High-Dose Parenteral Ascorbate Enhanced Chemosensitivity of Ovarian Cancer and Reduced Toxicity of Chemotherapy

Parenteral Ascorbate As a Cancer Therapeutic: A Reassessment Based on Pharmacokinetics

(2013) Nermi L. Parrow et al.   ANTIOXIDANTS & REDOX SIGNALING

Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): results from a phase I clinical trial

(2013) J. L. Welsh et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Autophagy and genomic integrity

(2013) A T Vessoni et al.   CELL DEATH AND DIFFERENTIATION

DNA damage associated with mitosis and cytokinesis failure

(2013) M T Hayashi et al.   ONCOGENE

Pharmacological concentrations of ascorbate radiosensitize glioblastoma multiforme primary cells by increasing oxidative DNA damage and inhibiting G2/M arrest

(2012) Patries M. Herst et al.   FREE RADICAL BIOLOGY AND MEDICINE

Various modes of cell death induced by DNA damage

(2012) O Surova et al.   ONCOGENE

Phase I Evaluation of Intravenous Ascorbic Acid in Combination with Gemcitabine and Erlotinib in Patients with Metastatic Pancreatic Cancer

(2012) Daniel A. Monti et al.   PLoS One

Vitamin C: A Concentration-Function Approach Yields Pharmacology and Therapeutic Discoveries

(2012) Mark Levine et al.   Advances in Nutrition

Intracellular ATP levels determine cell death fate of cancer cells exposed to both standard and redox chemotherapeutic agents

(2011) Julien Verrax et al.   BIOCHEMICAL PHARMACOLOGY

Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer

(2011) Michael Graham Espey et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ascorbate induces autophagy in pancreatic cancer

(2010) Joseph J. Cullen   Autophagy

Ascorbate exerts anti-proliferative effects through cell cycle inhibition and sensitizes tumor cells towards cytostatic drugs

(2010) Anja Frömberg et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Pemetrexed Indirectly Activates the Metabolic Kinase AMPK in Human Carcinomas

(2010) S. B. Rothbart et al.   CANCER RESEARCH

Mechanisms of Ascorbate-Induced Cytotoxicity in Pancreatic Cancer

(2010) J. Du et al.   CLINICAL CANCER RESEARCH

Changing the Paradigm in the Treatment of Platinum-Sensitive Recurrent Ovarian Cancer

(2010) Bradley J. Monk et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Vitamin C: Intravenous Use by Complementary and Alternative Medicine Practitioners and Adverse Effects

(2010) Sebastian J. Padayatty et al.   PLoS One

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

(2010) A. Alexander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacologic concentrations of ascorbate are achieved by parenteral administration and exhibit antitumoral effects

(2009) Julien Verrax et al.   FREE RADICAL BIOLOGY AND MEDICINE

Phase I clinical trial of i.v. ascorbic acid in advanced malignancy

(2008) L. J. Hoffer et al.   ANNALS OF ONCOLOGY

A novel function of poly(ADP-ribose) polymerase-1 in modulation of autophagy and necrosis under oxidative stress

(2008) Q Huang et al.   CELL DEATH AND DIFFERENTIATION

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice

(2008) Q. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA