PBX3/MEK/ERK1/2/LIN28/let-7b positive feedback loop enhances mesenchymal phenotype to promote glioblastoma migration and invasion

PBX3 Is Part of an EMT Regulatory Network and Indicates Poor Outcome in Colorectal Cancer

(2018) Sebastian Lamprecht et al.   CLINICAL CANCER RESEARCH

PIM1 mediates epithelial-mesenchymal transition by targeting Smads and c-Myc in the nucleus and potentiates clear-cell renal-cell carcinoma oncogenesis

(2018) Bin Zhao et al.   Cell Death & Disease

FAT1 modulates EMT and stemness genes expression in hypoxic glioblastoma

(2017) Chitrangda Srivastava et al.   INTERNATIONAL JOURNAL OF CANCER

PBX3 is essential for leukemia stem cell maintenance in MLL -rearranged leukemia

(2017) Huidong Guo et al.   INTERNATIONAL JOURNAL OF CANCER

Silencing Pre-B-cell leukemia homeobox 3 decreases the proliferation of human glioma cells in vitro and in vivo

(2017) Xiupeng Xu et al.   JOURNAL OF NEURO-ONCOLOGY

The LIN28/let-7 Pathway in Cancer

(2017) Julien Balzeau et al.   Frontiers in Genetics

Methyl-CpG-binding domain 3 inhibits epithelial–mesenchymal transition in pancreatic cancer cells via TGF-β/Smad signalling

(2016) Min Xu et al.   BRITISH JOURNAL OF CANCER

Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-κB-dependent Manner

(2016) Sung-Hak Kim et al.   CANCER CELL

RNA-binding protein Lin28 in cancer and immunity

(2016) Shuai Jiang et al.   CANCER LETTERS

Activation of the Lin28/let-7 Axis by Loss of ESE3/EHF Promotes a Tumorigenic and Stem-like Phenotype in Prostate Cancer

(2016) D. Albino et al.   CANCER RESEARCH

The LIN28B/let-7 axis is a novel therapeutic pathway in multiple myeloma

(2016) S Manier et al.   LEUKEMIA

Histone demethylase PHF8 promotes epithelial to mesenchymal transition and breast tumorigenesis

(2016) Peng Shao et al.   NUCLEIC ACIDS RESEARCH

SHP-2-upregulated ZEB1 is important for PDGFRα-driven glioma epithelial–mesenchymal transition and invasion in mice and humans

(2016) L Zhang et al.   ONCOGENE

PBX3 promotes gastric cancer invasion and metastasis by inducing epithelial-mesenchymal transition

(2016) Shuanhu Wang et al.   Oncology Letters

Mechanisms of TGFβ-Induced Epithelial–Mesenchymal Transition

(2016) Aristidis Moustakas et al.   Journal of Clinical Medicine

MicroRNAs as regulators and mediators of c-MYC function

(2015) Rene Jackstadt et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma

(2015) J. Lau et al.   CANCER RESEARCH

Connexin 43 Is Necessary for Salivary Gland Branching Morphogenesis and FGF10-induced ERK1/2 Phosphorylation

(2015) Aya Yamada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NF-κB induces miR-148a to sustain TGF-β/Smad signaling activation in glioblastoma

(2015) Hui Wang et al.   Molecular Cancer

PBX3 is targeted by multiple miRNAs and is essential for liver tumour-initiating cells

(2015) Haibo Han et al.   Nature Communications

PBX3 promotes migration and invasion of colorectal cancer cellsviaactivation of MAPK/ERK signaling pathway

(2015) Hai-Bo Han   WORLD JOURNAL OF GASTROENTEROLOGY

Insulin like growth factor binding protein 4 promotes GBM progression and regulates key factors involved in EMT and invasion

(2014) V. R. Praveen Kumar et al.   JOURNAL OF NEURO-ONCOLOGY

A complex mechanism for HDGF-mediated cell growth, migration, invasion, and TMZ chemosensitivity in glioma

(2014) Ye Song et al.   JOURNAL OF NEURO-ONCOLOGY

TGF-β is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion

(2014) J V Joseph et al.   Cell Death & Disease

Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1

(2014) Xiaoyu Ma et al.   Nature Communications

Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma

(2013) Krishna P.L. Bhat et al.   CANCER CELL

Understanding high grade glioma: Molecular mechanism, therapy and comprehensive management

(2013) Yongzhi Wang et al.   CANCER LETTERS

miR-16 inhibits cell proliferation by targeting IGF1R and the Raf1-MEK1/2-ERK1/2 pathway in osteosarcoma

(2013) Lei Chen et al.   FEBS LETTERS

The Wnt- -catenin pathway represses let-7 microRNA expression through transactivation of Lin28 to augment breast cancer stem cell expansion

(2013) W.-Y. Cai et al.   JOURNAL OF CELL SCIENCE

Sustained elevation of Snail promotes glial-mesenchymal transition after irradiation in malignant glioma

(2013) Roshan Mahabir et al.   NEURO-ONCOLOGY

MiRNA-181b suppresses IGF-1R and functions as a tumor suppressor gene in gliomas

(2013) Z.-m. Shi et al.   RNA

Epithelial-to-mesenchymal(-like) transition as a relevant molecular event in malignant gliomas

(2012) U.D. Kahlert et al.   CANCER LETTERS

CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2005-2009

(2012) T. A. Dolecek et al.   NEURO-ONCOLOGY

MicroRNA-125b/Lin28 Pathway Contributes to the Mesendodermal Fate Decision of Embryonic Stem Cells

(2012) Jia Wang et al.   STEM CELLS AND DEVELOPMENT

Angiogenesis and invasion in glioma

(2011) Manabu Onishi et al.   Brain Tumor Pathology

Molecular subclassification of diffuse gliomas: Seeing order in the chaos

(2011) Jason T. Huse et al.   GLIA

Let-7c functions as a metastasis suppressor by targeting MMP11 and PBX3 in colorectal cancer

(2011) Hai-Bo Han et al.   JOURNAL OF PATHOLOGY

Regulation of PBX3 expression by androgen and Let-7d in prostate cancer

(2011) Håkon Ramberg et al.   Molecular Cancer

Exciting New Advances in Neuro-Oncology: The Avenue to a Cure for Malignant Glioma

(2010) E. G. Van Meir et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Unsupervised Analysis of Transcriptomic Profiles Reveals Six Glioma Subtypes

(2009) A. Li et al.   CANCER RESEARCH

An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation

(2009) Dimitrios Iliopoulos et al.   CELL

Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7

(2009) Surabhi Dangi-Garimella et al.   EMBO JOURNAL

The transcriptional network for mesenchymal transformation of brain tumours

(2009) Maria Stella Carro et al.   NATURE