Epstein–Barr Virus Susceptibility in Activated PI3Kδ Syndrome (APDS) Immunodeficiency

Mutations in the adaptor-binding domain and associated linker region of p110δ cause Activated PI3K-δ Syndrome 1 (APDS1)

(2017) Lucie Heurtier et al.   HAEMATOLOGICA

Early diagnosis of PI3Kδ syndrome in a 2 years old girl with recurrent otitis and enlarged spleen

(2017) F. Saettini et al.   IMMUNOLOGY LETTERS

Novel PIK3CD mutations affecting N-terminal residues of p110δ cause activated PI3Kδ syndrome (APDS) in humans

(2017) Andrew J. Takeda et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study

(2017) Tanya I. Coulter et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Abnormal B-cell maturation in the bone marrow of patients with germline mutations in PIK3CD

(2017) Alina E. Dulau Florea et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Hematopoietic stem cell transplant in patients with activated PI3K delta syndrome

(2017) Zohreh Nademi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Finding patients using similarity measures in a rare diseases-oriented clinical data warehouse: Dr. Warehouse and the needle in the needle stack

(2017) Nicolas Garcelon et al.   JOURNAL OF BIOMEDICAL INFORMATICS

Persistent Impairment of T-Cell Regeneration in a Patient with Activated PI3K δ Syndrome

(2017) Fumihiro Goto et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Human immunity against EBV—lessons from the clinic

(2017) Stuart G. Tangye et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Variant PIK3R1 Hypermorphic Mutation and Clinical Phenotypes in a Family with Short Statures, Mild Immunodeficiency and Lymphoma

(2017) Fabian Hauck et al.   KLINISCHE PADIATRIE

Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells

(2017) Mara Compagno et al.   NATURE

Conformational disruption of PI3Kδ regulation by immunodeficiency mutations inPIK3CDandPIK3R1

(2017) Gillian L. Dornan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in the adaptor-binding domain and associated linker region of p110δ cause Activated PI3K-δ Syndrome 1 (APDS1)

(2017) Lucie Heurtier et al.   HAEMATOLOGICA

Immunodeficiency-Associated Lymphoid Hyperplasia As a Cause of Intussusception in a Case of Activated PI3K-δ Syndrome

(2017) Daniel Mettman et al.   Frontiers in Pediatrics

Genomics of Immune Diseases and New Therapies

(2016) Michael Lenardo et al.   Annual Review of Immunology

Kinetics of Epstein-Barr Virus (EBV) Neutralizing and Virus-Specific Antibodies after Primary Infection with EBV

(2016) Wei Bu et al.   Clinical and Vaccine Immunology

Precision treatment with sirolimus in a case of activated phosphoinositide 3-kinase δ syndrome

(2016) William Rae et al.   CLINICAL IMMUNOLOGY

Gain-of-function mutation in PIK3R1 in a patient with a narrow clinical phenotype of respiratory infections

(2016) María Teresa Martínez-Saavedra et al.   CLINICAL IMMUNOLOGY

De novo PIK3R1 gain-of-function with recurrent sinopulmonary infections, long-lasting chronic CMV-lymphadenitis and microcephaly

(2016) Michaela Kuhlen et al.   CLINICAL IMMUNOLOGY

Phosphatase and tensin homolog ( PTEN ) mutation can cause activated phosphatidylinositol 3-kinase δ syndrome–like immunodeficiency

(2016) Yuki Tsujita et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Increased PI3K/Akt activity and deregulated humoral immune response in human PTEN deficiency

(2016) Gertjan J. Driessen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Clinical and immunologic phenotype associated with activated phosphoinositide 3-kinase δ syndrome 2: A cohort study

(2016) Elodie Elkaim et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Adoptive immunotherapy for primary immunodeficiency disorders with virus-specific T lymphocytes

(2016) Swati Naik et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dominant Splice Site Mutations in PIK3R1 Cause Hyper IgM Syndrome, Lymphadenopathy and Short Stature

(2016) Slavé Petrovski et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Activated PI3Kδ syndrome type 2: Two patients, a novel mutation, and review of the literature

