RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics

High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry

(2016) Celi Sun et al.   NATURE GENETICS

The 2015 IUIS Phenotypic Classification for Primary Immunodeficiencies

(2015) Aziz Bousfiha et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Primary Immunodeficiency Diseases: an Update on the Classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency 2015

(2015) Capucine Picard et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Human Immunodeficiency Virus Type 1 Employs the Cellular Dynein Light Chain 1 Protein for Reverse Transcription through Interaction with Its Integrase Protein

(2015) Kallesh Danappa Jayappa et al.   JOURNAL OF VIROLOGY

RasGRP1 opposes proliferative EGFR–SOS1–Ras signals and restricts intestinal epithelial cell growth

(2015) Philippe Depeille et al.   NATURE CELL BIOLOGY

Individual Human Cytotoxic T Lymphocytes Exhibit Intraclonal Heterogeneity during Sustained Killing

(2015) Zilton Vasconcelos et al.   Cell Reports

Guidelines for genetic studies in single patients: lessons from primary immunodeficiencies

(2014) Jean-Laurent Casanova et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A general framework for estimating the relative pathogenicity of human genetic variants

(2014) Martin Kircher et al.   NATURE GENETICS

JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia

(2014) Kaan Boztug et al.   NATURE GENETICS

Serine-threonine kinases in TCR signaling

(2014) María N Navarro et al.   NATURE IMMUNOLOGY

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Easy quantitative assessment of genome editing by sequence trace decomposition

(2014) Eva K. Brinkman et al.   NUCLEIC ACIDS RESEARCH

Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity

(2014) Katharina L. Willmann et al.   Nature Communications

A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region

(2014) Courtney M Schroeder et al.   eLife

Functional T Cell Immunodeficiencies (with T Cells Present)

(2013) Luigi D. Notarangelo   Annual Review of Immunology

Exhausting T cells in CLL

(2013) T. Zenz   BLOOD

Chronic lymphocytic leukemia cells induce defective LFA-1-directed T-cell motility by altering Rho GTPase signaling that is reversible with lenalidomide

(2013) A. G. Ramsay et al.   BLOOD

Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4CRBN

(2013) Anita K. Gandhi et al.   BRITISH JOURNAL OF HAEMATOLOGY

DOCK8 Immune Deficiency as a Model for Primary Cytoskeletal Dysfunction

(2013) Sean A. McGhee et al.   DISEASE MARKERS

Human T follicular helper (Tfh) cells and disease

(2013) Cindy S Ma et al.   IMMUNOLOGY AND CELL BIOLOGY

Partial defects of T-cell development associated with poor T-cell function

(2013) Luigi D. Notarangelo   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Multiple Checkpoint Breach of B Cell Tolerance in Rasgrp1-Deficient Mice

(2013) A. Bartlett et al.   JOURNAL OF IMMUNOLOGY

Plug-and-Play Pairing via Defined Divalent Streptavidins

(2013) Michael Fairhead et al.   JOURNAL OF MOLECULAR BIOLOGY

The CRAPome: a contaminant repository for affinity purification–mass spectrometry data

(2013) Dattatreya Mellacheruvu et al.   NATURE METHODS

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Diacylglycerol promotes centrosome polarization in T cells via reciprocal localization of dynein and myosin II

(2013) X. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells

(2013) J. Kronke et al.   SCIENCE

Regulation of Ras Exchange Factors and Cellular Localization of Ras Activation by Lipid Messengers in T Cells

(2013) Jesse E. Jun et al.   Frontiers in Immunology

TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells

(2012) Nicole Warnecke et al.   EMBO REPORTS

Combined immunodeficiency with life-threatening EBV-associated lymphoproliferative disorder in patients lacking functional CD27

(2012) E. Salzer et al.   HAEMATOLOGICA

A novel primary human immunodeficiency due to deficiency in the WASP-interacting protein WIP

(2012) Gaetana Lanzi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differential Requirement of RasGRP1 for    T Cell Development and Activation

(2012) Y. Chen et al.   JOURNAL OF IMMUNOLOGY

Viral immune modulators perturb the human molecular network by common and unique strategies

(2012) Andreas Pichlmair et al.   NATURE

A pipeline for the generation of shRNA transgenic mice

(2012) Lukas E Dow et al.   Nature Protocols

Regulation of RasGRP1 Function in T Cell Development and Activation by Its Unique Tail Domain

(2012) Deirdre M. Fuller et al.   PLoS One

Microtubule-organizing center polarity and the immunological synapse: protein kinase C and beyond

(2012) Morgan Huse   Frontiers in Immunology

An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance

(2011) J. Zuber et al.   GENES & DEVELOPMENT

Human immunology: a case for the ascent of non-furry immunology

(2011) Rajiv Khanna et al.   IMMUNOLOGY AND CELL BIOLOGY

G i2 and ZAP-70 Mediate RasGRP1 Membrane Localization and Activation of SDF-1-Induced T Cell Functions

(2011) K. N. Kremer et al.   JOURNAL OF IMMUNOLOGY

Critical Roles of RasGRP1 for Invariant NKT Cell Development

(2011) S. Shen et al.   JOURNAL OF IMMUNOLOGY

Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma

(2010) P. G. Richardson et al.   BLOOD

Quantitative measurement of F-actin accumulation at the NK cell immunological synapse

(2010) Pinaki P. Banerjee et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Rapid Lytic Granule Convergence to the MTOC in Natural Killer Cells Is Dependent on Dynein But Not Cytolytic Commitment

(2010) Ashley N. Mentlik et al.   MOLECULAR BIOLOGY OF THE CELL

TCR–peptide–MHC interactions in situ show accelerated kinetics and increased affinity

(2010) Johannes B. Huppa et al.   NATURE

Mutations in the urocanase gene UROC1 are associated with urocanic aciduria

(2009) C Espinos et al.   JOURNAL OF MEDICAL GENETICS

An integrated workflow for charting the human interaction proteome: insights into the PP2A system

(2009) Timo Glatter et al.   Molecular Systems Biology

Functions of natural killer cells

(2008) Eric Vivier et al.   NATURE IMMUNOLOGY

Beyond polymer polarity: how the cytoskeleton builds a polarized cell

(2008) Rong Li et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY