Review
Pharmacology & Pharmacy
Xin-xing Yang, Rong Yang, Feng Zhang
Summary: Parkinson's disease is a common and chronic degenerative disease in the central nervous system. The main pathology involves the loss of dopaminergic neurons and the formation of Lewy bodies. The pathogenesis of PD is influenced by various independent factors, and regulating the Nrf2 pathway may be a promising strategy for preventing and treating PD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Environmental Sciences
Jui-Ming Sun, Surbhi Agarwal, Tushar Dnyaneshwar Desai, Da-Tong Ju, Yung-Ming Chang, Shih-Chieh Liao, Tsung-Jung Ho, Yu-Lan Yeh, Wei-Wen Kuo, Yu-Jung Lin, Chih-Yang Huang
Summary: This study demonstrates that cryptotanshinone can attenuate paraquat-induced oxidative stress and restore motor function and survival of dopaminergic neurons in cellular and animal models of Parkinson's disease, suggesting its therapeutic potential.
ENVIRONMENTAL TOXICOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Amanda Li, Joel Tyson, Shivni Patel, Meer Patel, Sruthi Katakam, Xiaobo Mao, Weiwei He
Summary: With the aging population, the prevalence of neurodegenerative diseases such as PD and AD is expected to rise. These diseases are classified as proteinopathies with misfolded proteins like alpha-synuclein, amyloid-beta, and tau. Nanomaterials offer advantages over traditional therapies in targeting specific mechanisms, such as reducing oxidative stress or disaggregating fibrils.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuhua Zhu, Ziyan Wang, Shuxuan Yu, Chong Zhao, Baofeng Xu, Rui Liu, Li Xu, Yi Guo
Summary: This study investigated the neuroprotective effects of ginseng fibrous root against oxidative stress in Alzheimer's disease (AD). The results showed that ginseng fibrous root enzymatic hydrolysate exhibited antioxidant activities, protected cells from oxidative damage, and improved the survival rate of Caenorhabditis elegans under oxidative stress.
Article
Food Science & Technology
Yujie Chen, Wuke Yuan, Qi Xu, Manju B. Reddy
Summary: Parkinson's disease (PD) and Alzheimer's disease (AD) are common neurodegenerative disorders with shared molecular mechanisms, and there is currently no effective treatment. However, research suggests that consuming phytochemicals may help delay the progression of these diseases.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Pharmacology & Pharmacy
Yumin Wang, Luyan Gao, Jichao Chen, Qiang Li, Liang Huo, Yanchao Wang, Hongquan Wang, Jichen Du
Summary: Parkinson's disease is a complex neurodegenerative disorder characterized by the loss of dopaminergic neurons in the brain. Oxidative stress has been implicated in its pathogenesis, with the transcription factor Nrf2 playing a key role in activating protective genes against oxidative stress. Recent studies have shown that bioactive compounds can activate Nrf2 and ameliorate neurotoxins associated with PD, suggesting a potential therapeutic target for the treatment of the disease.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jana Tchekalarova, Rumiana Tzoneva
Summary: Aging and neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, are linked by common features like mitochondrial dysfunction and protein aggregation. The rising costs of caring for elderly patients with these diseases is a major issue in today's demographic crisis. Oxidative stress and imbalanced antioxidant defense system play crucial roles in age-related neurodegeneration, and diminished melatonin release with aging further increases susceptibility to these diseases. Understanding the underlying mechanisms and melatonin's role is important for developing precise treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ritu Soni, Jigna Shah
Summary: Parkinson's disease is a progressive neurodegenerative disorder associated with metabolic syndrome, which may contribute to the development of the disease through various pathological pathways.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Engineering, Environmental
Xiaoyu Yuan, Ran Tang, Zhi Jia, Yutong Chen, Jie Liu, Yanan Liu
Summary: A novel Zn2+-responsive nano-drug delivery platform has been developed for the treatment of Alzheimer's disease. It effectively alleviates oxidative stress and modulates the microenvironment to provide therapeutic effects.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Neurosciences
Shalini Mani, Rajni Dubey, I-Chun Lai, M. Arockia Babu, Sakshi Tyagi, Geeta Swargiary, Deepansh Mody, Manisha Singh, Shriya Agarwal, Danish Iqbal, Sanjay Kumar, Munerah Hamed, Punya Sachdeva, Abdulmajeed G. Almutary, Hind Muteb Albadrani, Shreesh Ojha, Sandeep Kumar Singh, Niraj Kumar Jha
Summary: Alzheimer's disease is a neurodegenerative disease caused by aging, neuroinflammation, and oxidative stress. Compounds from natural sources have shown potential for treating AD due to their antioxidant, anti-inflammatory, and biological activities.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Victor Tapias, Paula Gonzalez-Andres, Laura F. Pena, Asuncion Barbero, Lucia Nunez, Carlos Villalobos
Summary: Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common neurodegenerative diseases in the elderly, characterized by abnormal protein aggregates and loss of neurons in specific brain regions. The exact mechanisms of these diseases are unknown, but oxidative stress, mitochondrial dysfunction, and disrupted Ca2+ homeostasis play a crucial role. With an increase in life expectancy, there is a need for preventive strategies and disease-modifying therapies for AD/PD. Modulating Ca2+ homeostasis and signaling, as well as controlling mitochondrial function with heterocyclic compounds, may provide potential neuroprotective treatments for these diseases.