(2016) Peter Olbrich et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Mechanisms Underlying T Cell Immunosenescence: Aging and Cytomegalovirus Infection

(2016) Wenjuan Tu et al.   Frontiers in Microbiology

Activated phosphoinositide 3-kinase δ syndrome in a patient with a former diagnosis of common variable immune deficiency, bronchiectasis, and lymphoproliferative disease

(2015) Jennifer A. Kannan et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Primary immunodeficiencies and the control of Epstein-Barr virus infection

(2015) Umaimainthan Palendira et al.   Annals of the New York Academy of Sciences

The Immunology of Epstein-Barr Virus–Induced Disease

(2015) Graham S. Taylor et al.   Annual Review of Immunology

Rational Design of an Epstein-Barr Virus Vaccine Targeting the Receptor-Binding Site

(2015) Masaru Kanekiyo et al.   CELL

Activating PI3Kδ mutations in a cohort of 669 patients with primary immunodeficiency

(2015) M. Elgizouli et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Altered germinal center reaction and abnormal B cell peripheral maturation in PI3KR1-mutated patients presenting with HIGM-like phenotype

(2015) Vassilios Lougaris et al.   CLINICAL IMMUNOLOGY

Identifying genetic determinants of autoimmunity and immune dysregulation

(2015) Carrie L Lucas et al.   CURRENT OPINION IN IMMUNOLOGY

X-linked Inhibitor of Apoptosis Protein Deficiency: More than an X-linked Lymphoproliferative Syndrome

(2015) Claire Aguilar et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Impaired Epstein-Barr Virus-Specific Neutralizing Antibody Response during Acute Infectious Mononucleosis Is Coincident with Global B-Cell Dysfunction

(2015) Archana Panikkar et al.   JOURNAL OF VIROLOGY

Effects of lymphocyte profile on development of EBV-induced lymphoma subtypes in humanized mice

(2015) Eun Kyung Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synergy in activating class I PI3Ks

(2015) John E. Burke et al.   TRENDS IN BIOCHEMICAL SCIENCES

The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside

(2015) XueQiao Liu et al.   VIROLOGY

Early Virological and Immunological Events in Asymptomatic Epstein-Barr Virus Infection in African Children

(2015) Shamanthi Jayasooriya et al.   PLoS Pathogens

Controlling T cell senescence in the tumor microenvironment for tumor immunotherapy

(2015) Jian Ye et al.   OncoImmunology

New advances in CMV and immunosenescence

(2014) Paolo Sansoni et al.   EXPERIMENTAL GERONTOLOGY

The interplay between Epstein–Barr virus and B lymphocytes: implications for infection, immunity, and disease

(2014) Olivia L. Hatton et al.   IMMUNOLOGIC RESEARCH

Occurrence of B-cell lymphomas in patients with activated phosphoinositide 3-kinase δ syndrome

(2014) Sven Kracker et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

XLP: Clinical Features and Molecular Etiology due to Mutations in SH2D1A Encoding SAP

(2014) Stuart G Tangye   JOURNAL OF CLINICAL IMMUNOLOGY

Gain of Function Mutations of PIK3CD as a Cause of Primary Sclerosing Cholangitis

(2014) Heather N. Hartman et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Mutations in PIK3CD Can Cause Hyper IgM Syndrome (HIGM) Associated with Increased Cancer Susceptibility

(2014) M. C. Crank et al.   JOURNAL OF CLINICAL IMMUNOLOGY

A human immunodeficiency caused by mutations in the PIK3R1 gene

(2014) Marie-Céline Deau et al.   JOURNAL OF CLINICAL INVESTIGATION

Heterozygous splice mutation inPIK3R1causes human immunodeficiency with lymphoproliferation due to dominant activation of PI3K

(2014) Carrie L. Lucas et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Telomerase-Based Pharmacologic Enhancement of Antiviral Function of Human CD8+ T Lymphocytes

(2014) S. R. Fauce et al.   JOURNAL OF IMMUNOLOGY

PI3K and cancer: lessons, challenges and opportunities

(2014) David A. Fruman et al.   NATURE REVIEWS DRUG DISCOVERY

Crosstalk between the Rb Pathway and AKT Signaling Forms a Quiescence-Senescence Switch

