X-linked Inhibitor of Apoptosis Protein Deficiency: More than an X-linked Lymphoproliferative Syndrome

cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner

(2014) W. W.-L. Wong et al.   BLOOD

Sphingolipids from a Symbiotic Microbe Regulate Homeostasis of Host Intestinal Natural Killer T Cells

(2014) Dingding An et al.   CELL

XLP: Clinical Features and Molecular Etiology due to Mutations in SH2D1A Encoding SAP

(2014) Stuart G Tangye   JOURNAL OF CLINICAL IMMUNOLOGY

Protective mucosal immunity mediated by epithelial CD1d and IL-10

(2014) Torsten Olszak et al.   NATURE

Small-molecule SMAC mimetics as new cancer therapeutics

(2014) Longchuan Bai et al.   PHARMACOLOGY & THERAPEUTICS

XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation

(2014) Monica Yabal et al.   Cell Reports

X-Linked Inhibitor of Apoptosis Protein – A Critical Death Resistance Regulator and Therapeutic Target for Personalized Cancer Therapy

(2014) Petra Obexer et al.   Frontiers in Oncology

Successful stem cell transplant with antibody-based conditioning for XIAP deficiency with refractory hemophagocytic lymphohistiocytosis

(2013) A. J. J. Worth et al.   BLOOD

Innate immune control of EBV-infected B cells by invariant natural killer T cells

(2013) B. K. Chung et al.   BLOOD

X-linked inhibitor of apoptosis (XIAP) deficiency: The spectrum of presenting manifestations beyond hemophagocytic lymphohistiocytosis

(2013) C. Speckmann et al.   CLINICAL IMMUNOLOGY

X-linked lymphoproliferative syndromes and related autosomal recessive disorders

(2013) André Veillette et al.   Current Opinion in Allergy and Clinical Immunology

XIAP inhibits autophagy via XIAP-Mdm2-p53 signalling

(2013) Xing Huang et al.   EMBO JOURNAL

Disease-causing mutations in the XIAPBIR2 domain impair NOD2-dependent immune signalling

(2013) Rune Busk Damgaard et al.   EMBO Molecular Medicine

IL-10 and IL-10 receptor defects in humans

(2012) Erik-Oliver Glocker et al.   Annals of the New York Academy of Sciences

Allogeneic hematopoietic cell transplantation for XIAP deficiency: an international survey reveals poor outcomes

(2012) R. A. Marsh et al.   BLOOD

Human iNKT and MAIT cells exhibit a PLZF-dependent proapoptotic propensity that is counterbalanced by XIAP

(2012) S. Gerart et al.   BLOOD

Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation

(2012) James E. Vince et al.   IMMUNITY

Clinical and Genetic Characteristics of XIAP Deficiency in Japan

(2012) Xi Yang et al.   JOURNAL OF CLINICAL IMMUNOLOGY

The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

(2012) Rune Busk Damgaard et al.   MOLECULAR CELL

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Two new families with X-linked inhibitor of apoptosis deficiency and a review of all 26 published cases

(2011) Peter C. Horn et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

NOD2, an intracellular innate immune sensor involved in host defense and Crohn's disease

(2011) W Strober et al.   Mucosal Immunology

X-linked lymphoproliferative syndromes: brothers or distant cousins?

(2010) A. H. Filipovich et al.   BLOOD

Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1 (XLP-1/SAP deficiency) versus type 2 (XLP-2/XIAP deficiency)

(2010) J. P. Schmid et al.   BLOOD

XIAP deficiency: a unique primary immunodeficiency best classified as X-linked familial hemophagocytic lymphohistiocytosis and not as X-linked lymphoproliferative disease

(2010) R. A. Marsh et al.   BLOOD

Making a definitive diagnosis: Successful clinical application of whole exome sequencing in a child with intractable inflammatory bowel disease

(2010) Elizabeth A Worthey et al.   GENETICS IN MEDICINE

Atypical familial hemophagocytic lymphohistiocytosis due to mutations in UNC13D and STXBP2 overlaps with primary immunodeficiency diseases

(2010) J. Rohr et al.   HAEMATOLOGICA

Using flow cytometry to screen patients for X-linked lymphoproliferative disease due to SAP deficiency and XIAP deficiency

(2010) Rebecca A. Marsh et al.   JOURNAL OF IMMUNOLOGICAL METHODS

XIAP as a ubiquitin ligase in cellular signaling

(2009) S Galbán et al.   CELL DEATH AND DIFFERENTIATION

Patients with X-linked lymphoproliferative disease due to BIRC4 mutation have normal invariant natural killer T-cell populations

(2009) Rebecca A. Marsh et al.   CLINICAL IMMUNOLOGY

Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease

(2009) Andrew M. Smith et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Revisiting Crohn's disease as a primary immunodeficiency of macrophages: Figure 1.

(2009) Jean-Laurent Casanova et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Wiskott-Aldrich Syndrome Protein Is Required for Homeostasis and Function of Invariant NKT Cells

(2009) A. Astrakhan et al.   JOURNAL OF IMMUNOLOGY

XIAP mediates NOD signaling via interaction with RIP2

(2009) A. Krieg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammatory Bowel Disease in CGD Reproduces the Clinicopathological Features of Crohn's Disease

(2008) Daniel J B Marks et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Interaction with XIAP prevents full caspase‐3/‐7 activation in proliferating human T lymphocytes

(2008) Maren Paulsen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The molecular basis of NOD2 susceptibility mutations in Crohn's disease

(2008) W Strober et al.   Mucosal Immunology