Signaling pathways involved in the T‐cell‐mediated immunity against Epstein‐Barr virus: Lessons from genetic diseases

Defective Epstein–Barr virus in chronic active infection and haematological malignancy

(2019) Yusuke Okuno et al.   Nature Microbiology

Epstein-Barr Virus-Associated γδ T-Cell Lymphoproliferative Disorder Associated With Hypomorphic IL2RG Mutation

(2019) Kay Tanita et al.   Frontiers in Pediatrics

SLAM receptors foster iNKT cell development by reducing TCR signal strength after positive selection

(2019) Yan Lu et al.   NATURE IMMUNOLOGY

Immunodeficiency and Epstein Barr virus induced lymphoproliferation caused by 4-1BB deficiency

(2019) Mohammed Alosaimi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inherited Interleukin 2–Inducible T-Cell (ITK) Kinase Deficiency in Siblings With Epidermodysplasia Verruciformis and Hodgkin Lymphoma

(2019) Leila Youssefian et al.   CLINICAL INFECTIOUS DISEASES

Immunization with Components of the Viral Fusion Apparatus Elicits Antibodies That Neutralize Epstein-Barr Virus in B Cells and Epithelial Cells

(2019) Wei Bu et al.   IMMUNITY

Genetic Deficiency and Biochemical Inhibition of ITK Affect Human Th17, Treg, and Innate Lymphoid Cells

(2019) Ahmet Eken et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Mg2+ regulation of kinase signaling and immune function

(2019) Chryssa Kanellopoulou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hematopoietic stem cell transplantation for cytidine triphosphate synthase 1 (CTPS1) deficiency

(2018) Zohreh Nademi et al.   BONE MARROW TRANSPLANTATION

CD21-independent Epstein-Barr virus entry into NK cells

(2018) Jeong Hoo Lee et al.   CELLULAR IMMUNOLOGY

The regulation of lymphocyte activation and proliferation

(2018) Susanne Heinzel et al.   CURRENT OPINION IN IMMUNOLOGY

Activating PIK3CD mutations impair human cytotoxic lymphocyte differentiation and function and EBV immunity

(2018) Emily S.J. Edwards et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Novel Mutations in RASGRP1 are Associated with Immunodeficiency, Immune Dysregulation, and EBV-Induced Lymphoma

(2018) Ido Somekh et al.   JOURNAL OF CLINICAL IMMUNOLOGY

4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses

(2018) Ashley V. Menk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dysregulation of Epstein-Barr Virus Infection in Hypomorphic ZAP70 Mutation

(2018) Akihiro Hoshino et al.   JOURNAL OF INFECTIOUS DISEASES

Reply to ‘Comment on: Evidence of innate lymphoid cell redundancy in humans’

(2018) Eric Vivier et al.   NATURE IMMUNOLOGY

EBV-positive B-cell lymphoma manifestation of the liver in an infant with RAG1 severe combined immunodeficiency disease

(2018) Constantin Maas et al.   PEDIATRIC BLOOD & CANCER

Signaling by the Epstein–Barr virus LMP1 protein induces potent cytotoxic CD4+and CD8+T cell responses

(2018) Il-Kyu Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epstein–Barr Virus+ Smooth Muscle Tumors as Manifestation of Primary Immunodeficiency Disorders

(2018) Thomas Magg et al.   Frontiers in Immunology

CD70 Deficiency due to a Novel Mutation in a Patient with Severe Chronic EBV Infection Presenting As a Periodic Fever

(2018) Roberta Caorsi et al.   Frontiers in Immunology

Inherited Immunodeficiencies With High Predisposition to Epstein–Barr Virus-Driven Lymphoproliferative Diseases

(2018) Sylvain Latour et al.   Frontiers in Immunology

Epstein–Barr Virus Susceptibility in Activated PI3Kδ Syndrome (APDS) Immunodeficiency

(2018) Jean-Marie Carpier et al.   Frontiers in Immunology

Novel CARMIL2 Mutations in Patients with Variable Clinical Dermatitis, Infections, and Combined Immunodeficiency

