Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity

SKN-1 and Nrf2 couples proline catabolism with lipid metabolism during nutrient deprivation

(2014) Shanshan Pang et al.   Nature Communications

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Bacterial Nitric Oxide Extends the Lifespan of C. elegans

(2013) Ivan Gusarov et al.   CELL

Discoidin Domain Receptors: Unique Receptor Tyrosine Kinases in Collagen-mediated Signaling

(2013) Hsueh-Liang Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat

(2013) Xiao Tian et al.   NATURE

A cytoprotective perspective on longevity regulation

(2013) David E. Shore et al.   TRENDS IN CELL BIOLOGY

Germline Signaling Mediates the Synergistically Prolonged Longevity Produced by Double Mutations in daf-2 and rsks-1 in C. elegans

(2013) Di Chen et al.   Cell Reports

The Conserved SKN-1/Nrf2 Stress Response Pathway Regulates Synaptic Function in Caenorhabditis elegans

(2013) Trisha A. Staab et al.   PLoS Genetics

Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension

(2013) Sebastian Schmeisser et al.   Molecular Metabolism

Rapamycin slows aging in mice

(2012) John E. Wilkinson et al.   AGING CELL

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

(2012) Stacey Robida-Stubbs et al.   Cell Metabolism

Impaired Insulin/IGF1 Signaling Extends Life Span by Promoting Mitochondrial L-Proline Catabolism to Induce a Transient ROS Signal

(2012) Kim Zarse et al.   Cell Metabolism

The extracellular matrix and ciliary signaling

(2012) Tamina Seeger-Nukpezah et al.   CURRENT OPINION IN CELL BIOLOGY

Endoplasmic Reticulum Thiol Oxidase Deficiency Leads to Ascorbic Acid Depletion and Noncanonical Scurvy in Mice

(2012) Ester Zito et al.   MOLECULAR CELL

RPN-6 determines C. elegans longevity under proteotoxic stress conditions

(2012) David Vilchez et al.   NATURE

Protein homeostasis: live long, won't prosper

(2012) Brandon H. Toyama et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Nematode Caenorhabditis elegans, Stress and Aging: Identifying the Complex Interplay of Genetic Pathways Following the Treatment with Humic Substances

(2012) Ralph Menzel et al.   Frontiers in Genetics

Meta-Analysis of Global Transcriptomics Suggests that Conserved Genetic Pathways are Responsible for Quercetin and Tannic Acid Mediated Longevity in C. elegans

(2012) Kerstin Pietsch et al.   Frontiers in Genetics

Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB

(2011) William Mair et al.   NATURE

Co-Regulation of the DAF-16 Target Gene, cyp-35B1/dod-13, by HSF-1 in C. elegans Dauer Larvae and daf-2 Insulin Pathway Mutants

(2011) Wendy B. Iser et al.   PLoS One

Cross Talk among TGF-  Signaling Pathways, Integrins, and the Extracellular Matrix

(2011) J. S. Munger et al.   Cold Spring Harbor Perspectives in Biology

PDP-1 Links the TGF-β and IIS Pathways to Regulate Longevity, Development, and Metabolism

(2011) Sri Devi Narasimhan et al.   PLoS Genetics

A novel zinc-carboxypeptidase SURO-1 regulates cuticle formation and body morphogenesis inCaenorhabditis elegans

(2010) Tai Hoon Kim et al.   FEBS LETTERS

Diverse transcription factor binding features revealed by genome-wide ChIP-seq in C. elegans

(2010) W. Niu et al.   GENOME RESEARCH

Tyrosylprotein sulfotransferase regulates collagen secretion in Caenorhabditis elegans

(2010) Tai Hoon Kim et al.   MOLECULES AND CELLS

A new DAF-16 isoform regulates longevity

(2010) Eun-Soo Kwon et al.   NATURE

Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans

(2010) Eric L. Greer et al.   NATURE

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Two Very Long Chain Fatty Acid Acyl-CoA Synthetase Genes, acs-20 and acs-22, Have Roles in the Cuticle Surface Barrier in Caenorhabditis elegans

(2010) Eriko Kage-Nakadai et al.   PLoS One

Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease

(2010) G. P. Sykiotis et al.   Science Signaling

Condition-adapted stress and longevity gene regulation byCaenorhabditis elegansSKN-1/Nrf

(2009) Riva P. Oliveira et al.   AGING CELL

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

The conserved NAD(H)-dependent corepressor CTBP-1 regulates Caenorhabditis elegans life span

(2009) S. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pparγ2 Is a Key Driver of Longevity in the Mouse

(2009) Carmen Argmann et al.   PLoS Genetics

A Regulated Response to Impaired Respiration Slows Behavioral Rates and Increases Lifespan in Caenorhabditis elegans

(2009) David Cristina et al.   PLoS Genetics

Selection and validation of a set of reliable reference genes for quantitative sod gene expression analysis in C. elegans

(2008) David Hoogewijs et al.   BMC MOLECULAR BIOLOGY

An elt-3/elt-5/elt-6 GATA Transcription Circuit Guides Aging in C. elegans

(2008) Yelena V. Budovskaya et al.   CELL

Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans

(2008) Jennifer M.A. Tullet et al.   CELL

Distinct Innate Immune Responses to Infection and Wounding in the C. elegans Epidermis

(2008) Nathalie Pujol et al.   CURRENT BIOLOGY

Clustering of Genetically Defined Allele Classes in the Caenorhabditis elegans DAF-2 Insulin/IGF-1 Receptor

(2008) D. S. Patel et al.   GENETICS

RSAT: regulatory sequence analysis tools

(2008) M. Thomas-Chollier et al.   NUCLEIC ACIDS RESEARCH

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH