TOR Signaling in Caenorhabditis elegans Development, Metabolism, and Aging

Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Modulates Lifespan

(2019) Jianling Xie et al.   CURRENT BIOLOGY

Dietary Restriction Extends Lifespan through Metabolic Regulation of Innate Immunity

(2019) Ziyun Wu et al.   Cell Metabolism

Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension

(2019) Ben Zhou et al.   CELL

Autophagy as a promoter of longevity: insights from model organisms

(2018) Malene Hansen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rictor/TORC2 mediates gut-to-brain signaling in the regulation of phenotypic plasticity in C. elegans

(2018) Michael P. O’Donnell et al.   PLoS Genetics

A salicylic acid derivative extends the lifespan of Caenorhabditis elegans by activating autophagy and the mitochondrial unfolded protein response

(2018) Mehrnaz Shamalnasab et al.   AGING CELL

Microbial Siderophore Enterobactin Promotes Mitochondrial Iron Uptake and Development of the Host via Interaction with ATP Synthase

(2018) Bin Qi et al.   CELL

mTOR Regulates Phase Separation of PGL Granules to Modulate Their Autophagic Degradation

(2018) Gangming Zhang et al.   CELL

C. elegans Eats Its Own Intestine to Make Yolk Leading to Multiple Senescent Pathologies

(2018) Marina Ezcurra et al.   CURRENT BIOLOGY

Physiological Starvation PromotesCaenorhabditis elegansVulval Induction

(2018) Stéphanie Grimbert et al.   G3-Genes Genomes Genetics

mTOR as a central hub of nutrient signalling and cell growth

(2018) Joungmok Kim et al.   NATURE CELL BIOLOGY

Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms

(2018) Gregory M Solis et al.   eLife

Sesamin extends lifespan through pathways related to dietary restriction in Caenorhabditis elegans

(2017) Yumiko Nakatani et al.   EUROPEAN JOURNAL OF NUTRITION

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

(2017) Daniel Garcia et al.   MOLECULAR CELL

RNA polymerase III limits longevity downstream of TORC1

(2017) Danny Filer et al.   NATURE

Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan

(2017) Shuo Han et al.   NATURE

The mitochondrial UPR: mechanisms, physiological functions and implications in ageing

(2017) Tomer Shpilka et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The intestinal TORC2 signaling pathway contributes to associative learning in Caenorhabditis elegans

(2017) Naoko Sakai et al.   PLoS One

Twenty-five years of mTOR: Uncovering the link from nutrients to growth

(2017) David M. Sabatini   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects

(2017) Mark Lucanic et al.   Nature Communications

The beneficial effects of dietary restriction on learning are distinct from its effects on longevity and mediated by depletion of a neuroinhibitory metabolite

(2017) Mihir Vohra et al.   PLOS BIOLOGY

C. elegans DAF-16/FOXO interacts with TGF-ß/BMP signaling to induce germline tumor formation via mTORC1 activation

(2017) Wenjing Qi et al.   PLoS Genetics

The homeodomain-interacting protein kinase HPK-1 preserves protein homeostasis and longevity through master regulatory control of the HSF-1 chaperone network and TORC1-restricted autophagy in Caenorhabditis elegans

(2017) Ritika Das et al.   PLoS Genetics

Metformin extends C. elegans lifespan through lysosomal pathway

(2017) Jie Chen et al.   eLife

A vitamin-B2-sensing mechanism that regulates gut protease activity to impact animal’s food behavior and growth

(2017) Bin Qi et al.   eLife

A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs

(2017) Silvan R. Urfer et al.   GeroScience

Metformin: Restraining Nucleocytoplasmic Shuttling to Fight Cancer and Aging

(2016) Jorge Iván Castillo-Quan et al.   CELL

An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer

(2016) Lianfeng Wu et al.   CELL

Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder

(2016) Dora C. Tărlungeanu et al.   CELL

A Systems Approach to Reverse Engineer Lifespan Extension by Dietary Restriction

(2016) Lei Hou et al.   Cell Metabolism

A Ribosomal Perspective on Proteostasis and Aging

(2016) Kristan K. Steffen et al.   Cell Metabolism

The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

(2016) Brian K. Kennedy et al.   Cell Metabolism

A microRNA program in theC. eleganshypodermis couples to intestinal mTORC2/PQM-1 signaling to modulate fat transport

(2016) Robert H. Dowen et al.   GENES & DEVELOPMENT

Time to move the fat

(2016) Benjamin P. Weaver et al.   GENES & DEVELOPMENT

Starvation-Induced Stress Response Is Critically Impacted by Ceramide Levels in Caenorhabditis elegans

(2016) Mingxue Cui et al.   GENETICS

TFEB at a glance

(2016) Gennaro Napolitano et al.   JOURNAL OF CELL SCIENCE

Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans

(2016) Caroline Heintz et al.   NATURE

PGL germ granule assembly protein is a base-specific, single-stranded RNase

(2016) Scott T. Aoki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles for ROS and hydrogen sulfide in the longevity response to germline loss inCaenorhabditis elegans

(2016) Yuehua Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Investigating Connections between Metabolism, Longevity, and Behavior in Caenorhabditis elegans

(2016) George A. Lemieux et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Small nucleoli are a cellular hallmark of longevity

(2016) Varnesh Tiku et al.   Nature Communications

Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals

(2016) Shuhei Nakamura et al.   Nature Communications

C. elegans S6K Mutants Require a Creatine-Kinase-like Effector for Lifespan Extension

(2016) Philip R. McQuary et al.   Cell Reports

Mg2+ Extrusion from Intestinal Epithelia by CNNM Proteins Is Essential for Gonadogenesis via AMPK-TORC1 Signaling in Caenorhabditis elegans

(2016) Tasuku Ishii et al.   PLoS Genetics

AMPK acts as a molecular trigger to coordinate glutamatergic signals and adaptive behaviours during acute starvation

(2016) Moloud Ahmadi et al.   eLife

Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1

(2016) Nicolas J Lehrbach et al.   eLife

Starvation-Induced Stress Response Is Critically Impacted by Ceramide Levels in Caenorhabditis elegans

(2016) Mingxue Cui et al.   GENETICS

A network pharmacology approach reveals new candidate caloric restriction mimetics inC. elegans

(2015) Shaun Calvert et al.   AGING CELL

The Roles of mTOR Complexes in Lipid Metabolism

(2015) Alexandre Caron et al.   Annual Review of Nutrition

Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans

(2015) Clare Edwards et al.   BMC GENETICS

Promoting Health and Longevity through Diet: From Model Organisms to Humans

(2015) Luigi Fontana et al.   CELL

2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling

(2015) Xudong Fu et al.   Cell Metabolism

The C. elegans Hypodermis Couples Progenitor Cell Quiescence to the Dietary State

(2015) Masamitsu Fukuyama et al.   CURRENT BIOLOGY

A Lipid-TORC1 Pathway Promotes Neuronal Development and Foraging Behavior under Both Fed and Fasted Conditions in C. elegans

(2015) Marina Kniazeva et al.   DEVELOPMENTAL CELL

SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans

(2015) T. Keith Blackwell et al.   FREE RADICAL BIOLOGY AND MEDICINE

Intestinal apical polarity mediates regulation of TORC1 by glucosylceramide inC. elegans

(2015) Huanhu Zhu et al.   GENES & DEVELOPMENT

Repression of the Heat Shock Response Is a Programmed Event at the Onset of Reproduction

(2015) Johnathan Labbadia et al.   MOLECULAR CELL

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

(2015) Konstantinos Palikaras et al.   NATURE

Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans

(2015) A. Folick et al.   SCIENCE

Regulation of mTORC1 by PI3K signaling

(2015) Christian C. Dibble et al.   TRENDS IN CELL BIOLOGY

Branched-chain amino acid catabolism is a conserved regulator of physiological ageing

(2015) Johannes Mansfeld et al.   Nature Communications

RNAi Interrogation of Dietary Modulation of Development, Metabolism, Behavior, and Aging in C. elegans

(2015) Rui Xiao et al.   Cell Reports

Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence

(2015) Michael J Steinbaugh et al.   eLife

mTORC2-SGK-1 acts in two environmentally responsive pathways with opposing effects on longevity

(2014) Masaki Mizunuma et al.   AGING CELL

Dietary restriction involves NAD+-dependent mechanisms and a shift toward oxidative metabolism

(2014) Natalie Moroz et al.   AGING CELL

Diacylglycerol lipaseregulates lifespan and oxidative stress response by inversely modulating TOR signaling inDrosophilaandC. elegans

(2014) Yen-Hung Lin et al.   AGING CELL

Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan

(2014) Dudley W. Lamming et al.   AGING CELL

AMPK at the Nexus of Energetics and Aging

(2014) Kristopher Burkewitz et al.   Cell Metabolism

Rapamycin: One Drug, Many Effects

(2014) Jing Li et al.   Cell Metabolism

P granules

(2014) Jennifer T. Wang et al.   CURRENT BIOLOGY

Intestinal Amino Acid Availability via PEPT-1 Affects TORC1/2 Signaling and the Unfolded Protein Response

(2014) Kerstin E. Geillinger et al.   JOURNAL OF PROTEOME RESEARCH

Ral and Rheb GTPase Activating Proteins Integrate mTOR and GTPase Signaling in Aging, Autophagy, and Tumor Cell Invasion

(2014) Timothy D. Martin et al.   MOLECULAR CELL

The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR

(2014) Randall M. Chin et al.   NATURE

Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity

(2014) Collin Y. Ewald et al.   NATURE

Prohibitin-Mediated Lifespan and Mitochondrial Stress Implicate SGK-1, Insulin/IGF and mTORC2 in C. elegans

(2014) Roxani Gatsi et al.   PLoS One

Steroid hormone signalling links reproduction to lifespan in dietary-restricted Caenorhabditis elegans

(2014) Manjunatha Thondamal et al.   Nature Communications

Co-option of the piRNA Pathway for Germline-Specific Alternative Splicing of C. elegans TOR

(2014) Sergio Barberán-Soler et al.   Cell Reports

TOR Signaling Couples Oxygen Sensing to Lifespan in C. elegans

(2014) Michael Schieber et al.   Cell Reports

The Caenorhabditis elegans Myc-Mondo/Mad Complexes Integrate Diverse Longevity Signals

(2014) David W. Johnson et al.   PLoS Genetics

Germline Signals Deploy NHR-49 to Modulate Fatty-Acid β-Oxidation and Desaturation in Somatic Tissues of C. elegans

(2014) Ramesh Ratnappan et al.   PLoS Genetics

The general control nonderepressible-2 kinase mediates stress response and longevity induced by target of rapamycin inactivation inCaenorhabditis elegans

(2013) Aris Rousakis et al.   AGING CELL

Effects ofCaenorhabditis elegans sgk-1mutations on lifespan, stress resistance, and DAF-16/FoxO regulation

(2013) Albert Tzong-Yang Chen et al.   AGING CELL

Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways inC. elegans

(2013) Keunhee Seo et al.   AGING CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Serotonin and the Neuropeptide PDF Initiate and Extend Opposing Behavioral States in C. elegans

(2013) Steven W. Flavell et al.   CELL

A Genetic Program Promotes C. elegans Longevity at Cold Temperatures via a Thermosensitive TRP Channel

(2013) Rui Xiao et al.   CELL

Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism

(2013) Filipe Cabreiro et al.   CELL

The Regulation of Cell Size

(2013) Alison C. Lloyd   CELL

A Central Role for mTOR in Lipid Homeostasis

(2013) Dudley W. Lamming et al.   Cell Metabolism

Autophagy regulation by nutrient signaling

(2013) Ryan C Russell et al.   CELL RESEARCH

A non-canonical role for the C. elegans dosage compensation complex in growth and metabolic regulation downstream of TOR complex 2