(2018) Anas M. Alazami et al.   Frontiers in Immunology

Emerging insights into human health and NK cell biology from the study of NK cell deficiencies

(2018) Emily M. Mace et al.   IMMUNOLOGICAL REVIEWS

Hemophagocytic Lymphohistiocytosis: Clinical Presentations and Diagnosis

(2018) Kimberly A. Risma et al.   Journal of Allergy and Clinical Immunology-In Practice

Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study

(2017) Tanya I. Coulter et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

RASGRP1 mutation in autoimmune lymphoproliferative syndrome-like disease

(2017) Huawei Mao et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Two alternate strategies for innate immunity to Epstein-Barr virus: One using NK cells and the other NK cells and γδ T cells

(2017) Zakia Djaoud et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human immunity against EBV—lessons from the clinic

(2017) Stuart G. Tangye et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inducible T Cell Kinase Regulates the Acquisition of Cytolytic Capacity and Degranulation in CD8+CTLs

(2017) Senta M. Kapnick et al.   JOURNAL OF IMMUNOLOGY

A human immunodeficiency syndrome caused by mutations in CARMIL2

(2017) T. Schober et al.   Nature Communications

The role of CD27 in anti-viral T-cell immunity

(2017) Emma J Grant et al.   Current Opinion in Virology

GATA2 Deficiency and Epstein–Barr Virus Disease

(2017) Jeffrey I. Cohen   Frontiers in Immunology

Epstein–Barr Virus-Specific Immune Control by Innate Lymphocytes

(2017) Christian Münz   Frontiers in Immunology

Course of IL-2-inducible T-cell kinase deficiency in a family: lymphomatoid granulomatosis, lymphoma and allogeneic bone marrow transplantation in one sibling; and death in the other

(2016) D Çağdaş et al.   BONE MARROW TRANSPLANTATION

Association of GATA2 Deficiency With Severe Primary Epstein-Barr Virus (EBV) Infection and EBV-associated Cancers

(2016) Jeffrey I. Cohen et al.   CLINICAL INFECTIOUS DISEASES

N-linked glycosylation and homeostasis of the endoplasmic reticulum

(2016) Natalia Cherepanova et al.   CURRENT OPINION IN CELL BIOLOGY

SLAM family receptors in normal immunity and immune pathologies

(2016) Ning Wu et al.   CURRENT OPINION IN IMMUNOLOGY

Variable phenotype and discrete alterations of immune phenotypes in CTP synthase 1 deficiency: Report of 2 siblings

(2016) Johannes Trück et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Large Deletion of MAGT1 Gene in a Patient with Classic Kaposi Sarcoma, CD4 Lymphopenia, and EBV Infection

(2016) Immacolata Brigida et al.   JOURNAL OF CLINICAL IMMUNOLOGY

CTP Synthase 1 Deficiency in Successfully Transplanted Siblings with Combined Immune Deficiency and Chronic Active EBV Infection

(2016) Zeynep Yesim Kucuk et al.   JOURNAL OF CLINICAL IMMUNOLOGY

NF-κB1 Haploinsufficiency Causing Immunodeficiency and EBV-Driven Lymphoproliferation

(2016) Heidrun Boztug et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Inherited CD70 deficiency in humans reveals a critical role for the CD70–CD27 pathway in immunity to Epstein-Barr virus infection

(2016) Kazushi Izawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Combined immunodeficiency and Epstein-Barr virus–induced B cell malignancy in humans with inherited CD70 deficiency

(2016) Hassan Abolhassani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dual T cell– and B cell–intrinsic deficiency in humans with biallelicRLTPRmutations

(2016) Yi Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A hematopoietic cell–driven mechanism involving SLAMF6 receptor, SAP adaptors and SHP-1 phosphatase regulates NK cell education

(2016) Ning Wu et al.   NATURE IMMUNOLOGY

Evidence of innate lymphoid cell redundancy in humans

(2016) Frédéric Vély et al.   NATURE IMMUNOLOGY

RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics

(2016) Elisabeth Salzer et al.   NATURE IMMUNOLOGY

Inhibition of diacylglycerol kinase α restores restimulation-induced cell death and reduces immunopathology in XLP-1

