Saponins fromPanax japonicusattenuate D-galactose-induced cognitive impairment through its anti-oxidative and anti-apoptotic effects in rats

SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism

(2014) Hongwei Yao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Lactobacillus pentosus var. plantarum C29 ameliorates memory impairment and inflammaging in a d-galactose-induced accelerated aging mouse model

(2014) Jae-Yeon Woo et al.   ANAEROBE

CD36 Upregulation Mediated by Intranasal LV-NRF2 Treatment Mitigates Hypoxia-Induced Progression of Alzheimer's-Like Pathogenesis

(2014) Chun-Yan Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Pathophysiological importance of aggregated damaged proteins

(2014) Annika Höhn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Luteolin provides neuroprotection in models of traumatic brain injury via the Nrf2–ARE pathway

(2014) Jianguo Xu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial aldehyde dehydrogenase 2 accentuates aging-induced cardiac remodeling and contractile dysfunction: role of AMPK, Sirt1, and mitochondrial function

(2014) Yingmei Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Radioprotective and Antioxidant Effect of Resveratrol in Hippocampus by Activating Sirt1

(2014) Jianguo Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Delayed Remote Ischemic Preconditioning Produces an Additive Cardioprotection to Sevoflurane Postconditioning Through an Enhanced Heme Oxygenase 1 Level Partly Via Nuclear Factor Erythroid 2-Related Factor 2 Nuclear Translocation

(2014) Chenghui Zhou et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Apolipoprotein D takes center stage in the stress response of the aging and degenerative brain

(2014) Sarah Dassati et al.   NEUROBIOLOGY OF AGING

Gene Expression Changes for Antioxidants Pathways in the Mouse Cochlea: Relations to Age-related Hearing Deficits

(2014) Sherif F. Tadros et al.   PLoS One

The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet

(2014) Sarah J. Mitchell et al.   Cell Reports

Oxidative Stress, Hypoxia, and Autophagy in the Neovascular Processes of Age-Related Macular Degeneration

(2014) Janusz Blasiak et al.   Biomed Research International

Protective effects of a catechin-rich extract on the hippocampal formation and spatial memory in aging rats

(2013) Jorge Rodrigues et al.   BEHAVIOURAL BRAIN RESEARCH

Sirtuin1 and autophagy protect cells from fluoride-induced cell stress

(2013) Maiko Suzuki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

Nuclear Factor Erythroid 2 - Related Factor 2 Signaling in Parkinson Disease: A Promising Multi Therapeutic Target Against Oxidative Stress, Neuroinflammation and Cell Death

(2013) Hemant Kumar et al.   CNS & Neurological Disorders-Drug Targets

Targeting Sirtuin-1 in Huntington’s Disease: Rationale and Current Status

(2013) Wenzhen Duan   CNS DRUGS

SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury

(2013) Yang Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Citicoline (CDP-choline) increases Sirtuin1 expression concomitant to neuroprotection in experimental stroke

(2013) Olivia Hurtado et al.   JOURNAL OF NEUROCHEMISTRY

Neuroprotection by Curcumin in Ischemic Brain Injury Involves the Akt/Nrf2 Pathway

(2013) Jingxian Wu et al.   PLoS One

Sirtuin1: A Promising Serum Protein Marker for Early Detection of Alzheimer’s Disease

(2013) Rahul Kumar et al.   PLoS One

Sesamin ameliorates doxorubicin-induced cardiotoxicity: Involvement of Sirt1 and Mn-SOD pathway

(2013) Suwen Su et al.   TOXICOLOGY LETTERS

The transcription factor NF-E2-related Factor 2 (Nrf2): a protooncogene?

(2012) Phillip Shelton et al.   FASEB JOURNAL

Cardioprotective effects of saponins from Panax japonicus on acute myocardial ischemia against oxidative stress-triggered damage and cardiac cell death in rats

(2012) Haibo He et al.   JOURNAL OF ETHNOPHARMACOLOGY

Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis

(2011) Tej K. Pareek et al.   Scientific Reports

Saponins from Panax japonicus Protect Against Alcohol-Induced Hepatic Injury in Mice by Up-regulating the Expression of GPX3, SOD1 and SOD3

(2010) Y.-G. Li et al.   ALCOHOL AND ALCOHOLISM

Purple Sweet Potato Color Alleviates D-galactose-induced Brain Aging in Old Mice by Promoting Survival of Neurons via PI3K Pathway and Inhibiting Cytochrome C-mediated Apoptosis

(2009) Jun Lu et al.   BRAIN PATHOLOGY

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

Synergy research: Vitamins and secondary plant components in the maintenance of the redox-homeostasis and in cell signaling

(2009) Gudrun Ulrich-Merzenich et al.   PHYTOMEDICINE

Epigallocatechin-3-gallate augments antioxidant activities and inhibits inflammation during bleomycin-induced experimental pulmonary fibrosis through Nrf2–Keap1 signaling

(2008) Narayanan Sriram et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS