Over 1000 genetic loci influencing blood pressure with multiple systems and tissues implicated

Haploinsufficiency of ARHGAP42 is associated with hypertension

(2019) Amanda S. Fjorder et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Recent Findings in the Genetics of Blood Pressure: How to Apply in Practice or Is a Moonshot Required?

(2018) Sandosh Padmanabhan et al.   CURRENT HYPERTENSION REPORTS

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

(2018) Evangelos Evangelou et al.   NATURE GENETICS

Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Jeffrey D Stanaway et al.   LANCET

Trans-ethnic association study of blood pressure determinants in over 750,000 individuals

(2018) Ayush Giri et al.   NATURE GENETICS

Therapeutic potential of ectopic olfactory and taste receptors

(2018) Sung-Joon Lee et al.   NATURE REVIEWS DRUG DISCOVERY

Risk for hypertension crosses generations in the community: a multi-generational cohort study

(2017) Teemu J. Niiranen et al.   EUROPEAN HEART JOURNAL

Global Burden of Hypertension and Systolic Blood Pressure of at Least 110 to 115 mm Hg, 1990-2015

(2017) Mohammad H. Forouzanfar et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Blood pressure–associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding

(2017) Xue Bai et al.   JOURNAL OF CLINICAL INVESTIGATION

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

(2017) Helen R Warren et al.   NATURE GENETICS

Association analyses based on false discovery rate implicate new loci for coronary artery disease

(2017) Christopher P Nelson et al.   NATURE GENETICS

The Encyclopedia of DNA elements (ENCODE): data portal update

(2017) Carrie A Davis et al.   NUCLEIC ACIDS RESEARCH

Contribution of independent and pleiotropic genetic effects in the metabolic syndrome in a hypertensive rat

(2017) Man Chun John Ma et al.   PLoS One

New Blood Pressure–Associated Loci Identified in Meta-Analyses of 475 000 IndividualsCLINICAL PERSPECTIVE

(2017) Aldi T. Kraja et al.   Circulation-Cardiovascular Genetics

ANTXR2 Knock-Out Does Not Result in the Development of Hypertension in Rats

(2016) Xiaoyan Liu et al.   AMERICAN JOURNAL OF HYPERTENSION

Vascular Biology of Glucagon Receptor Superfamily Peptides: Mechanistic and Clinical Relevance

(2016) Gemma Pujadas et al.   ENDOCRINE REVIEWS

A blood pressure-associated variant of theSLC39A8gene influences cellular cadmium accumulation and toxicity

(2016) Ruoxin Zhang et al.   HUMAN MOLECULAR GENETICS

Million Veteran Program: A mega-biobank to study genetic influences on health and disease

(2016) John Michael Gaziano et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci

(2016) Chunyu Liu et al.   NATURE GENETICS

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

(2016) Praveen Surendran et al.   NATURE GENETICS

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

(2016) Georg B Ehret et al.   NATURE GENETICS

Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation

(2016) Thomas J Hoffmann et al.   NATURE GENETICS

The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)

(2016) Jacqueline MacArthur et al.   NUCLEIC ACIDS RESEARCH

A Compendium of Chromatin Contact Maps Reveals Spatially Active Regions in the Human Genome

(2016) Anthony D. Schmitt et al.   Cell Reports

Direct effect of incretin hormones on glucose and glycerol metabolism and hemodynamics

(2015) Kristian Karstoft et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Genotyping Informatics and Quality Control for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort

(2015) Mark N. Kvale et al.   GENETICS

Lymphocyte adaptor protein LNK deficiency exacerbates hypertension and end-organ inflammation

(2015) Mohamed A. Saleh et al.   JOURNAL OF CLINICAL INVESTIGATION

A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease

(2015) Majid Nikpay et al.   NATURE GENETICS

Direct Estimates of the Genomic Contributions to Blood Pressure Heritability within a Population-Based Cohort (ARIC)

(2015) Elias Salfati et al.   PLoS One

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

(2015) et al.   SCIENCE

Exploring hypertension genome-wide association studies findings and impact on pathophysiology, pathways, and pharmacogenetics

(2015) Claudia P Cabrera et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Mutation within the hinge region of the transcription factor Nr2f2 attenuates salt-sensitive hypertension

(2015) Sivarajan Kumarasamy et al.   Nature Communications

Biological interpretation of genome-wide association studies using predicted gene functions

(2015) Tune H. Pers et al.   Nature Communications

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

(2015) Cathie Sudlow et al.   PLOS MEDICINE

Genotyping Informatics and Quality Control for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort

(2015) Mark N. Kvale et al.   GENETICS

Effects of Long-Term Averaging of Quantitative Blood Pressure Traits on the Detection of Genetic Associations

(2014) Santhi K. Ganesh et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Gene-Age Interactions in Blood Pressure Regulation: A Large-Scale Investigation with the CHARGE, Global BPgen, and ICBP Consortia

(2014) Jeannette Simino et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci

(2014) Vinicius Tragante et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genome-wide Association Analysis of Blood-Pressure Traits in African-Ancestry Individuals Reveals Common Associated Genes in African and Non-African Populations

(2013) Nora Franceschini et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Advances in Blood Pressure Genomics

