Mitogen-Activated Protein Kinases (MAPKs) and Cholangiocarcinoma: The Missing Link

MEK inhibition suppresses K-Ras wild-type cholangiocarcinoma in vitro and in vivo via inhibiting cell proliferation and modulating tumor microenvironment

(2019) Pan Wang et al.   Cell Death & Disease

Clinical presentation, diagnosis and staging of cholangiocarcinoma

(2019) Alejandro Forner et al.   LIVER INTERNATIONAL

Diagnostic and prognostic biomarkers in cholangiocarcinoma

(2019) Rocio I.R. Macias et al.   LIVER INTERNATIONAL

Cancer-associated fibroblasts: how do they contribute to metastasis?

(2019) Mei Qi Kwa et al.   CLINICAL & EXPERIMENTAL METASTASIS

Molecular Pathogenesis of Cholangiocarcinoma

(2019) Peter L. Labib et al.   BMC CANCER

Causes of hOCT1‐Dependent Cholangiocarcinoma Resistance to Sorafenib and Sensitization by Tumor‐Selective Gene Therapy

(2019) Elisa Lozano et al.   HEPATOLOGY

Clinical pharmacokinetics and pharmacodynamics of ivosidenib, an oral, targeted inhibitor of mutant IDH1, in patients with advanced solid tumors

(2019) Bin Fan et al.   INVESTIGATIONAL NEW DRUGS

Efficacy and Safety of Pembrolizumab in Previously Treated Advanced Cervical Cancer: Results From the Phase II KEYNOTE-158 Study

(2019) Hyun Cheol Chung et al.   JOURNAL OF CLINICAL ONCOLOGY

Assessment of the effect of erdafitinib on cardiac safety: analysis of ECGs and exposure–QTc in patients with advanced or refractory solid tumors

(2019) Elodie Valade et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Cancer-associated fibroblasts in desmoplastic tumors: emerging role of integrins

(2019) Cédric Zeltz et al.   SEMINARS IN CANCER BIOLOGY

Regulation and function of apoptosis signal-regulating kinase 1 in rheumatoid arthritis

(2018) Gyrid Nygaard et al.   BIOCHEMICAL PHARMACOLOGY

Chemoresistance and chemosensitization in cholangiocarcinoma

(2018) Jose J.G. Marin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The search for novel diagnostic and prognostic biomarkers in cholangiocarcinoma

(2018) Rocio I.R. Macias et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

New insights into the role and mechanism of c-Jun-N-terminal kinase signaling in the pathobiology of liver diseases

(2018) Sanda Win et al.   HEPATOLOGY

Phase 1b investigation of the MEK inhibitor binimetinib in patients with advanced or metastatic biliary tract cancer

(2018) R. S. Finn et al.   INVESTIGATIONAL NEW DRUGS

Phase II Study of BGJ398 in Patients With FGFR-Altered Advanced Cholangiocarcinoma

(2018) Milind Javle et al.   JOURNAL OF CLINICAL ONCOLOGY

Cancer Associated Fibroblasts: The Architects of Stroma Remodeling

(2018) Alice Santi et al.   PROTEOMICS

Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers

(2018) Janeta Popovici-Muller et al.   ACS Medicinal Chemistry Letters

Primary Liver Cancers—Part 1

(2018) Kun Jiang et al.   Cancer Control

Palbociclib enhances radiosensitivity of hepatocellular carcinoma and cholangiocarcinoma via inhibiting ataxia telangiectasia–mutated kinase–mediated DNA damage response

(2018) Chao-Yuan Huang et al.   EUROPEAN JOURNAL OF CANCER

Immunohistochemical characterization of cancer-associated fibroblasts at the primary sites and in the metastatic lymph nodes of human intrahepatic cholangiocarcinoma

(2018) Rei Atono Itou et al.   HUMAN PATHOLOGY

Acidic Bile Salts Induce Epithelial to Mesenchymal Transition via VEGF Signaling in Non-Neoplastic Barrett’s Cells

