Progressive alterations in multipotent hematopoietic progenitors underlie lymphoid cell loss in aging

Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells

(2016) Amit Grover et al.   Nature Communications

Human and Murine Hematopoietic Stem Cell Aging Is Associated with Functional Impairments and Intrinsic Megakaryocytic/Erythroid Bias

(2016) Alexandra Rundberg Nilsson et al.   PLoS One

Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions

(2015) Eric M. Pietras et al.   Cell Stem Cell

The non-canonical Wnt pathway negatively regulates dendritic cell differentiation by inhibiting the expansion of Flt3+ lymphocyte-primed multipotent precursors

(2015) Jing Xiao et al.   Cellular & Molecular Immunology

Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells

(2015) Monika S. Kowalczyk et al.   GENOME RESEARCH

Fundamental properties of unperturbed haematopoiesis from stem cells in vivo

(2015) Katrin Busch et al.   NATURE

Identification of Regulatory Networks in HSCs and Their Immediate Progeny via Integrated Proteome, Transcriptome, and DNA Methylome Analysis

(2014) Nina Cabezas-Wallscheid et al.   Cell Stem Cell

Clonal dynamics of native haematopoiesis

(2014) Jianlong Sun et al.   NATURE

Concise Review: Hematopoietic Stem Cell Aging and the Prospects for Rejuvenation

(2014) Martin Wahlestedt et al.   Stem Cells Translational Medicine

Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy

(2013) Alejandra Sanjuan-Pla et al.   NATURE

Essential role of EBF1 in the generation and function of distinct mature B cell types

(2012) Bojan Vilagos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Multilineage Priming of Enhancer Repertoires Precedes Commitment to the B and Myeloid Cell Lineages in Hematopoietic Progenitors

(2011) Elinore M. Mercer et al.   IMMUNITY

Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells

(2011) Brad Dykstra et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Distinct Hematopoietic Stem Cell Subtypes Are Differentially Regulated by TGF-β1

(2010) Grant A. Challen et al.   Cell Stem Cell

Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment

(2010) Yohei Morita et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

(2010) I. Beerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Genome-wide Lineage-Specific Transcriptional Networks Underscore Ikaros-Dependent Lymphoid Priming in Hematopoietic Stem Cells

(2009) Samuel Yao-Ming Ng et al.   IMMUNITY

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

(2008) Anne Wilson et al.   CELL