(2016) Elisa Ruffo et al.   Science Translational Medicine

The Immunology of Epstein-Barr Virus–Induced Disease

(2015) Graham S. Taylor et al.   Annual Review of Immunology

Faster T-cell development following gene therapy compared with haploidentical HSCT in the treatment of SCID-X1

(2015) F. Touzot et al.   BLOOD

A case of XMEN syndrome presented with severe auto-immune disorders mimicking autoimmune lymphoproliferative disease

(2015) Turkan Patiroglu et al.   CLINICAL IMMUNOLOGY

Novel mutations in TNFRSF7/CD27: Clinical, immunologic, and genetic characterization of human CD27 deficiency

(2015) Omar K. Alkhairy et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Functional analysis of naturally occurring DCLRE1C mutations and correlation with the clinical phenotype of ARTEMIS deficiency

(2015) Kerstin Felgentreff et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

X-linked Inhibitor of Apoptosis Protein Deficiency: More than an X-linked Lymphoproliferative Syndrome

(2015) Claire Aguilar et al.   JOURNAL OF CLINICAL IMMUNOLOGY

DOCK8 Deficiency: Clinical and Immunological Phenotype and Treatment Options - a Review of 136 Patients

(2015) Susanne E. Aydin et al.   JOURNAL OF CLINICAL IMMUNOLOGY

ITK Deficiency: How can EBV be Treated Before Lymphoma?

(2015) Funda Erol Cipe et al.   PEDIATRIC BLOOD & CANCER

CD70: An emerging target in cancer immunotherapy

(2015) J. Jacobs et al.   PHARMACOLOGY & THERAPEUTICS

Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations

(2015) S. Okada et al.   SCIENCE

Cytomegalovirus infection enhances the immune response to influenza

(2015) David Furman et al.   Science Translational Medicine

XIAP deficiency syndrome in humans

(2015) Sylvain Latour et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Identification of ITK deficiency as a novel genetic cause of idiopathic CD4+ T-cell lymphopenia

(2014) N. K. Serwas et al.   BLOOD

Role for early-differentiated natural killer cells in infectious mononucleosis

(2014) T. Azzi et al.   BLOOD

Exome sequencing reveals novel mutation targets in diffuse large B-cell lymphomas derived from Chinese patients

(2014) N. F. C. C. de Miranda et al.   BLOOD

A new functional assay for the diagnosis of X-linked inhibitor of apoptosis (XIAP) deficiency

(2014) S. Ammann et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Characterization of Crohn disease in X-linked inhibitor of apoptosis–deficient male patients and female symptomatic carriers

(2014) Claire Aguilar et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Identification of a Novel Mutation in MAGT1 and Progressive Multifocal Leucoencephalopathy in a 58-Year-Old Man with XMEN Disease

(2014) Fatima Dhalla et al.   JOURNAL OF CLINICAL IMMUNOLOGY

XLP: Clinical Features and Molecular Etiology due to Mutations in SH2D1A Encoding SAP

(2014) Stuart G Tangye   JOURNAL OF CLINICAL IMMUNOLOGY

The role of Epstein-Barr virus in epithelial malignancies

(2014) Sai-Wah Tsao et al.   JOURNAL OF PATHOLOGY

CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation

(2014) Emmanuel Martin et al.   NATURE

An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome

(2014) Scott W Canna et al.   NATURE GENETICS

Current research on chronic active Epstein-Barr virus infection in Japan

(2014) Shigeyoshi Fujiwara et al.   PEDIATRICS INTERNATIONAL

Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansion

(2014) J. M. Marchingo et al.   SCIENCE

XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation

(2014) Monica Yabal et al.   Cell Reports

Innate immune control of EBV-infected B cells by invariant natural killer T cells

(2013) B. K. Chung et al.   BLOOD

Hydroa vacciniforme-like lymphoma: a chronic EBV+ lymphoproliferative disorder with risk to develop a systemic lymphoma

(2013) L. Quintanilla-Martinez et al.   BLOOD

EBV-induced post transplant lymphoproliferative disorders: a persisting challenge in allogeneic hematopoetic SCT

(2013) L Rasche et al.   BONE MARROW TRANSPLANTATION

Disease-causing mutations in the XIAPBIR2 domain impair NOD2-dependent immune signalling

(2013) Rune Busk Damgaard et al.   EMBO Molecular Medicine

The costimulatory molecule CD70 is regulated by distinct molecular mechanisms and is associated with overall survival in diffuse large B-cell lymphoma

(2013) P. Bertrand et al.   GENES CHROMOSOMES & CANCER

The contextual role of TNFR family members in CD8+T-cell control of viral infections

(2013) Michael E. Wortzman et al.   IMMUNOLOGICAL REVIEWS

Haploidentical hematopoietic stem cell transplantation can lead to viral clearance in severe combined immunodeficiency

(2013) Mary Slatter et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Whole-exome sequencing identifies Coronin-1A deficiency in 3 siblings with immunodeficiency and EBV-associated B-cell lymphoproliferation

(2013) Despina Moshous et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood

(2013) Minji Byun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effects of Aging, Cytomegalovirus Infection, and EBV Infection on Human B Cell Repertoires

(2013) C. Wang et al.   JOURNAL OF IMMUNOLOGY

Mg2+ Regulates Cytotoxic Functions of NK and CD8 T Cells in Chronic EBV Infection Through NKG2D

(2013) B. Chaigne-Delalande et al.   SCIENCE

Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells

(2013) Robert L. Kortum et al.   TRENDS IN IMMUNOLOGY

Massive expansion of maternal T cells in response to EBV infection in a patient with SCID-Xl

(2012) F. Touzot et al.   BLOOD

The phenotype of human STK4 deficiency

(2012) H. Abdollahpour et al.   BLOOD

TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells

(2012) Nicole Warnecke et al.   EMBO REPORTS

Combined immunodeficiency with life-threatening EBV-associated lymphoproliferative disorder in patients lacking functional CD27

(2012) E. Salzer et al.   HAEMATOLOGICA

Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation

(2012) James E. Vince et al.   IMMUNITY

The Adaptor SAP Controls NK Cell Activation by Regulating the Enzymes Vav-1 and SHIP-1 and by Enhancing Conjugates with Target Cells

(2012) Zhongjun Dong et al.   IMMUNITY

Positive and Negative Signaling through SLAM Receptors Regulate Synapse Organization and Thresholds of Cytolysis

(2012) Fang Zhao et al.   IMMUNITY

IL-2-Inducible T-Cell Kinase Deficiency with Pulmonary Manifestations due to Disseminated Epstein-Barr Virus Infection

(2012) D. Mansouri et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Expansion of somatically reverted memory CD8+T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus

(2012) Umaimainthan Palendira et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Loss-of-function mutations within the IL-2 inducible kinase ITK in patients with EBV-associated lymphoproliferative diseases

(2012) R M Linka et al.   LEUKEMIA

Familial and Acquired Hemophagocytic Lymphohistiocytosis

(2011) G.E. Janka   Annual Review of Medicine

Major histocompatibility complex class II expression deficiency caused by a RFXANK founder mutation: a survey of 35 patients

(2011) M. Ouederni et al.   BLOOD

EBV-associated T/NK-cell lymphoproliferative diseases in nonimmunocompromised hosts: prospective analysis of 108 cases

(2011) H. Kimura et al.   BLOOD

MST1 mutations in autosomal recessive primary immunodeficiency characterized by defective naive T-cell survival

(2011) N. T. Nehme et al.   BLOOD

The Costimulatory Molecule CD27 Maintains Clonally Diverse CD8+ T Cell Responses of Low Antigen Affinity to Protect against Viral Variants

(2011) Klaas P.J.M. van Gisbergen et al.   IMMUNITY

Recurrent deletions of the TNFSF7 and TNFSF9 genes in 19p13.3 in diffuse large B-cell and Burkitt lymphomas

(2011) René Scholtysik et al.   INTERNATIONAL JOURNAL OF CANCER

CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia

(2011) Joris M. van Montfrans et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Antiviral and Regulatory T Cell Immunity in a Patient with Stromal Interaction Molecule 1 Deficiency

