Insights into membrane-bound presenilin 2 from all-atom molecular dynamics simulations
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Title
Insights into membrane-bound presenilin 2 from all-atom molecular dynamics simulations
Authors
Keywords
-
Journal
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
Volume -, Issue -, Pages 1-15
Publisher
Informa UK Limited
Online
2019-08-13
DOI
10.1080/07391102.2019.1655481
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Note: Only part of the references are listed.- Recognition of the amyloid precursor protein by human γ-secretase
- (2019) Rui Zhou et al. SCIENCE
- Familial Alzheimer’s disease-linked presenilin mutants and intracellular Ca2+ handling: A single-organelle, FRET-based analysis
- (2019) Elisa Greotti et al. CELL CALCIUM
- DynaMut: predicting the impact of mutations on protein conformation, flexibility and stability
- (2018) Carlos HM Rodrigues et al. NUCLEIC ACIDS RESEARCH
- Aβ42/Aβ40 Ratios of Presenilin 1 Mutations Correlate with Clinical Onset of Alzheimer’s Disease
- (2018) Ning Tang et al. JOURNAL OF ALZHEIMERS DISEASE
- Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
- (2018) Emma Nichols et al. LANCET NEUROLOGY
- Structural basis of Notch recognition by human γ-secretase
- (2018) Guanghui Yang et al. NATURE
- SDM: a server for predicting effects of mutations on protein stability
- (2017) Arun Prasad Pandurangan et al. NUCLEIC ACIDS RESEARCH
- Presenilin-1 mutations and Alzheimer’s disease
- (2017) Raymond J. Kelleher et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Characterizing the structural ensemble of γ-secretase using a multiscale molecular dynamics approach
- (2017) Rodrigo Aguayo-Ortiz et al. Chemical Science
- Presenilin 2-Dependent Maintenance of Mitochondrial Oxidative Capacity and Morphology
- (2017) Sabrina Contino et al. Frontiers in Physiology
- Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1
- (2017) Frank Raven et al. EBioMedicine
- An extensive simulation study of lipid bilayer properties with different head groups, acyl chain lengths, and chain saturations
- (2016) Xiaohong Zhuang et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Force Field Development for Lipid Membrane Simulations
- (2016) Alexander P. Lyubartsev et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Beyond γ-secretase activity: The multifunctional nature of presenilins in cell signalling pathways
- (2016) Stephen P. Duggan et al. CELLULAR SIGNALLING
- Structural biology of intramembrane proteases: mechanistic insights from rhomboid and S2P to γ-secretase
- (2016) Linfeng Sun et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- The amyloid hypothesis of Alzheimer's disease at 25 years
- (2016) Dennis J Selkoe et al. EMBO Molecular Medicine
- Ten Challenges of the Amyloid Hypothesis of Alzheimer’s Disease
- (2016) Kasper Planeta Kepp JOURNAL OF ALZHEIMERS DISEASE
- Loss of stability and hydrophobicity of presenilin 1 mutations causing Alzheimer's disease
- (2016) Arun Kumar Somavarapu et al. JOURNAL OF NEUROCHEMISTRY
- Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid- 42 Production
- (2016) A. Tominaga et al. JOURNAL OF NEUROSCIENCE
- CHARMM36m: an improved force field for folded and intrinsically disordered proteins
- (2016) Jing Huang et al. NATURE METHODS
- The dynamic mechanism of presenilin-1 function: Sensitive gate dynamics and loop unplugging control protein access
- (2016) Arun Kumar Somavarapu et al. NEUROBIOLOGY OF DISEASE
- Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase
- (2016) Linfeng Sun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Presenilin 2 Modulates Endoplasmic Reticulum-Mitochondria Coupling by Tuning the Antagonistic Effect of Mitofusin 2
- (2016) Riccardo Filadi et al. Cell Reports
- The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase
- (2016) David M Bolduc et al. eLife
- Towards a “Golden Standard” for computing globin stability: Stability and structure sensitivity of myoglobin mutants
- (2015) Kasper P. Kepp BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- MAESTRO - multi agent stability prediction upon point mutations
- (2015) Josef Laimer et al. BMC BIOINFORMATICS
- Molecular dynamics simulation study reveals potential substrate entry path into γ-secretase/presenilin-1
- (2015) Ren Kong et al. JOURNAL OF STRUCTURAL BIOLOGY
- An atomic structure of human γ-secretase
- (2015) Xiao-chen Bai et al. NATURE
- Nicastrin functions to sterically hinder γ-secretase–substrate interactions driven by substrate transmembrane domain
- (2015) David M. Bolduc et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural basis of human γ-secretase assembly
- (2015) Linfeng Sun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sampling the conformational space of the catalytic subunit of human γ-secretase
- (2015) Xiao-chen Bai et al. eLife
- Pen-2 Is Essential for γ-Secretase Complex Stability and Trafficking but Partially Dispensable for Endoproteolysis
- (2014) Oliver Holmes et al. BIOCHEMISTRY
- A systematic molecular dynamics simulation study of temperature dependent bilayer structural properties
- (2014) Xiaohong Zhuang et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Molecular mechanism of intramembrane proteolysis by γ-secretase
- (2014) Taisuke Tomita JOURNAL OF BIOCHEMISTRY
- Computing Stability Effects of Mutations in Human Superoxide Dismutase 1
- (2014) Kasper P. Kepp JOURNAL OF PHYSICAL CHEMISTRY B
- Three-dimensional structure of human γ-secretase
- (2014) Peilong Lu et al. NATURE
- Symptom onset in autosomal dominant Alzheimer disease: A systematic review and meta-analysis
- (2014) D. C. Ryman et al. NEUROLOGY
- DUET: a server for predicting effects of mutations on protein stability using an integrated computational approach
- (2014) D. E. V. Pires et al. NUCLEIC ACIDS RESEARCH
- A Structure-Based Model of Substrate Discrimination by a Noncanonical PDZ Tandem in the Intramembrane-Cleaving Protease RseP
- (2014) Yohei Hizukuri et al. STRUCTURE
- mCSM: predicting the effects of mutations in proteins using graph-based signatures
- (2013) Douglas E. V. Pires et al. BIOINFORMATICS
- Structure and Mechanism of Rhomboid Protease
- (2013) Ya Ha et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- GalaxyRefine: protein structure refinement driven by side-chain repacking
- (2013) Lim Heo et al. NUCLEIC ACIDS RESEARCH
- Presenilins and -Secretase: Structure, Function, and Role in Alzheimer Disease
- (2013) B. De Strooper et al. Cold Spring Harbor Perspectives in Medicine
- Presenilin-1 adopts pathogenic conformation in normal aging and in sporadic Alzheimer’s disease
- (2012) Lara Wahlster et al. ACTA NEUROPATHOLOGICA
- Effects of Membrane Lipids on the Activity and Processivity of Purified γ-Secretase
- (2012) Oliver Holmes et al. BIOCHEMISTRY
- The mechanism of γ-Secretase dysfunction in familial Alzheimer disease
- (2012) Lucía Chávez-Gutiérrez et al. EMBO JOURNAL
- Presenilins: Role in calcium homeostasis
- (2012) Kamran Honarnejad et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Contribution of the γ-Secretase Subunits to the Formation of Catalytic Pore of Presenilin 1 Protein
- (2012) Koji Takeo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lack of Evidence for Presenilins as Endoplasmic Reticulum Ca2+Leak Channels
- (2012) Dustin Shilling et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Repression of transcription of presenilin-1 inhibits γ-secretase independent ER Ca2+ leak that is impaired by FAD mutations
- (2012) Hriday K. Das et al. JOURNAL OF NEUROCHEMISTRY
- Structure of a presenilin family intramembrane aspartate protease
- (2012) Xiaochun Li et al. NATURE
- Mutagenesis Mapping of the Presenilin 1 Calcium Leak Conductance Pore
- (2011) Omar Nelson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Alzheimer's disease
- (2011) Clive Ballard et al. LANCET
- OPM database and PPM web server: resources for positioning of proteins in membranes
- (2011) Mikhail A. Lomize et al. NUCLEIC ACIDS RESEARCH
- SDM--a server for predicting effects of mutations on protein stability and malfunction
- (2011) C. L. Worth et al. NUCLEIC ACIDS RESEARCH
- Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk
- (2011) E. Zampese et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Performance of protein stability predictors
- (2010) Sofia Khan et al. HUMAN MUTATION
- Functional Analysis of the Transmembrane Domains of Presenilin 1
- (2010) Naoto Watanabe et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Role of Presenilins in Neuronal Calcium Homeostasis
- (2010) H. Zhang et al. JOURNAL OF NEUROSCIENCE
- WIWS: a protein structure bioinformatics Web service collection
- (2010) M. L. Hekkelman et al. NUCLEIC ACIDS RESEARCH
- ER Calcium and Alzheimer's Disease: In a State of Flux
- (2010) M. P. Mattson Science Signaling
- MolProbity: all-atom structure validation for macromolecular crystallography
- (2009) Vincent B. Chen et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Presenilin-2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptake
- (2009) Lucia Brunello et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- -Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of -Carboxyl Terminal Fragment
- (2009) M. Takami et al. JOURNAL OF NEUROSCIENCE
- Allosteric Modulation of PS1/γ-Secretase Conformation Correlates with Amyloid β42/40 Ratio
- (2009) Kengo Uemura et al. PLoS One
- A three-state prediction of single point mutations on protein stability changes
- (2008) Emidio Capriotti et al. BMC BIOINFORMATICS
- Transmembrane Domain 9 of Presenilin Determines the Dynamic Conformation of the Catalytic Site of γ-Secretase
- (2008) Alexandra Tolia et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- CHARMM-GUI: A web-based graphical user interface for CHARMM
- (2008) Sunhwan Jo et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- The C-Terminal PAL Motif and Transmembrane Domain 9 of Presenilin 1 Are Involved in the Formation of the Catalytic Pore of the -Secretase
- (2008) C. Sato et al. JOURNAL OF NEUROSCIENCE
- Altered Calcium Homeostasis and Mitochondrial Dysfunction in Cortical Synaptic Compartments of Presenilin-1 Mutant Mice
- (2003) James G. Begley et al. JOURNAL OF NEUROCHEMISTRY
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