JNK signalling in cancer: in need of new, smarter therapeutic targets

Identification and characterization of bi-thiazole-2,2′-diamines as kinase inhibitory scaffolds

(2013) Kevin R.W. Ngoei et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Myeloid malignancies: mutations, models and management

(2012) Anne Murati et al.   BMC CANCER

Activation of JNK and high expression level of CD133 predict a poor response to sorafenib in hepatocellular carcinoma

(2012) S Hagiwara et al.   BRITISH JOURNAL OF CANCER

Discovery of Potent and Selective Covalent Inhibitors of JNK

(2012) Tinghu Zhang et al.   CHEMISTRY & BIOLOGY

A Liver Full of JNK: Signaling in Regulation of Cell Function and Disease Pathogenesis, and Clinical Approaches

(2012) Ekihiro Seki et al.   GASTROENTEROLOGY

Primary brain tumours in adults

(2012) Damien Ricard et al.   LANCET

Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin

(2012) Lihua Min et al.   NATURE CELL BIOLOGY

c-Jun N-terminal kinase has a pivotal role in the maintenance of self-renewal and tumorigenicity in glioma stem-like cells

(2012) C-H Yoon et al.   ONCOGENE

Poly(ADP-ribose) polymerase family member 14 (PARP14) is a novel effector of the JNK2-dependent pro-survival signal in multiple myeloma

(2012) A Barbarulo et al.   ONCOGENE

The JNK Inhibitor XG-102 Protects against TNBS-Induced Colitis

(2012) Kirstin Reinecke et al.   PLoS One

Development of JNK2-Selective Peptide Inhibitors That Inhibit Breast Cancer Cell Migration

(2011) Tamer S. Kaoud et al.   ACS Chemical Biology

Characterization of a novel JNK (c-Jun N-terminal kinase) inhibitory peptide

(2011) Kevin R. W. Ngoei et al.   BIOCHEMICAL JOURNAL

Synthesis and SAR of novel quinazolines as potent and brain-penetrant c-jun N-terminal kinase (JNK) Inhibitors

(2011) Yuanjun He et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor

(2011) Véronique Plantevin Krenitsky et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Role of JNK in Mammary Gland Development and Breast Cancer

(2011) C. Cellurale et al.   CANCER RESEARCH

Molecular Pathways: BCR-ABL

(2011) D. Cilloni et al.   CLINICAL CANCER RESEARCH

The role of JNK in the development of hepatocellular carcinoma

(2011) Madhumita Das et al.   GENES & DEVELOPMENT

PUMA-mediated apoptosis drives chemical hepatocarcinogenesis in mice

(2011) Wei Qiu et al.   HEPATOLOGY

JNK1 and JNK2 play redundant functions in Myc-induced B cell lymphoma formation

(2011) Moorthy Anbalagan et al.   INTERNATIONAL JOURNAL OF CANCER

Requirement of c-Jun NH2-Terminal Kinase for Ras-Initiated Tumor Formation

(2011) C. Cellurale et al.   MOLECULAR AND CELLULAR BIOLOGY

The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression

(2011) Daniel Schramek et al.   NATURE GENETICS

Glycolytic rate and lymphomagenesis depend on PARP14, an ADP ribosyltransferase of the B aggressive lymphoma (BAL) family

(2011) S. H. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tobacco Smoke Promotes Lung Tumorigenesis by Triggering IKKβ- and JNK1-Dependent Inflammation

(2010) Hiroyuki Takahashi et al.   CANCER CELL

The c-Jun NH2-Terminal Kinase 2 Plays a Dominant Role in Human Epidermal Neoplasia

(2010) H. Ke et al.   CANCER RESEARCH

The Mitogen-Activated Protein Kinase Kinase 4 Has a Pro-Oncogenic Role in Skin Cancer

(2010) K. G. Finegan et al.   CANCER RESEARCH

Small Molecule JNK (c-Jun N-Terminal Kinase) Inhibitors

(2010) M. Arshad Siddiqui et al.   JOURNAL OF MEDICINAL CHEMISTRY

Regulation of Multidrug Resistance Protein 1 by Tumor Necrosis Factor   in Cultured Glial Cells: Involvement of Nuclear Factor- B and c-Jun N-Terminal Kinase Signaling Pathways