(2018) Qiuyang Zhang et al.   GASTROENTEROLOGY

Cholangiocarcinoma: Current Knowledge and New Developments

(2017) Boris Blechacz   Gut and Liver

Autocrine and Paracrine Mechanisms Promoting Chemoresistance in Cholangiocarcinoma

(2017) Massimiliano Cadamuro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metformin potentiates the effect of arsenic trioxide suppressing intrahepatic cholangiocarcinoma: roles of p38 MAPK, ERK3, and mTORC1

(2017) Sunbin Ling et al.   Journal of Hematology & Oncology

Epithelial-mesenchymal transition in cholangiocarcinoma: From clinical evidence to regulatory networks

(2017) Javier Vaquero et al.   JOURNAL OF HEPATOLOGY

Activity of Entrectinib in a Patient With the First Reported NTRK Fusion in Neuroendocrine Cancer

(2017) Darren Sigal et al.   Journal of the National Comprehensive Cancer Network

Cholangiocarcinoma — evolving concepts and therapeutic strategies

(2017) Sumera Rizvi et al.   Nature Reviews Clinical Oncology

Survival pathway of cholangiocarcinoma via AKT/mTOR signaling to escape RAF/MEK/ERK pathway inhibition by sorafenib

(2017) Kenta Yokoi et al.   ONCOLOGY REPORTS

ROS1 protein-tyrosine kinase inhibitors in the treatment of ROS1 fusion protein-driven non-small cell lung cancers

(2017) Robert Roskoski   PHARMACOLOGICAL RESEARCH

PD-L1 expression in perihilar and intrahepatic cholangiocarcinoma

(2017) Jacqueline Fontugne et al.   Oncotarget

Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH -Mutant Molecular Profiles

(2017) Farshad Farshidfar et al.   Cell Reports

Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH -Mutant Molecular Profiles

(2017) Farshad Farshidfar et al.   Cell Reports

Program Death 1 Immune Checkpoint and Tumor Microenvironment: Implications for Patients With Intrahepatic Cholangiocarcinoma

(2016) Faiz Gani et al.   ANNALS OF SURGICAL ONCOLOGY

Comparison of gemcitabine plus cisplatin versus capecitabine plus cisplatin as first-line chemotherapy for advanced biliary tract cancer

(2016) Kwonoh Park et al.   Asia-Pacific Journal of Clinical Oncology

Solutions that enable ablative radiotherapy for large liver tumors: Fractionated dose painting, simultaneous integrated protection, motion management, and computed tomography image guidance

(2016) Christopher H. Crane et al.   CANCER

Another solution that enables ablative radiotherapy for large liver tumors: Percutaneous interstitial high-dose rate brachytherapy

(2016) Shyamal Patel et al.   CANCER

EMT, cell plasticity and metastasis

(2016) Christine L. Chaffer et al.   CANCER AND METASTASIS REVIEWS

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src

(2016) Sanda Win et al.   HEPATOLOGY

A Hippo and Fibroblast Growth Factor Receptor Autocrine Pathway in Cholangiocarcinoma

(2016) Sumera Rizvi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multi-Institutional Phase II Study of High-Dose Hypofractionated Proton Beam Therapy in Patients With Localized, Unresectable Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma

(2016) Theodore S. Hong et al.   JOURNAL OF CLINICAL ONCOLOGY

Role of epithelial to mesenchymal transition in hepatocellular carcinoma

(2016) Gianluigi Giannelli et al.   JOURNAL OF HEPATOLOGY

Collaboration of cancer-associated fibroblasts and tumour-associated macrophages for neuroblastoma development

(2016) Okito Hashimoto et al.   JOURNAL OF PATHOLOGY

CAFs and TAMs: maestros of the tumour microenvironment

(2016) Yoshihiro Komohara et al.   JOURNAL OF PATHOLOGY

The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size

(2016) Lara Planas-Paz et al.   NATURE CELL BIOLOGY

Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)

(2016) Jesus M. Banales et al.   Nature Reviews Gastroenterology & Hepatology

Role of C-Jun N-terminal Kinase in Hepatocellular Carcinoma Development

(2016) Juan Wang et al.   Targeted Oncology

Integrin β6 serves as an immunohistochemical marker for lymph node metastasis and promotes cell invasiveness in cholangiocarcinoma

(2016) Zequn Li et al.   Scientific Reports

Signal Transduction Pathways of EMT Induced by TGF-β, SHH, and WNT and Their Crosstalks

(2016) Jingyu Zhang et al.   Journal of Clinical Medicine

Fibroblast growth factor receptor 2 fusions as a target for treating cholangiocarcinoma

(2015) Mitesh J. Borad et al.   CURRENT OPINION IN GASTROENTEROLOGY

Sox9 expression in carcinogenesis and its clinical significance in intrahepatic cholangiocarcinoma

(2015) Hajime Matsushima et al.   DIGESTIVE AND LIVER DISEASE

Endoscopically inserted nasobiliary catheters for high dose-rate brachytherapy as part of neoadjuvant therapy for perihilar cholangiocarcinoma

(2015) Saurabh Mukewar et al.   ENDOSCOPY

525 Safety and efficacy of pembrolizumab (MK-3475) in patients (pts) with advanced biliary tract cancer: Interim results of KEYNOTE-028

(2015) Y.J. Bang et al.   EUROPEAN JOURNAL OF CANCER

Differential effects of targeting Notch receptors in a mouse model of liver cancer

(2015) Erik G. Huntzicker et al.   HEPATOLOGY

Phase I Dose-Escalation Study of JNJ-42756493, an Oral Pan–Fibroblast Growth Factor Receptor Inhibitor, in Patients With Advanced Solid Tumors

(2015) Josep Tabernero et al.   JOURNAL OF CLINICAL ONCOLOGY

Haematopoietic cell-derived Jnk1 is crucial for chronic inflammation and carcinogenesis in an experimental model of liver injury

(2015) Francisco Javier Cubero et al.   JOURNAL OF HEPATOLOGY

Impact of microenvironment and stem-like plasticity in cholangiocarcinoma: Molecular networks and biological concepts

(2015) Chiara Raggi et al.   JOURNAL OF HEPATOLOGY

Genomic spectra of biliary tract cancer

(2015) Hiromi Nakamura et al.   NATURE GENETICS

Hilar Cholangiocarcinoma: expert consensus statement

(2015) John C. Mansour et al.   HPB

The interplay of the Notch signaling in hepatic stellate cells and macrophages determines the fate of liver fibrogenesis

(2015) Ruchi Bansal et al.   Scientific Reports

The Ability to Diagnose Intrahepatic Cholangiocarcinoma Definitively Using Novel Branched DNA-Enhanced Albumin RNA In Situ Hybridization Technology

(2014) Cristina R. Ferrone et al.   ANNALS OF SURGICAL ONCOLOGY

S0941: a phase 2 SWOG study of sorafenib and erlotinib in patients with advanced gallbladder carcinoma or cholangiocarcinoma

(2014) A B El-Khoueiry et al.   BRITISH JOURNAL OF CANCER

Dual Inhibition of PI3K-AKT-mTOR- and RAF-MEK-ERK-signaling is synergistic in cholangiocarcinoma and reverses acquired resistance to MEK-inhibitors

(2014) Florian Ewald et al.   INVESTIGATIONAL NEW DRUGS

Pathogenesis and classification of intrahepatic cholangiocarcinoma: different characters of perihilar large duct type versus peripheral small duct type

(2014) Shinichi Aishima et al.   Journal of Hepato-Biliary-Pancreatic Sciences

Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma

(2014) John Bridgewater et al.   JOURNAL OF HEPATOLOGY

Cholangiocarcinoma

(2014) Nataliya Razumilava et al.   LANCET

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

(2014) Jan Mauer et al.   NATURE IMMUNOLOGY

New Routes to Targeted Therapy of Intrahepatic Cholangiocarcinomas Revealed by Next-Generation Sequencing

(2014) J. S. Ross et al.   ONCOLOGIST

Notch1 is overexpressed in human intrahepatic cholangiocarcinoma and is associated with its proliferation, invasiveness and sensitivity to 5-fluorouracil in vitro

(2014) WEN-RUI WU et al.   ONCOLOGY REPORTS

JNK Contributes to the Tumorigenic Potential of Human Cholangiocarcinoma Cells through the mTOR Pathway Regulated GRP78 Induction

(2014) Chunhong Feng et al.   PLoS One

Aberrant Expression of NF-κB in Liver Fluke Associated Cholangiocarcinoma: Implications for Targeted Therapy

(2014) Wunchana Seubwai et al.   PLoS One

Mutation Profiling in Cholangiocarcinoma: Prognostic and Therapeutic Implications

(2014) Chaitanya R. Churi et al.   PLoS One

Cholangiocarcinoma: Molecular Pathways and Therapeutic Opportunities

(2014) Sumera Rizvi et al.   SEMINARS IN LIVER DISEASE

JNK signalling in cancer: in need of new, smarter therapeutic targets

(2013) Concetta Bubici et al.   BRITISH JOURNAL OF PHARMACOLOGY

CXCL5 contributes to tumor metastasis and recurrence of intrahepatic cholangiocarcinoma by recruiting infiltrative intratumoral neutrophils

(2013) Shao-Lai Zhou et al.   CARCINOGENESIS

Pathogenesis, Diagnosis, and Management of Cholangiocarcinoma

(2013) Sumera Rizvi et al.   GASTROENTEROLOGY

Integrative Molecular Analysis of Intrahepatic Cholangiocarcinoma Reveals 2 Classes That Have Different Outcomes

(2013) Daniela Sia et al.   GASTROENTEROLOGY

Platelet-derived growth factor-D and Rho GTPases regulate recruitment of cancer-associated fibroblasts in cholangiocarcinoma

(2013) Massimiliano Cadamuro et al.   HEPATOLOGY

Platelet-derived growth factor D: A new player in the complex cross-talk between cholangiocarcinoma cells and cancer-associated fibroblasts

(2013) Carmen Berasain et al.   HEPATOLOGY

Hepatic myofibroblasts promote the progression of human cholangiocarcinoma through activation of epidermal growth factor receptor

(2013) Audrey Clapéron et al.   HEPATOLOGY

Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma

(2013) Yasuhito Arai et al.   HEPATOLOGY

Notch-driven carcinogenesis: The merging of hepatocellular cancer and cholangiocarcinoma into a common molecular liver cancer subtype

(2013) Nataliya Razumilava et al.   JOURNAL OF HEPATOLOGY

Intrahepatic Cholangiocarcinoma: Management Options and Emerging Therapies

(2013) Rebecca M. Dodson et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

JNK inhibitor SP600125 enhances TGF-β-induced apoptosis of RBE human cholangiocarcinoma cells in a Smad-dependent manner

(2013) YOUZHI LIN et al.   Molecular Medicine Reports

Influence of tumour micro-environment heterogeneity on therapeutic response

(2013) Melissa R. Junttila et al.   NATURE

Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas

(2013) Yuchen Jiao et al.   NATURE GENETICS

Intrahepatic cholangiocarcinoma: pathogenesis and rationale for molecular therapies

(2013) D Sia et al.   ONCOGENE

An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells

(2013) D. Rohle et al.   SCIENCE

Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation

(2013) F. Wang et al.   SCIENCE

Increased activation of PI3K/AKT signaling pathway is associated with cholangiocarcinoma metastasis and PI3K/mTOR inhibition presents a possible therapeutic strategy

