The network of epithelial–mesenchymal transition: potential new targets for tumor resistance
Published 2014 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The network of epithelial–mesenchymal transition: potential new targets for tumor resistance
Authors
Keywords
Epithelial–mesenchymal transition, Metastasis, Cancer stem cell, Tumor aggressiveness, Therapeutic resistance
Journal
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
Volume 141, Issue 10, Pages 1697-1713
Publisher
Springer Nature
Online
2014-09-30
DOI
10.1007/s00432-014-1840-y
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Epithelial-to-mesenchymal transition and the cancer stem cell phenotype: insights from cancer biology with therapeutic implications for colorectal cancer
- (2014) V J Findlay et al. CANCER GENE THERAPY
- Radiation-enhanced cell migration/invasion process: A review
- (2014) Coralie Moncharmont et al. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
- Tackling the cancer stem cells — what challenges do they pose?
- (2014) Diwakar R. Pattabiraman et al. NATURE REVIEWS DRUG DISCOVERY
- Three-dimensional cell migration does not follow a random walk
- (2014) P.-H. Wu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting EMT in cancer: opportunities for pharmacological intervention
- (2014) Felicity M. Davis et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor -1α in hepatocellular carcinoma
- (2013) Lin Zhang et al. BMC CANCER
- FOXC2 Expression Links Epithelial-Mesenchymal Transition and Stem Cell Properties in Breast Cancer
- (2013) B. G. Hollier et al. CANCER RESEARCH
- Suppression of FOXQ1 in benzyl isothiocyanate-mediated inhibition of epithelial-mesenchymal transition in human breast cancer cells
- (2013) A. Sehrawat et al. CARCINOGENESIS
- Wnt/β-catenin signaling enhances hypoxia-induced epithelial–mesenchymal transition in hepatocellular carcinoma via crosstalk with hif-1α signaling
- (2013) Qi Zhang et al. CARCINOGENESIS
- Regulation of epithelial–mesenchymal and mesenchymal–epithelial transitions by microRNAs
- (2013) Samy Lamouille et al. CURRENT OPINION IN CELL BIOLOGY
- Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition
- (2013) David Balli et al. EMBO JOURNAL
- Mitochondrial retrograde signaling induces epithelial–mesenchymal transition and generates breast cancer stem cells
- (2013) M Guha et al. ONCOGENE
- Hypoxia Stimulates the EMT of Gastric Cancer Cells through Autocrine TGFβ Signaling
- (2013) Junko Matsuoka et al. PLoS One
- Hypoxia Promotes Epithelial - Mesenchymal Transition of Hepatocellular Carcinoma Cells via Inducing GLIPR-2 Expression
- (2013) Shao-guang Huang et al. PLoS One
- Loss of corepressor PER2 under hypoxia up-regulates OCT1-mediated EMT gene expression and enhances tumor malignancy
- (2013) W. W. Hwang-Verslues et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The rejuvenated scenario of epithelial–mesenchymal transition (EMT) and cancer metastasis
- (2012) Fanyan Meng et al. CANCER AND METASTASIS REVIEWS
- EMT in breast cancer stem cell generation
- (2012) Stéphane Ansieau CANCER LETTERS
- Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State
- (2012) Wenjun Guo et al. CELL
- An Epithelial-Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance
- (2012) L. A. Byers et al. CLINICAL CANCER RESEARCH
- HER2-Associated Radioresistance of Breast Cancer Stem Cells Isolated from HER2-Negative Breast Cancer Cells
- (2012) N. Duru et al. CLINICAL CANCER RESEARCH
- Epithelial-mesenchymal transition and fibrosis are mutually exclusive reponses in shear-activated proximal tubular epithelial cells
- (2012) Bryan M. Grabias et al. FASEB JOURNAL
- Induction of Cancerous Stem Cells during Embryonic Stem Cell Differentiation
- (2012) Hiroaki Fujimori et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Down-Regulation of HtrA1 Activates the Epithelial-Mesenchymal Transition and ATM DNA Damage Response Pathways
- (2012) Ning Wang et al. PLoS One
- FoxQ1 Overexpression Influences Poor Prognosis in Non-Small Cell Lung Cancer, Associates with the Phenomenon of EMT
- (2012) Jian Feng et al. PLoS One
- Epithelial to Mesenchymal Transition Is a Determinant of Sensitivity to Chemoradiotherapy in Non-Small Cell Lung Cancer
- (2011) Yasushi Shintani et al. ANNALS OF THORACIC SURGERY
- Low doses ionizing radiation enhances the invasiveness of breast cancer cells by inducing epithelial–mesenchymal transition