(2010) P. T. Ronaldson et al.   MOLECULAR PHARMACOLOGY

The role of the c-Jun N-terminal kinase 2-α-isoform in non-small cell lung carcinoma tumorigenesis

(2010) R T Nitta et al.   ONCOGENE

Jnk2 Effects on Tumor Development, Genetic Instability and Replicative Stress in an Oncogene-Driven Mouse Mammary Tumor Model

(2010) Peila Chen et al.   PLoS One

Role of JNK in a Trp53-Dependent Mouse Model of Breast Cancer

(2010) Cristina Cellurale et al.   PLoS One

Identification of small-molecule inhibitors of the JIP–JNK interaction

(2009) Tracy Chen et al.   BIOCHEMICAL JOURNAL

c-Jun N-terminal kinase (JNK) signaling: Recent advances and challenges

(2009) Marie A. Bogoyevitch et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Mechanisms of liver disease: cross-talk between the NF-κB and JNK pathways

(2009) Salvatore Papa et al.   BIOLOGICAL CHEMISTRY

Biologic sequelae of I B kinase (IKK) inhibition in multiple myeloma: therapeutic implications

(2009) T. Hideshima et al.   BLOOD

Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model

(2009) Yong-Jing Gao et al.   EXPERIMENTAL NEUROLOGY

A selective small-molecule inhibitor of c-JunN-terminal kinase 1

(2009) Ke Yao et al.   FEBS LETTERS

Inhibition of c-Jun NH2-terminal kinase switches Smad3 signaling from oncogenesis to tumor- suppression in rat hepatocellular carcinoma

(2009) Hiromitsu Nagata et al.   HEPATOLOGY

JNK1-dependent PUMA Expression Contributes to Hepatocyte Lipoapoptosis

(2009) Sophie C. Cazanave et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis, Biological Evaluation, X-ray Structure, and Pharmacokinetics of Aminopyrimidine c-jun-N-terminal Kinase (JNK) Inhibitors

(2009) Ted Kamenecka et al.   JOURNAL OF MEDICINAL CHEMISTRY

c-Jun N-terminal kinase 2 (JNK2) antagonizes the signaling of differentiation by JNK1 in human myeloid leukemia cells resistant to vitamin D

(2009) Xiangwen Chen-Deutsch et al.   LEUKEMIA RESEARCH

c-Jun N-Terminal Kinase 1 Phosphorylates Myt1 To Prevent UVA-Induced Skin Cancer

(2009) H. S. Choi et al.   MOLECULAR AND CELLULAR BIOLOGY

JNK1 activation predicts the prognostic outcome of the human hepatocellular carcinoma

(2009) Qingshan Chang et al.   Molecular Cancer

Basal c-Jun NH2-terminal protein kinase activity is essential for survival and proliferation of T-cell acute lymphoblastic leukemia cells

(2009) J. Cui et al.   MOLECULAR CANCER THERAPEUTICS

Basal Cancer Cell Survival Involves JNK2 Suppression of a Novel JNK1/c-Jun/Bcl-3 Apoptotic Network

(2009) Shafiq Uddin Ahmed et al.   PLoS One

Targeting the Eukaryotic Translation Initiation Factor 4E for Cancer Therapy

(2008) J. R. Graff et al.   CANCER RESEARCH

JNK inhibition sensitises hepatocellular carcinoma cells but not normal hepatocytes to the TNF-related apoptosis-inducing ligand

(2008) S R Mucha et al.   GUT

Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation

(2008) Lijian Hui et al.   JOURNAL OF CLINICAL INVESTIGATION

Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer

(2008) Qingshan Chang et al.   JOURNAL OF HEPATOLOGY

Constitutive activation of c-Jun N-terminal kinase correlates with histologic grade and EGFR expression in diffuse gliomas

(2008) Jian Yi Li et al.   JOURNAL OF NEURO-ONCOLOGY

Inhibitors of c-jun-N-Terminal Kinase (JNK)

(2008) Philip LoGrasso et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Identification of a new JNK inhibitor targeting the JNK-JIP interaction site

(2008) J. L. Stebbins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the JNK signal transduction pathway in inflammatory bowel disease

(2008) Praveen K Roy et al.   WORLD JOURNAL OF GASTROENTEROLOGY