(2014) Yoshinori Imai et al.   Cell Reports

A Gammaherpesvirus Bcl-2 Ortholog Blocks B Cell Receptor-Mediated Apoptosis and Promotes the Survival of Developing B Cells In Vivo

(2014) Carrie B. Coleman et al.   PLoS Pathogens

PI3Kδ Inhibition Augments the Efficacy of Rapamycin in Suppressing Proliferation of Epstein−Barr Virus (EBV)+ B Cell Lymphomas

(2013) S. Furukawa et al.   AMERICAN JOURNAL OF TRANSPLANTATION

T Cell Replicative Senescence in Human Aging

(2013) Jennifer P. Chou et al.   CURRENT PHARMACEUTICAL DESIGN

2013 Annual Meeting: Regulation & Dysregulation of Immunity

(2013)   JOURNAL OF CLINICAL IMMUNOLOGY

Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency

(2013) Carrie L Lucas et al.   NATURE IMMUNOLOGY

Phosphoinositide 3-Kinase   Gene Mutation Predisposes to Respiratory Infection and Airway Damage

(2013) I. Angulo et al.   SCIENCE

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Protein kinase inhibitors that inhibit induction of lytic program and replication of Epstein–Barr virus

(2012) R. Goswami et al.   ANTIVIRAL RESEARCH

Expansion of somatically reverted memory CD8+T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus

(2012) Umaimainthan Palendira et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adoptive immunotherapy with unselected or EBV-specific T cells for biopsy-proven EBV+ lymphomas after allogeneic hematopoietic cell transplantation

(2011) E. Doubrovina et al.   BLOOD

Long-term carriers generate Epstein-Barr virus (EBV)-specific CD4+ and CD8+ polyfunctional T-cell responses which show immunodominance hierarchies of EBV proteins

(2011) Raymond J. Ning et al.   IMMUNOLOGY

Tumor-induced changes in the phenotype of blood-derived and tumor-associated T cells of early stage breast cancer patients

(2011) I. Poschke et al.   INTERNATIONAL JOURNAL OF CANCER

Syk Activation of Phosphatidylinositol 3-Kinase/Akt Prevents HtrA2-dependent Loss of X-linked Inhibitor of Apoptosis Protein (XIAP) to Promote Survival of Epstein-Barr Virus+ (EBV+) B Cell Lymphomas

(2011) Olivia Hatton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy

(2011) M V Astle et al.   ONCOGENE

Impaired Epstein-Barr virus-specific CD8+ T-cell function in X-linked lymphoproliferative disease is restricted to SLAM family-positive B-cell targets

(2010) A. D. Hislop et al.   BLOOD

Immature and Transitional B Cells Are Latency Reservoirs for a Gammaherpesvirus

(2010) C. B. Coleman et al.   JOURNAL OF VIROLOGY

Epstein-Barr virus colonization of tonsillar and peripheral blood B-cell subsets in primary infection and persistence

(2009) S. Chaganti et al.   BLOOD

Akt Activation Synergizes with Trp53 Loss in Oral Epithelium to Produce a Novel Mouse Model for Head and Neck Squamous Cell Carcinoma

(2009) M. Moral et al.   CANCER RESEARCH

Phosphatidylinositol 3-Kinase/Akt Pathway Targets Acetylation of Smad3 through Smad3/CREB-binding Protein Interaction

(2009) Lassad Oussaief et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency

(2009) Andrew L. Snow et al.   JOURNAL OF CLINICAL INVESTIGATION

Effect of ageing on CMV-specific CD8 T cells from CMV seropositive healthy donors

(2009) María Pita-Lopez et al.   Immunity & Ageing

Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis

(2008) Veronique Nogueira et al.   CANCER CELL

Tumorigenic activity and therapeutic inhibition of Rheb GTPase

(2008) K. J. Mavrakis et al.   GENES & DEVELOPMENT

SAP-controlled T–B cell interactions underlie germinal centre formation

(2008) Hai Qi et al.   NATURE