The interplay of the Notch signaling in hepatic stellate cells and macrophages determines the fate of liver fibrogenesis

Pathobiology of liver fibrosis: a translational success story

(2015) Youngmin A Lee et al.   GUT

NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation

(2015) Jun Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatic fibrosis: Concept to treatment

(2015) Christian Trautwein et al.   JOURNAL OF HEPATOLOGY

Impact of Sox9 Dosage and Hes1-mediated Notch Signaling in Controlling the Plasticity of Adult Pancreatic Duct Cells in Mice

(2015) Shinichi Hosokawa et al.   Scientific Reports

Emerging roles of Notch signaling in liver disease

(2014) Fabian Geisler et al.   HEPATOLOGY

Macrophage heterogeneity in liver injury and fibrosis

(2014) Frank Tacke et al.   JOURNAL OF HEPATOLOGY

Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage–stellate cell interaction

(2014) Chanjuan Shi et al.   LABORATORY INVESTIGATION

Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice

(2013) Jean-Philippe Pradere et al.   HEPATOLOGY

Macrophage plasticity and polarization in liver homeostasis and pathology

(2013) Antonio Sica et al.   HEPATOLOGY

Recent Developments in Myofibroblast Biology

(2012) Boris Hinz et al.   AMERICAN JOURNAL OF PATHOLOGY

Activated hepatic stellate cells mediate the differentiation of macrophages

(2012) Jonathan Chang et al.   HEPATOLOGY RESEARCH

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Morphogens and hepatic stellate cell fate regulation in chronic liver disease

(2012) Hidekazu Tsukamoto et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Notch–RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization

(2012) Haixia Xu et al.   NATURE IMMUNOLOGY

Inhibition of Notch Signaling by a γ-Secretase Inhibitor Attenuates Hepatic Fibrosis in Rats

(2012) Yixiong Chen et al.   PLoS One

Notch and disease: A growing field

(2012) Angeliki Louvi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Pathogenesis of Liver Fibrosis

(2011) Virginia Hernandez-Gea et al.   Annual Review of Pathology-Mechanisms of Disease

Notch signaling: simplicity in design, versatility in function

(2011) E. R. Andersson et al.   DEVELOPMENT

Preventive Effect of Notch Signaling Inhibition by a γ-Secretase Inhibitor on Peritoneal Dialysis Fluid-Induced Peritoneal Fibrosis in Rats

(2010) Fengxin Zhu et al.   AMERICAN JOURNAL OF PATHOLOGY

Cell–cell signaling in co-cultures of macrophages and fibroblasts

(2010) Dolly J. Holt et al.   BIOMATERIALS

Notch Signaling Determines the M1 versus M2 Polarization of Macrophages in Antitumor Immune Responses

(2010) Yao-Chun Wang et al.   CANCER RESEARCH

Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans

(2010) Bernhard Bielesz et al.   JOURNAL OF CLINICAL INVESTIGATION

Blockade of Notch1 Signaling Alleviates Murine Lupus via Blunting Macrophage Activation and M2b Polarization

(2010) W. Zhang et al.   JOURNAL OF IMMUNOLOGY

Macrophages: Master Regulators of Inflammation and Fibrosis

(2010) Thomas Wynn et al.   SEMINARS IN LIVER DISEASE

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Notch1 upregulates LPS-induced macrophage activation by increasing NF-κB activity

(2009) Eva Monsalve et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

Ectopic SOX9 Mediates Extracellular Matrix Deposition Characteristic of Organ Fibrosis

(2008) Karen Piper Hanley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liver cirrhosis

(2008) Detlef Schuppan et al.   LANCET

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS

Hepatic fibrosis—Overview

(2008) Scott L. Friedman   TOXICOLOGY