(2013) C. M. Webster et al.   DEVELOPMENT

TORC2 signaling antagonizes SKN-1 to induce C. elegans mesendodermal embryonic development

(2013) Vanessa Ruf et al.   DEVELOPMENTAL BIOLOGY

SESN-1 is a positive regulator of lifespan in Caenorhabditis elegans

(2013) Ya-Luen Yang et al.   EXPERIMENTAL GERONTOLOGY

To Grow or Not to Grow: Nutritional Control of Development During Caenorhabditis elegans L1 Arrest

(2013) L. R. Baugh   GENETICS

Nutrient Sensing, Metabolism, and Cell Growth Control

(2013) Hai-Xin Yuan et al.   MOLECULAR CELL

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Nutrient sensing lost in cancer

(2013) Suchithra Menon et al.   NATURE

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability

(2013) Eyleen J. O’Rourke et al.   NATURE CELL BIOLOGY

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Amino acid signalling upstream of mTOR

(2013) Jenna L. Jewell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

(2013) L. Bar-Peled et al.   SCIENCE

A cytoprotective perspective on longevity regulation

(2013) David E. Shore et al.   TRENDS IN CELL BIOLOGY

The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

(2013) Louis R. Lapierre et al.   Nature Communications

Germline Signaling Mediates the Synergistically Prolonged Longevity Produced by Double Mutations in daf-2 and rsks-1 in C. elegans

(2013) Di Chen et al.   Cell Reports

Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression

(2013) J. Julie Wu et al.   Cell Reports

Genetic Regulation of Caenorhabditis elegans Lysosome Related Organelle Function

(2013) Alexander A. Soukas et al.   PLoS Genetics

A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in Caenorhabditis elegans

(2013) Huanhu Zhu et al.   eLife

Rapamycin slows aging in mice

(2012) John E. Wilkinson et al.   AGING CELL

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

(2012) Stacey Robida-Stubbs et al.   Cell Metabolism

Sensory Regulation of the C. elegans Germline through TGF-β-Dependent Signaling in the Niche

(2012) Diana Dalfó et al.   CURRENT BIOLOGY

Organ Size Control by Hippo and TOR Pathways

(2012) Karen Tumaneng et al.   CURRENT BIOLOGY

The lifespan of Korean eunuchs

(2012) Kyung-Jin Min et al.   CURRENT BIOLOGY

S6K links cell fate, cell cycle and nutrient response in C. elegans germline stem/progenitor cells

(2012) D. Z. Korta et al.   DEVELOPMENT

Regulation of maternal phospholipid composition and IP3-dependent embryonic membrane dynamics by a specific fatty acid metabolic event in C. elegans

(2012) M. Kniazeva et al.   GENES & DEVELOPMENT

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

Cell-Nonautonomous Signaling of FOXO/DAF-16 to the Stem Cells of Caenorhabditis elegans

(2012) Wenjing Qi et al.   PLoS Genetics

C. elegansAMPKs promote survival and arrest germline development during nutrient stress

(2012) Masamitsu Fukuyama et al.   Biology Open

Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

(2011) Brian Magnuson et al.   BIOCHEMICAL JOURNAL

Rapamycin decelerates cellular senescence

(2011) Zoya N. Demidenko et al.   CELL CYCLE

Life Span Extension via eIF4G Inhibition Is Mediated by Posttranscriptional Remodeling of Stress Response Gene Expression in C. elegans

(2011) Aric N. Rogers et al.   Cell Metabolism

Autophagy and Lipid Metabolism Coordinately Modulate Life Span in Germline-less C. elegans

(2011) Louis R. Lapierre et al.   CURRENT BIOLOGY

N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans

(2011) Mark Lucanic et al.   NATURE

OrthoList: A Compendium of C. elegans Genes with Human Orthologs

(2011) Daniel D. Shaye et al.   PLoS One

A Glutathione Peroxidase, Intracellular Peptidases and the TOR Complexes Regulate Peptide Transporter PEPT-1 in C. elegans

