Insights into membrane-bound presenilin 2 from all-atom molecular dynamics simulations

Recognition of the amyloid precursor protein by human γ-secretase

(2019) Rui Zhou et al.   SCIENCE

Familial Alzheimer’s disease-linked presenilin mutants and intracellular Ca2+ handling: A single-organelle, FRET-based analysis

(2019) Elisa Greotti et al.   CELL CALCIUM

DynaMut: predicting the impact of mutations on protein conformation, flexibility and stability

(2018) Carlos HM Rodrigues et al.   NUCLEIC ACIDS RESEARCH

Aβ42/Aβ40 Ratios of Presenilin 1 Mutations Correlate with Clinical Onset of Alzheimer’s Disease

(2018) Ning Tang et al.   JOURNAL OF ALZHEIMERS DISEASE

Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) Emma Nichols et al.   LANCET NEUROLOGY

Structural basis of Notch recognition by human γ-secretase

(2018) Guanghui Yang et al.   NATURE

SDM: a server for predicting effects of mutations on protein stability

(2017) Arun Prasad Pandurangan et al.   NUCLEIC ACIDS RESEARCH

Presenilin-1 mutations and Alzheimer’s disease

(2017) Raymond J. Kelleher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterizing the structural ensemble of γ-secretase using a multiscale molecular dynamics approach

(2017) Rodrigo Aguayo-Ortiz et al.   Chemical Science

Presenilin 2-Dependent Maintenance of Mitochondrial Oxidative Capacity and Morphology

(2017) Sabrina Contino et al.   Frontiers in Physiology

Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1

(2017) Frank Raven et al.   EBioMedicine

An extensive simulation study of lipid bilayer properties with different head groups, acyl chain lengths, and chain saturations

(2016) Xiaohong Zhuang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Force Field Development for Lipid Membrane Simulations

(2016) Alexander P. Lyubartsev et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Beyond γ-secretase activity: The multifunctional nature of presenilins in cell signalling pathways

(2016) Stephen P. Duggan et al.   CELLULAR SIGNALLING

Structural biology of intramembrane proteases: mechanistic insights from rhomboid and S2P to γ-secretase

(2016) Linfeng Sun et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Ten Challenges of the Amyloid Hypothesis of Alzheimer’s Disease

(2016) Kasper Planeta Kepp   JOURNAL OF ALZHEIMERS DISEASE

Loss of stability and hydrophobicity of presenilin 1 mutations causing Alzheimer's disease

(2016) Arun Kumar Somavarapu et al.   JOURNAL OF NEUROCHEMISTRY

Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid-  42 Production

(2016) A. Tominaga et al.   JOURNAL OF NEUROSCIENCE

CHARMM36m: an improved force field for folded and intrinsically disordered proteins

(2016) Jing Huang et al.   NATURE METHODS

The dynamic mechanism of presenilin-1 function: Sensitive gate dynamics and loop unplugging control protein access

(2016) Arun Kumar Somavarapu et al.   NEUROBIOLOGY OF DISEASE

Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase

(2016) Linfeng Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Presenilin 2 Modulates Endoplasmic Reticulum-Mitochondria Coupling by Tuning the Antagonistic Effect of Mitofusin 2

(2016) Riccardo Filadi et al.   Cell Reports

The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase

(2016) David M Bolduc et al.   eLife

Towards a “Golden Standard” for computing globin stability: Stability and structure sensitivity of myoglobin mutants

(2015) Kasper P. Kepp   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

MAESTRO - multi agent stability prediction upon point mutations

(2015) Josef Laimer et al.   BMC BIOINFORMATICS

Molecular dynamics simulation study reveals potential substrate entry path into γ-secretase/presenilin-1

(2015) Ren Kong et al.   JOURNAL OF STRUCTURAL BIOLOGY

An atomic structure of human γ-secretase

(2015) Xiao-chen Bai et al.   NATURE

Nicastrin functions to sterically hinder γ-secretase–substrate interactions driven by substrate transmembrane domain

(2015) David M. Bolduc et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of human γ-secretase assembly

(2015) Linfeng Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sampling the conformational space of the catalytic subunit of human γ-secretase

(2015) Xiao-chen Bai et al.   eLife

Pen-2 Is Essential for γ-Secretase Complex Stability and Trafficking but Partially Dispensable for Endoproteolysis

(2014) Oliver Holmes et al.   BIOCHEMISTRY

A systematic molecular dynamics simulation study of temperature dependent bilayer structural properties

(2014) Xiaohong Zhuang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Molecular mechanism of intramembrane proteolysis by γ-secretase

(2014) Taisuke Tomita   JOURNAL OF BIOCHEMISTRY

Computing Stability Effects of Mutations in Human Superoxide Dismutase 1

(2014) Kasper P. Kepp   JOURNAL OF PHYSICAL CHEMISTRY B

Three-dimensional structure of human γ-secretase

(2014) Peilong Lu et al.   NATURE

Symptom onset in autosomal dominant Alzheimer disease: A systematic review and meta-analysis

(2014) D. C. Ryman et al.   NEUROLOGY

DUET: a server for predicting effects of mutations on protein stability using an integrated computational approach

(2014) D. E. V. Pires et al.   NUCLEIC ACIDS RESEARCH

A Structure-Based Model of Substrate Discrimination by a Noncanonical PDZ Tandem in the Intramembrane-Cleaving Protease RseP

(2014) Yohei Hizukuri et al.   STRUCTURE

mCSM: predicting the effects of mutations in proteins using graph-based signatures

(2013) Douglas E. V. Pires et al.   BIOINFORMATICS

Structure and Mechanism of Rhomboid Protease

(2013) Ya Ha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GalaxyRefine: protein structure refinement driven by side-chain repacking

(2013) Lim Heo et al.   NUCLEIC ACIDS RESEARCH

Presenilins and  -Secretase: Structure, Function, and Role in Alzheimer Disease

(2013) B. De Strooper et al.   Cold Spring Harbor Perspectives in Medicine

Presenilin-1 adopts pathogenic conformation in normal aging and in sporadic Alzheimer’s disease

(2012) Lara Wahlster et al.   ACTA NEUROPATHOLOGICA

Effects of Membrane Lipids on the Activity and Processivity of Purified γ-Secretase

(2012) Oliver Holmes et al.   BIOCHEMISTRY

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

(2012) Lucía Chávez-Gutiérrez et al.   EMBO JOURNAL

Presenilins: Role in calcium homeostasis

(2012) Kamran Honarnejad et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Contribution of the γ-Secretase Subunits to the Formation of Catalytic Pore of Presenilin 1 Protein

(2012) Koji Takeo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lack of Evidence for Presenilins as Endoplasmic Reticulum Ca2+Leak Channels

(2012) Dustin Shilling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Repression of transcription of presenilin-1 inhibits γ-secretase independent ER Ca2+ leak that is impaired by FAD mutations

(2012) Hriday K. Das et al.   JOURNAL OF NEUROCHEMISTRY

Structure of a presenilin family intramembrane aspartate protease

(2012) Xiaochun Li et al.   NATURE

Mutagenesis Mapping of the Presenilin 1 Calcium Leak Conductance Pore

(2011) Omar Nelson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

OPM database and PPM web server: resources for positioning of proteins in membranes

(2011) Mikhail A. Lomize et al.   NUCLEIC ACIDS RESEARCH

SDM--a server for predicting effects of mutations on protein stability and malfunction

(2011) C. L. Worth et al.   NUCLEIC ACIDS RESEARCH

Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk

(2011) E. Zampese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Performance of protein stability predictors

(2010) Sofia Khan et al.   HUMAN MUTATION

Functional Analysis of the Transmembrane Domains of Presenilin 1

(2010) Naoto Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Presenilins in Neuronal Calcium Homeostasis

(2010) H. Zhang et al.   JOURNAL OF NEUROSCIENCE

WIWS: a protein structure bioinformatics Web service collection

(2010) M. L. Hekkelman et al.   NUCLEIC ACIDS RESEARCH

ER Calcium and Alzheimer's Disease: In a State of Flux

(2010) M. P. Mattson   Science Signaling

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Presenilin-2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptake

(2009) Lucia Brunello et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

 -Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of  -Carboxyl Terminal Fragment

(2009) M. Takami et al.   JOURNAL OF NEUROSCIENCE

Allosteric Modulation of PS1/γ-Secretase Conformation Correlates with Amyloid β42/40 Ratio

(2009) Kengo Uemura et al.   PLoS One

A three-state prediction of single point mutations on protein stability changes

(2008) Emidio Capriotti et al.   BMC BIOINFORMATICS

Transmembrane Domain 9 of Presenilin Determines the Dynamic Conformation of the Catalytic Site of γ-Secretase

(2008) Alexandra Tolia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHARMM-GUI: A web-based graphical user interface for CHARMM

(2008) Sunhwan Jo et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

The C-Terminal PAL Motif and Transmembrane Domain 9 of Presenilin 1 Are Involved in the Formation of the Catalytic Pore of the  -Secretase

(2008) C. Sato et al.   JOURNAL OF NEUROSCIENCE

Altered Calcium Homeostasis and Mitochondrial Dysfunction in Cortical Synaptic Compartments of Presenilin-1 Mutant Mice

(2003) James G. Begley et al.   JOURNAL OF NEUROCHEMISTRY