A hematopoietic cell–driven mechanism involving SLAMF6 receptor, SAP adaptors and SHP-1 phosphatase regulates NK cell education

Cytomegalovirus Infection Drives Adaptive Epigenetic Diversification of NK Cells with Altered Signaling and Effector Function

(2015) Heinrich Schlums et al.   IMMUNITY

Epigenetic Modification and Antibody-Dependent Expansion of Memory-like NK Cells in Human Cytomegalovirus-Infected Individuals

(2015) Jaewon Lee et al.   IMMUNITY

DNAM-1 controls NK cell activation via an ITT-like motif

(2015) Zhanguang Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SHIP1 Intrinsically Regulates NK Cell Signaling and Education, Resulting in Tolerance of an MHC Class I–Mismatched Bone Marrow Graft in Mice

(2015) Matthew Gumbleton et al.   JOURNAL OF IMMUNOLOGY

A shed NKG2D ligand that promotes natural killer cell activation and tumor rejection

(2015) W. Deng et al.   SCIENCE

Costimulatory Molecule DNAM-1 Is Essential for Optimal Differentiation of Memory Natural Killer Cells during Mouse Cytomegalovirus Infection

(2014) Tsukasa Nabekura et al.   IMMUNITY

XLP: Clinical Features and Molecular Etiology due to Mutations in SH2D1A Encoding SAP

(2014) Stuart G Tangye   JOURNAL OF CLINICAL IMMUNOLOGY

EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase Cγ, Ca++, and Erk, leading to granule polarization

(2014) Luis-Alberto Pérez-Quintero et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NK cell self tolerance, responsiveness and missing self recognition

(2014) Nataliya Shifrin et al.   SEMINARS IN IMMUNOLOGY

SHP-1-mediated inhibitory signals promote responsiveness and anti-tumour functions of natural killer cells

(2014) Charlotte Viant et al.   Nature Communications

X-linked lymphoproliferative syndromes and related autosomal recessive disorders

(2013) André Veillette et al.   Current Opinion in Allergy and Clinical Immunology

The Adaptor Molecule Signaling Lymphocytic Activation Molecule (SLAM)-associated Protein (SAP) Is Essential in Mechanisms Involving the Fyn Tyrosine Kinase for Induction and Progression of Collagen-induced Arthritis

(2013) Ming-Chao Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Adaptor SAP Controls NK Cell Activation by Regulating the Enzymes Vav-1 and SHIP-1 and by Enhancing Conjugates with Target Cells

(2012) Zhongjun Dong et al.   IMMUNITY

SLAM Family Receptors and SAP Adaptors in Immunity

(2011) Jennifer L. Cannons et al.   Annual Review of Immunology

Confinement of Activating Receptors at the Plasma Membrane Controls Natural Killer Cell Tolerance

(2011) S. Guia et al.   Science Signaling

Unifying concepts of MHC-dependent natural killer cell education

(2011) Julie M. Elliott et al.   TRENDS IN IMMUNOLOGY

Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1 (XLP-1/SAP deficiency) versus type 2 (XLP-2/XIAP deficiency)

(2010) J. P. Schmid et al.   BLOOD

Natural Killer Cell Education and Tolerance

(2010) Mark T. Orr et al.   CELL

The Phosphatase PTP-PEST Promotes Secondary T Cell Responses by Dephosphorylating the Protein Tyrosine Kinase Pyk2

(2010) Dominique Davidson et al.   IMMUNITY

Mature natural killer cells reset their responsiveness when exposed to an altered MHC environment

(2010) Nathalie T. Joncker et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MHC class I–deficient natural killer cells acquire a licensed phenotype after transfer into an MHC class I–sufficient environment

(2010) Julie M. Elliott et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SLAM family receptors and the SLAM-associated protein (SAP) modulate T cell functions

(2010) Cynthia Detre et al.   Seminars in Immunopathology

SLAM-Family Receptors: Immune Regulators with or without SAP-Family Adaptors

(2010) A. Veillette   Cold Spring Harbor Perspectives in Biology

A Role for cis Interaction between the Inhibitory Ly49A Receptor and MHC Class I for Natural Killer Cell Education

(2009) Anick Chalifour et al.   IMMUNITY

Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells

(2009) Zhongjun Dong et al.   NATURE IMMUNOLOGY

Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function

(2009) Mario-Ernesto Cruz-Munoz et al.   NATURE IMMUNOLOGY

Line of attack: NK cell specificity and integration of signals

(2008) Yenan T Bryceson et al.   CURRENT OPINION IN IMMUNOLOGY

Control of T Lymphocyte Signaling by Ly108, a Signaling Lymphocytic Activation Molecule Family Receptor Implicated in Autoimmunity

(2008) Ming-Chao Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Continuous engagement of a self-specific activation receptor induces NK cell tolerance

(2008) Sandeep K. Tripathy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Functions of natural killer cells

(2008) Eric Vivier et al.   NATURE IMMUNOLOGY