- (2011) Xin Zhang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- MicroRNA-138 suppresses epithelial–mesenchymal transition in squamous cell carcinoma cell lines
- (2011) Xiqiang Liu et al. BIOCHEMICAL JOURNAL
- MicroRNAs: critical regulators of epithelial to mesenchymal (EMT) and mesenchymal to epithelial transition (MET) in cancer progression
- (2011) Marc D. Bullock et al. BIOLOGY OF THE CELL
- Activation of β-catenin and Akt pathways by Twist are critical for the maintenance of EMT associated cancer stem cell-like characters
- (2011) Junlin Li et al. BMC CANCER
- Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis
- (2011) Myriam Labelle et al. CANCER CELL
- FOXQ1 Regulates Epithelial-Mesenchymal Transition in Human Cancers
- (2011) Y. Qiao et al. CANCER RESEARCH
- TGF /TNF -Mediated Epithelial-Mesenchymal Transition Generates Breast Cancer Stem Cells with a Claudin-Low Phenotype
- (2011) M. K. Asiedu et al. CANCER RESEARCH
- MicroRNAs as regulators of epithelial-mesenchymal transition
- (2011) Philip A. Gregory et al. CELL CYCLE
- Let-7 and miR-200 microRNAs: Guardians against pluripotency and cancer progression
- (2011) Marcus E. Peter CELL CYCLE
- Increased Slug and decreased E-cadherin expression is related to poor prognosis in patients with gastric cancer
- (2011) Yasuto Uchikado et al. Gastric Cancer
- Epithelial-mesenchymal transition in renal fibrosis - evidence for and against
- (2011) Maria Fragiadaki et al. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
- Ionizing Radiation Promotes Migration and Invasion of Cancer Cells Through Transforming Growth Factor-Beta–Mediated Epithelial–Mesenchymal Transition
- (2011) Yong-Chun Zhou et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial–mesenchymal transition
- (2011) Nam Hee Kim et al. JOURNAL OF CELL BIOLOGY
- Signal transduction by reactive oxygen species
- (2011) Toren Finkel JOURNAL OF CELL BIOLOGY
- Over-expression of FoxM1 leads to epithelial-mesenchymal transition and cancer stem cell phenotype in pancreatic cancer cells
- (2011) Bin Bao et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?
- (2011) Wilhelm Kriz et al. JOURNAL OF CLINICAL INVESTIGATION
- p53 regulates epithelial–mesenchymal transition through microRNAs targeting ZEB1 and ZEB2
- (2011) Taewan Kim et al. JOURNAL OF EXPERIMENTAL MEDICINE
- MicroRNA-194 inhibits epithelial to mesenchymal transition of endometrial cancer cells by targeting oncogene BMI-1
- (2011) Peixin Dong et al. Molecular Cancer
- p53 regulates epithelial–mesenchymal transition and stem cell properties through modulating miRNAs
- (2011) Chun-Ju Chang et al. NATURE CELL BIOLOGY
- NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation
- (2011) C R Jeter et al. ONCOGENE
- Resveratrol Inhibits Pancreatic Cancer Stem Cell Characteristics in Human and KrasG12D Transgenic Mice by Inhibiting Pluripotency Maintaining Factors and Epithelial-Mesenchymal Transition
- (2011) Sharmila Shankar et al. PLoS One
- Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses
- (2011) N. Chiba et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition
- (2011) J. R. Rock et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- E-Cadherin loss associated with EMT promotes radioresistance in human tumor cells
- (2011) Jan Theys et al. RADIOTHERAPY AND ONCOLOGY
- A Perspective on Cancer Cell Metastasis
- (2011) C. L. Chaffer et al. SCIENCE
- Transcription factors that mediate epithelial–mesenchymal transition lead to multidrug resistance by upregulating ABC transporters
- (2011) M Saxena et al. Cell Death & Disease
- NF-κB promotes epithelial–mesenchymal transition, migration and invasion of pancreatic carcinoma cells
- (2010) Harald J. Maier et al. CANCER LETTERS
- Expression of Snail in Epidermal Keratinocytes Promotes Cutaneous Inflammation and Hyperplasia Conducive to Tumor Formation
- (2010) F. Du et al. CANCER RESEARCH
- Immune Promotion of Epithelial-mesenchymal Transition and Generation of Breast Cancer Stem Cells
- (2010) J. M. Reiman et al. CANCER RESEARCH
- Coexpression of Oct4 and Nanog Enhances Malignancy in Lung Adenocarcinoma by Inducing Cancer Stem Cell-Like Properties and Epithelial-Mesenchymal Transdifferentiation
- (2010) S.-H. Chiou et al. CANCER RESEARCH
- TWIST activation by hypoxia inducible factor-1 (HIF-1): Implications in metastasis and development
- (2010) Muh-Hwa Yang et al. CELL CYCLE
- Epithelial Mesenchymal Transition and Cancer Stem Cell-Like Phenotypes Facilitate Chemoresistance in Recurrent Ovarian Cancer
- (2010) N. Ahmed et al. CURRENT CANCER DRUG TARGETS
- Targeting miRNAs involved in cancer stem cell and EMT regulation: An emerging concept in overcoming drug resistance
- (2010) Zhiwei Wang et al. DRUG RESISTANCE UPDATES
- miR-194 is a marker of hepatic epithelial cells and suppresses metastasis of liver cancer cells in mice
- (2010) Zhipeng Meng et al. HEPATOLOGY
- Epithelial-Mesenchymal Transition in Cancer: Parallels Between Normal Development and Tumor Progression
- (2010) Douglas S. Micalizzi et al. JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
- Downregulation of microRNAs directs the EMT and invasive potential of anaplastic thyroid carcinomas
- (2010) J Braun et al. ONCOGENE
- EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
- (2010) A Singh et al. ONCOGENE
- Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes
- (2010) J. H. Taube et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Epithelial-to-mesenchymal transition and c-myc expression are the determinants of cetuximab-induced enhancement of squamous cell carcinoma radioresponse
- (2010) Ira Skvortsova et al. RADIOTHERAPY AND ONCOLOGY
- Hypoxia-induced alveolar epithelial-mesenchymal transition requires mitochondrial ROS and hypoxia-inducible factor 1
- (2009) Guofei Zhou et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- PI3 kinase/Akt signaling mediates epithelial–mesenchymal transition in hypoxic hepatocellular carcinoma cells
- (2009) Wei Yan et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Cancer Metastasis Is Accelerated through Immunosuppression during Snail-Induced EMT of Cancer Cells
- (2009) Chie Kudo-Saito et al. CANCER CELL
- Up-regulation of miR-200 and let-7 by Natural Agents Leads to the Reversal of Epithelial-to-Mesenchymal Transition in Gemcitabine-Resistant Pancreatic Cancer Cells
- (2009) Y. Li et al. CANCER RESEARCH
- Characterization of a Naturally Occurring Breast Cancer Subset Enriched in Epithelial-to-Mesenchymal Transition and Stem Cell Characteristics
- (2009) B. T. Hennessy et al. CANCER RESEARCH
- Epithelial-Mesenchymal Transition and Cell Cooperativity in Metastasis
- (2009) T. Tsuji et al. CANCER RESEARCH
- Acquisition of Epithelial-Mesenchymal Transition Phenotype of Gemcitabine-Resistant Pancreatic Cancer Cells Is Linked with Activation of the Notch Signaling Pathway
- (2009) Z. Wang et al. CANCER RESEARCH
- Immune-Induced Epithelial to Mesenchymal Transition In vivo Generates Breast Cancer Stem Cells
- (2009) M. Santisteban et al. CANCER RESEARCH
- Epithelial to Mesenchymal Transition Contributes to Drug Resistance in Pancreatic Cancer
- (2009) T. Arumugam et al. CANCER RESEARCH
- Epithelial-Mesenchymal Transitions in Development and Disease
- (2009) Jean Paul Thiery et al. CELL
- TGF-β-induced epithelial to mesenchymal transition
- (2009) Jian Xu et al. CELL RESEARCH
- Twist, an independent prognostic marker for predicting distant metastasis and survival rates of esophageal squamous cell carcinoma patients
- (2009) Fangwei Xie et al. CLINICAL & EXPERIMENTAL METASTASIS
- Twist1-Mediated Adriamycin-Induced Epithelial-Mesenchymal Transition Relates to Multidrug Resistance and Invasive Potential in Breast Cancer Cells
- (2009) Q.-Q. Li et al. CLINICAL CANCER RESEARCH
- VEGF elicits epithelial-mesenchymal transition (EMT) in prostate intraepithelial neoplasia (PIN)-like cells via an autocrine loop
- (2009) Oscar Gonzalez-Moreno et al. EXPERIMENTAL CELL RESEARCH
- Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice
- (2009) Kojiro Taura et al. HEPATOLOGY
- Direct contribution of epithelium to organ fibrosis: epithelial-mesenchymal transition
- (2009) Marcello Guarino et al. HUMAN PATHOLOGY
- Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease
- (2009) Hervé Acloque et al. JOURNAL OF CLINICAL INVESTIGATION
- EMT: When epithelial cells decide to become mesenchymal-like cells
- (2009) Raghu Kalluri JOURNAL OF CLINICAL INVESTIGATION
- Biomarkers for epithelial-mesenchymal transitions
- (2009) Michael Zeisberg et al. JOURNAL OF CLINICAL INVESTIGATION
- The basics of epithelial-mesenchymal transition
- (2009) Raghu Kalluri et al. JOURNAL OF CLINICAL INVESTIGATION
- Beyond Epithelial to Mesenchymal Transition: A Novel Role for the Transcription Factor Snail in Inflammation and Wound Healing
