Exploring hypertension genome-wide association studies findings and impact on pathophysiology, pathways, and pharmacogenetics

Effects of Long-Term Averaging of Quantitative Blood Pressure Traits on the Detection of Genetic Associations

(2014) Santhi K. Ganesh et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Gene-Age Interactions in Blood Pressure Regulation: A Large-Scale Investigation with the CHARGE, Global BPgen, and ICBP Consortia

(2014) Jeannette Simino et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci

(2014) Vinicius Tragante et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Novel and Nonpharmacologic Approaches to Cardio-Protection in Hypertension

(2014) Luca Donazzan et al.   CURRENT HYPERTENSION REPORTS

Identifying Common Genetic Variants in Blood Pressure Due to Polygenic Pleiotropy With Associated Phenotypes

(2014) Ole A. Andreassen et al.   HYPERTENSION

Genome-wide Association Analysis of Blood-Pressure Traits in African-Ancestry Individuals Reveals Common Associated Genes in African and Non-African Populations

(2013) Nora Franceschini et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Advances in Blood Pressure Genomics

(2013) Patricia B. Munroe et al.   CIRCULATION RESEARCH

Pleiotropic effects of obesity-susceptibility loci on metabolic traits: a meta-analysis of up to 37,874 individuals

(2013) J. V. van Vliet-Ostaptchouk et al.   DIABETOLOGIA

Loci influencing blood pressure identified using a cardiovascular gene-centric array

(2013) Santhi K. Ganesh, Vinicius Tragante, Wei Guo, Yiran Guo, Matthew B. Lanktree, Erin N. Smith, Toby Johnson, Berta Almoguera Castillo, John Barnard, Jens Baumert, Yen-Pei Christy Chang, Clara C. Elbers, Martin Farrall, Mary E. Fischer, Nora Franceschini, Tom R. Gaunt, Johannes M.I.H. Gho, Christian Gieger, Yan Gong, Aaron Isaacs, Marcus E. Kleber, Irene Mateo Leach, Caitrin W. McDonough, Matthijs F.L. Meijs, Olle Mellander, Cliona M. Molony, Ilja M. Nolte, Sandosh Padmanabhan, Tom S. Price, Ramakrishnan Rajagopalan, Jonathan Shaffer, Sonia Shah, Haiqing Shen, Nicole Soranzo, Peter J. van der Most, Erik P.A. Van Iperen, Jessic A. Van Setten, Judith M. Vonk, Li Zhang, Amber L. Beitelshees, Gerald S. Berenson, Deepak L. Bhatt, Jolanda M.A. Boer, Eric Boerwinkle, Ben Burkley, Amber Burt, Aravinda Chakravarti, Wei Chen, Rhonda M. Cooper-DeHoff, Sean P. Curtis, Albert Dreisbach, David Duggan, Georg B. Ehret, Richard R. Fabsitz, Myriam Fornage, Ervin Fox, Clement E. Furlong, Ron T. Gansevoort, Marten H. Hofker, G. Kees Hovingh, Susan A. Kirkland, Kandice Kottke-Marchant, Abdullah Kutlar, Andrea Z. LaCroix, Taimour Y. Langaee, Yun R. Li, Honghuang Lin, Kiang Liu, Steffi Maiwald, Rainer Malik, Gurunathan Murugesan, Christopher Newton-Cheh, Jeffery R. O'Connell, N. Charlotte Onland-Moret, Willem H. Ouwehand et al.   HUMAN MOLECULAR GENETICS

Target Sequencing, Cell Experiments, and a Population Study Establish Endothelial Nitric Oxide Synthase ( eNOS ) Gene as Hypertension Susceptibility Gene

(2013) Erika Salvi et al.   HYPERTENSION

Genomic Association Analysis of Common Variants Influencing Antihypertensive Response to Hydrochlorothiazide

(2013) Stephen T. Turner et al.   HYPERTENSION

Validation of Uromodulin as a Candidate Gene for Human Essential Hypertension

(2013) Lesley A. Graham et al.   HYPERTENSION

Atrial natriuretic peptide is negatively regulated by microRNA-425

(2013) Pankaj Arora et al.   JOURNAL OF CLINICAL INVESTIGATION

Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression

(2013) Matteo Trudu et al.   NATURE MEDICINE

DGIdb: mining the druggable genome

(2013) Malachi Griffith et al.   NATURE METHODS

Riociguat for the Treatment of Chronic Thromboembolic Pulmonary Hypertension

(2013) Hossein-Ardeschir Ghofrani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Riociguat for the Treatment of Pulmonary Arterial Hypertension

(2013) Hossein-Ardeschir Ghofrani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Data, information, knowledge and principle: back to metabolism in KEGG

(2013) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

Advancing management of hypertension through pharmacogenomics

(2012) Julie A. Johnson   ANNALS OF MEDICINE

Hypertension Susceptibility Loci and Blood Pressure Response to Antihypertensives

(2012) Yan Gong et al.   Circulation-Cardiovascular Genetics

Performance and Robustness of Penalized and Unpenalized Methods for Genetic Prediction of Complex Human Disease

(2012) Gad Abraham et al.   GENETIC EPIDEMIOLOGY

Mice Lacking Hypertension Candidate Gene ATP2B1 in Vascular Smooth Muscle Cells Show Significant Blood Pressure Elevation

(2012) Yusuke Kobayashi et al.   HYPERTENSION

Genomic Association Analysis Identifies Multiple Loci Influencing Antihypertensive Response to an Angiotensin II Receptor Blocker

(2012) Stephen T. Turner et al.   HYPERTENSION

What makes UK Biobank special?

