Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

PhenoScanner: a database of human genotype–phenotype associations

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Retinoblastoma-associated protein 140 as a candidate for a novel etiological gene to hypertension

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An Update on Nutrients and Blood Pressure

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Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis

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Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci

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Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

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The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

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Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation

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Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease

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Brain-derived neurotrophic factor modulates angiotensin signaling in the hypothalamus to increase blood pressure in rats

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Targeting transporters: Promoting blood–brain barrier repair in response to oxidative stress injury

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Hypertension

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Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

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Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

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Exploring hypertension genome-wide association studies findings and impact on pathophysiology, pathways, and pharmacogenetics

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Biological interpretation of genome-wide association studies using predicted gene functions

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Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel

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Genome-Wide Association Study with Targeted and Non-targeted NMR Metabolomics Identifies 15 Novel Loci of Urinary Human Metabolic Individuality

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UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

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Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank

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Primary culture of avian embryonic heart forming region cells to study the regulation of vertebrate early heart morphogenesis by vitamin A

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The Airwave Health Monitoring Study of police officers and staff in Great Britain: Rationale, design and methods

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Blood pressure lowering and cardiovascular risk – Authors' reply

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An atlas of genetic influences on human blood metabolites

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Nox4 and redox signaling mediate TGF-β-induced endothelial cell apoptosis and phenotypic switch

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Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease

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ADAMTS7 Cleavage and Vascular Smooth Muscle Cell Migration Is Affected by a Coronary-Artery-Disease-Associated Variant

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Genome-wide association study of coronary and aortic calcification implicates risk loci for coronary artery disease and myocardial infarction

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Advances in Blood Pressure Genomics

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Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration

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Gene expression in peripheral blood of patients with hypertension and patients with type 2 diabetes

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Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders

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Nox4 modulates collagen production stimulated by transforming growth factor β1 in vivo and in vitro

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Vascular Nox4

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Endothelial Nox4 NADPH Oxidase Enhances Vasodilatation and Reduces Blood Pressure In Vivo

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miR-146a is modulated in human endothelial cell with aging

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A coronary artery disease-associated gene product, JCAD/KIAA1462, is a novel component of endothelial cell–cell junctions

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GenomeRunner: automating genome exploration

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Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature

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Genome-wide identification of SNPs in microRNA genes and the SNP effects on microRNA target binding and biogenesis

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Structural abnormalities of small resistance arteries in essential hypertension

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Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians

(2011) Norihiro Kato et al.   NATURE GENETICS

Phosphodiesterase 10A Upregulation Contributes to Pulmonary Vascular Remodeling

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METAL: fast and efficient meta-analysis of genomewide association scans

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Transcriptional Upregulation of Brain-Derived Neurotrophic Factor in Rostral Ventrolateral Medulla by Angiotensin II

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Metabolic Profiling and the Metabolome-Wide Association Study: Significance Level For Biomarker Identification

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GREAT improves functional interpretation of cis-regulatory regions

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ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

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Accumulation of common polymorphisms is associated with development of hypertension: a 12-year follow-up from the Ohasama study

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Elevated levels of activin A in clinical and experimental pulmonary hypertension

(2009) Arne Yndestad et al.   JOURNAL OF APPLIED PHYSIOLOGY

Genome-wide association study identifies eight loci associated with blood pressure

(2009) Christopher Newton-Cheh et al.   NATURE GENETICS

Genome-wide association study of blood pressure and hypertension

(2009) Daniel Levy et al.   NATURE GENETICS

Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2  mutation

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The UK Biobank sample handling and storage protocol for the collection, processing and archiving of human blood and urine

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