(2013) Patricia B. Munroe et al.   CIRCULATION RESEARCH

Loci influencing blood pressure identified using a cardiovascular gene-centric array

(2013) Santhi K. Ganesh, Vinicius Tragante, Wei Guo, Yiran Guo, Matthew B. Lanktree, Erin N. Smith, Toby Johnson, Berta Almoguera Castillo, John Barnard, Jens Baumert, Yen-Pei Christy Chang, Clara C. Elbers, Martin Farrall, Mary E. Fischer, Nora Franceschini, Tom R. Gaunt, Johannes M.I.H. Gho, Christian Gieger, Yan Gong, Aaron Isaacs, Marcus E. Kleber, Irene Mateo Leach, Caitrin W. McDonough, Matthijs F.L. Meijs, Olle Mellander, Cliona M. Molony, Ilja M. Nolte, Sandosh Padmanabhan, Tom S. Price, Ramakrishnan Rajagopalan, Jonathan Shaffer, Sonia Shah, Haiqing Shen, Nicole Soranzo, Peter J. van der Most, Erik P.A. Van Iperen, Jessic A. Van Setten, Judith M. Vonk, Li Zhang, Amber L. Beitelshees, Gerald S. Berenson, Deepak L. Bhatt, Jolanda M.A. Boer, Eric Boerwinkle, Ben Burkley, Amber Burt, Aravinda Chakravarti, Wei Chen, Rhonda M. Cooper-DeHoff, Sean P. Curtis, Albert Dreisbach, David Duggan, Georg B. Ehret, Richard R. Fabsitz, Myriam Fornage, Ervin Fox, Clement E. Furlong, Ron T. Gansevoort, Marten H. Hofker, G. Kees Hovingh, Susan A. Kirkland, Kandice Kottke-Marchant, Abdullah Kutlar, Andrea Z. LaCroix, Taimour Y. Langaee, Yun R. Li, Honghuang Lin, Kiang Liu, Steffi Maiwald, Rainer Malik, Gurunathan Murugesan, Christopher Newton-Cheh, Jeffery R. O'Connell, N. Charlotte Onland-Moret, Willem H. Ouwehand et al.   HUMAN MOLECULAR GENETICS

Validation of Uromodulin as a Candidate Gene for Human Essential Hypertension

(2013) Lesley A. Graham et al.   HYPERTENSION

Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data

(2013) Joshua C Denny et al.   NATURE BIOTECHNOLOGY

Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression

(2013) Matteo Trudu et al.   NATURE MEDICINE

Effects of smell loss (hyposmia) on salt usage

(2013) Robert I. Henkin   NUTRITION

Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation

(2013) Jennifer L. Pluznick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of 9p21.3 Coronary Artery Disease Locus Neighboring Genes on Atherosclerosis in Mice

(2012) Juyong Brian Kim et al.   CIRCULATION

Endothelial Cells Are Able to Synthesize and Release Catecholamines Both In Vitro and In Vivo

(2012) Daniela Sorriento et al.   HYPERTENSION

Glucose-Dependent Insulinotropic Polypeptide Prevents the Progression of Macrophage-Driven Atherosclerosis in Diabetic Apolipoprotein E-Null Mice

(2012) Yukinori Nogi et al.   PLoS One

Blood Pressure Loci Identified with a Gene-Centric Array

(2011) Toby Johnson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Association of Hypertension Drug Target Genes With Blood Pressure and Hypertension in 86 588 Individuals

(2011) Andrew D. Johnson et al.   HYPERTENSION

Activation of the Bumetanide-sensitive Na+,K+,2Cl−Cotransporter (NKCC2) Is Facilitated by Tamm-Horsfall Protein in a Chloride-sensitive Manner

(2011) Kerim Mutig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

(2011) Georg B. Ehret et al.   NATURE

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

(2011) Louise V Wain et al.   NATURE GENETICS

Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians

(2011) Norihiro Kato et al.   NATURE GENETICS

REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms

(2011) Fran Supek et al.   PLoS One

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

Blood Pressure and Hypertension Are Associated With 7 Loci in the Japanese Population

(2010) Fumihiko Takeuchi et al.   CIRCULATION

The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis

(2010) A Alcina et al.   GENES AND IMMUNITY

Discovery and replication of novel blood pressure genetic loci in the Womenʼs Genome Health Study

(2010) Jennifer E Ho et al.   JOURNAL OF HYPERTENSION

ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

(2010) K. Wang et al.   NUCLEIC ACIDS RESEARCH

Genome-Wide Association Study of Blood Pressure Extremes Identifies Variant near UMOD Associated with Hypertension

(2010) Sandosh Padmanabhan et al.   PLoS Genetics

Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

(2009) Daniel F Gudbjartsson et al.   NATURE GENETICS

A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits

(2009) Yoon Shin Cho et al.   NATURE GENETICS

Genome-wide association study identifies eight loci associated with blood pressure

(2009) Christopher Newton-Cheh et al.   NATURE GENETICS

Genome-wide association study of blood pressure and hypertension

(2009) Daniel Levy et al.   NATURE GENETICS

Prevalence of primary hyperaldosteronism in resistant hypertension: a retrospective observational study

(2008) Stella Douma et al.   LANCET

Newly identified genetic risk variants for celiac disease related to the immune response

(2008) Karen A Hunt et al.   NATURE GENETICS