Effective Elimination of Cancer Stem Cells By a Novel Drug Combination Strategy

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

(2011) Amparo Wolf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chemoresistance of glioblastoma cancer stem cells - much more complex than expected

(2011) Dagmar Beier et al.   Molecular Cancer

The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype

(2010) John M. Heddleston et al.   CELL CYCLE

Glycomic and Transcriptomic Response of GSC11 Glioblastoma Stem Cells to STAT3 Phosphorylation Inhibition and Serum-Induced Differentiation

(2010) Huan He et al.   JOURNAL OF PROTEOME RESEARCH

A clinically relevant orthotopic xenograft model of ependymoma that maintains the genomic signature of the primary tumor and preserves cancer stem cells in vivo

(2010) L. Yu et al.   NEURO-ONCOLOGY

Role of mitochondria-associated hexokinase II in cancer cell death induced by 3-bromopyruvate

(2009) Zhao Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Arrested neural and advanced mesenchymal differentiation of glioblastoma cells-comparative study with neural progenitors

(2009) Piotr Rieske et al.   BMC CANCER

Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells

(2009) Zhizhong Li et al.   CANCER CELL

Cancer stem cells: Cell culture, markers, and targets for new therapies

(2009) Candace A. Gilbert et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Targets of 3-Bromopyruvate, A New, Energy Depleting, Anticancer Agent

(2009) P. Dell'Antone   Medicinal Chemistry

Bifunctional DNA Alkylator 1,3-Bis(2-chloroethyl)-1-nitrosourea Activates the ATR-Chk1 Pathway Independently of the Mismatch Repair Pathway

(2009) B. Cui et al.   MOLECULAR PHARMACOLOGY

Highly infiltrative brain tumours show reduced chemosensitivity associated with a stem cell-like phenotype

(2009) T.-C. A. Johannessen et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Regulation of HIF-1α and VEGF by miR-20b Tunes Tumor Cells to Adapt to the Alteration of Oxygen Concentration

(2009) Zhang Lei et al.   PLoS One

Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate1

(2008) Ana Paula Pereira Da Silva et al.   BIOCHEMICAL JOURNAL

3-Bromopyruvate as inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs

(2008) Linda Strandberg Ihrlund et al.   Molecular Oncology

The progenitor cell marker NG2/MPG promotes chemoresistance by activation of integrin-dependent PI3K/Akt signaling

(2008) M Chekenya et al.   ONCOGENE