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Title
Targeting mRNA processing as an anticancer strategy
Authors
Keywords
-
Journal
NATURE REVIEWS DRUG DISCOVERY
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2019-09-26
DOI
10.1038/s41573-019-0042-3
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- (2019) Arthur A. Levin NEW ENGLAND JOURNAL OF MEDICINE
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- (2019) Daniel Aird et al. Nature Communications
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- (2019) Ruijia Wang et al. Cell Reports
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- (2018) Zahava Siegfried et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
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- (2016) Eva Absmeier et al. CELL CYCLE
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- (2016) Noélia Custódio et al. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
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