Prohibitin-Mediated Lifespan and Mitochondrial Stress Implicate SGK-1, Insulin/IGF and mTORC2 in C. elegans

Intracellular protein glycosylation modulates insulin mediated lifespan in C. elegans

(2016) Mohammad M. Rahman et al.   Aging-US

mTORC2-SGK-1 acts in two environmentally responsive pathways with opposing effects on longevity

(2014) Masaki Mizunuma et al.   AGING CELL

Mitochondrial Proteostasis in the Control of Aging and Longevity

(2014) Martin Borch Jensen et al.   Cell Metabolism

Mitochondrial stress: Balancing friend and foe

(2014) Eva Diana Runkel et al.   EXPERIMENTAL GERONTOLOGY

Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans

(2014) Christopher F. Bennett et al.   Nature Communications

Effects ofCaenorhabditis elegans sgk-1mutations on lifespan, stress resistance, and DAF-16/FoxO regulation

(2013) Albert Tzong-Yang Chen et al.   AGING CELL

Molecular mechanisms underlying genotype-dependent responses to dietary restriction

(2013) Jennifer Schleit et al.   AGING CELL

A Genetic Program Promotes C. elegans Longevity at Cold Temperatures via a Thermosensitive TRP Channel

(2013) Rui Xiao et al.   CELL

Knockdown of the C. elegans Kinome identifies Kinases required for normal protein Homeostasis, Mitochondrial network structure, and Sarcomere structure in muscle

(2013) Susann Lehmann et al.   Cell Communication and Signaling

Prohibitin Ligands in Cell Death and Survival: Mode of Action and Therapeutic Potential

(2013) Frédéric Thuaud et al.   CHEMISTRY & BIOLOGY

A non-canonical role for the C. elegans dosage compensation complex in growth and metabolic regulation downstream of TOR complex 2

(2013) C. M. Webster et al.   DEVELOPMENT

TORC2 signaling antagonizes SKN-1 to induce C. elegans mesendodermal embryonic development

(2013) Vanessa Ruf et al.   DEVELOPMENTAL BIOLOGY

Insulin/IGF-1-mediated longevity is marked by reduced protein metabolism

(2013) G. J. Stout et al.   Molecular Systems Biology

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

A cytoprotective perspective on longevity regulation

(2013) David E. Shore et al.   TRENDS IN CELL BIOLOGY

Surveillance-Activated Defenses Block the ROS–Induced Mitochondrial Unfolded Protein Response

(2013) Eva D. Runkel et al.   PLoS Genetics

Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging

(2012) Joe R. Delaney et al.   AGING CELL

AMPK and GCN2–ATF4 signal the repression of mitochondria in colon cancer cells

(2012) Inmaculada Martínez-Reyes et al.   BIOCHEMICAL JOURNAL

The retrograde response: When mitochondrial quality control is not enough

(2012) S. Michal Jazwinski   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses

(2012) Justine A. Melo et al.   CELL

Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy

(2012) Eva Andres-Mateos et al.   EMBO Molecular Medicine

Mitochondrial dynamics and autophagy aid in removal of persistent mitochondrial DNA damage in Caenorhabditis elegans

(2012) Amanda S. Bess et al.   NUCLEIC ACIDS RESEARCH

Protective Coupling of Mitochondrial Function and Protein Synthesis via the eIF2α Kinase GCN-2

(2012) Brooke M. Baker et al.   PLoS Genetics

Induction of Cytoprotective Pathways Is Central to the Extension of Lifespan Conferred by Multiple Longevity Pathways

(2012) David E. Shore et al.   PLoS Genetics

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

EAK-7 Controls Development and Life Span by Regulating Nuclear DAF-16/FoxO Activity

(2010) Hena Alam et al.   Cell Metabolism

The mitochondrial UPR - protecting organelle protein homeostasis

(2010) C. M. Haynes et al.   JOURNAL OF CELL SCIENCE

Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans

(2009) A. A. Soukas et al.   GENES & DEVELOPMENT

Prohibitins and the functional compartmentalization of mitochondrial membranes

(2009) C. Osman et al.   JOURNAL OF CELL SCIENCE

mTOR signaling at a glance

(2009) M. Laplante et al.   JOURNAL OF CELL SCIENCE

C. elegans longevity pathways converge to decrease mitochondrial membrane potential

(2009) Bernard D. Lemire et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Prohibitin couples diapause signalling to mitochondrial metabolism during ageing in C. elegans

(2009) Marta Artal-Sanz et al.   NATURE

Rictor/TORC2 Regulates Caenorhabditis elegans Fat Storage, Body Size, and Development through sgk-1

(2009) Kevin T Jones et al.   PLOS BIOLOGY

The DAF-2 insulin-like signaling pathway independently regulates aging and immunity inC. elegans

(2008) Eric A. Evans et al.   AGING CELL

Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans

(2008) Jennifer M.A. Tullet et al.   CELL

Human prohibitin 1 maintains the organization and stability of the mitochondrial nucleoids

(2008) Katsumi Kasashima et al.   EXPERIMENTAL CELL RESEARCH

Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria

(2008) C. Merkwirth et al.   GENES & DEVELOPMENT

C. elegans dauer formation and the molecular basis of plasticity

(2008) N. Fielenbach et al.   GENES & DEVELOPMENT

Transcriptional Regulation of SDHa Flavoprotein by Nuclear Respiratory Factor-1 Prevents Pseudo-hypoxia in Aerobic Cardiac Cells

(2008) Claude A. Piantadosi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduced cytosolic protein synthesis suppresses mitochondrial degeneration

(2008) Xiaowen Wang et al.   NATURE CELL BIOLOGY

A Repressive Role for Prohibitin in Estrogen Signaling

(2007) Bin He et al.   MOLECULAR ENDOCRINOLOGY

A structure for the yeast prohibitin complex: Structure prediction and evidence from chemical crosslinking and mass spectrometry

(2002) Jaap W. Back et al.   PROTEIN SCIENCE