(2011) Jacqueline Benner et al.   PLoS One

microRNAs play critical roles in the survival and recovery of Caenorhabditis elegans from starvation-induced L1 diapause

(2011) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal and molecular substrates for optimal foraging in Caenorhabditis elegans

(2011) K. Milward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling

(2011) Y. Yu et al.   SCIENCE

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

(2011) P. P. Hsu et al.   SCIENCE

A shift of the TOR adaptor from Rictor towards Raptor by semaphorin in C. elegans

(2011) Akira Nukazuka et al.   Nature Communications

Fatty Acid Desaturation Links Germ Cell Loss to Longevity Through NHR-80/HNF4 in C. elegans

(2011) Jérôme Goudeau et al.   PLOS BIOLOGY

Specific SKN-1/Nrf Stress Responses to Perturbations in Translation Elongation and Proteasome Activity

(2011) Xuan Li et al.   PLoS Genetics

drr-2 encodes an eIF4H that acts downstream of TOR in diet-restriction-induced longevity of C. elegans

(2010) Tsui-Ting Ching et al.   AGING CELL

C. elegans Screen Identifies Autophagy Genes Specific to Multicellular Organisms

(2010) Ye Tian et al.   CELL

Insulin signaling promotes germline proliferation in C. elegans

(2010) D. Michaelson et al.   DEVELOPMENT

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1

(2010) Brian Onken et al.   PLoS One

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Manipulation of Behavioral Decline in Caenorhabditis elegans with the Rag GTPase raga-1

(2010) Matthew A. Schreiber et al.   PLoS Genetics

RNAi Screening Implicates a SKN-1–Dependent Transcriptional Response in Stress Resistance and Longevity Deriving from Translation Inhibition

(2010) Jinling Wang et al.   PLoS Genetics

Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans

(2009) A. A. Soukas et al.   GENES & DEVELOPMENT

An eIF4E-binding protein regulates katanin protein levels inC. elegansembryos

(2009) Wei Li et al.   JOURNAL OF CELL BIOLOGY

Caenorhabditis elegansHas a Phosphoproteome Atypical for Metazoans That Is Enriched in Developmental and Sex Determination Proteins

(2009) Dorota F. Zielinska et al.   JOURNAL OF PROTEOME RESEARCH

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular and Sensory Basis of a Food Related Two-State Behavior in C. elegans

(2009) Juliette Ben Arous et al.   PLoS One

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

Rictor/TORC2 Regulates Caenorhabditis elegans Fat Storage, Body Size, and Development through sgk-1

(2009) Kevin T Jones et al.   PLOS BIOLOGY

HIF-1 Modulates Dietary Restriction-Mediated Lifespan Extension via IRE-1 in Caenorhabditis elegans

(2009) Di Chen et al.   PLoS Genetics

A Genome-Wide Screen for Regulators of TORC1 in Response to Amino Acid Starvation Reveals a Conserved Npr2/3 Complex

(2009) Taavi K. Neklesa et al.   PLoS Genetics

Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans

(2008) Jennifer M.A. Tullet et al.   CELL

The Target of Rapamycin Pathway Antagonizes pha-4/FoxA to Control Development and Aging

(2008) Karyn L. Sheaffer et al.   CURRENT BIOLOGY

Inhibition of a eukaryotic initiation factor (eIF2Bδ/F11A3.2) during adulthood extends lifespan in Caenorhabditis elegans

(2008) Daisuke Tohyama et al.   FASEB JOURNAL

A branched-chain fatty acid is involved in post-embryonic growth control in parallel to the insulin receptor pathway and its biosynthesis is feedback-regulated in C. elegans

(2008) M. Kniazeva et al.   GENES & DEVELOPMENT

Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans

(2008) Sakiko Honjoh et al.   NATURE

PhosphoPep—a database of protein phosphorylation sites in model organisms

(2008) Bernd Bodenmiller et al.   NATURE BIOTECHNOLOGY

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

(2008) Malene Hansen et al.   PLoS Genetics

Drosophila germ-line modulation of insulin signaling and lifespan

(2008) T. Flatt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA