Inducible T Cell Kinase Regulates the Acquisition of Cytolytic Capacity and Degranulation in CD8+CTLs

Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4

(2016) Julio Gomez-Rodriguez et al.   Nature Communications

Actin Depletion Initiates Events Leading to Granule Secretion at the Immunological Synapse

(2015) Alex T. Ritter et al.   IMMUNITY

Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response

(2015) Yonglian Sun et al.   Science Signaling

T Cells Integrate Local and Global Cues to Discriminate between Structurally Similar Antigens

(2015) Guillaume Voisinne et al.   Cell Reports

Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response

(2015) Yonglian Sun et al.   Science Signaling

Interleukin-2-Inducible T-Cell Kinase (ITK) Deficiency - Clinical and Molecular Aspects

(2014) Sujal Ghosh et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells

(2014) Julio Gomez-Rodriguez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Selective Expression Rather than Specific Function of Txk and Itk Regulate Th1 and Th2 Responses

(2014) N. Sahu et al.   JOURNAL OF IMMUNOLOGY

Diacylglycerol promotes centrosome polarization in T cells via reciprocal localization of dynein and myosin II

(2013) X. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In the Crosshairs: Investigating Lytic Granules by High-Resolution Microscopy and Electrophysiology

(2013) Varsha Pattu et al.   Frontiers in Immunology

Positive and Negative Signaling through SLAM Receptors Regulate Synapse Organization and Thresholds of Cytolysis

(2012) Fang Zhao et al.   IMMUNITY

IL-2-Inducible T-Cell Kinase Deficiency with Pulmonary Manifestations due to Disseminated Epstein-Barr Virus Infection

(2012) D. Mansouri et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+T cells

(2012) David K. Finlay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of lymphocyte function by ORAI and STIM proteins in infection and autoimmunity

(2012) Patrick J. Shaw et al.   JOURNAL OF PHYSIOLOGY-LONDON

Loss-of-function mutations within the IL-2 inducible kinase ITK in patients with EBV-associated lymphoproliferative diseases

(2012) R M Linka et al.   LEUKEMIA

Two modes of lytic granule fusion during degranulation by natural killer cells

(2011) Dongfang Liu et al.   IMMUNOLOGY AND CELL BIOLOGY

IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function

(2011) Jordan S. Orange et al.   JOURNAL OF CLINICAL INVESTIGATION

A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells

(2011) Emily J Quann et al.   NATURE IMMUNOLOGY

ORAI1-mediated calcium influx is required for human cytotoxic lymphocyte degranulation and target cell lysis

(2011) A. Maul-Pavicic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Itk Controls the Spatiotemporal Organization of T Cell Activation

(2011) K. L. Singleton et al.   Science Signaling

Molecular Pathogenesis of EBV Susceptibility in XLP as Revealed by Analysis of Female Carriers with Heterozygous Expression of SAP

(2011) Umaimainthan Palendira et al.   PLOS BIOLOGY

Impaired Epstein-Barr virus-specific CD8+ T-cell function in X-linked lymphoproliferative disease is restricted to SLAM family-positive B-cell targets

(2010) A. D. Hislop et al.   BLOOD

The synapse and cytolytic machinery of cytotoxic T cells

(2010) Misty R Jenkins et al.   CURRENT OPINION IN IMMUNOLOGY

Atypical familial hemophagocytic lymphohistiocytosis due to mutations in UNC13D and STXBP2 overlaps with primary immunodeficiency diseases

(2010) J. Rohr et al.   HAEMATOLOGICA

Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells

(2010) Matthew E. Pipkin et al.   IMMUNITY

T-Cell Signaling Regulated by the Tec Family Kinase, Itk

(2010) A. H. Andreotti et al.   Cold Spring Harbor Perspectives in Biology

The Strength of T Cell Receptor Signal Controls the Polarization of Cytotoxic Machinery to the Immunological Synapse

(2009) Misty R. Jenkins et al.   IMMUNITY

Differential Expression of Interleukin-17A and -17F Is Coupled to T Cell Receptor Signaling via Inducible T Cell Kinase

(2009) Julio Gomez-Rodriguez et al.   IMMUNITY

Girls homozygous for an IL-2–inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation

(2009) Kirsten Huck et al.   JOURNAL OF CLINICAL INVESTIGATION

Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency

(2009) Andrew L. Snow et al.   JOURNAL OF CLINICAL INVESTIGATION

Localized diacylglycerol drives the polarization of the microtubule-organizing center in T cells

(2009) Emily J Quann et al.   NATURE IMMUNOLOGY