive nanoparticles, in particular, have proven to be highly efficient in delivering drugs to tumors compared to conventional nanoparticles. This review summarizes the different strategies used to develop pH-sensitive nanoparticles for cancer therapy.
Review
Pharmacology & Pharmacy
Zhouyun Chen, Xiaoxiao Wang, Na Zhao, Haifeng Chen, Gang Guo
Summary: This article introduces the application of pH-responsive nanocarriers in tumor therapy. The acidic tumor microenvironment produced by tumor cells can be used to design targeted tumor therapy, and pH-responsive nanocarriers can achieve targeted drug delivery and controlled release, improving the effectiveness of tumor therapy.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Pharmacology & Pharmacy
Jie Zhu, Rui Gao, Zhongshi Wang, Zhiming Cheng, Zhonghua Xu, Zaiyang Liu, Yiqun Wu, Min Wang, Yuan Zhang
Summary: A pH-responsive nonapeptide hydrogel was designed and fabricated for tumor-targeted drug delivery, which exhibited good injectability and biocompatibility. The drug-loaded hydrogel showed high sensitivity to acidic conditions and could amplify the therapeutic effect and increase drug accumulation at the tumor site in vivo.
Article
Chemistry, Physical
Yinglan Yu, Chang Zu, Dongsheng He, Yanan Li, Qinying Chen, Qian Chen, Huimin Wang, Ruijuan Wang, Birendra Chaurasiya, Jennica L. Zaro, Yiran Wang, Jiasheng Tu, Chunmeng Sun
Summary: Artemisinin, well known as an antimalarial drug, can also be used for inflammation and cancer treatment. Studies have shown that utilizing a reversibly activatable cell-penetrating peptide can enhance the concentration of artemisinin in tumors, leading to improved antitumor effects.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Physical
Longmeng Li, Aaron R. Lindstrom, Andrew C. Birkeland, Menghuan Tang, Tzu-Yin Lin, Yikai Zhou, Bai Xiang, Xiangdong Xue, Yuanpei Li
Summary: Nanoprodrugs assembled by prodrugs hold promise for cancer treatment, but their stability and tumor-targeted delivery efficiency are challenging. In this study, a deep tumor-penetrating nano-delivery strategy was developed by optimizing a porphyrin-doxorubicin-based nanoprodrug through PEGylation/crosslinks and co-administration of targeting peptide iRGD. The optimized nanoprodrug showed enhanced accumulation and penetration in tumor vascular and tissue, improving therapeutic efficacy through both passive tumor targeting dependent and independent modes.
Article
Chemistry, Physical
Longmeng Li, Aaron R. Lindstrom, Andrew C. Birkeland, Menghuan Tang, Tzu-Yin Lin, Yikai Zhou, Bai Xiang, Xiangdong Xue, Yuanpei Li
Summary: This study presents a novel strategy for deep tumor-penetrating nano-delivery, in which a porphyrin-doxorubicin-based nanoprodrug is optimized through PEGylations/crosslinks and co-administration of the targeting peptide iRGD. The optimized nanoprodrug demonstrates enhanced anti-cancer performance and improved tumor penetration in both animal models and human tissue samples. It is a promising approach to strengthen the clinical implementation of nanoprodrugs.
Review
Pharmacology & Pharmacy
Manon Berger, Anna Lechanteur, Brigitte Evrard, Geraldine Piel
Summary: RNA interference is a promising mechanism for gene silencing and disease treatment, but the stability of siRNA in blood is a challenge. Lipoplexes and LNPs are commonly used to deliver and protect siRNA, yet clinical translation remains difficult with only few RNAi drugs approved by the FDA. Innovative formulations incorporating pH-sensitive lipids, peptides, and polymers aim to enhance siRNA efficacy for effective antitumor effects in complex tumor environments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Olga Korovkina, Dmitry Polyakov, Viktor Korzhikov-Vlakh, Evgenia Korzhikova-Vlakh
Summary: The synthesis of pH- and redox-responsive amphiphilic polypeptides for intracellular DNA delivery is reported in this paper. The polypeptide nanoparticles demonstrated pH sensitivity and redox responsiveness, allowing for stable self-assembly in the extracellular environment and degradation and nucleic acid release inside the cell.
Article
Biophysics
Nanyang Tang, Qian Ning, Zewei Wang, Yifang Tao, Xuhong Zhao, Shengsong Tang
Summary: Intelligent delivery systems incorporating sensitive materials in response to endogenous stimuli of the tumor microenvironment have shown potential for tumor-specific genome editing and reduced side effects of CRISPR/Cas in cancer gene therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Fangli Gao, Liting Jiang, Jie Zhang, Yi Chang, Weihua Gao, Lina Ding, Guanglei Ma, Xiaoming Ma, Yuming Guo
Summary: Researchers have developed a near-infrared light-triggered delivery system that enhances the penetration and accumulation of nanomedicines, leading to improved tumor therapeutic efficacy. The system combines thermosensitive liposomes, photosensitizers, and ultrasmall copper sulfide nanoparticles, and has shown promising results in vitro and in vivo using photodynamic therapy and photothermal therapy.
ACS MATERIALS LETTERS
(2023)
Article
Medicine, Research & Experimental
Jianyang Zhao, Yi-Yang Peng, Diana Diaz-Dussan, Jacinta White, Wei Duan, Lingxue Kong, Ravin Narain, Xiaojuan Hao
Summary: This study investigates the use of block copolymer micelles as nanocarriers for precise delivery and release of TPZD to enhance its anti-tumor effect. The grafted TPZD exhibits pH-responsive drug release through the cleavage of an imine bond under acidic conditions.
MOLECULAR PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Maryam Besharati, Mahmoud Amouzadeh Tabrizi, Fatemeh Molaabasi, Reza Saber, Mojtaba Shamsipur, Javad Hamedi, Saman Hosseinkhani
Summary: Two biosensing methods utilizing NAD(P)H-dependent TetX2 enzyme activity and thionine were developed to detect tetracycline in milk. The methods showed great potential for being portable instruments for on-site TC measurements.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2022)
Article
Biochemical Research Methods
Mohsen Isazadeh, Mojdeh Amandadi, Farnaz Haghdoust, Shima Lotfollazadeh, Mar Orzaez, Saman Hosseinkhani
Summary: This study used the split luciferase complementation assay to investigate the interactions of NLRP3 during inflammasome formation. By mutating the phosphomimetic residue at the interface of NLRP3 interactions, the designed biosensor was able to monitor the NLRP3PYD-NLRP3PYD interaction in vitro. This assay provides a specific method to study the PYD-PYD interaction and can be used to screen chemicals and drugs.
ANALYTICAL BIOCHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Soroush Moasses Ghafary, Elnaz Rahimjazi, Hadiseh Hamzehil, Sayed Mostafa Modarres Mousavi, Maryam Nikkhah, Saman Hosseinkhani
Summary: There is a need for a novel targeted drug delivery system to overcome the drawbacks of conventional chemotherapy. In this study, nano-carriers based on MiRGD peptides and graphene quantum dots were used for targeted delivery of two different drug models. The results indicate that the prepared nano-composites are suitable for targeted drug delivery and tracking in cancer cells.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Review
Chemistry, Physical
Yasaman-Sadat Borghei, Saman Hosseinkhani, Mohammad Reza Ganjali
Summary: This review provides a guideline for physicist/chemist/biologist/physician in the introduction of metallic nanocluster applications in biomedicine. It introduces the physicochemical properties of metallic nanoclusters and the potential biomedical opportunities, guiding researchers in developing new scaffolds for biomedical engineering.
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
(2022)
Article
Biochemistry & Molecular Biology
Yasaman-Sadat Borghei, Saman Hosseinkhani
Summary: DNA-functionalized gold nanoparticles hold great promise in biomedical applications. A novel approach of in-situ synthesis of gold nanoparticles on polyguanine strands is reported, leading to the formation of polyvalent DNA-functionalized gold nanoparticles. This method demonstrates general applicability and shows higher attractiveness in biomedical diagnosis and specific sequence detection.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2022)
Article
Toxicology
Jalil Mehrzad, Taghi Zahraei Salehi, Alireza Khosravi, Saman Hosseinkhani, Yaser Tahamtani, Ensiyeh Hajizadeh-Saffar, Maedeh Moazenchi, Amir Mohammad Malvandi
Summary: This study analyzed the effects of aflatoxins on rat pancreatic islet cells, finding that these environmental toxins can impair the quality and function of the cells, potentially leading to endocrine disorders such as type-2 diabetes.
Article
Multidisciplinary Sciences
Amir Amiri-Sadeghan, Ali Dinari, Soheila Mohammadi, Tayebeh Zohrabi, Reza Khodarahmi, Saman Hosseinkhani, Jungwon Yoon
Summary: The photo-physical properties of metal nano clusters are sensitive to their surrounding medium, and this sensitivity, combined with the unique properties of self-assembled structures, opens up new opportunities for sensing applications.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Yasaman-Sadat Borghei, Saman Hosseinkhani, Mohammad Reza Ganjali
Summary: This review focuses on the basic physicochemical properties of plasmonic nanoparticles and their applications in biomedical and tissue engineering. It aims to provide a comprehensive and authoritative overview to the scientific community. The review introduces the fundamental characteristics of nanomaterials and illustrates their applications in the field through selected case studies.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Soroush Moasses Ghafary, Paula M. Soriano-Teruel, Shima Lotfollahzadeh, Monica Sancho, Eva Serrano-Candelas, Fatemeh Karami, Stephen J. Barigye, Ivan Fernandez-Perez, Rafael Gozalbes, Maryam Nikkhah, Mar Orzaez, Saman Hosseinkhani
Summary: This study identified QM380 and QM381 as inhibitors of NLRP3(PYD) homo-oligomerization, which interfere with the formation of inflammasomes and reduce inflammatory responses. Spectroscopic techniques and computational docking analyses confirmed the experimental results and predicted possible mechanisms underlying the inhibition of NLRP3(PYD) homo-interactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Optics
Yasaman-Sadat Borghei, Saman Hosseinkhani
Summary: This review focuses on the physico-chemical basis of semiconductor quantum dots in various medical applications, emphasizing more on the strategy and method rather than the target molecules.
JOURNAL OF LUMINESCENCE
(2022)
Article
Multidisciplinary Sciences
Shima Lotfollahzadeh, Elaheh Sadat Hosseini, Hooman Mahmoudi Aznaveh, Maryam Nikkhah, Saman Hosseinkhani
Summary: This study successfully fabricated a promising nanohybrid system to improve the therapeutic efficacy of TRAIL. By conjugating TRAIL with graphene quantum dots, the study demonstrated enhanced functional stability and effective anticancer activity.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Y-S Borghei, S. Hosseinkhani, M. R. Ganjali
Summary: Magnetic nanoparticles (MNPs) have biomedical applications that can be classified based on their unique properties in the presence or removal of an external magnetic field. Magnetite nanoparticles, with their unique physicochemical and catalytic properties, have gained increasing attention in medical fields for diagnosis, imaging, therapy, and cellular/tissue engineering.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Maryam Hosseini, Zahed Ahmadi, Amirhosein Kefayat, Fatemeh Molaabasi, Anita Ebrahimpour, Yousef Naderi Khojasteh Far, Mehdi Khoobi
Summary: In this study, a helical structure of gold nanoparticles was engineered using Spirulina platensis as a biotemplate for the treatment and diagnosis of cancer. The biohybrid showed excellent imaging performance and tumor suppression effects, as well as biodegradability and good biocompatibility.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Fatemeh Molaabasi, Amirhosein Kefayat, Abbas Ghasemzadeh, Mojdeh Amandadi, Mojtaba Shamsipur, Mozhgan Alipour, Seyyed Ebrahim Moosavifard, Maryam Besharati, Saman Hosseinkhani, Ramin Sarrami-Forooshani
Summary: A label-, antibody-, enzyme-, and amplification-free ratiometric fluorescent biosensor has been developed for the rapid and low-cost diagnosis of COVID-19. The biosensor exhibits high sensitivity and specificity, and can detect the virus using isolated RNA samples.
ANALYTICAL CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Mojtaba Shamsipur, Elaheh Babaee, Mohammad-Bagher Gholivand, Fatemeh Molaabasi, Farimah Mousavi, Ali Barati, Behnam Hajipour Verdom, Behnaz Shojaedin-Givi, Hossein Naderi-Manesh
Summary: In this study, a new fluorescence probe based on insulin-capped gold nanoclusters (Ins/Au-NCs) was developed for selective detection of Cu2+ ions and glutathione (GSH). The probe showed high sensitivity and stability. Cu2+ ions caused fluorescence quenching of Ins/Au-NCs, which could be recovered in the presence of GSH. The probe had low detection limits and broad linear ranges for Cu2+ ions and GSH. It also showed promising application in detecting low levels of Cu2+ ions and GSH in water and human serum samples.
ACS APPLIED NANO MATERIALS
(2023)
Article
Oncology
Yuxin Liu, Swati Bhardwaj, Keith Sigel, John Winters, Joseph Terlizzi, Michael M. Gaisa
Summary: This study investigated the prevalence and severity of anal HPV disease among MSM LWH under the age of 35, finding a high prevalence of HPV infection and precancer but no cases of invasive anal cancer. This supports the adoption of age-based anal cancer screening for this population.
INTERNATIONAL JOURNAL OF CANCER
(2024)
Correction
Oncology
J. Gu, S. Xie, S. Wang
INTERNATIONAL JOURNAL OF CANCER
(2024)