Structure and Mechanism of Rhomboid Protease

Large Lateral Movement of Transmembrane Helix S5 Is Not Required for Substrate Access to the Active Site of Rhomboid Intramembrane Protease

(2013) Yi Xue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activity-Based Protein Profiling of the Escherichia coli GlpG Rhomboid Protein Delineates the Catalytic Core

(2012) Allison R. Sherratt et al.   BIOCHEMISTRY

Conformational Change in Rhomboid Protease GlpG Induced by Inhibitor Binding to Its S′ Subsites

(2012) Yi Xue et al.   BIOCHEMISTRY

Architectural and thermodynamic principles underlying intramembrane protease function

(2012) Rosanna P Baker et al.   Nature Chemical Biology

Exosome-Related Multi-Pass Transmembrane Protein TSAP6 Is a Target of Rhomboid Protease RHBDD1-Induced Proteolysis

(2012) Chunhua Wan et al.   PLoS One

Tumor Necrosis Factor Signaling Requires iRhom2 to Promote Trafficking and Activation of TACE

(2012) C. Adrain et al.   SCIENCE

iRhom2 Regulation of TACE Controls TNF-Mediated Protection Against Listeria and Responses to LPS

(2012) D. R. McIlwain et al.   SCIENCE

Rhomboid Family Pseudoproteases Use the ER Quality Control Machinery to Regulate Intercellular Signaling

(2011) Markus Zettl et al.   CELL

Mammalian EGF receptor activation by the rhomboid protease RHBDL2

(2011) Colin Adrain et al.   EMBO REPORTS

Catalytic Mechanism of Rhomboid Protease GlpG Probed by 3,4-Dichloroisocoumarin and Diisopropyl Fluorophosphonate

(2011) Yi Xue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into Substrate Gating in H. influenzae Rhomboid

(2011) Cory L. Brooks et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of Rhomboid Protease in a Lipid Environment

(2011) Kutti R. Vinothkumar   JOURNAL OF MOLECULAR BIOLOGY

Monocyclic β-Lactams Are Selective, Mechanism-Based Inhibitors of Rhomboid Intramembrane Proteases

(2010) Olivier A. Pierrat et al.   ACS Chemical Biology

The structural basis for catalysis and substrate specificity of a rhomboid protease

(2010) Kutti R Vinothkumar et al.   EMBO JOURNAL

Intramembrane Proteolysis of Mgm1 by the Mitochondrial Rhomboid Protease Is Highly Promiscuous Regarding the Sequence of the Cleaved Hydrophobic Segment

(2010) Anja Schäfer et al.   JOURNAL OF MOLECULAR BIOLOGY

Intramembrane Cleavage of AMA1 Triggers Toxoplasma to Switch from an Invasive to a Replicative Mode

(2010) J. M. Santos et al.   SCIENCE

The PARL family of mitochondrial rhomboid proteases

(2010) R. Blake Hill et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Rhomboid 4 (ROM4) Affects the Processing of Surface Adhesins and Facilitates Host Cell Invasion by Toxoplasma gondii

(2010) Jeffrey S. Buguliskis et al.   PLoS Pathogens

Cleavage of a Multispanning Membrane Protein by an Intramembrane Serine Protease

(2009) Elinor Erez et al.   BIOCHEMISTRY

Insights into the effect of detergents on the full-length rhomboid protease from Pseudomonas aeruginosa and its cytosolic domain

(2009) Allison R. Sherratt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Sequence-Specific Intramembrane Proteolysis: Identification of a Recognition Motif in Rhomboid Substrates

(2009) Kvido Strisovsky et al.   MOLECULAR CELL

Rhomboid Protease Dynamics and Lipid Interactions

(2009) Ana-Nicoleta Bondar et al.   STRUCTURE

Rhomboid Proteases and their Biological Functions

(2008) Matthew Freeman   Annual Review of Genetics

In vivo analysis reveals substrate-gating mutants of a rhomboid intramembrane protease display increased activity in living cells

(2008) Sinisa Urban et al.   BIOLOGICAL CHEMISTRY

Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons

(2008) Jyh-Rong Chao et al.   NATURE

Structure and mechanism of intramembrane protease

(2008) Ya Ha   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY