The role of cancer-associated myofibroblasts in intrahepatic cholangiocarcinoma

Development of a Fully Human Anti-PDGFRβ Antibody That Suppresses Growth of Human Tumor Xenografts and Enhances Antitumor Activity of an Anti-VEGFR2 Antibody

(2015) Juqun Shen et al.   NEOPLASIA

Cancer-Stellate Cell Interactions Perpetuate the Hypoxia-Fibrosis Cycle in Pancreatic Ductal Adenocarcinoma

(2015) Mert Erkan et al.   NEOPLASIA

Discovery of Small Molecule c-Met Inhibitors: Evolution and Profiles of Clinical Candidates

(2012) Ted Underiner et al.   Anti-Cancer Agents in Medicinal Chemistry

Tenascin C Induces Epithelial-Mesenchymal Transition–Like Change Accompanied by SRC Activation and Focal Adhesion Kinase Phosphorylation in Human Breast Cancer Cells

(2011) Keiki Nagaharu et al.   AMERICAN JOURNAL OF PATHOLOGY

Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth

(2011) Michael Quante et al.   CANCER CELL

Hypoxia activates the hedgehog signaling pathway in a ligand-independent manner by upregulation of Smo transcription in pancreatic cancer

(2011) Hideya Onishi et al.   CANCER SCIENCE

The Discovery of MMP7 Inhibitors Exploiting a Novel Selectivity Trigger

(2011) Karl Edman et al.   ChemMedChem

Targeting Galectin-1 in Carcinoma-Associated Fibroblasts Inhibits Oral Squamous Cell Carcinoma Metastasis by Downregulating MCP-1/CCL2 Expression

(2011) Ming-Heng Wu et al.   CLINICAL CANCER RESEARCH

Hedgehog signaling in cholangiocytes

(2011) Alessia Omenetti et al.   CURRENT OPINION IN GASTROENTEROLOGY

Cancer-associated fibroblasts in intrahepatic cholangiocarcinoma

(2011) Alphonse E Sirica et al.   CURRENT OPINION IN GASTROENTEROLOGY

Myc, Max, and Mnt: Molecular Mechanisms of Enhancement of Cholangiocarcinogenesis by Cholestasis

(2011) Ikuo Nakamura et al.   GASTROENTEROLOGY

Cholangiocarcinoma: principles and current trends

(2011) George N Zografos et al.   Hepatobiliary & Pancreatic Diseases International

Development of molecularly targeted therapies in biliary tract cancers: Reassessing the challenges and opportunities

(2011) Andrew X. Zhu et al.   HEPATOLOGY

Identification of Novel and Distinct Binding Sites within Tenascin-C for Soluble and Fibrillar Fibronectin

(2011) Wing S. To et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mucin 1 C-Terminal Subunit Oncoprotein Is a Target for Small-Molecule Inhibitors

(2011) Y. Zhou et al.   MOLECULAR PHARMACOLOGY

Cholangiocarcinoma—controversies and challenges

(2011) Tushar Patel   Nature Reviews Gastroenterology & Hepatology

Periostin, a matrix protein, has potential as a novel serodiagnostic marker for cholangiocarcinoma

(2011) Fujimoto   ONCOLOGY REPORTS

Intrahepatic Cholangiocarcinoma: New Insights in Pathology

(2011) Christine Sempoux et al.   SEMINARS IN LIVER DISEASE

Enhanced proliferation, invasion, and epithelial-mesenchymal transition of nicotine-promoted gastric cancer by periostin

(2011) Yu Liu   WORLD JOURNAL OF GASTROENTEROLOGY

Epithelial-Mesenchymal Transition Induced by Transforming Growth Factor-β1/Snail Activation Aggravates Invasive Growth of Cholangiocarcinoma

(2010) Yasunori Sato et al.   AMERICAN JOURNAL OF PATHOLOGY

Epithelial-Mesenchymal Transition Induced by Hepatitis C Virus Core Protein in Cholangiocarcinoma

(2010) Tianyu Li et al.   ANNALS OF SURGICAL ONCOLOGY

Hepatic Stellate Cells Accelerate the Malignant Behavior of Cholangiocarcinoma Cells

(2010) Hirohisa Okabe et al.   ANNALS OF SURGICAL ONCOLOGY

Hypoxic preconditioning advances CXCR4 and CXCR7 expression by activating HIF-1α in MSCs