(2013) Supak Yothaisong et al.   TUMOR BIOLOGY

Immunohistochemical Markers on Needle Biopsies Are Helpful for the Diagnosis of Focal Nodular Hyperplasia and Hepatocellular Adenoma Subtypes

(2012) Paulette Bioulac-Sage et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Evolution of Surgical Treatment for Perihilar Cholangiocarcinoma

(2012) Masato Nagino et al.   ANNALS OF SURGERY

K-ras Mutation is Strongly Associated with Perineural Invasion and Represents an Independent Prognostic Factor of Intrahepatic Cholangiocarcinoma after Hepatectomy

(2012) Tse-Ching Chen et al.   ANNALS OF SURGICAL ONCOLOGY

Surgical outcomes of 230 resected hilar cholangiocarcinoma in a single centre

(2012) Sun Choon Song et al.   ANZ JOURNAL OF SURGERY

Roles of p38 MAPKs in invasion and metastasis

(2012) Ivan del Barco Barrantes et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

JNK-Induced Apoptosis, Compensatory Growth, and Cancer Stem Cells

(2012) F. Chen   CANCER RESEARCH

A Liver Full of JNK: Signaling in Regulation of Cell Function and Disease Pathogenesis, and Clinical Approaches

(2012) Ekihiro Seki et al.   GASTROENTEROLOGY

Guidelines for the diagnosis and treatment of cholangiocarcinoma: an update

(2012) Shahid A Khan et al.   GUT

Predictors of pretransplant dropout and posttransplant recurrence in patients with perihilar cholangiocarcinoma

(2012) Sarwa Darwish Murad et al.   HEPATOLOGY

Histological diversity in cholangiocellular carcinoma reflects the different cholangiocyte phenotypes

(2012) Mina Komuta et al.   HEPATOLOGY

Complexities of TGF-β Targeted Cancer Therapy

(2012) Erin C. Connolly et al.   International Journal of Biological Sciences

Periostin activates integrin α5β1 through a PI3K/AKT-dependent pathway in invasion of cholangiocarcinoma

(2012) KUSUMAWADEE UTISPAN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The Tyrosine Kinase c-Met Contributes to the Pro-tumorigenic Function of the p38 Kinase in Human Bile Duct Cholangiocarcinoma Cells

(2012) Rongyang Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholangiocarcinomas can originate from hepatocytes in mice

(2012) Biao Fan et al.   JOURNAL OF CLINICAL INVESTIGATION

Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes

(2012) Sayaka Sekiya et al.   JOURNAL OF CLINICAL INVESTIGATION

Recent advances in cancer stem cell research for cholangiocarcinoma

(2012) Toshio Kokuryo et al.   Journal of Hepato-Biliary-Pancreatic Sciences

Exome sequencing of liver fluke–associated cholangiocarcinoma

(2012) Choon Kiat Ong et al.   NATURE GENETICS

Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas

(2012) P Wang et al.   ONCOGENE

c-Jun N-terminal kinase has a pivotal role in the maintenance of self-renewal and tumorigenicity in glioma stem-like cells

(2012) C-H Yoon et al.   ONCOGENE

FGFR Genetic Alterations Predict for Sensitivity to NVP-BGJ398, a Selective Pan-FGFR Inhibitor

(2012) V. Guagnano et al.   Cancer Discovery

Multiple cells of origin in cholangiocarcinoma underlie biological, epidemiological and clinical heterogeneity

(2012) Vincenzo Cardinale   World Journal of Gastrointestinal Oncology

Comparative Analysis of Resection and Liver Transplantation for Intrahepatic and Hilar Cholangiocarcinoma

(2011) Johnny C. Hong   ARCHIVES OF SURGERY

Prognostic significance of overexpression of c-Met oncoprotein in cholangiocarcinoma

(2011) M Miyamoto et al.   BRITISH JOURNAL OF CANCER

Phosphorylation of Serine 68 of Twist1 by MAPKs Stabilizes Twist1 Protein and Promotes Breast Cancer Cell Invasiveness

(2011) J. Hong et al.   CANCER RESEARCH

TGF-β1/ALK5-induced monocyte migration involves PI3K and p38 pathways and is not negatively affected by diabetes mellitus

(2011) Servé Olieslagers et al.   CARDIOVASCULAR RESEARCH

Cancer-associated fibroblasts in intrahepatic cholangiocarcinoma

(2011) Alphonse E Sirica et al.   CURRENT OPINION IN GASTROENTEROLOGY

Simvastatin stimulates apoptosis in cholangiocarcinoma by inhibition of Rac1 activity

(2011) Timothy Miller et al.   DIGESTIVE AND LIVER DISEASE

Genomic and Genetic Characterization of Cholangiocarcinoma Identifies Therapeutic Targets for Tyrosine Kinase Inhibitors

(2011) Jesper B. Andersen et al.   GASTROENTEROLOGY

PUMA-mediated apoptosis drives chemical hepatocarcinogenesis in mice

(2011) Wei Qiu et al.   HEPATOLOGY

Risk factors for cholangiocarcinoma

(2011) Gia L. Tyson et al.   HEPATOLOGY

Gemcitabine and oxaliplatin with or without erlotinib in advanced biliary-tract cancer: a multicentre, open-label, randomised, phase 3 study

(2011) Jeeyun Lee et al.   LANCET ONCOLOGY

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

(2011) M. Cargnello et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

The role of cancer-associated myofibroblasts in intrahepatic cholangiocarcinoma

(2011) Alphonse E. Sirica   Nature Reviews Gastroenterology & Hepatology

Loss of EBP50 stimulates EGFR activity to induce EMT phenotypic features in biliary cancer cells

(2011) A Clapéron et al.   ONCOGENE

Differential regulation of the two RhoA-specific GEF isoforms Net1/Net1A by TGF-β and miR-24: role in epithelial-to-mesenchymal transition

(2011) E Papadimitriou et al.   ONCOGENE

Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad-Based Tumor Genotyping

(2011) D. R. Borger et al.   ONCOLOGIST

Partners in crime: the TGFβ and MAPK pathways in cancer progression

(2011) Douglas A Chapnick et al.   Cell and Bioscience

Molecular carcinogenesis of hepatocellular carcinoma and intrahepatic cholangiocarcinoma: one step closer to personalized medicine?

(2011) Mia Kumar et al.   Cell and Bioscience

Epithelial-Mesenchymal Transition Induced by Transforming Growth Factor-β1/Snail Activation Aggravates Invasive Growth of Cholangiocarcinoma

(2010) Yasunori Sato et al.   AMERICAN JOURNAL OF PATHOLOGY

Hepatic Stellate Cells Accelerate the Malignant Behavior of Cholangiocarcinoma Cells

(2010) Hirohisa Okabe et al.   ANNALS OF SURGICAL ONCOLOGY

Acquisition of chemoresistance in intrahepatic cholangiocarcinoma cells by activation of AKT and extracellular signal-regulated kinase (ERK)1/2

(2010) Hyunho Yoon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TAK1 Suppresses a NEMO-Dependent but NF-κB-Independent Pathway to Liver Cancer

(2010) Kira Bettermann et al.   CANCER CELL

The c-Jun NH2-Terminal Kinase 2 Plays a Dominant Role in Human Epidermal Neoplasia

(2010) H. Ke et al.   CANCER RESEARCH

The Use of Immunohistochemistry in Liver Tumors

(2010) Elaine S. Chan et al.   Clinics in Liver Disease

The MAP3K TAK1: A chock block to liver cancer formation

(2010) Yann Malato et al.   HEPATOLOGY

Antibody to cytokeratin (CK8/CK18) is not derived from CAM5.2 clone, and anticytokeratin CAM5.2 (Becton Dickinson) is not synonymous with the antibody (CK8/CK18)

(2010) Chih-Ping Han et al.   HUMAN PATHOLOGY

IKK  controls canonical TGF -SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in Panc1 cells

(2010) M. Brandl et al.   JOURNAL OF CELL SCIENCE

c-Jun N-terminal kinase is largely involved in the regulation of tricellular tight junctions via tricellulin in human pancreatic duct epithelial cells

(2010) Takashi Kojima et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Report of a Multicenter Phase II Trial Testing a Combination of Biweekly Bevacizumab and Daily Erlotinib in Patients With Unresectable Biliary Cancer: A Phase II Consortium Study

(2010) Sam J. Lubner et al.   JOURNAL OF CLINICAL ONCOLOGY

Descriptive Epidemiology of Cholangiocarcinoma and Clonorchiasis in Korea

(2010) Hai-Rim Shin et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Reactive oxygen species in TNFα-induced signaling and cell death

(2010) Michael J. Morgan et al.   MOLECULES AND CELLS

Cisplatin plus Gemcitabine versus Gemcitabine for Biliary Tract Cancer

(2010) Juan Valle et al.   NEW ENGLAND JOURNAL OF MEDICINE

Involvement of PI3K and ERK1/2 pathways in hepatocyte growth factor-induced cholangiocarcinoma cell invasion

(2010) Apaporn Menakongka   WORLD JOURNAL OF GASTROENTEROLOGY

Intrahepatic Cholangiocarcinoma

(2009) Itaru Endo et al.   ANNALS OF SURGERY

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

The roles of ASK family proteins in stress responses and diseases

(2009) Kazuki Hattori et al.   Cell Communication and Signaling

Differential activation of p38MAPK isoforms by MKK6 and MKK3

(2009) Gaëlle Remy et al.   CELLULAR SIGNALLING

Mechanism of TGF-β signaling to growth arrest, apoptosis, and epithelial–mesenchymal transition

(2009) Carl-Henrik Heldin et al.   CURRENT OPINION IN CELL BIOLOGY

Notch signaling controls liver development by regulating biliary differentiation

(2009) Y. Zong et al.   DEVELOPMENT

Cholangiocyte proliferation and liver fibrosis

(2009) Shannon S. Glaser et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Regulation of the immune response by stress-activated protein kinases

(2009) Mercedes Rincón et al.   IMMUNOLOGICAL REVIEWS

p38delta/MAPK13 as a diagnostic marker for cholangiocarcinoma and its involvement in cell motility and invasion

(2009) Felicia Li-Sher Tan et al.   INTERNATIONAL JOURNAL OF CANCER

JNK1-dependent PUMA Expression Contributes to Hepatocyte Lipoapoptosis

(2009) Sophie C. Cazanave et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fibroblast Activation Protein and Its Relationship to Clinical Outcome in Pancreatic Adenocarcinoma

(2009) Steven J. Cohen et al.   PANCREAS

Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis

(2009) S. Inokuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-Smad pathways in TGF-β signaling

(2008) Ying E Zhang   CELL RESEARCH

HMGA2 and Smads Co-regulate SNAIL1 Expression during Induction of Epithelial-to-Mesenchymal Transition

(2008) Sylvie Thuault et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer

(2008) Qingshan Chang et al.   JOURNAL OF HEPATOLOGY

TRAF6 Mediates Smad-Independent Activation of JNK and p38 by TGF-β

(2008) Motozo Yamashita et al.   MOLECULAR CELL

JNK signaling in apoptosis

(2008) D N Dhanasekaran et al.   ONCOGENE

Evidence for the epithelial to mesenchymal transition in biliary atresia fibrosis

(2007) Rosalyn Díaz et al.   HUMAN PATHOLOGY