(2011) S. Fuchs et al.   JOURNAL OF IMMUNOLOGY

Second messenger role for Mg2+ revealed by human T-cell immunodeficiency

(2011) Feng-Yen Li et al.   NATURE

Molecular Pathogenesis of EBV Susceptibility in XLP as Revealed by Analysis of Female Carriers with Heterozygous Expression of SAP

(2011) Umaimainthan Palendira et al.   PLOS BIOLOGY

Impaired Epstein-Barr virus-specific CD8+ T-cell function in X-linked lymphoproliferative disease is restricted to SLAM family-positive B-cell targets

(2010) A. D. Hislop et al.   BLOOD

Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1 (XLP-1/SAP deficiency) versus type 2 (XLP-2/XIAP deficiency)

(2010) J. P. Schmid et al.   BLOOD

X-linked lymphoproliferative disease due to SAP/SH2D1A deficiency: a multicenter study on the manifestations, management and outcome of the disease

(2010) C. Booth et al.   BLOOD

CD70-CD27 interactions provide survival and proliferative signals that regulate T cell receptor-driven activation of human γδ peripheral blood lymphocytes

(2010) Ana deBarros et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-2-inducible T-cell kinase deficiency: clinical presentation and therapeutic approach

(2010) P. Stepensky et al.   HAEMATOLOGICA

Diffuse large B-cell lymphoma as presenting feature of Zap-70 deficiency

(2010) Andrea Newell et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Kinetics of Epstein-Barr virus load and virus-specific CD8+ T cells in acute infectious mononucleosis

(2010) Yo Hoshino et al.   JOURNAL OF CLINICAL VIROLOGY

Lymphoproliferative Disorders After Solid Organ Transplantation—Classification, Incidence, Risk Factors, Early Detection and Treatment Options

(2010) Gyula Végső et al.   PATHOLOGY & ONCOLOGY RESEARCH

Hodgkin's and Non-Hodgkin's Lymphomas Occurring in Two Brothers with Wiskott-Aldrich Syndrome and Review of the Literature

(2010) Shouying Du et al.   PEDIATRIC AND DEVELOPMENTAL PATHOLOGY

T-Cell Signaling Regulated by the Tec Family Kinase, Itk

(2010) A. H. Andreotti et al.   Cold Spring Harbor Perspectives in Biology

Non-Hodgkin lymphoma incidence in the Swiss HIV Cohort Study before and after highly active antiretroviral therapy

(2009) Jerry Polesel et al.   AIDS

Familial Hemophagocytic Lymphohistiocytosis Type 5 (FHL-5) Is Caused by Mutations in Munc18-2 and Impaired Binding to Syntaxin 11

(2009) Udo zur Stadt et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Redefining Chronic Viral Infection

(2009) Herbert W. Virgin et al.   CELL

Neutralization of IFNγ defeats haemophagocytosis in LCMV-infected perforin- and Rab27a-deficient mice

(2009) Jana Pachlopnik Schmid et al.   EMBO Molecular Medicine

NKG2D and its ligands

(2009) Peyman Obeidy et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Girls homozygous for an IL-2–inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation

(2009) Kirsten Huck et al.   JOURNAL OF CLINICAL INVESTIGATION

Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells

(2009) Marjorie Côte et al.   JOURNAL OF CLINICAL INVESTIGATION

Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells

(2009) Zhongjun Dong et al.   NATURE IMMUNOLOGY

STIM1Mutation Associated with a Syndrome of Immunodeficiency and Autoimmunity

(2009) Capucine Picard et al.   NEW ENGLAND JOURNAL OF MEDICINE

XIAP mediates NOD signaling via interaction with RIP2

(2009) A. Krieg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-associated lymphomas and gamma-herpesviruses

(2008) A. Carbone et al.   BLOOD

SAP-controlled T–B cell interactions underlie germinal centre formation

(2008) Hai Qi et al.   NATURE

An Immunodeficiency Disease withRAGMutations and Granulomas

(2008) Catharina Schuetz et al.   NEW ENGLAND JOURNAL OF MEDICINE