Review
Biochemistry & Molecular Biology
Mohammad Rafi Khezri, Morteza Ghasemnejad-Berenji
Summary: Alzheimer's disease and Parkinson's disease are the most common neurodegenerative diseases worldwide, with no definitive treatment. Icariin, a natural compound with anti-inflammatory and anti-oxidant properties, may have potential in slowing the progression of neurodegenerative diseases.
NEUROCHEMICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Sandro Huenchuguala, Juan Segura-Aguilar
Summary: Iron plays a fundamental role in various aspects of human life, but an imbalance in iron levels can lead to certain pathologies. Maintaining iron homeostasis is crucial in preventing these pathologies. While there is evidence suggesting iron's involvement in the degenerative process of Parkinson's disease, clinical studies have not shown positive effects of iron chelators in treating the disease.
Article
Biochemistry & Molecular Biology
Marika Lanza, Rossella Basilotta, Salvatore Cuzzocrea, Maria Bulzomi, Salvatore Oddo, Giovanna Casili, Emanuela Esposito
Summary: The prevalence of obesity worldwide is rapidly increasing and is considered a leading cause of death. Added sugar consumption is one of the main factors contributing to this, as it is associated with a higher risk of obesity, heart disease, diabetes, and brain illnesses such as Alzheimer's disease (AD). Excess sugar can worsen oxidative damage and brain inflammation, which are neuropathological signs of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Nickolay K. Isaev, Elizaveta E. Genrikhs, Elena V. Stelmashook
Summary: Oxidative stress is a main factor in neuron damage, making it a therapeutic target for neuroprotectors. Thymoquinone, a drug with wide pharmacological activity, including neuroprotective effects, has shown promise in experimental modeling of neurodegenerative diseases. Its neuroprotective effect is attributed to its antioxidant ability. Thymoquinone has been found to effectively reduce the negative consequences of cerebral pathology and normalize antioxidant enzyme levels, making it a promising candidate for treating degenerative diseases of the central nervous system.
Article
Biochemistry & Molecular Biology
Inayat Ur Rehman, Riaz Ahmad, Ibrahim Khan, Hyeon Jin Lee, Jungsung Park, Rahat Ullah, Myeong Jun Choi, Hee Young Kang, Myeong Ok Kim
Summary: Alzheimer's disease is a prevalent age-related neurodegenerative disease characterized by the accumulation of amyloid beta A beta(1-42) and tau hyperphosphorylation in the brain. Nicotinamide (NAM) Vitamin B3 has shown neuroprotective effects against A beta(1-42)-induced neurotoxicity by ameliorating neuronal inflammation and apoptosis. This study suggests that NAM may be a potential preventive and therapeutic candidate for A beta(1-42)-induced neuroinflammation, neurodegeneration, and neurotoxicity.
Article
Biology
Shailima Rampogu, Rajesh Goud Gajula, Gihwan Lee, Myeong Ok Kim, Keun Woo Lee
Summary: The study redirected marine compounds towards targeting SARS-CoV-2, demonstrating the potential of eribulin mesylate and soblidotin as inhibitors of the virus's main protease.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Sareer Ahmad, Myeung Hoon Jo, Muhammad Ikram, Amjad Khan, Myeong Ok Kim
Summary: The study revealed that Luteolin has protective effects against amyloid-beta-induced neuroinflammation, amyloidogenesis, and synaptic dysfunction in mice, potentially through inhibition of JNK signaling and modulation of inflammatory and cell death markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Shailima Rampogu, Gihwan Lee, Jun Sung Park, Keun Woo Lee, Myeong Ok Kim
Summary: This study investigates the inhibitory activity of curcumin on COVID-19 and cancer using computational techniques. The binding affinities of curcumin and similar compounds to viral protease and DDX3 were assessed, and molecular dynamics simulation was conducted to evaluate stability. The findings identify a compound with good antiviral and anticancer activity, suggesting its potential as a therapeutic inhibitor and as a chemical scaffold for drug development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jun Sung Park, Kamran Saeed, Myeung Hoon Jo, Min Woo Kim, Hyeon Jin Lee, Chan-Bae Park, Gwang Lee, Myeong Ok Kim
Summary: Age-related decline in mitochondrial function and oxidative stress plays a critical role in neurodegeneration. LDHB deficiency may lead to brain oxidative stress-mediated progression of neurodegeneration via regulating p-AMPK/SIRT1/PGC-1alpha signaling. Treatment with osmotin could improve mitochondrial functions, abrogate oxidative stress and alleviate neuroinflammation and neurodegeneration in adult Ldhb(-/-) mice.