(2012) Rory Collins   LANCET

An integrated map of genetic variation from 1,092 human genomes

(2012)   NATURE

The human MTHFR rs4846049 polymorphism increases coronary heart disease risk through modifying miRNA binding

(2012) C. Wu et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Gene panels to help identify subgroups at high and low risk of coronary heart disease among those randomized to antihypertensive treatment

(2012) Amy I. Lynch et al.   Pharmacogenetics and Genomics

Association of chromosome 12 locus with antihypertensive response to hydrochlorothiazide may involve differential YEATS4 expression

(2012) J D Duarte et al.   PHARMACOGENOMICS JOURNAL

Can Genetic Pleiotropy Replicate Common Clinical Constellations of Cardiovascular Disease and Risk?

(2012) Omri Gottesman et al.   PLoS One

Elevated blood pressure in cytochrome P4501A1 knockout mice is associated with reduced vasodilation to omega−3 polyunsaturated fatty acids

(2012) Larry N. Agbor et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Blood Pressure Loci Identified with a Gene-Centric Array

(2011) Toby Johnson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Abundant Pleiotropy in Human Complex Diseases and Traits

(2011) Shanya Sivakumaran et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Disruption of Na + ,HCO 3 − Cotransporter NBCn1 (slc4a7) Inhibits NO-Mediated Vasorelaxation, Smooth Muscle Ca 2+ Sensitivity, and Hypertension Development in Mice

(2011) Ebbe Boedtkjer et al.   CIRCULATION

A systematic review on pharmacogenetics in cardiovascular disease: is it ready for clinical application?

(2011) Jeffrey J.W. Verschuren et al.   EUROPEAN HEART JOURNAL

Association of Hypertension Drug Target Genes With Blood Pressure and Hypertension in 86 588 Individuals

(2011) Andrew D. Johnson et al.   HYPERTENSION

Activation of the Bumetanide-sensitive Na+,K+,2Cl−Cotransporter (NKCC2) Is Facilitated by Tamm-Horsfall Protein in a Chloride-sensitive Manner

(2011) Kerim Mutig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

(2011) Georg B. Ehret et al.   NATURE

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

(2011) Louise V Wain et al.   NATURE GENETICS

Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians

(2011) Norihiro Kato et al.   NATURE GENETICS

Integrating Genome-Wide Genetic Variations and Monocyte Expression Data Reveals Trans-Regulated Gene Modules in Humans

(2011) Maxime Rotival et al.   PLoS Genetics

Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis

(2010) A. Hinks et al.   ANNALS OF THE RHEUMATIC DISEASES

Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease

(2010) Dawn M. Waterworth et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations

(2010) J. C. Denny et al.   BIOINFORMATICS

Blood Pressure and Hypertension Are Associated With 7 Loci in the Japanese Population

(2010) Fumihiko Takeuchi et al.   CIRCULATION

Genetics of Hypertension and Cardiovascular Disease and Their Interconnected Pathways: Lessons from Large Studies

(2010) Aldi T. Kraja et al.   CURRENT HYPERTENSION REPORTS

The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis

(2010) A Alcina et al.   GENES AND IMMUNITY

Discovery and replication of novel blood pressure genetic loci in the Womenʼs Genome Health Study

(2010) Jennifer E Ho et al.   JOURNAL OF HYPERTENSION

Genome-Wide Association Study of Blood Pressure Extremes Identifies Variant near UMOD Associated with Hypertension

(2010) Sandosh Padmanabhan et al.   PLoS Genetics

Has pharmacogenetics brought us closer to ‘personalized medicine’ for initial drug treatment of hypertension?

(2009) Donna K Arnett et al.   CURRENT OPINION IN CARDIOLOGY

Uromodulin Levels Associate with a Common UMOD Variant and Risk for Incident CKD

(2009) A. Kottgen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

(2009) Daniel F Gudbjartsson et al.   NATURE GENETICS

A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits

(2009) Yoon Shin Cho et al.   NATURE GENETICS

Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure

(2009) Christopher Newton-Cheh et al.   NATURE GENETICS

Genome-wide association study identifies eight loci associated with blood pressure

(2009) Christopher Newton-Cheh et al.   NATURE GENETICS

Genome-wide association study of blood pressure and hypertension

(2009) Daniel Levy et al.   NATURE GENETICS

Pharmacogenetics of antihypertensive treatment: detailing disciplinary dissonance

(2009) Donna K Arnett et al.   PHARMACOGENOMICS

Role of β adrenergic receptor polymorphisms in heart failure: Systematic review and meta-analysis

(2008) Amal Muthumala et al.   EUROPEAN JOURNAL OF HEART FAILURE

Genomic Association Analysis Suggests Chromosome 12 Locus Influencing Antihypertensive Response to Thiazide Diuretic

(2008) Stephen T. Turner et al.   HYPERTENSION

Newly identified genetic risk variants for celiac disease related to the immune response

(2008) Karen A Hunt et al.   NATURE GENETICS

Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies

(2008) Brendan J. Keating et al.   PLoS One