(2010) Hongbao Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of binding partners interacting with the α1-N-propeptide of type V collagen

(2010) Sofie Symoens et al.   BIOCHEMICAL JOURNAL

Important role of integrins in the cancer biology

(2010) R. Rathinam et al.   CANCER AND METASTASIS REVIEWS

Hypoxia, inflammation, and the tumor microenvironment in metastatic disease

(2010) Elizabeth C. Finger et al.   CANCER AND METASTASIS REVIEWS

Functional targeting of the MUC1 oncogene in human cancers

(2010) Donald W. Kufe   CANCER BIOLOGY & THERAPY

MET Kinase Inhibitor SGX523 Synergizes with Epidermal Growth Factor Receptor Inhibitor Erlotinib in a Hepatocyte Growth Factor-Dependent Fashion to Suppress Carcinoma Growth

(2010) Y.-W. Zhang et al.   CANCER RESEARCH

Periostin, a Cell Adhesion Molecule, Facilitates Invasion in the Tumor Microenvironment and Annotates a Novel Tumor-Invasive Signature in Esophageal Cancer

(2010) C. Z. Michaylira et al.   CANCER RESEARCH

Novel STAT3 Phosphorylation Inhibitors Exhibit Potent Growth-Suppressive Activity in Pancreatic and Breast Cancer Cells

(2010) L. Lin et al.   CANCER RESEARCH

Immunotherapy targeting fibroblast activation protein inhibits tumor growth and increases survival in a murine colon cancer model

(2010) Yuan Wen et al.   CANCER SCIENCE

Significance of alternatively activated macrophages in patients with intrahepatic cholangiocarcinoma

(2010) Horlad Hasita et al.   CANCER SCIENCE

Hypoxia inducible factor-1 mediates expression of galectin-1: the potential role in migration/invasion of colorectal cancer cells

(2010) Xu-Yun Zhao et al.   CARCINOGENESIS

Evaluation of a CXCR4 antagonist in a xenograft mouse model of inflammatory breast cancer

(2010) Balraj Singh et al.   CLINICAL & EXPERIMENTAL METASTASIS

Overexpression of Smoothened Activates the Sonic Hedgehog Signaling Pathway in Pancreatic Cancer-Associated Fibroblasts

(2010) K. Walter et al.   CLINICAL CANCER RESEARCH

Molecular Targeted Therapy of Biliary Tract Cancer – Results of the First Clinical Studies

(2010) Marcus W. Wiedmann et al.   CURRENT DRUG TARGETS

Cholangiocarcinoma: Update and future perspectives

(2010) Manuela Gatto et al.   DIGESTIVE AND LIVER DISEASE

Differential gene expression profiling of cultured neu-transformed versus spontaneously-transformed rat cholangiocytes and of corresponding cholangiocarcinomas

(2010) Catherine I. Dumur et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Activation of fibroblasts in cancer stroma

(2010) Kati Räsänen et al.   EXPERIMENTAL CELL RESEARCH

Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance

(2010) Suriyan Ponnusamy et al.   Future Oncology

Preclinical assessment of simultaneous targeting of epidermal growth factor receptor (ErbB1) and ErbB2 as a strategy for cholangiocarcinoma therapy

(2010) Zichen Zhang et al.   HEPATOLOGY

Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells

(2010) Jörg Schrader et al.   HEPATOLOGY

Involvement of MMP-9 in peribiliary fibrosis and cholangiocarcinogenesis via Rac1-dependent DNA damage in a hamster model

(2010) Suksanti Prakobwong et al.   INTERNATIONAL JOURNAL OF CANCER

Angiotensin II induces tumor progression and fibrosis in intrahepatic cholangiocarcinoma through an interaction with hepatic stellate cells

(2010) Okamoto   INTERNATIONAL JOURNAL OF ONCOLOGY

Clinical Experience With Hedgehog Pathway Inhibitors

(2010) Jennifer A. Low et al.   JOURNAL OF CLINICAL ONCOLOGY

HGF upregulates CXCR4 expression in gliomas via NF-κB: implications for glioma cell migration

(2010) Mine Esencay et al.   JOURNAL OF NEURO-ONCOLOGY

Gene expression profiling of cholangiocarcinoma-derived fibroblast reveals alterations related to tumor progression and indicates periostin as a poor prognostic marker

(2010) Kusumawadee Utispan et al.   Molecular Cancer

Cyclooxygenase-Deficient Pancreatic Cancer Cells Use Exogenous Sources of Prostaglandins

(2010) N. Omura et al.   MOLECULAR CANCER RESEARCH

GLI1 facilitates the migration and invasion of pancreatic cancer cells through MUC5AC-mediated attenuation of E-cadherin

(2010) S Inaguma et al.   ONCOGENE

Fibroblast-secreted hepatocyte growth factor plays a functional role in esophageal squamous cell carcinoma invasion

(2010) K. D. Grugan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of PI3K and ERK1/2 pathways in hepatocyte growth factor-induced cholangiocarcinoma cell invasion

(2010) Apaporn Menakongka   WORLD JOURNAL OF GASTROENTEROLOGY

Prospective study of MMP7 serum levels in the diagnosis of cholangiocarcinoma

(2010) Kawin Leelawat   WORLD JOURNAL OF GASTROENTEROLOGY

Surgical treatment of intrahepatic cholangiocarcinoma: outcomes and predictive factors

(2010) Michelle C. Ellis et al.   HPB

Intra-hepatic and extra-hepatic cholangiocarcinoma: New insight into epidemiology and risk factors

(2010) Vincenzo Cardinale   World Journal of Gastrointestinal Oncology

The Fibrotic Phenotype Induced by IGFBP-5 Is Regulated by MAPK Activation and Egr-1-Dependent and -Independent Mechanisms

(2009) Hidekata Yasuoka et al.   AMERICAN JOURNAL OF PATHOLOGY

Quantitative Analysis of Three-Dimensional Human Mammary Epithelial Tissue Architecture Reveals a Role for Tenascin-C in Regulating c-Met Function

(2009) Agne Taraseviciute et al.   AMERICAN JOURNAL OF PATHOLOGY

Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis

(2009) Steve S. Choi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Hepatic Stellate Cells May Relate to Progression of Intrahepatic Cholangiocarcinoma

(2009) Hirohisa Okabe et al.   ANNALS OF SURGICAL ONCOLOGY

IGFBP-5 induces epithelial and fibroblast responses consistent with the fibrotic response

(2009) Angara Sureshbabu et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The regulation of tenascin expression by tissue microenvironments

(2009) Richard P. Tucker et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inhibiting Tumor Growth by Targeting Tumor Vasculature with Galectin-1 Antagonist Anginex Conjugated to the Cytotoxic Acylfulvene, 6-Hydroxylpropylacylfulvene

(2009) Ruud P. M. Dings et al.   BIOCONJUGATE CHEMISTRY

Detection of serum MMP-7 and MMP-9 in cholangiocarcinoma patients: evaluation of diagnostic accuracy

(2009) Kawin Leelawat et al.   BMC GASTROENTEROLOGY

A phase II study of lapatinib in patients with advanced biliary tree and hepatocellular cancer

(2009) Ramesh K. Ramanathan et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Upregulated expression of periostin by hypoxia in non-small-cell lung cancer cells promotes cell survival via the Akt/PKB pathway

(2009) Gaoliang Ouyang et al.   CANCER LETTERS

Paracrine Hedgehog Signaling in Cancer

(2009) J.-W. Theunissen et al.   CANCER RESEARCH

MUC1, a New Hypoxia Inducible Factor Target Gene, Is an Actor in Clear Renal Cell Carcinoma Tumor Progression

(2009) S. Aubert et al.   CANCER RESEARCH

Tumor-stromal interactions with direct cell contacts enhance proliferation of human pancreatic carcinoma cells

(2009) Hayato Fujita et al.   CANCER SCIENCE

Epidemiology of cholangiocarcinoma: An update focusing on risk factors

(2009) Hai-Rim Shin et al.   CANCER SCIENCE

The multifaceted role of periostin in tumorigenesis

(2009) Kai Ruan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Targeting the tumour stroma to increase efficacy of chemo- and radiotherapy

(2009) Gretel Chometon et al.   Clinical & Translational Oncology

Intrahepatic Cholangiocarcinoma Progression: Prognostic Factors and Basic Mechanisms

(2009) Alphonse E. Sirica et al.   Clinical Gastroenterology and Hepatology

Inhibition of HGF/MET as therapy for malignancy

(2009) Sanjay Naran et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Sorafenib inhibits signal transducer and activator of transcription-3 signaling in cholangiocarcinoma cells by activating the phosphatase shatterproof 2

(2009) Boris R. A. Blechacz et al.   HEPATOLOGY

Portal fibroblasts: Underappreciated mediators of biliary fibrosis

(2009) Jonathan A. Dranoff et al.   HEPATOLOGY

Hepatic stellate cells express functional CXCR4: Role in stromal cell-derived factor-1α-mediated stellate cell activation

(2009) Feng Hong et al.   HEPATOLOGY

CD10+ fibroblasts are more involved in the progression of hilar/extrahepatic cholangiocarcinoma than of peripheral intrahepatic cholangiocarcinoma

(2009) Yunosuke Nishihara et al.   HISTOPATHOLOGY

Incorporation of Tenascin-C into the Extracellular Matrix by Periostin Underlies an Extracellular Meshwork Architecture

(2009) Isao Kii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice

(2009) Angélica M. Santos et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia-inducible factor-1α induces Twist expression in tubular epithelial cells subjected to hypoxia, leading to epithelial-to-mesenchymal transition

(2009) Shiren Sun et al.   KIDNEY INTERNATIONAL

Twist: a new link from hypoxia to fibrosis

(2009) Wibke Bechtel et al.   KIDNEY INTERNATIONAL

The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects

(2009) D. L. Schwartz et al.   MOLECULAR CANCER THERAPEUTICS

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-β signaling

(2009) L Lin et al.   ONCOGENE

CXCR4 and SDF-1 Production Are Stimulated by Hepatocyte Growth Factor and Promote Glioma Cell Invasion

(2009) Hanjun Tu et al.   ONKOLOGIE

Fibroblast Activation Protein and Its Relationship to Clinical Outcome in Pancreatic Adenocarcinoma

(2009) Steven J. Cohen et al.   PANCREAS

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression

(2009) Masayuki Shimoda et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Role of Stromal Fibroblasts in Cancer: Promoting or Impeding?

(2009) Flora Angeli et al.   TUMOR BIOLOGY

Insulin-like growth factor binding protein-7 induces activation and transdifferentiation of hepatic stellate cells in vitro

(2009) Li-Xin Liu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Matricellular proteins: an overview

(2009) Paul Bornstein   Journal of Cell Communication and Signaling

Sphingosine kinase-1 is a hypoxia-regulated gene that stimulates migration of human endothelial cells

(2008) Stephanie Schwalm et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Global Hypomethylation of Genomic DNA in Cancer-Associated Myofibroblasts

(2008) L. Jiang et al.   CANCER RESEARCH

Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer

(2008) Yoshihiko Kitajima et al.   CANCER SCIENCE

CXCR4, Inhibitors and Mechanisms of Action

(2008) Xiangyang Liang   Chemical Biology & Drug Design

Targeting SphK1 as a New Strategy against Cancer

(2008) Dai Shida et al.   CURRENT DRUG TARGETS

Periostin, secreted from stromal cells, has biphasic effect on cell migration and correlates with the epithelial to mesenchymal transition of human pancreatic cancer cells

(2008) Atsushi Kanno et al.   INTERNATIONAL JOURNAL OF CANCER

Pancreatic stellate cells: Molecular mechanism of pancreatic fibrosis

(2008) Kyoko Shimizu   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

RNA interfering connective tissue growth factor prevents rat hepatic stellate cell activation and extracellular matrix production

(2008) Guangming Li et al.   JOURNAL OF GENE MEDICINE

Identification of novel candidate tumour marker genes for intrahepatic cholangiocarcinoma

(2008) Ryuhei Nishino et al.   JOURNAL OF HEPATOLOGY

Lymphatic spread is related to VEGF-C expression and D2-40-positive myofibroblasts in intrahepatic cholangiocarcinoma

(2008) Shinichi Aishima et al.   MODERN PATHOLOGY

Stabilization of hepatocyte growth factor mRNA by hypoxia-inducible factor 1

(2008) Sheng-Hua Chu et al.   MOLECULAR BIOLOGY REPORTS

An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer

(2008) G. Feldmann et al.   MOLECULAR CANCER THERAPEUTICS

Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells

(2007) Liu Yang et al.   JOURNAL OF HEPATOLOGY