Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms

Hypermetabolism is a deleterious prognostic factor in patients with amyotrophic lateral sclerosis

(2017) P. Jésus et al.   EUROPEAN JOURNAL OF NEUROLOGY

Neuronal inhibition of the autophagy nucleation complex extends life span in post-reproductive C. elegans

(2017) Thomas Wilhelm et al.   GENES & DEVELOPMENT

Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan

(2017) Shuo Han et al.   NATURE

Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans

(2017) Caroline Kumsta et al.   Nature Communications

Computational Analysis of Lifespan Experiment Reproducibility

(2017) Michael Petrascheck et al.   Frontiers in Genetics

Aging causes decreased resistance to multiple stresses and a failure to activate specific stress response pathways

(2016) Dylan J. Dues et al.   Aging-US

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

Vulnerability of newly synthesized proteins to proteostasis stress

(2016) Guilian Xu et al.   JOURNAL OF CELL SCIENCE

Failure of RQC machinery causes protein aggregation and proteotoxic stress

(2016) Young-Jun Choe et al.   NATURE

C. elegans S6K Mutants Require a Creatine-Kinase-like Effector for Lifespan Extension

(2016) Philip R. McQuary et al.   Cell Reports

Modulating protein quality control

(2016) Lars Plate et al.   eLife

A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging

(2015) Mark A. McCormick et al.   Cell Metabolism

Measuring Food Intake and Nutrient Absorption in Caenorhabditis elegans

(2015) Rafael L. Gomez-Amaro et al.   GENETICS

Repression of the Heat Shock Response Is a Programmed Event at the Onset of Reproduction

(2015) Johnathan Labbadia et al.   MOLECULAR CELL

Uncoupling lifespan and healthspan inCaenorhabditis eleganslongevity mutants

(2015) Ankita Bansal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit

(2015) I. Das et al.   SCIENCE

Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality

(2015) Sunitha Rangaraju et al.   eLife

The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly

(2015) Carmela Sidrauski et al.   eLife

Measuring Food Intake and Nutrient Absorption in Caenorhabditis elegans

(2015) Rafael L. Gomez-Amaro et al.   GENETICS

Organelle-Based Aggregation and Retention of Damaged Proteins in Asymmetrically Dividing Cells

(2014) Chuankai Zhou et al.   CELL

Ribosomal Protein s15 Phosphorylation Mediates LRRK2 Neurodegeneration in Parkinson’s Disease

(2014) Ian Martin et al.   CELL

Increases in β-amyloid protein in the hippocampus caused by diabetic metabolic disorder are blocked by minocycline through inhibition of NF-κB pathway activation

(2014) Zhiyou Cai et al.   Pharmacological Reports

A pharmacological network for lifespan extension inCaenorhabditis elegans

(2013) Xiaolan Ye et al.   AGING CELL

Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways inC. elegans

(2013) Keunhee Seo et al.   AGING CELL

Minocycline: far beyond an antibiotic

(2013) N Garrido-Mesa et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

(2013) Louis R. Lapierre et al.   Nature Communications

Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments

(2013) Matthew D. Shoulders et al.   Cell Reports

Minocycline alleviates beta-amyloid protein and tau pathology via restraining neuroinflammation induced by diabetic metabolic disorder

(2013) Zhiyou Cai et al.   Clinical Interventions in Aging

Doxycycline plus tauroursodeoxycholic acid for transthyretin amyloidosis: a phase II study

(2012) Laura Obici et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

(2012) Stacey Robida-Stubbs et al.   Cell Metabolism

Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology

(2012) Maria Teresa Ferretti et al.   Journal of Neuroinflammation

Aggregation Pathways of the Amyloid β(1–42) Peptide Depend on Its Colloidal Stability and Ordered β-Sheet Stacking

(2012) Dianlu Jiang et al.   LANGMUIR

Utility of an improved model of amyloid-beta (Aβ1-42) toxicity in Caenorhabditis elegans for drug screening for Alzheimer’s disease

(2012) Gawain McColl et al.   Molecular Neurodegeneration

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

Minocycline prevents paraquat-induced cell death through attenuating endoplasmic reticulum stress and mitochondrial dysfunction

(2012) Chuen-Lin Huang et al.   TOXICOLOGY LETTERS

Protective Coupling of Mitochondrial Function and Protein Synthesis via the eIF2α Kinase GCN-2

(2012) Brooke M. Baker et al.   PLoS Genetics

Induction of Cytoprotective Pathways Is Central to the Extension of Lifespan Conferred by Multiple Longevity Pathways

(2012) David E. Shore et al.   PLoS Genetics

Life Span Extension via eIF4G Inhibition Is Mediated by Posttranscriptional Remodeling of Stress Response Gene Expression in C. elegans

(2011) Aric N. Rogers et al.   Cell Metabolism

Transgenic nematodes as biosensors for metal stress in soil pore water samples

(2011) Charumathi Anbalagan et al.   ECOTOXICOLOGY

Absence of Mitochondrial Translation Control Proteins Extends Life Span by Activating Sirtuin-Dependent Silencing

(2011) Antonio Caballero et al.   MOLECULAR CELL

Aging as an Event of Proteostasis Collapse

(2011) R. C. Taylor et al.   Cold Spring Harbor Perspectives in Biology

Measuring Caenorhabditis elegans Life Span in 96 Well Microtiter Plates

(2011) Gregory M. Solis et al.   Jove-Journal of Visualized Experiments

Early life growth hormone treatment shortens longevity and decreases cellular stress resistance in long-lived mutant mice

(2010) Jacob A. Panici et al.   FASEB JOURNAL

Doxycycline Attenuates Protein Aggregation in Cardiomyocytes and Improves Survival of a Mouse Model of Cardiac Proteinopathy

(2010) Hanqiao Zheng et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity

(2010) S. Henis-Korenblit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks

(2009) Gabriela Bindea et al.   BIOINFORMATICS

The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments

(2009) S. A. Bustin et al.   CLINICAL CHEMISTRY

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans

(2008) Katherine A. Steinkraus et al.   AGING CELL

Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans

(2008) Erica D Smith et al.   BMC DEVELOPMENTAL BIOLOGY

Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans

(2008) Jennifer M.A. Tullet et al.   CELL

Minocycline reduces the development of abnormal tau species in models of Alzheimer’s disease

(2008) Wendy Noble et al.   FASEB JOURNAL

Heat shock and oxygen radicals stimulate ubiquitin-dependent degradation mainly of newly synthesized proteins

(2008) Balasubrahmanyam Medicherla et al.   JOURNAL OF CELL BIOLOGY

Minocycline for patients with ALS

(2008) Peter N Leigh et al.   LANCET NEUROLOGY

Regulation of the Cellular Heat Shock Response in Caenorhabditis elegans by Thermosensory Neurons

(2008) V. Prahlad et al.   SCIENCE

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE

C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During Aging

(2008) Tjakko J. van Ham et al.   PLoS Genetics