Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals

MDL-1, a growth- and tumor-suppressor, slows aging and prevents germline hyperplasia and hypertrophy in C. elegans

(2016) Michèle Riesen et al.   Aging-US

Reduced Expression of MYC Increases Longevity and Enhances Healthspan

(2015) Jeffrey W. Hofmann et al.   CELL

Calorie restriction and methionine restriction in control of endogenous hydrogen sulfide production by the transsulfuration pathway

(2015) Christopher Hine et al.   EXPERIMENTAL GERONTOLOGY

Nutrient-sensing mechanisms and pathways

(2015) Alejo Efeyan et al.   NATURE

A Long Noncoding RNA on the Ribosome Is Required for Lifespan Extension

(2015) Paul B. Essers et al.   Cell Reports

DRE-1/FBXO11-Dependent Degradation of BLMP-1/BLIMP-1 Governs C. elegans Developmental Timing and Maturation

(2014) Moritz Horn et al.   DEVELOPMENTAL CELL

MondoA-Mlx Transcriptional Activity Is Limited by mTOR-MondoA Interaction

(2014) Mohan R. Kaadige et al.   MOLECULAR AND CELLULAR BIOLOGY

Steroid hormone signalling links reproduction to lifespan in dietary-restricted Caenorhabditis elegans

(2014) Manjunatha Thondamal et al.   Nature Communications

The Caenorhabditis elegans Myc-Mondo/Mad Complexes Integrate Diverse Longevity Signals

(2014) David W. Johnson et al.   PLoS Genetics

Germline Signals Deploy NHR-49 to Modulate Fatty-Acid β-Oxidation and Desaturation in Somatic Tissues of C. elegans

(2014) Ramesh Ratnappan et al.   PLoS Genetics

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability

(2013) Eyleen J. O’Rourke et al.   NATURE CELL BIOLOGY

Novel insights into ChREBP regulation and function

(2013) Gaëlle Filhoulaud et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Coordination of Nutrient Availability and Utilization by MAX- and MLX-Centered Transcription Networks

(2013) J. M. O'Shea et al.   Cold Spring Harbor Perspectives in Medicine

Dietary Restriction Induced Longevity Is Mediated by Nuclear Receptor NHR-62 in Caenorhabditis elegans

(2013) Bree N. Heestand et al.   PLoS Genetics

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway

(2012) Jung Min Han et al.   CELL

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

(2012) Stacey Robida-Stubbs et al.   Cell Metabolism

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Leucyl-tRNA Synthetase Controls TORC1 via the EGO Complex

(2012) Grégory Bonfils et al.   MOLECULAR CELL

A Steroid Receptor-MicroRNA Switch Regulates Life Span in Response to Signals from the Gonad

(2012) Y. Shen et al.   SCIENCE

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

Glucose sensing by ChREBP/MondoA–Mlx transcription factors

(2012) Essi Havula et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Autophagy and Lipid Metabolism Coordinately Modulate Life Span in Germline-less C. elegans

(2011) Louis R. Lapierre et al.   CURRENT BIOLOGY

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Fatty Acid Desaturation Links Germ Cell Loss to Longevity Through NHR-80/HNF4 in C. elegans

(2011) Jérôme Goudeau et al.   PLOS BIOLOGY

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Integrative Analysis of the Caenorhabditis elegans Genome by the modENCODE Project

(2010) M. B. Gerstein et al.   SCIENCE

The Somatic Reproductive Tissues of C. elegans Promote Longevity through Steroid Hormone Signaling

(2010) Tracy M. Yamawaki et al.   PLOS BIOLOGY

A Multiparameter Network Reveals Extensive Divergence between C. elegans bHLH Transcription Factors

(2009) Christian A. Grove et al.   CELL

Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans

(2008) Jennifer M.A. Tullet et al.   CELL

The Target of Rapamycin Pathway Antagonizes pha-4/FoxA to Control Development and Aging

(2008) Karyn L. Sheaffer et al.   CURRENT BIOLOGY

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

(2008) Elizabeth L. Axe et al.   JOURNAL OF CELL BIOLOGY

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

(2008) Malene Hansen et al.   PLoS Genetics