Article
Biochemistry & Molecular Biology
Riaz Ahmad, Amjad Khan, Inayat Ur Rehman, Hyeon Jin Lee, Ibrahim Khan, Myeong Ok Kim
Summary: Research shows that lupeol has inhibitory effects on inflammation, oxidative stress, and apoptosis caused by TBI. Experimental results indicate that lupeol can reverse behavioral and memory disturbances induced by TBI, reduce ROS/LPO generation, increase antioxidant protein levels, and inhibit neuronal apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Murad-Ali Shah, Ju-Bin Kang, Dong-Ju Park, Myeong-Ok Kim, Phil-Ok Koh
Summary: Chlorogenic acid exhibits neuroprotective effects by reducing oxidative stress and controlling pro-inflammatory proteins in cerebral ischemic damage.
NEUROSCIENCE LETTERS
(2022)
Article
Cell Biology
Min Woo Kim, Kyonghwan Choe, Jun Sung Park, Hyeon Jin Lee, Min Hwa Kang, Riaz Ahmad, Myeong Ok Kim
Summary: The findings suggest that BAY61-3606 can effectively suppress neuroinflammation, reduce microglia-mediated neuronal cell death, and restore synaptic markers. Furthermore, it has a protective effect on cognitive and memory functions.
Review
Cell Biology
Kyonghwan Choe, Hyun Young Park, Muhammad Ikram, Hyeon Jin Lee, Tae Ju Park, Rahat Ullah, Myeong Ok Kim
Summary: This article explores the links between COVID-19 and Alzheimer's disease, finding common factors such as the release of inflammatory cytokines and neurodegeneration. Activation of the immune system may induce neurological disorders through neuroinflammation and oxidative stress.
Article
Cell Biology
Tae Hwan Shin, Da Yeon Lee, Yong Eun Jang, Do Hyeon Kwon, Ji Su Hwang, Seok Gi Kim, Chan Seo, Man Jeong Paik, Ju Yeon Lee, Jin Young Kim, Seokho Park, Sung-E Choi, Shaherin Basith, Myeong Ok Kim, Gwang Lee
Summary: Nanoparticles have been of great interest in neurological research due to their ability to penetrate the blood-brain barrier. However, their potential harmful effects, particularly on the immune response in the brain, have raised concerns. This study examined the cytotoxic effects of silica-coated magnetic nanoparticles containing rhodamine B isothiocyanate dye on a microglial cell line. By integrating transcriptomics, proteomics, and metabolomics data using a machine learning algorithm, alterations in the mechanisms of nanotoxic effects were identified.
Review
Biochemistry & Molecular Biology
Arifa Un-Nisa, Amjad Khan, Muhammad Zakria, Sami Siraj, Shakir Ullah, Muhammad Khalid Tipu, Muhammad Ikram, Myeong Ok Kim
Summary: This review article discusses the beneficial effects of Lactobacillus against various diseases, with a special emphasis on its effects on neurological disorders such as depression, multiple sclerosis, Alzheimer's, and Parkinson's disease. Probiotics are live microbes found in fermented foods and beverages, which, when administered in adequate doses, provide health benefits to the host. Imbalance in gut microbiota can lead to the development of several diseases affecting the gastrointestinal tract, skin, immune system, inflammation, and gut-brain axis. Recent research has shown promising effects of probiotics in alleviating symptoms in different disease models, highlighting their potential for prevention and treatment. The review also covers current probiotics-based products, disease models, measured markers, and evidence from past studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Inayat Ur Rehman, Amjad Khan, Riaz Ahmad, Kyonghwan Choe, Hyun Young Park, Hyeon Jin Lee, Abubakar Atiq, Jungsung Park, Jong Ryeal Hahm, Myeong Ok Kim
Summary: This study found that nicotinamide exhibits neuroprotective properties in a mouse model of Parkinson's disease, reducing PD-like pathological changes and regulating oxidative stress and neuroinflammation.
Article
Biochemistry & Molecular Biology
Jun Sung Park, Kyonghwan Choe, Amjad Khan, Myeung Hoon Jo, Hyun Young Park, Min Hwa Kang, Tae Ju Park, Myeong Ok Kim
Summary: The aim of this study was to establish a functional in vitro co-cultured BBB model to investigate BBB-related physiological conditions. A co-cultured model consisting of brain-derived endothelial and astrocyte cells was successfully established on transwell membranes. The co-cultured model showed effective barrier properties and enhanced expression of tight junction proteins. Under disease conditions, the co-cultured model mimicked BBB damages. This in vitro BBB model can be a useful tool for studying BBB-related pathological and physiological processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Veterinary Sciences
Murad-Ali Shah, Ju-Bin Kang, Myeong-Ok Kim, Phil-Ok Koh
Summary: Chlorogenic acid exerts neuroprotective effects by activating the Akt-Bad signaling pathway and maintaining the interaction between phosphoBad and 14-3-3 in the ischemic stroke model.
JOURNAL OF VETERINARY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Hyeon Jin Lee, Kyonghwan Choe, Jun Sung Park, Amjad Khan, Min Woo Kim, Tae Ju Park, Myeong Ok Kim
Summary: This study demonstrated the neuroprotective effects of cPS1P on mouse models of Parkinson's disease, showing it can reverse motor function impairments, restore dopamine-related proteins, and reduce neuroinflammation.