- (2009) Birgit Hotz et al. JOURNAL OF GASTROINTESTINAL SURGERY
- New Insights into Epithelial-Mesenchymal Transition in Kidney Fibrosis
- (2009) Y. Liu JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Association of reactive oxygen species levels and radioresistance in cancer stem cells
- (2009) Maximilian Diehn et al. NATURE
- The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
- (2009) Ulrich Wellner et al. NATURE CELL BIOLOGY
- Inhibition of epithelial to mesenchymal transition in metastatic prostate cancer cells by the novel proteasome inhibitor, NPI-0052: pivotal roles of Snail repression and RKIP induction
- (2009) S Baritaki et al. ONCOGENE
- Snail and Slug Mediate Radioresistance and Chemoresistance by Antagonizing p53-Mediated Apoptosis and Acquiring a Stem-Like Phenotype in Ovarian Cancer Cells
- (2009) Nawneet K. Kurrey et al. STEM CELLS
- miR-200 Regulates PDGF-D-Mediated Epithelial-Mesenchymal Transition, Adhesion, and Invasion of Prostate Cancer Cells
- (2009) Dejuan Kong et al. STEM CELLS
- The role of endothelial-to-mesenchymal transition in cancer progression
- (2008) S Potenta et al. BRITISH JOURNAL OF CANCER
- The prognostic impact of NF-κB p105, vimentin, E-cadherin and Par6 expression in epithelial and stromal compartment in non-small-cell lung cancer
- (2008) S Al-Saad et al. BRITISH JOURNAL OF CANCER
- Redox mechanisms switch on hypoxia-dependent epithelial–mesenchymal transition in cancer cells
- (2008) Stefania Cannito et al. CARCINOGENESIS
- The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
- (2008) Sendurai A. Mani et al. CELL
- Non-Smad pathways in TGF-β signaling
- (2008) Ying E Zhang CELL RESEARCH
- P-Cadherin and β-catenin are useful prognostic markers in breast cancer patients; β-catenin interacts with heat shock protein Hsp27
- (2008) Mariel A. Fanelli et al. CELL STRESS & CHAPERONES
- Matrix metalloproteinases stimulate epithelial-mesenchymal transition during tumor development
- (2008) Lidiya S. Orlichenko et al. CLINICAL & EXPERIMENTAL METASTASIS
- Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis
- (2008) Jing Yang et al. DEVELOPMENTAL CELL
- A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
- (2008) Ulrike Burk et al. EMBO REPORTS
- Twist Is Transcriptionally Induced by Activation of STAT3 and Mediates STAT3 Oncogenic Function
- (2008) George Z. Cheng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The miR-200 Family Inhibits Epithelial-Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-cadherin Transcriptional RepressorsZEB1andZEB2
- (2008) Manav Korpal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Survival of the Fittest: Cancer Stem Cells in Therapeutic Resistance and Angiogenesis
- (2008) Christine E. Eyler et al. JOURNAL OF CLINICAL ONCOLOGY
- Intrinsic Resistance of Tumorigenic Breast Cancer Cells to Chemotherapy
- (2008) X. Li et al. JNCI-Journal of the National Cancer Institute
- Epithelial to mesenchymal transition derived from repeated exposure to gefitinib determines the sensitivity to EGFR inhibitors in A549, a non-small cell lung cancer cell line
- (2008) Jin Kyung Rho et al. LUNG CANCER
- Snail and Slug Promote Epithelial-Mesenchymal Transition through β-Catenin–T-Cell Factor-4-dependent Expression of Transforming Growth Factor-β3
- (2008) Damian Medici et al. MOLECULAR BIOLOGY OF THE CELL
- Melanoma in mice casts doubt on scarcity of cancer stem cells
- (2008) Monya Baker NATURE
- Direct regulation of TWIST by HIF-1α promotes metastasis
- (2008) Muh-Hwa Yang et al. NATURE CELL BIOLOGY
- The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
- (2008) Philip A. Gregory et al. NATURE CELL BIOLOGY
- Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition
- (2008) Anne-Pierre Morel et al. PLoS One
- NF-κB-MediatedHER2Overexpression inRadiation-Adaptive Resistance
- (2008) Ning Cao et al. RADIATION RESEARCH
- Transitions between epithelial and mesenchymal states in development and disease
- (2008) Buzz Baum et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Mechanisms of Disease: epithelial–mesenchymal transition—does cellular plasticity fuel neoplastic progression?
- (2008) Eva A Turley et al. Nature clinical practice. Oncology
- NF-κB-mediated adaptive resistance to ionizing radiation
- (2007) Kazi Mokim Ahmed et al. FREE RADICAL BIOLOGY AND MEDICINE
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started