Allosteric Modulation of PS1/γ-Secretase Conformation Correlates with Amyloid β42/40 Ratio

 -Secretase Inhibition Reduces Spine Density In Vivo via an Amyloid Precursor Protein-Dependent Pathway

(2009) T. Bittner et al.   JOURNAL OF NEUROSCIENCE

Mutations in amyloid precursor protein affect its interactions with presenilin/γ-secretase

(2009) Lauren Herl et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

 -Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer's Disease

(2009) L. Serneels et al.   SCIENCE

Transmembrane Domain 9 of Presenilin Determines the Dynamic Conformation of the Catalytic Site of γ-Secretase

(2008) Alexandra Tolia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The C-Terminal PAL Motif and Transmembrane Domain 9 of Presenilin 1 Are Involved in the Formation of the Catalytic Pore of the  -Secretase

(2008) C. Sato et al.   JOURNAL OF NEUROSCIENCE

Substrate-targeting γ-secretase modulators

(2008) Thomas L. Kukar et al.   NATURE

Differential Evanescence Nanometry: Live-Cell Fluorescence Measurements with 10-nm Axial Resolution on the Plasma Membrane

(2007) Saveez Saffarian et al.   BIOPHYSICAL JOURNAL